What you eat, drink and how you move can radically influence the health and happiness of your joints! Learn how to make powerful science based decisions about your personal health and keep your joints healthy and pain free.
This workshop is delivered by Dr. Daniel Santa Mina, a Registered Kinesiologist and Certified Exercise Physiologist with specialization in oncology. Dr. Daniel Santa Mina is a Scientist at the Princess Margaret Cancer Centre where he leads the Wellness and Exercise for Cancer Survivors Program (WE-Can) and an Assistant Professor in the Faculty of Kinesiology and Physical Education at the University of Toronto. His main areas of clinical-research focus are on the physiological, functional, and psychosocial effects of exercise for cancer survivors.
The Challenges of Sarcopenia: Definition, Underlying Mechanisms, Intervention...InsideScientific
During this webinar, Drs. Peterson and Guralnik will discuss sarcopenia, the physiological mechanisms underlying the disease, and the current avenues of treatment and assessment that are being researched and developed for patients.
Sarcopenia is the age-related loss of muscle that causes decreased strength and functional limitations. Muscle loss occurs universally in people as we age, but some people lose muscle at an accelerated rate compared to others. While chronic disease can cause sarcopenia, it can also result from a sedentary lifestyle, hospitalizations and extended bed rest due to other conditions.
A gradual decline in muscle mass and strength begins around 30 years of age with this condition, and annual losses get larger throughout life. The self-reporting of functional difficulties to health care providers may give an indication that sarcopenia is present, but a more precise definition is needed for research and clinical use.
Efforts made in Europe and the US have used grip strength, gait speed and lean mass to define sarcopenia, but these definitions lead to large differences in prevalence rate and discordance in who is labelled as “sarcopenic”. To assess this condition, lean mass as measured by dual x-ray absorptiometry (DXA) may not accurately reflect actual muscle mass, but a new technique using dilution of deuterium-labelled creatine may prove to be superior in clinically diagnosing sarcopenia. Currently, a consensus has not been reached on the clinical outcome assessments that can be used by regulatory agencies to judge the effectiveness of drugs for sarcopenia.
A number of potential interventions are being explored to treat sarcopenia in older people, but no drugs are currently approved for this condition. The antidiabetic drug metformin shows promise in preventing many age-associated conditions, but appears to blunt the benefits of exercise on muscle. Senolytic drugs, which clear senescent cells, may improve muscle repair following injury preferentially in older individuals.
This workshop is delivered by Dr. Daniel Santa Mina, a Registered Kinesiologist and Certified Exercise Physiologist with specialization in oncology. Dr. Daniel Santa Mina is a Scientist at the Princess Margaret Cancer Centre where he leads the Wellness and Exercise for Cancer Survivors Program (WE-Can) and an Assistant Professor in the Faculty of Kinesiology and Physical Education at the University of Toronto. His main areas of clinical-research focus are on the physiological, functional, and psychosocial effects of exercise for cancer survivors.
The Challenges of Sarcopenia: Definition, Underlying Mechanisms, Intervention...InsideScientific
During this webinar, Drs. Peterson and Guralnik will discuss sarcopenia, the physiological mechanisms underlying the disease, and the current avenues of treatment and assessment that are being researched and developed for patients.
Sarcopenia is the age-related loss of muscle that causes decreased strength and functional limitations. Muscle loss occurs universally in people as we age, but some people lose muscle at an accelerated rate compared to others. While chronic disease can cause sarcopenia, it can also result from a sedentary lifestyle, hospitalizations and extended bed rest due to other conditions.
A gradual decline in muscle mass and strength begins around 30 years of age with this condition, and annual losses get larger throughout life. The self-reporting of functional difficulties to health care providers may give an indication that sarcopenia is present, but a more precise definition is needed for research and clinical use.
Efforts made in Europe and the US have used grip strength, gait speed and lean mass to define sarcopenia, but these definitions lead to large differences in prevalence rate and discordance in who is labelled as “sarcopenic”. To assess this condition, lean mass as measured by dual x-ray absorptiometry (DXA) may not accurately reflect actual muscle mass, but a new technique using dilution of deuterium-labelled creatine may prove to be superior in clinically diagnosing sarcopenia. Currently, a consensus has not been reached on the clinical outcome assessments that can be used by regulatory agencies to judge the effectiveness of drugs for sarcopenia.
