1) Neurons maintain a resting potential of around -70 mV through the balanced distribution of ions across the cell membrane. Positively charged potassium (K+) ions are concentrated inside the neuron while positively charged sodium (Na+) and negatively charged chloride (Cl-) ions are concentrated outside.
2) This balance is maintained through the opposing forces of electrostatic attraction/repulsion and concentration gradients, as well as selective permeability of the membrane to different ions. The sodium-potassium pump also works to maintain the balance.
3) When a neuron is at its resting potential, some K+ can leak out while Cl- and Na+ are prevented from entering or leaving due to selective permeability and balancing forces.
My first attempt at this presentation for the IB Diploma Programme Biology course: topic 6.5 neurons and synapses. I'm hoping another great educator out there can take this, make it look a lot better, and then share it :)
Thanks to Steven Taylor and Chris Paine for all of their work and inspiration.
Please download and modify as you wish.
final note: I actually made this in google slides - I just checked the presentation and none of the links to the videos I used are there. Here is a link to the google slide presentation so you can find the videos: https://docs.google.com/a/igbis.edu.my/presentation/d/1eabpxEtwlDGt7EPRqQ_GPwxUBerszZQquWAhjRnU_WE/edit?usp=sharing
these slides contain a brief introduction of neurons and its classification as well as details of generation of action potential, resting potential and eletrotonic potential.
It is over 60 years since Hodgkin and
Huxley1 made the first direct recording of
the electrical changes across the neuronal
membrane that mediate the action
potential. Using an electrode placed inside a
squid giant axon they were able to measure a
transmembrane potential of around 260 mV
inside relative to outside, under resting
conditions (this is called the resting membrane
potential). The action potential is a
transient (,1 millisecond) reversal in the
polarity of this transmembrane potential
which then moves from its point of initiation,
down the axon, to the axon terminals. In a
subsequent series of elegant experiments
Hodgkin and Huxley, along with Bernard
Katz, discovered that the action potential
results from transient changes in the permeability
of the axon membrane to sodium (Na+)
and potassium (K+) ions. Importantly, Na+ and
K+ cross the membrane through independent
pathways that open in response to a change
in membrane potential.
As testimony to their pioneering work, the
fundamental mechanisms described by
Hodgkin, Huxley and Katz remain applicable
to all excitable cells today. Indeed, the
predictions they made about the molecular
mechanisms that might underlie the changes
in membrane permeability showed remarkable
foresight. The molecular basis of the action
potential lies in the presence of proteins
called ion channels that form the permeation
pathways across the neuronal membrane.
Although the first electrophysiological
recordings from individual ion channels were
not made until the mid 1970s,2 Hodgkin and
Huxley predicted many of the properties now
known to be key components of their
function: ion selectivity, the electrical basis
of voltage-sensitivity and, importantly, a
mechanism for quickly closing down the
permeability pathways to ensure that the
action potential only moves along the axon in
one direction.
My first attempt at this presentation for the IB Diploma Programme Biology course: topic 6.5 neurons and synapses. I'm hoping another great educator out there can take this, make it look a lot better, and then share it :)
Thanks to Steven Taylor and Chris Paine for all of their work and inspiration.
Please download and modify as you wish.
final note: I actually made this in google slides - I just checked the presentation and none of the links to the videos I used are there. Here is a link to the google slide presentation so you can find the videos: https://docs.google.com/a/igbis.edu.my/presentation/d/1eabpxEtwlDGt7EPRqQ_GPwxUBerszZQquWAhjRnU_WE/edit?usp=sharing
these slides contain a brief introduction of neurons and its classification as well as details of generation of action potential, resting potential and eletrotonic potential.
It is over 60 years since Hodgkin and
Huxley1 made the first direct recording of
the electrical changes across the neuronal
membrane that mediate the action
potential. Using an electrode placed inside a
squid giant axon they were able to measure a
transmembrane potential of around 260 mV
inside relative to outside, under resting
conditions (this is called the resting membrane
potential). The action potential is a
transient (,1 millisecond) reversal in the
polarity of this transmembrane potential
which then moves from its point of initiation,
down the axon, to the axon terminals. In a
subsequent series of elegant experiments
Hodgkin and Huxley, along with Bernard
Katz, discovered that the action potential
results from transient changes in the permeability
of the axon membrane to sodium (Na+)
and potassium (K+) ions. Importantly, Na+ and
K+ cross the membrane through independent
pathways that open in response to a change
in membrane potential.
