2014.01.22
Calit2 Director Larry Smarr speaks as part of the Pensacola Evening Lecture Series, organized by the Florida Institute for Human and Machine Cognition, in Pensacola, FL.
Big Data and Superorganism Genomics: Microbial Metagenomics Meets Human GenomicsLarry Smarr
This presentation on February 27, 2014 to NGS and the Future of Medicine at Illumina Headquarters in La Jolla, CA, was made by Calit2 Director Larry Smarr.
Quantifying Your Dynamic Human Body (Including Its Microbiome), Will Move Us ...Larry Smarr
Invited Presentation Microbiology and the Microbiome and the Implications for Human Health Analytic, Life Science & Diagnostic Association (ALDA) 2016 Senior Management Conference
Half Moon Bay, CA
October 3, 2016
Linking Phenotype Changes to Internal/External Longitudinal Time Series in a ...Larry Smarr
Invited Presentation at EMBC ‘16
38th International Conference of the IEEE Engineering in Medicine and Biology Society Symposium: The Quantified Self: Visions for the Next Decade of Persistent Physiological Monitoring
Orlando, FL
August 18, 2016
2014.02.06
Calit2 Director Larry Smarr lecture to the Osher Lifelong Learning Institute as part of the Winter 2014 Qualcomm Institute lecture series for Osher.
Big Data and Superorganism Genomics: Microbial Metagenomics Meets Human GenomicsLarry Smarr
This presentation on February 27, 2014 to NGS and the Future of Medicine at Illumina Headquarters in La Jolla, CA, was made by Calit2 Director Larry Smarr.
Quantifying Your Dynamic Human Body (Including Its Microbiome), Will Move Us ...Larry Smarr
Invited Presentation Microbiology and the Microbiome and the Implications for Human Health Analytic, Life Science & Diagnostic Association (ALDA) 2016 Senior Management Conference
Half Moon Bay, CA
October 3, 2016
Linking Phenotype Changes to Internal/External Longitudinal Time Series in a ...Larry Smarr
Invited Presentation at EMBC ‘16
38th International Conference of the IEEE Engineering in Medicine and Biology Society Symposium: The Quantified Self: Visions for the Next Decade of Persistent Physiological Monitoring
Orlando, FL
August 18, 2016
2014.02.06
Calit2 Director Larry Smarr lecture to the Osher Lifelong Learning Institute as part of the Winter 2014 Qualcomm Institute lecture series for Osher.
Know Thyself: Quantifying Your Human Body and Its One Hundred Trillion MicrobesLarry Smarr
Understanding Cultures and Addressing Disparities in Society: Degrees of Health and Well-Being Public Lecture Series
University of California, San Diego
January 20, 2016
In a speech for the Global Health Program at the Council on Foreign Relations in New York City, Calit2 director Larry Smarr addresses the issue of biological diversity and the importance of monitoring the microbiome.
The Emerging Personalized Medicine Paradigm of Time-Series Tracking of Mind, ...Larry Smarr
Invited Zoom Remote Lecture
For Sara Gottfried, MD Personalized Medicine for Mental Health Course
Integrative Psychiatry Institute
Recorded June 28, 2022
Individual, Consumer-Driven Care of the Future: Taking Wellness One Step FurtherLarry Smarr
Calit2 Director Larry Smarr gives the closing keynote address to the 2nd annual Learning Conference on Integrated Delivery Systems in San Diego on May 7, 2014.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The Human Microbiome and the Revolution in Digital Health
1. “The Human Microbiome and
the Revolution in Digital Health”
The Florida Institute for Human and Machine Cognition
Pensacola Evening Lecture Series
Pensacola, FL
January 22, 2014
Dr. Larry Smarr
Director, California Institute for Telecommunications and Information Technology
Harry E. Gruber Professor,
Dept. of Computer Science and Engineering
Jacobs School of Engineering, UCSD
http://lsmarr.calit2.net
2. Abstract
The human body is host to 100 trillion microorganisms, ten times the number of cells
in the human body and these microbes contain 100 times the number of DNA genes
that our human DNA does. The microbial component of our “superorganism” is
comprised of hundreds of species with immense biodiversity. Thanks to the National
Institutes of Health’s Human Microbiome Program researchers have been discovering
the states of the human microbiome in health and disease. To put a more personal
face on the “patient of the future,” I have been collecting massive amounts of data
from my own body over the last five years, which reveals detailed examples of the
episodic evolution of this coupled immune-microbial system. To decode the details of
the microbial ecology requires high resolution genome sequencing feeding Big Data
parallel supercomputers. Since modern medicine has not taken into account the
nature and changes in the human microbiome, we can look forward to revolutionary
changes in medical practice over the next decade.