A number of potential interventions are being explored to treat sarcopenia in older people, but no drugs are currently approved for this condition. The antidiabetic drug metformin shows promise in preventing many age-associated conditions, but appears to blunt the benefits of exercise on muscle. Senolytic drugs, which clear senescent cells, may improve muscle repair following injury preferentially in older individuals.
Dr. Vicki Harber of the University of Alberta describes the kind of nutrition female athletes build strong, resilient bodies and stave off the Female Triad: disordered eating, bone loss and dysmenorrhoea.
Osteoporosis is estimated to affect about 200 million women worldwide with more patients from Europe, USA and Japan. Do you knwo that about 1 fracture is taking place every 3 reasons just because of this ailment. This ailment is most affected by womens who are more than 60 years of age and several factors pave the way to this condition and the main reason is the lack of physical activity and low intake of calcium rich diet during the earlier stage of life.
If a person is affected with osteoporosis he / she should take in more calcium and continue with moderate physical activity. Take in dietary products to supplement the lack of calcium in the body and use natural remedies / herbal food supplements to cure it.
The Intersection of Sports and Spine Medicine and Plant Based Nutrition EsserHealth
Whether it is pain, performance or recovery, plant based nutrition has a great deal to offer orthopedic patients. Enjoy reviewing this presentation and learning.
Dr. Vicki Harber of the University of Alberta describes the kind of nutrition female athletes build strong, resilient bodies and stave off the Female Triad: disordered eating, bone loss and dysmenorrhoea.
Osteoporosis is estimated to affect about 200 million women worldwide with more patients from Europe, USA and Japan. Do you knwo that about 1 fracture is taking place every 3 reasons just because of this ailment. This ailment is most affected by womens who are more than 60 years of age and several factors pave the way to this condition and the main reason is the lack of physical activity and low intake of calcium rich diet during the earlier stage of life.
If a person is affected with osteoporosis he / she should take in more calcium and continue with moderate physical activity. Take in dietary products to supplement the lack of calcium in the body and use natural remedies / herbal food supplements to cure it.
The Intersection of Sports and Spine Medicine and Plant Based Nutrition EsserHealth
Whether it is pain, performance or recovery, plant based nutrition has a great deal to offer orthopedic patients. Enjoy reviewing this presentation and learning.
Myths and legacy of exercisemedicine in chronic diseasesAnn Gates
London Sports and Exercise Medicine Presentation.
December 2015.
Copyright Exercise Works Ltd. All rights reserved.
Contact ann@exercise-works.org for permissions.
Prime Fifty UK's only vitamin brand focused on the 50sRichard Chandler
We are committed to making a difference to the lives of the over 50s
Welcome to Prime Fifty, the only brand exclusively dedicated to the nutritional and wellbeing needs of the over 50s.
Benefits of Physical Activities (PA) in Cancer SurvivorsRajat Chauhan
On 4th March 2012, I had the privelege of talking at Asian Breast Cancer Conference. But I wasn't planning on going there and be a yes man.
I took the oncology fraternity to task. If they have known for a long time that exercise and physical activity reduces cancer risk by 25-50% and side effects in survivors from inactivity is as bad as disease itself, then why don't they talk and promote more about it. Only a quarter bring up exercise to their patients. I was looking to get a reaction, whether it be a shoe thrown at me or saying, wow... Let's work together on this... But the audience was very sedated... courtesy the pharmaceutical industry that sponsors conferences like these. There was no response. I finished my talk by saying "my role model is Lance Armstrong, a man who did amazing things in world of sports after he was diagnosed, treated and then survived cancer."
Enjoy the presentation.
29Oct14 - ILC Global Alliance Ageing and Mobility SymposiumILC- UK
This event was a half day symposium which showcased international research by ILC Global Alliance members on frailty and mobility in old age.
This event took place as part of the ILC Global Alliance visit to the UK.
