AutoImmune Disease can seem scary, overwhelming and complicated. In this powerpoint we break down the science into applicable nuggets for your life. Enjoy it live on facebooklive as well at esserhealth
3. Goals
• Review definitions and tenets
• Overview of the Statistics
• Visit the classroom: anatomy, physiology
• Brief review of common autoimmune dz.
• Propose some models for cause
• Review the influence of Lifestyle
• Discuss opportunities for prevention,
management and reversal
4. Definitions
• Auto-Immune Disease
– Auto = Self Immune= Defense, Protected
– “A disease in which the body misdirects an
immune attack against it’s own cells resulting in
damage and injury”
5. Why this matters?
• 3rd
most common category of disease in US
• 5-8% of population have an AI disease
• Approx. 20-50 million Americans
• 78% are women
9. What we know?
• AI Disease is common
• It can affect almost any tissue in the body
• Women are more commonly affected then
Men
• Each AI Disease has a unique predilection
11. The Immune System
• Immunity: The ability of the body to protect
itself from harmful environmental and
internal influences
– Composed of multiple organs, tissues and cells
12.
13. Immune System
• Bone Marrow: Where immune cells are
formed
• Thymus: Small gland near the heart where
immune cells are educated
• Lymph Nodes: Small “organs” that function as
filters, short term storage and education sites
• Lymphatics: Highways of the Immune system
• Spleen: Where blood is filtered of old blood
cells and non “self” particles
14. Immune System
• Gut Associated Lymphatic Tissue (GALT)
– 70-80% of your immune system surrounds your
intestines
15.
16.
17.
18. Types of Immunity
• Innate
– 1st
line of defense
– Basic, early, always ready
– Fever, Mucus, Macrophages etc
• Acquired
– 2nd
line of defense
– “Adaptive,” responds to stimulus
– Develops learned memory
19. Definitions
• Antigen: a toxin or other foreign substance
that induces an immune response in the body
• Antibody: a blood protein produced in
response to and counteracting a specific
antigen.
20. Other Factoids
• Infants lack fully developed immune systems
• Chronic Stress impairs immune function
• Inadequate Sleep impairs immune function
• Poor Nutrition impairs immune function
• With Age immune function declines
21. What we Know?
• Immunity is complex
• Immunity is tightly regulated
• Immunity has both basic and adaptive abilities
23. What we Know
• 80% of the immune system is in the Gut
• “Mucosal” layers are a primary interface
through which we develop immunity
• If “steps” are skipped/shortened,
early/inappropriate “exposure” can occur
30. • Leaky Gut Hypothesis
– Dietary/Stress/Exercise Exposures result in loose
cell membrane connections in the gut
– Incompletely processed materials ( Proteins,
bacteria, etc) enter the blood stream
– Abnormal signaling and autoimmune dysfunction
occurs
35. The hygiene hypothesis proposes that as the living environment
is improved, children become less exposed to infectious agents,
which leads to inadequate maturation of their immune systems.
The hygiene hypothesis proposes that as the living environment
is improved, children become less exposed to infectious agents,
which leads to inadequate maturation of their immune systems.
36. Theories
• Genetically Primed Individual
• Gut Integrity is Lost/Compromised Immune
State
• Toxic/Infectious Exposure
• Misdirected or Overzealous Response
39. Prevention
• Reduce Gut Permeability
– Increase Fiber
– Enhance “probiotic” health
– Primarily consume whole minimally processed
foods
– Avoid food additives, processing
– Minimize or eliminate Meat, Dairy use especially
– Avoid Gluten as a “primary calorie” source
40. Gut Permeability
• Fiber:
– Cultivates “healthy bacteria”
• Reduces toxin production
– Reduces Bowel exposure to toxins
• Enhances Bowel Motility
– Crowds out low fiber foods
41. Gut Permeability
• Probiotic Health
– Synergistic Bacteria
– Alters Immune Modulation, Inflammation, Disease
– Eg:
• Probiotic as effective as Mesalamine for Ulcerative
Colitis Gut 2004
• Gut Biome is altered in patient’s with Hashimotos
Thyroiditis Thyroid 2018
• Probiotics help reduce Rheumatoid Arthritis
Inflammation Annals of Rheumatic Disease 2018
42. • Plants: Vegetable and Fruit Consumption
– Only Source of Fiber
– Alter Inflammatory cell activity Frontiers in Immunology 2018
– Alter Bacterial Species in the Gut Nutrients 2018
– “Prevent CNS autoimmunity and warrants a focus on nutritional
approaches in human MS” Scientific Reports 2018
– Reduces symptoms and progression of Rheumatoid Arthritis Scandinavian
Journal of Rheumatology 2001
– Fibromyalgia pain and symptoms improve BMC Complementary and Integrative
Medicine 2001
– Reduce the risk of Inflammatory Bowel Disease American Journal of
Gastroenterology 2011
– Prevents recurrence in 94% of semivegetarian diet vs only 33% of
those on omnivorous diet World Journal of Gastroenterology 2010
43. Gut Permeability and Toxins
• Remember Molecular Mimicry
– Avoid Chemical Toxins as possible
• Purify Water
• Minimize plastics when possible
• Use Glass, Stainless Steel, Wood
• Eat Organic, Wash fruit/Veggies well
• Minimize food processing
44. Meat and Dairy
• Ultimate “Molecular Mimicry” when leaky gut
– Children who consume most meat and dairy have highest rates of T1D Clinical
