The document discusses the role of endothelial progenitor cells (EPCs) in atherosclerosis and aging. It summarizes that EPCs help repair damaged endothelial lining and prevent atherosclerosis. However, EPC levels and functionality decline with old age. Lifestyle factors like diet, exercise, and antioxidants as well as EPC therapy may help slow atherosclerosis and aging by maintaining EPC levels and functionality. Many questions remain around optimizing EPC therapy and fully understanding EPC biology.
Patients with systemic autoimmune diseases such as lupus and rheumatoid arthritis have a striking increase in risk to develop vascular complications such as myocardial infarction and stroke. Immune dysregulation characteristic of these diseases appears to play a prominent role in this enhanced risk.
In this presentation, Dr. Mariana Kaplan highlights the role of the immune system in the development of vasculopathy and premature atherosclerosis in systemic autoimmunity and discuss potential strategies to prevent these devastating complications.
Key Topics Include:
- To review the epidemiology of premature vascular disease in systemic autoimmunity
- To review the pathogenic mechanisms that lead to vascular damage in patients with autoimmunity
- To discuss potential therapeutic strategies to prevent/treat vascular damage in patients with autoimmune diseases
Patients with systemic autoimmune diseases such as lupus and rheumatoid arthritis have a striking increase in risk to develop vascular complications such as myocardial infarction and stroke. Immune dysregulation characteristic of these diseases appears to play a prominent role in this enhanced risk.
In this presentation, Dr. Mariana Kaplan highlights the role of the immune system in the development of vasculopathy and premature atherosclerosis in systemic autoimmunity and discuss potential strategies to prevent these devastating complications.
Key Topics Include:
- To review the epidemiology of premature vascular disease in systemic autoimmunity
- To review the pathogenic mechanisms that lead to vascular damage in patients with autoimmunity
- To discuss potential therapeutic strategies to prevent/treat vascular damage in patients with autoimmune diseases
Life is extremely precious and no one is guaranteed anything. Injuries, neurological disorders, and autoimmune disorders can make life extremely difficult. If a person has any of these conditions, he or she can be put on a transplant list to be given a second chance.
Stem cells are found in the umbilical cord of a newborn baby and they have been used to treat over 80 diseases. Banking your cord blood is vital because it will give your baby a perfect match for transplant if something should happen later. Your baby’s cord blood could be a possible match for you and for the rest of your family, too.
Our new eBook, the Latest Clinical Update for Stem Cell Therapies, is designed to show you how umbilical cord blood can treat nearly 20 different diseases and disorders. This is just a small insight into the importance of cord blood and why banking can save a family member’s life. With each informed person, more lives are saved.
Health and Sciences has been the ultimate innovators of society, together with research, we could prolong life expectancy globally. Molecular healing is a scientific breakthrough everyone should be knowledgeable with. For more information please message us at m.me/Stemcellinmanila
Get the bone marrow transplant treatment in Delhi by best doctor / surgeon in world class hospital. We ensure you get the best medical care and even stay in touch for more assistance. website :- http://www.transplantsurgeryindia.com/bone-marrow-transplants/
Life is extremely precious and no one is guaranteed anything. Injuries, neurological disorders, and autoimmune disorders can make life extremely difficult. If a person has any of these conditions, he or she can be put on a transplant list to be given a second chance.
Stem cells are found in the umbilical cord of a newborn baby and they have been used to treat over 80 diseases. Banking your cord blood is vital because it will give your baby a perfect match for transplant if something should happen later. Your baby’s cord blood could be a possible match for you and for the rest of your family, too.
Our new eBook, the Latest Clinical Update for Stem Cell Therapies, is designed to show you how umbilical cord blood can treat nearly 20 different diseases and disorders. This is just a small insight into the importance of cord blood and why banking can save a family member’s life. With each informed person, more lives are saved.
Health and Sciences has been the ultimate innovators of society, together with research, we could prolong life expectancy globally. Molecular healing is a scientific breakthrough everyone should be knowledgeable with. For more information please message us at m.me/Stemcellinmanila
Get the bone marrow transplant treatment in Delhi by best doctor / surgeon in world class hospital. We ensure you get the best medical care and even stay in touch for more assistance. website :- http://www.transplantsurgeryindia.com/bone-marrow-transplants/
Biochemistry of Aging
Presented by Shanzay Annum Malik
Aging
Gradual change in an organism that leads to increased risk of weakness, disease, and death over the entire adult life span of any living thing.
There is a decline in biological functions and in ability to adapt to metabolic stress.