Speakers at the event included:
Rosy Pereyra – ILC-Dominican Republic: Sarcopenia: A forgotten cause of mobility problems in old age
Susana Concordo Harding – ILC-Singapore: Are we living longer and healthier? Exploring gender differences in health expectancy among older Singaporeans
Sebastiana Kalula – ILC-South Africa: Prevalence and risks factors for falls, and the impact on mobility in later life: The Cape Town study
Didier Halimi – ILC-France: MOBILAGE: how to maintain frail people mobility? An ongoing experiment at Broca Hospital in Paris.
Kunio Mizuta – ILC-Japan: Long-term care prevention in Japan: To maintain older people’s mobility
Lia Daichman – ILC-Argentina: Loss of mobility, loss of Autonomy, loss of quality of life
Iva Holmerová – ILC-Czech Republic: Local and national initiatives to support active ageing and improve quality of long-term care in the Czech Republic.
Panel members at the event included: Marieke van der Waal – ILC-Netherlands; Jayant Umranikar – ILC-India
The root cause of chronic diseases, cancer and aging is recently understood. It includes 1- A state of chronic low grade inflammation secondary to hyperglycemia and obesity leading to insulin resistance. 2- Mitochondrial dysfunction. Exercise play a significant rule in the salvage of these problems. Exercise is any bodily activity that enhances or maintain physical fitness and overall health, Exercise with its Countless Benefits is the logical salvage for a group of diseases related to inactivity . In view of the prevalence, global reach and health effect of these physical inactivity related diseases, the issue should be appropriately described as pandemic, with far-reaching health, economic, social and Environmental consequences.These diseases include, Obesity, Coronary artery disease, Diabetes, Hypertension, Cancer, Depression and anxiety, Arthritis, Osteoporosis, Etc, etc, etc… I think we have no option except doing regular exercises if we seriously searching for a salvage to escape the bad and serious consequences of these new life style diseases.
Autoimmune Disease: Understanding the Inflammation WithinEsserHealth
AutoImmune Disease can seem scary, overwhelming and complicated. In this powerpoint we break down the science into applicable nuggets for your life. Enjoy it live on facebooklive as well at esserhealth
The mind is powerful. Emotions are perhaps the most powerful influence of our personal choices every day. As you transition to a more healthy tomorrow, be sure you evaluate your personal thoughts, emotions and feelings on a daily basis. These thoughts and feelings might just be the key to your long term success.
Learn the basics of Diabetes Prevention, reversal and Management. The Science is clear, follow the five key behavior changes to live a diabetes-free life.
Back to the Swing of Things: Golf InjuryEsserHealth
Golf Injury is a real risk of participation, Dr Esser teaches other medical providers about some common golf injuries and both management and prevention in this presentation.
All too often we hear nutrition myths. They confuse many people and result in personal choices that compromise health and increase the risk of disease. In this powerpoint, Dr Esser reviews some foundational and a few specific myths and presents compelling science to set the record straight. Enjoy and remember to keep on asking questions and learning how you can achieve your best health in 2018.
A recent presentation on health and healthy living. Learn how you personal choices just may be the most powerful predictors of your personal health. Be empowered and inspired to achieve your best health in 2018.
Learn why heart disease is a major issue and what you can do to prevent and reverse the number one killer of American's today. Review extensive science and studies demonstrating the effect of nutrient dense foods, exercise and mental health on heart health. Establish your own personal heart health program today.
Many of us know we should eat more of those healthy foods but find it hard to stick with our "healthy" goals. Why is that and what can you do to make maintaining healthy habits easier.
The Ties that Bind: Depression and DisabilityEsserHealth
The Disability status of an individual and their risk of concomitant mental health needs is linked. If you or a loved one are considering going out on " disability" be sure you have the tools to deal with depression and the like. Reach out, find support and be proactive.
Tennis Injuries can keep athletes off the court and unable to achieve their personal on court goals. Learn how to reduce the risk of these injuries and to enhance function.
Conservative Management of Knee osteoarthritisEsserHealth
Osteoarthritis is a major burden on personal health and international health care expenditures. Learn the basics of osteoarthritis and conservative management options for the physician.