Nutrition 2000
– High fat meals increase gut permeability Clinical and Translational Gastroenterology 2013
– Inc. Meat and Dairy appears to inc. risk of UC and Crohns JGH 2008
– Inc. Meat and Dairy Inc. risk of IBD AJG 2010 Inc risk of SLE TJEM 1993 IMJ 2015
– Inc. Meat, Inc relapse rate in Ulcerative Colitis Gut 2004
– Those who ate highest levels of meat have highest rates of “Polyarthritis”
Arthritis and Rheumatology 2004
– Those who ate most fruits and veg. had lowest rates of Psoriasis BJD 1996
– Dairy Consumption was associated with Developing MS Neuroepidemiology 1992
– Animal Based Foods and High Fat Foods increased risk of MS IJ Epidemiology 1998
Mixed data since
– Meat consumption may inc. risk of RA Scan. Jrn. Of Rheum. 2006
– Meat consumption increased pain and symptoms of RA BR. Jnl. Nut 2000
45. Gluten and AI Disease
• Gluten
– Gluten Sensitivity/Allergy appears to be related to the risk of Hashimotos,
T1D, Grave’s Disease etc Nutrients 2018
– Genetically at risk Children who consumed increased gluten consumption
were more likely to develop T1D. Am. Diabetes Association 2018
– Gluten-Free diets can reduce symptoms in Non-Celiac Autoimmune
Diseases Nutrition Reviews 2017, Int. Jnl of Celiac Disease 2017
46. • Avoid/Minimize Toxic Exposures
– Minimize number of “drugs” you need
– Use “natural” substances for food containers,
water containers etc
– Strive for “natural” skin care, sun protectants,
soaps, cleaners
– Use appropriate protection when working with
chemicals, dusts etc ( Face, Eyes, Skin, Lungs etc)
– Purify water, Change air filters
47. • Infectious Exposures
– Minimize sick contacts
– Use appropriate precautions
– Enhance Immune function to minimize duration
and extent of symptoms if infected
– Minimize meat and dairy and contaminated foods
48. “likelihood of contamination of raw milk with MAP in most studied regions is substantial. The presence of
MAP in raw and pasteurized milk has been the subject of several studies which show that pasteurized milk
is not always MAP‐free and that the effectiveness of pasteurization in inactivating MAP depends on the
initial concentration of the agent in raw milk.
The most recent studies indicated that beef can be contaminated with MAP via dissemination of the
pathogen in the tissues of infected animals. Currently available data suggests that the likelihood of dairy
and meat products being contaminated with MAP on retail sale should not be ignored.”
“likelihood of contamination of raw milk with MAP in most studied regions is substantial. The presence of
MAP in raw and pasteurized milk has been the subject of several studies which show that pasteurized milk
is not always MAP‐free and that the effectiveness of pasteurization in inactivating MAP depends on the
initial concentration of the agent in raw milk.
The most recent studies indicated that beef can be contaminated with MAP via dissemination of the
pathogen in the tissues of infected animals. Currently available data suggests that the likelihood of dairy
and meat products being contaminated with MAP on retail sale should not be ignored.”
49. Meat Contamination
• Retail Meat is contaminated Applied and Environmental Microbiology 2001
– 90% of stores had contaminated chicken
• 70% Chicken with Camplyobacter
• 38% Chicken with E.Coli
50. Sleep and Stress
• Sleep < 7 hrs in an at risk population may
increase risk of Lupus Lupus 2018
• Stress Related Disorders Inc. risk of AI Dis. JAMA
2018
• Stress may Inc risk of Lupus Nature Reviews 2018
52. Your Prevention Plan
• Eat
– More minimally processed pure plant based foods
– Minimize Gluten
– Minimize or Eliminate Meats and Dairy
• Avoid
– Repeat Infections, Food Sources with infectious
agents
– Toxins/ Drugs where possible
• Maximize
– Sleep, Stress reducing behaviors
53. Your Treatment Plan
• Consider a period of an elimination diet to
– Strip out common allergens from your diet
• Gluten, Nuts, Eggs, Soy, Nightshades
• Identify Personal Triggers
– Rebuild your intestinal wall
• Supplement with Probiotics
– Reduce Inflammatory molecule production
• Enhance Immune System
– Increase rest/sleep Reduce Chronic Stressors
– Vitamin D ( Sunlight), Selenium, Vit C, Omega 3’s
54. Plan
• Evaluate your risk
– Personal, Strong Family History, Past Exposures
• Develop a Goal Oriented Plan
– Prevention/Symptom Reduction/ Medication
Reduction/ Reversal
• Evaluate Success every 3 months and modify
55. Conclusion
• Autoimmune Disease is a complex,
multifaceted process
• Both Genetic and Environmental factors
influence onset and progression
• There are many “choices” we can make which
can reduce risk and improve management
56. Goals
• Keep Learning
• Apply the Science to your life
• Transition from Surviving to Thriving
Infants fed Soy Formulas had later life higher rates of autoimmune thyroid disease
It takes time to see these disease even if exposure was 1-2 years prior
Gluten timing of exposure if &lt; 4 months of age increased risk of celiac disease
Using military perspective. The unseasoned/new member of the force is more likely to shoot quickly, lose his/her cool, cause friendly fire
NSAIDs increase gut permeability
DC area and sampled 825 meats at different stores and tested them
More then ½ of all beef was contaminated with bacteria