Changes in organs include
reduced immunity,
loss of muscle strength,
decline in memory and cognition,
loss of colour in the hair
elasticity in the skin.
Gerontology and Geriatrics
Gerontology is concerned with the changes that occur between maturity and death along with factors that influence these changes.
Geriatrics focuses on health care of elderly people and promote health by preventing and treating diseases and disabilities in older adults.
Factors of Aging
Mitochondria: main unit of chemical power supply
During the synthesis of macroergical bio-molecules(high energy releasing potentials e.g. ATP) free radicals are being produced as the by-product.
Free radicals released in large quantities cause intercellular oxidative stress (e.g. oxidative damage of mitochondria)
damaging mitochondria and cause early apoptosis
Free radical
A molecule that contains one or more unpaired electrons &is capable of independent existence.
Eg : Superoxide H2O2,
hydroperoxy radical (HOO+2 )
lipid peroxideradical (ROO)
Nitric oxide (NO)
Harmful effect of free radicals
Because of their reactive nature, free radical can provoke inflammation or altered cellular function through
Lipid peroxidation
Protein modification
DNA modification
Lipid peroxidation product:
React with amino acid mainly CYS, HIS,LYS to modify protein structure & function.
Can crosslink lipid in cell membrane interrupting structure & fluidity.
Protein modification
DNA modification :
Free radical induced DNA damage includes
strand break.
DNA protein crosslink.
large range of base & sugar modification.
Telomeres
Repetitive DNA sequences at the ends of all human chromosomes
aging cells have shorter telomeres
length differs between species
in humans 8-14kb long
Telomeres are thought to be the "clock" that regulates how many times an individual cell can divide.
Telomeric sequences shorten each time the DNA replicates.
Once the telomere shrinks to a certain level, the cell can no longer divide. Its metabolism slows down, it ages, and dies
Apoptosis and Necrosis
There are two ways that a cell can die:
Necrosis occurs when a cell is damaged by an external force, such as poison, a bodily injury, an infection or getting cut off from the blood supply (which might occur during a heart attack or stroke). When cells die from necrosis, it's a rather messy affair. The death causes inflammation that can cause further distress or injury within the body.
Apoptosis or programmed cell death
When a cell is compelled to commit suicide proteins called caspases go into action.
They break down the cellular components needed for surviva
The Aging process is a broad topic. This power point hopes to help you understand the process and what can be done to help you age gracefully and positively.
Dr. David Steenblock has been specializing in regenerative medicine for over 40 years. This power point discusses how stem cells can regenerate the body and help you heal. To learn more about stem cell treatments, call 1-800-300-1063.
Treatment for congestive heart failure with stem cellsSriramNagarajan16
Heart failure is one of the leading death causes in world which records nearly 20% of deaths in India. Medical therapy,
surgical procedures including heart transplantation and cardiac assist devices has only limited efficiency in such condition
stem cell therapy represents as the new strategy for better therapeutic outcome. Generally stem cells are derived from few
and they generated various organs and tissues. Few scientist has performed research on the stem cell therapy for congestive
heart failure condition some of them has shown a good effect. Scientist has to keep effects regarding the development of the
cell regeneration therapy with the use of stem cells. Currently in global clinical trails only few trails has been enrolled. At
present BMMNC has shown a good effect in heart related treatment.
That’s important because right now, doctors have to rely on a set of 11 criteria, which can overlap with many other diseases, to try to make a diagnosis.
“It is one of the most complex clinical diagnoses,” says Pascual, who is also a practicing pediatric rheumatologist.
“It might lead to better diagnostic tests, but we don’t know that yet,” Pascual says. Other experts say the discoveries will most certainly lead to new drug targets.
Systemic lupus erythematosus (also called SLE or lupus)
is an autoimmune condition. The normal role of your
body’s immune system is to fight off infections and
diseases to keep you healthy. In an autoimmune disease
like lupus, your immune system starts attacking your
own healthy tissues. For some people lupus may just
affect the skin and/or joints. In other people the lungs,
kidneys, blood vessels,
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
How to Give Better Lectures: Some Tips for Doctors
The Role of EPC in Old Age and Atherosclerosis
1. The Role of EPC in Old Age and Atherosclerosis Dr.Boenjamin Setiawan, Ph.D. 25 October 2008
2.
3. TEN LEADING CAUSES OF DEATH IN THE U.S.A., 2004 Heart disease is the leading cause of death of Americans 24 years of age and older, 30.3% or 724,269 annual deaths are due to heart disease. Sixteen percent of those deaths, 115,883, occur in smokers. Cancer is the second leading cause of death causing 23% or 538,947 deaths. Twenty-three percent of those are lung cancer, 83% of lung cancers occur in smokers and exsmokers (101, 724).