What you eat is powerful "medicine." The foods, you choose to eat or to skip can radically influence your risk of disease. Learn what you can do and why it matters to your breast cancer risk in this presentation.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
4. What I Do at SOS?
• All Ages 7 - Banana Peel
• Top of Head to Bottom of Feet
• All Problems
• Non Surgical Options/ Maximize Natural
options
• Eg: Evaluations, PT, Injections, Medx,
Supplements, Acupuncture, Nerve Blocks, PRP,
Stem Cell, Hydrodistentions, Exercise
Programs, Weight Loss Programs etc
5. Food, Movement and Orthopedics:
Why What you do Matters!
Stephan Esser MD, USPTA
Follow me at Esserhealth
on Facebook and Instagram
6.
7. Tenets of a Healthy Life
• Clean Food
• Clean Water
• Exercise
• Sleep
• Emotional Poise
• Sunlight
• ( Avoidance of Toxins)
12. Biomechanical
• Weight:
– Lower Extremity Joints
• 1lb above the waist = 3-10 below
– Upper Extremity Joints
• Inc. Weight = Inc. work for RTC, neck muscles
– Alters Spinal Mechanics
• Inc. Lumbar Lordosis and “facet based pain”
• Inc. Risk of Spinal Stenosis
13. Weight and Plants
• Vegetarian diets are associated with reduced body weight, lower
incidence of certain chronic disease, and lower medical costs compared with
non-vegetarian diets Vegetarian Diets and Weight Status Nutrition Reviews
2006.
• Self-identified semivegetarian, lactovegetarian, and vegan women have a
lower risk of overweight and obesity than do omnivorous women.
The advice to consume more plant foods and less animal products may help
individuals control their weight. Risk of overweight and obesity among
semivegetarian, lactovegetarian, and vegan women American Journal of
Clinical Nutrition 2005
• The 5-unit BMI difference between vegans and nonvegetarians indicates a
substantial potential of vegetarianism to protect against obesity. Increased
conformity to vegetarian diets protected against risk of type 2 diabetes after
lifestyle characteristics and BMI were taken into account. Pesco- and semi-
vegetarian diets afforded intermediate protection. Type of Vegetarian Diet,
Body Weight, and Prevalence of Type 2 Diabetes Diabetes Care 2009
15. Weight and Joint OA
• Obesity is a primary risk factor for disease onset, and mechanical factors increased
the risk for disease progression. Moreover, inflammatory mediators, in particular, adipose tissue‐derived
cytokines (better known as adipokines) play a critical role linking obesity and osteoarthritis Biomechanics, obesity, and
osteoarthritis. The role of adipokines: When the levee breaks Journal of Orthopedic Research, 2017
• Obesity enhances the cross-talk between chondrocytes and synovial
fibroblasts via raised levels of the pro-inflammatory adipokine leptin, leading to greater production of IL-6 in OA
patients. IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced
by obesity Scientific Reports 2017
• Higher body mass index was associated with an increased risk of hip
replacement due to osteoarthritis (P for trend = 0.0001). Compared with women in the lowest category of body
mass index (<22 kg/m2), those in the highest category of body mass index (≥35 kg/m2) had a twofold increased risk
(95% confidence interval [CI]: 1.4 to 2.8), whereas those in the highest category of body mass
index at age 18 years had more than a fivefold increased risk (95% CI: 2.5 to
10.7). Total hip replacement due to osteoarthritis: the importance of age, obesity, and other modifiable risk factors The
American Journal of Medicine 2003
• Increased weight = increased risk of OA and resultant need for THA and TKA. Role of Obesity on
the Risk for Total Hip or Knee Arthroplasty Clinical orthopedics and Research, 2007
• This underscores the immediate need for greater use of clinical and public health interventions, especially those that
address weight loss and self‐management, to reduce the impact of having knee OA. Lifetime risk of symptomatic knee
osteoarthritis Arthritis Care and Research 2008
18. Muscle Balance
• Stronger Quad Muscles = Less Osteoarthritis
Goldman et al Osteoarthritis Cartilage 2016
• Improving Quad Strength = decreased knee
pain, reduced knee osteoarthritis and
decreased risk of knee replacement Wang, Y et al Arthritis Rheum 2012
• Improving Lateral Hip Strength reduces knee
pain in patient’s with knee OA Sled et al, Physical Therapy 2010
19. Muscle Balance
• Neck: Deep Flexors, Upper Back
• Shoulder: Upper Back, Back of Shoulders
• Low Back: Hip flexors, gluteal muscles, lateral
hips
• Hips: Flexors and lateral hip muscles
• Knees: Quads, lateral hip
20. Flexibility
• Improved Hip, hip flexor, hamstring flexibility
improves back pain, quality of life > NSAIDs
• Quad, Hip Flexor, Lateral Hip Flexibility for
knee, hip pain
• Pec stretching for shoulder and neck issues
24. “There may be no single feature of age-related
decline that could more dramatically affect
ambulation, mobility, calorie intake, and
overall nutrient intake and status,
independence, breathing, etc. than the
decline in lean body mass.”