As testimony to their pioneering work, the
fundamental mechanisms described by
Hodgkin, Huxley and Katz remain applicable
to all excitable cells today. Indeed, the
predictions they made about the molecular
mechanisms that might underlie the changes
in membrane permeability showed remarkable
foresight. The molecular basis of the action
potential lies in the presence of proteins
called ion channels that form the permeation
pathways across the neuronal membrane.
Although the first electrophysiological
recordings from individual ion channels were
not made until the mid 1970s,2 Hodgkin and
Huxley predicted many of the properties now
known to be key components of their
function: ion selectivity, the electrical basis
of voltage-sensitivity and, importantly, a
mechanism for quickly closing down the
permeability pathways to ensure that the
action potential only moves along the axon in
one direction.
Nerve Impulse is defined as a wave of electrical chemical changes across the neuron that helps in the generation of the action potential in response to the stimulus. This transmission of a nerve impulse across the neuron membrane as a result of a change in membrane potential is known as Nerve impulse conduction.
Mechanism of Nerve Impulse Conduction
Nerve impulse conduction is a major process occurring in the body responsible for organized functions of the body. So, for conduction of nerve impulse there are two mechanisms:
Continuous conduction
Saltatory conduction
Nerve Impulse is defined as a wave of electrical chemical changes across the neuron that helps in the generation of the action potential in response to the stimulus. This transmission of a nerve impulse across the neuron membrane as a result of a change in membrane potential is known as Nerve impulse conduction.
Mechanism of Nerve Impulse Conduction
Nerve impulse conduction is a major process occurring in the body responsible for organized functions of the body. So, for conduction of nerve impulse there are two mechanisms:
Continuous conduction
Saltatory conduction
Why do ion channels not function like open poresWhat is membrane .pdfjaronkyleigh59760
Why do ion channels not function like open pores?
What is membrane potential?
How do K+ leak channels work? Why is the membrane potential of a resting cell negative?
What is patch clamp recording? What is one of the major insights gained from patch clamp
reporting experiments?
Compare and contrast the three types of gated ion channels.
Be familiar with the different parts of a neuron.
During an action potential, what happens to the membrane potential, voltage-gated Na+
channels, Na+ ions, voltage gated K+ channels, K+ ions, and Na+-K+ ion pumps?
When an action potential reaches a synapse, what happens to the Ca2+ channels, Ca2+ ions,
neurotransmitters, transmitter-gated ion channels, and the post synaptic neuron?
What effect do excitatory or inhibitory neurotransmitters have on postsynaptic cells?
What is an example of a mechanically gated ion channel?
Solution
1.Excitable cells, such as fast-acting neurons and muscle cells, have specialized channels that
open in response to a signal and permit rapid ion movement across the cell membrane. The
opening of just a single ion channel alters the electrical charge on both sides of the membrane.
The resulting charge differential then causes adjacent voltage-sensitive channels to open in
chain-reaction fashion, creating a self-propagating electrical signal that travels down the entire
length of the cell. Sometimes, this sequence of events is triggered when a chemical signal —
such as a neurotransmitter — binds to an ion channel receptor on cell\'s surface. Other times, a
cell\'s ion channels open in response to mechanical (rather than chemical) stimuli.
2.In cells of all types, there is an electrical potential difference between the inside of the cell and
the surrounding extracellular fluid. This is termed the membrane potential of the cell. When a
nerve or muscle cell is at \"rest\", its membrane potential is called the resting membrane
potential. In a typical neuron, this is about –70 millivolts (mV). The minus sign indicates that the
inside of the cell is negative with respect to the surrounding extracellular fluid.
3.The leak channels allow K+ to move across the cell membrane down their gradients (from a
high concentration toward a lower concentration).
With the combined ion pumping and leakage of ions, the cell can maintain a stable resting
membrane potential and create membrane potential of a resting cell negative.
4.Patch clamp recording is an extremely useful technique for investigating the biophysical
properties of the ion channels that control neuronal activation.
The procedure involves pressing a glass micropipette against a cell in order to isolate a small
“patch” of membrane that contains one or more ion channels.
The experimental setup further allows scientists to “clamp” the electrical environment of the
patched area by precisely controlling the voltage across the cell membrane, which, depending on
the ion channels present, impacts the flow of ions through the membrane and allow for int.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
What is the purpose of the Sabbath Law in the Torah. It is interesting to compare how the context of the law shifts from Exodus to Deuteronomy. Who gets to rest, and why?