4. Ten leading causes of death, all WHO member states, 2000 TEN LEADING CAUSES OF DEATH, ALL WHO MEMBER STATES, 2000 2.2% (10) Trachea, Bronchus, Lung Cancers 2.3% (9) Road Traffic Injuries 3.0% (8) Tuberculosis 3.8% (7) Diarrhoeal Diseases 4.4% (6) Perinatal conditions 4.5% (5) Chronic Obstructive Pulmonary Disease 5.3% (4) HIV/AIDS 6.9% (3) Lower Respiratory Infections 9.2% (2) Cerebrovascular Disease 12.4% (1) Ischemic Heart Disease PERCENT OF TOTAL CAUSE
7. Multiple embryos are produced in vitro for clinical purposes. Donated surplus embryos are used as a source of ES cells. These surplus embryos would otherwise be discarded or remain unused How are ES Cells Generated?
9. Harvesting ES Cells The blastocyst is the stage of development (~1,000 cells) at which the embryos inner cell mass (ICM) forms. It is the ICM that harbors ES cells. Stem cells exist only fleetingly at this stage of development
10. Generating an ES Cell Line The trophoblast is removed from the embryo, the inner cell mass is isolated and, using a micropipette, ES cells are extracted and placed in tissue culture. These cells are passaged for many generations until some spontaneously form “immortal” lines
11. Stem Cells are taken from the Inner Cell Mass at the blastocyst stage and cultured in a Petri disk
21. World’s oldest person celebrates 129 th birthday, died March 2007 According to national records, Hernandez was born on May 3, 1878, in one of the country's central provinces, where she gave birth to 13 children. She now has 60 grandchildren, 80 great-grandchildren and 25 great-great grandchildren.
23. FIGURE 2. Variation of maximal lifespan across species. From the following article: Stem cells, ageing and the quest for immortality Thomas A. Rando Nature 441, 1080-1086 (29 June 2006) doi:10.1038/nature04958
24. Stem cells, ageing and the quest for immortality Thomas A. Rando Influence on Stem Cell Functionality
28. Figure 1. Origin and differentiation of endothelial progenitor cells . Scheme depicts the potential origin and differentiation of endothelial progenitor
33. Figure 2. Sustained ROS signaling induces senescence of endothelial cells. Left, This is reflected in detachment of endothelial cells or parts of the endothelial cell membrane (endothelial microparticles). Right, With increasing age and persisting ROS signaling, the capacity of neighboring endothelial cells to repair the endothelial injury is limited, and vascular integrity becomes dependent on the incorporation of circulating PC
42. Spinal Cord Injuries seminar Active Aging 17 Juli 2008 dr.Boenjamin Setiawan, Ph.D. Hwang Mi-Soon: South Korea Paralyzed 19 years Multipotent adult stem cells injected into her spinal cord Currently: debilitating pain Published in 2005 ( Cytotherapy )
45. Figure 1 Possible influences of age on endothelial progenitor levels. VEGF = vascular endothelial growth factor.
46. Fig. 1 Regeneration of the endothelial monolayer after injury. After induction of endothelial injury ( 1 ) two possibilities exist to regenerate the injured endothelial monolayer ( 2 , 3 ). 2 Regeneration by mature endothelial cells which migrate and proliferate to regenerate the endothelial layer. 3 Regeneration by bone marrow derived endothelial progenitor cells
47.
48. Fig. 3 Possible targets of risk factors for coronary artery disease to reduce circulating endothelial progenitor cells ( 1 – 4 ). Risk factors for coronary artery disease may interfere with hematopoietic stem cells in the bone marrow, reducing mobilization or affecting survival and differentiation of circulating progenitor cells. Additionally, risk factors such as age may also reduce homing by reducing stimulatory factors such as VEGF and the block receptor independent kinases
52. Fig. 2 Different effects of physical exercise on redox status of the cell. Abbreviations: ROS, reactive oxygen species.
53.
54. Figure 1 EPC origins. EPCs could be released from bone marrow, fat tissues, vessel wall, especially adventitia and spleen, liver, and intestine, where they form a circulating EPC pool. They can then contribute to the repair of damaged vessels in pathological conditions.
55. Figure 3 EPC mobilization and differentiation. Schematic graphics summarize cytokines, growth factors, and other mediators inducing EPC release from tissues and homing to the surface of arteries where endothelial cells are damaged. After attachment to the vessel wall, EPCs differentiate into endothelial cells induced by the micro-environment.