3. In My Teenage Years,
I Spent Time Every Summer at Pensacola Beach
My Mother and Two Brothers, Photo by My Father
4. Pensacola Created My Life-Long Interest
in the Living Ecology of the Sea
www.pinterest.com/pin/65231894575478740/
5. I Spent Decades Studying
the Ecological Dynamics of Coral Reefs
Pristine
Degraded
My 120 Gallon Home Salt Water
Coral Reef Aquarium in Illinois
My Snorkeling Photos
From Coral Reefs
6. By Measuring theDecade I My Body and “Tuning” It
Over the Last State of Have Been Studying
Using Nutrition and Exercise, I Became Healthier
the Ecological Dynamics of My Own Body
Age
41
Age
51
Age
61
1999
2000
1999
1989
I Reversed My Body’s Decline By
Quantifying and Altering Nutrition and Exercise
http://lsmarr.calit2.net/repository/LS_reading_recommendations_FiRe_2011.pdf
2010
7. I Used a Variety of Emerging Personal Sensors
To Quantify My Body & Drive Behavioral Change
Withings/iPhoneBlood Pressure
FitBit Daily Steps &
Calories Burned
MyFitnessPalCalories Ingested
Azumio-Heart Rate
Withings WiFi Scale Daily Weight
Zeo-Sleep
9. From One to a Billion Data Points Defining Me:
The Exponential Rise in Body Data in Just One Decade!
Billion:Microbial Genome
My Full DNA,
MRI/CT Images
Improving Body
SNPs
Million: My DNA SNPs,
Zeo, FitBit
Blood
Variables
One:
My
Weight Weight
Discovering Disease
Hundred: My Blood Variables
10. Visualizing Time Series of
150 LS Blood and Stool Variables, Each Over 5-10 Years
Calit2 64 megapixel VROOM
11. I Discovered I Had Chronic Inflammation by
Tracking Complex Reactive Protein In My Blood Samples
27x Upper Limit
Antibiotics
Normal Range
<1 mg/L
Antibiotics
Normal
CRP is a Generic Measure of Inflammation in the Blood
12. But by Using Stool Analysis Time Series, I Discovered
I Had Episodically Excursions of My Immune System
Typical
Lactoferrin
Value for
Active
IBD
124x Upper Limit
So I Reasoned My Gut Microbiome Ecology
Must Be Disrupted and Dynamically Changing
Normal Range
<7.3 µg/mL
Antibiotics
Antibiotics
Lactoferrin is a Protein Shed from Neutrophils An Immune System Antibacterial that Sequesters Iron
13. Indeed, My Cultured Gut Bacterial Abundance Time Series
Revealed an Oscillatory Microbiome Ecology
LS Data from Yourfuturehealth.com
14. Confirming the IBD Hypothesis:
Finding the “Smoking Gun” with MRI Imaging
Liver
Transverse Colon
Small Intestine
I Obtained the MRI Slices
From UCSD Medical Services
and Converted to Interactive 3D
Working With
Calit2 Staff & DeskVOX Software
Descending Colon
MRI Jan 2012
Cross Section
Diseased Sigmoid Colon
Major Kink
Sigmoid Colon
Threading Iliac Arteries
15. Why Did I Have an Autoimmune Disease like IBD?
Despite decades of research,
the etiology of Crohn's disease
remains unknown.
Its pathogenesis may involve
a complex interplay between
host genetics,
immune dysfunction,
and microbial or environmental factors.
--The Role of Microbes in Crohn's Disease
So I Set Out to Quantify All Three!
Paul B. Eckburg & David A. Relman
Clin Infect Dis. 44:256-262 (2007)
16. The Cost of Sequencing a Human Genome
Has Fallen Over 10,000x in the Last Ten Years!
This Has Enabled Sequencing of
Both Human and Microbial Genomes
17. Single Nucleotide Polymorphisms (SNPs) Make Up
About 90% of All Human Genetic Variation
Person A
SNPs Occur Every
100 to 300 Bases
Along Human DNA
Person B
www.23andme.com Tracks One Million SNPs
18. I Wondered if Crohn’s is an Autoimmune Disease,
Did I Have a Personal Genomic Polymorphism?