Aging, Atrophy and Apoptosis:Failing “A’s” for Frailty
National Conference on Aging
25. Sarcopenia
• The only proven approach to slow or prevent
or reverse sarcopenia is…………..
Exercise
26. “Physical fitness can neither be
achieved by wishful thinking nor
outright
purchase.” Jos
eph Pilates
27. • “You have to work at living, period. You’ve got
to train like you are training for an athletic
event. Most older people just give up. They
think, “I’m too old for that,” because they
have an ache here or a pain there. Life is a
pain in the butt; you’ve got to work at it.”
Jack LaLanne
28. Exercise and Physical Health
• Reduces risk of
– Heart Disease ≈ 40%
– Obesity: ≈ 30-100%
– Stroke ≈ 50%
– Type 2 Diabetes ≈ 50%
– Hypertension ≈ 50%
– Disability delayed ≈15 years
– Colon Cancer ≈ 25-40%
– Breast Cancer ≈ 20%-44%
– Osteoporosis ≈ 20+%
• As many as 250,000 deaths per year in the United
States areattributable to a lack of regular physical
activity
36. Cytokine Release
• Diet influences Cytokine Release
– Fruit and Vegetable Intake reduce levels of Pro-Inflammatory Cytokines Root, M et al. Combined
Fruit and Vegetable Intake Is Correlated with Improved Inflammatory and Oxidant Status from a
Cross-Sectional Study in a Community Setting Nutrients 2012, 4(1), 29-41
37. Spices
• Turmeric: 1500mg/day
– Knee Osteoarthritis: Clinical Intervention in Aging 2014
– 1500mg/day vs 1200mg/day Ibuprofen
• Boswellia: Indian Journal of Pharmacology 2007
– 1000mg/day vs Valdecoxib 10mg/day
• Ginger: Archives of Iranian Medicine 2005
– 30mg/day Ginger Extract vs 400mg Ibuprofen/day
– Osteoarthritis and Cartilage 2015
41. Rheumatology
• Inflammatory/Autoimmune Conditions
– “Leaky Gut” Hypothesis
– Tissue Mimicry
– Excess Purines leads to excess Uric Acid
• 27 patients were allocated to a four-week stay at a health farm. After an initial 7-10 day subtotal fast, they were put on an individually
adjusted gluten-free vegan diet for 3·5 months. improvement in number of tender joints, Ritchie's articular index, number of swollen
joints, pain score, duration of morning stiffness, grip strength, erythrocyte sedimentation rate, C-reactive protein, white blood cell
count, and a health assessment questionnaire score Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis
Lancet 1991
• A vegan diet free of gluten improves the signs and symptoms of rheumatoid arthritis: the effects on arthritis correlate with a reduction
in antibodies to food antigens Rheumatology 2001
• 4-week, very low-fat (~10%), vegan diet on 24 free-living subjects with RA, average age, 56 ± 11 years old. All measures of RA
symptomatology decreased significantly (p < 0.05), except for duration of morning stiffness (p > 0.05). Weight also decreased
significantly (p < 0.001). At 4 weeks, C-reactive protein decreased 16% (ns, p > 0.05), RA factor decreased 10% (ns, p > 0.05), while
erythrocyte sedimentation rate was unchanged (p > 0.05). Effects of a Very Low-Fat, Vegan Diet in Subjects with Rheumatoid Arthritis
The Journal of Alternative and Complementary Medicine 2004
43. Perfusion
• Blood Flow is essential for
– performance, healing, function, prevention
• High Fat/High Cholesterol meals
– Impair vascular dilation
– Produce Fatty streaks, CVD precursors
– Impair blood flow to MSK tissues
– Reduce O2 and micronutrient delivery
– Alter regional pH
44. Perfusion
• High Total Fat, High Saturated Fat, High
Refined sugar meals inhibit blood flow and
arterial dilatation
– Effect of a Single High-Fat Meal on Endothelial Function in Healthy Subjects single high-fat
meal transiently impairs endothelial function by up to 50% at 4 hrs after the meal AJC 1997