How to Split Bills in the Odoo 17 POS ModuleCeline George
Bills have a main role in point of sale procedure. It will help to track sales, handling payments and giving receipts to customers. Bill splitting also has an important role in POS. For example, If some friends come together for dinner and if they want to divide the bill then it is possible by POS bill splitting. This slide will show how to split bills in odoo 17 POS.
How to Create Map Views in the Odoo 17 ERPCeline George
The map views are useful for providing a geographical representation of data. They allow users to visualize and analyze the data in a more intuitive manner.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
1. What Neurons Do Resting Potential Adapted from AP Psychology: 2006-2007 Workshop Materials “Special Focus: The Brain, the Nervous System, and Behavior”, Basic Neuroscience. Thomas, David G.
2. Neuron function The function of a neuron is to take in information from the environment or from other neurons, integrate that information, and then send information along to other neurons.
3. Let’s explicate! Environmental input – We’ll leave out external stimuli for now and focus on neuron-to-neuron transmission. Information – Substitute “chemical messengers” Dopamine Seratonin GABA Integrate – To add together, for example, both the excitatory and inhibitory chemical messages.
4. Revised definition The function of a neuron is to take in the chemical messages that other neurons send it, add together the excitatory and inhibitory messages they carry, and pass on chemical messengers to other neurons if the excitation is great enough.
5. How it works Recall 5th grade math. Positive and negative numbers… Say you are the treasurer of an organization, and to aid your bookkeeping you keep a cash box. In that box are two types of paper slips. Some represent debits and are thus negative numbers; others represent deposits and are positive numbers. Figure 1 shows the contents of your treasury box with a net value of –5 dollars. A potential donor has said that, if your club can reach a net value of +5 dollars, she will provide a gift of $1,000. Therefore, adding a deposit slip of +2 dollars nudges you toward that threshold value of +5, while adding a debit slip of –1 or subtracting a deposit slip of +1 pushes you away from the threshold. Figure 1: Treasury Box Analogy This and the other images in this article were created by the author, David G. Thomas.
6. Resting Potential Now let us map our treasury box onto neural function. The box represents a neuron that is a living cell. The debit slips represent molecules within the neuron that carry a negative electrical charge. In real neurons, these negatively charged ions are mostly large protein molecules that cannot move out of the neuron. We will use the symbol –P to refer to these. The deposit slips represent positively charged ions, which can be either potassium or sodium. Potassium ions (which we will abbreviate as +K) are concentrated inside of neurons; sodium ions (+Na) are concentrated outside of neurons. Also concentrated outside are negatively charged chloride ions (–Cl). Although the –P ions always stay inside the neuron, the other three ions can pass through the wall, or membrane, of the cell. Analogous to the treasury box, adding and subtracting these ions will influence the net value, or potential, within the cell. And, as with the treasury box, if that potential becomes positive enough and the threshold value is met, a major event occurs.
7. Resting Potential The delicate balance of these four ions creates what is called the resting potential inside the neuron. This means that when no information (no excitatory or inhibitory chemical messenger) is picked up by the neuron, the four ions are in equilibrium. -P = negatively charge Proteins inside the neuron. Cannot pass through the cell membrane. +K = Potassium ions. Concentrated inside the neuron, can pass through membrane. +Na = Sodium ions. Concentrated outside the neuron, can pass through membrane. -Cl = Chloride ions Concentrated outside neuron, can pass through membrane.
8. Resting Potential We should call this a dynamic equilibrium because three major forces are at work here that produce the delicate balance. The first force is called electrostatic pressure and can best be described as “opposites attract,” meaning that areas of negative charge, like the –70 mV charge inside the neuron, attract positively charged ions like +Na. Conversely, charges that are alike repel each other. The –70 mV resting potential within the neuron repels the negatively charged chloride ions (–Cl). The second force of this dynamic equilibrium is the tendency for molecules to move from areas of high concentration to areas of lower concentration. Therefore, since –Cl ions are concentrated outside of the neuron, they will tend to move into the cell where there are few –Cl ions.
9.
10. Notice now +Na. We can see that both forces are acting on +Na ions to push them into the neuron. Why, then, is our –70 mV electrical potential not quickly drained in a manner similar to what would occur if the two terminals of a car battery were connected by a wire?
11. The answer is that the permeability of the membrane at rest is very low for Na+ ions, while it is relatively high for +K (and –Cl). Figure 2: The Four Ions That Determine the Resting Potential