• Minimally Processed, Plant-Based Foods have
vasodilatory effect
– Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: a
randomized controlled trial Free Radical Biology and Medicine 2012
– An increase in F&Vs, regardless of flavonoid content in the groups as a whole, mitigated increases in vascular stiffness measured by PWA (P =
0.0065) and reductions in NO (P = 0.0299) in the control group Flavonoid-rich fruit and vegetables improve microvascular reactivity and
inflammatory status in men at risk of cardiovascular disease—FLAVURS: a randomized controlled trial AJCR 2014
– In healthy overweight and slightly obese men a single dose of beetroot juice attenuates the postprandial impairment of FMD following a
mixed meal, possibly through increases in plasma NO concentrations. Beetroot juice improves in overweight and slightly obese men
postprandial endothelial function after consumption of a mixed meal Athersclerosis 2013
45. Perfusion
• Spinal Degeneration and Impaired Perfusion
• Aortic Calcifications as a risk for back pain
– Advanced aortic atherosclerosis, presenting as calcific deposits in the posterior wall of the aorta, increases a person's risk for
development of disc degeneration and is associated with the occurrence of back pain. Disc Degeneration/Back Pain and
Calcification of the Abdominal Aorta: A 25-Year Follow-Up Study in Framingham Spine 1997
– A significant association is indicated between atheromatous lesions in the abdominal aorta and low back pain. Association of
Atherosclerosis with Low Back Pain and the Degree of Disc Degeneration Spine 1999
– Aortic atherosclerosis and stenosis of the feeding arteries of the lumbar spine were associated with DD and LBP. Atherosclerosis
and Disc Degeneration/Low-Back Pain – A Systematic Review EJVES 2009
– High serum lipids predicted incident radiating LBP, consistent with the atherosclerosis-LBP hypothesis. Serum Lipids and Low
Back Pain: An Association?: A Follow-up Study of a Working Population Sample Spine 2006
46. Perfusion/Cholesterol
• Serum Lipids and risk of Rotator Cuff Tear
– Impaired micro-perfusion
– Increased risk of injury
– Increased risk of re-tear and slowed healing
• Patients with rotator cuff tears were more likely to have hypercholesterolemia when compared with the control
group.
• The Effect of Hypercholesterolemia on Rotator Cuff Disease Clinical Orthopedics and Related Research 2010
• Dyslipidemia may decrease the improvement of patient-reported outcomes in
• patients undergoing treatment for RCTs; high triglycerides and low HDL may have
• the most impact.The effect of lipid levels on patient-reported outcomes in patients
• with rotator cuff tears JSES Open Access 2017 The present study found a significant
• association between moderate and high perioperative total cholesterol and LDL
• levels and the rate of revision surgery after primary arthros copic rotator cuff
• repair. Perioperative Serum Lipid Status and Statin Use Affect the Revision Surgery
• Rate After Arthroscopic Rotator Cuff Repair AJSM 2017
47. Perfusion/Increased Cholesterol
• Achilles Tendon Rupture
– Impaired healing
– Increased risk of tear/re-tear
• Total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) concentrations of the patients with ATR were higher
(p<0.001), and their high-density lipoprotein cholesterol (HDL-C) was lower than the control group (p<0.05). Moreover,
the concentrations of triglyceride (TG) and very low-density lipoprotein cholesterol (VLDL-C) were significantly higher
than controls (p<0.05). Is high concentration of serum lipids a risk factor for Achilles tendon rupture?
• People with altered tendon structure or tendon pain had significantly higher total cholesterol, low-density lipoprotein
cholesterol and triglycerides, as well as lower high-density lipoprotein cholesterol. Is higher serum cholesterol associated
with altered tendon structure or tendon pain? A systematic review BJSM 2015
• One intrinsic factor that appears to have an association with tendinopathy is body composition; more specifically central
adiposity Adiposity and tendinopathy Disability and Rehabilitation 2008
50. Perfusion
• Beet Juice
– reduced time to exhaustion and improved
performance ( V02Max) Cermak et al Sports Nutrition and Exercise Metabolism 2012
– improves submaximal aerobic endurance and
blood pressure Eggebeen et al JACC 2016
– Improved time trial performance in cyclists and
kayak racers Peeling et al SNEM 2015
• Pomegranate Juice
– Improves running time to exhaustion Trexler et al 2015
62. Case
• A 72 y/o male presents with low back pain.
– PMH: HTN, HLD, Psoriasis, Obesity, Hand OA
– Xrays: Aortic Calcifications noted
• Patient comments he is tired of his 5 medx.
• Plan: Offered PT and a 4 week plant based
“detox”
• At 6 weeks, 30lbs lighter, off all BP medx,
Psoriasis resolved, back pain 60% improved,
resizing wedding ring to fit fingers
63. Case
• A 54 y/o female with advanced knee OA
presents to discuss stem cell treatment
– PMH: HTN, HLD, Obese
– Plan: 6 week plant based “detox,” Pool swimming,
HEP
– Results: 28lbs weight loss, Knee pain 75%
improved
– Plan: PRP injections and continued knee PT
65. Tracking
• What will you track?
– Pain, Performance, Labs, Weight ?
• Are the goals SMART?
– Specific, Measurable, Achievable, Realistic, Timely
66. Case
• 65 y/o male with bilateral leg numbness and
burning and knee pain and foot drop
– PMH: S/p spinal surgery, Borderline T2D, HTN, HLD
– Plan:
• Reduce inflammation thru 4 week Plant-based detox
• Add in high dose B vitamins, Omega 3, Inositol, Mag. G.
• Continue PT, Follow up on all recent films, labs, EMG
• Provide AFO for foot drop
– Follow Up
• Foot Drop Unchanged
• 24lbs weight loss, Stopped 1 BP, 60% reduction in leg pain
67. Case
• A 56 y/o male presents to clinic walking with
crutches due to severe knee pain. Knees are
swollen, painful to move at all. Labs show
highly elevated serum uric acid levels.
– Plan: Standard discussed, patient requests
alternative (agrees to 1 week juicing, 3 week
plant-based detox)
– Follow up: 3 weeks with update
Need was real, Readiness was present
Uric Acid 9---0.9
ESR 30----2
Lawn
70. Conclusion
• There are multiple levels of intersection where
plant based nutrition, exercise and MSK care
overlap
• Excellent Nutrition and Exercise can
– Reduce Pain
– Reduce Inflammation/Swelling/Edema
– Reduce Weight/Alter Biomechanics
– Improve Perfusion and Nutrition delivery
– Reduce and slow “disease” risk
– Improve performance and function
71. Take Home
• Do YOU have: Pain, Loss of Function
• Do YOU want to Reduce, Eliminate or Prevent
Pain and improve function and performance
THEN
• What is your daily exercise plan?
• What is your daily nutrition plan?
72. Plan
• Add more color and micronutrient rich plants
to your daily diet
• Add Spices like turmeric, ginger, boswellia to
your food and your supplements
• Be sure you get some form of exercise every
day…..flexibility, balance, CV, strength
• Achieve a BMI in the 18-24 range, and a
normal waist-hip cicumference
73. YOUmay be the most powerful influence of
health in your life today, tomorrow and for
years to come!
Page 1
1Aging, Atrophy and Apoptosis:Failing “A’s” for FrailtyCharlotte A. Peterson, Ph.D.and Esther E. Dupont-Versteegden, Ph.D.University of KentuckyLexington, KYPage 2
(Journal of the American Medical AssociationJAMA: 2000, Vol. 283. No. 22, pp. 2961-2967)
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