From www.23andme.com
ATG16L1
Polymorphism in
Interleukin-23 Receptor Gene
— 80% Higher Risk
of Pro-inflammatory
Immune Response
IRGM
NOD2
SNPs Associated with CD
Now Comparing
163 Known IBD SNPs
with 23andme SNP Chip
and My Full Human Genome
19. I Had Carried Out Observations in Optical, Radio, and X-Ray
on the Andromeda Galaxy in the 1980s
A Galaxy Contains
One Hundred Billion Stars
But the Human Gut Contains
1000 Times As Many Microbes!
20. Now I am Observing the 100 Trillion
Non-Human Cells in My Body
Your Body Has 10 Times
As Many Microbe Cells As Human Cells
99% of Your
DNA Genes
Are in Microbe Cells
Not Human Cells
Inclusion of the Microbiome
Will Radically Change Medicine
22. When We Think About Biological Diversity
We Typically Think of the Wide Range of Animals
But All These Animals Are in One SubPhylum Vertebrata
of the Chordata Phylum
All images from Wikimedia Commons.
Photos are public domain or by Trisha Shears & Richard Bartz
23. Think of These Phyla of Animals When
You Consider the Biodiversity of Microbes Inside You
Phylum
Chordata
Phylum
Cnidaria
Phylum
Echinodermata
Phylum
Annelida
Phylum
Mollusca
Phylum
Arthropoda
All images from WikiMedia Commons.
Photos are public domain or by Dan Hershman, Michael Linnenbach, Manuae, B_cool
24. However, The Evolutionary Distance Between Your Gut Microbes
Is Much Greater Than Between All Animals
Last Slide
Green Circles Are
Human Gut Microbes
Evolutionary Distance Derived from
Comparative Sequencing of 16S or 18S Ribosomal RNA
Source: Carl Woese, et al
25. Quantifying Our Human Superorganism:
Distribution of Microorganism Ecology on Our Bodies
Nature Reviews
Microbiology
v.9, p. 279 (2011)
26. Intense Scientific Research is Underway
on Understanding the Human Microbiome
June 8, 2012
June 14, 2012
From Culturing Bacteria to Sequencing Them
27. Early Medically Relevant Results: Delivery Mode
Determines Infant’s Initial Microbiome
“The composition of the initial microbiota may have implications
for nutritional and immune functions associated with the
developing microbiota. For example, recent studies suggest that
Cesarean-delivered babies may be more susceptible to allergies
and asthma.”
Maria Dominguez-Belloa, et al. PNAS (2010) 107 11971–11975
28. The Infant Gut Microbiome Rapidly
Increases its Diversity After Birth
Adult Gut Microbiome Dominated
By Bacteroidetes/Firmicutes
“Succession of microbial consortia in the developing infant gut microbiome,”
Jeremy Koeniga, et al. PNAS 108 Suppl 1:4578-85 (2011)
29. The Adult Healthy Gut Microbiome
Is Remarkably Stable Over Time
Source: Eric Alm, MIT
30. To Map Out the Dynamics of My Microbiome Ecology
I Partnered with the J. Craig Venter Institute
• JCVI Did Metagenomic
Sequencing on Six of My
Stool Samples Over 1.5 Years
• Sequencing on
Illumina HiSeq 2000
– Generates Reads (100 Bases)
– Run Takes ~14 Days
– My 6 Samples Produced
Illumina HiSeq 2000 at JCVI
– 190.2 Gbases of Data
• JCVI Lab Manager,
Genomic Medicine
– Manolito Torralba
• IRB PI Karen Nelson
– President JCVI
Manolito Torralba, JCVI
Karen Nelson, JCVI
31. We Downloaded Additional Human Gut Microbiome Data
from the NIH For Comparative Analysis
35 “Healthy” Individuals:
1 Point in Time
2 Ulcerative Colitis Patients:
1 Point in Time
and 5 Points in Time
5 Ileal Crohn’s Patients:
3 Points in Time
Total of 5 Billion Illumina Reads
Source: Jerry Sheehan, Calit2; Weizhong Li, Sitao Wu, CRBS, UCSD
32. We Used SDSC’s Gordon Data-Intensive Supercomputer
to Analyze a Wide Range of Gut Microbiomes
Source: Weizhong Li, Sitao Wu, CRBS, UCSD
Our Team Used 25 CPU-Decades
To Compute
the Comparative Gut Microbiome
of My Time Samples
and Our Healthy and IBD Controls
Starting With
the 5 Billion Illumina Reads
Received from JCVI
Enabled by
a Grant of Time
on Gordon from SDSC
Director Mike Norman
33. Using Scalable Visualization Allows Comparison of
the Relative Abundance of 200 Microbe Species
Comparing 3 LS Time Snapshots (Left)
with Healthy, Crohn’s, UC (Right Top to Bottom)
Calit2 VROOM-FuturePatient Expedition
34. Lessons from Ecological Dynamics I:
Gut Microbiome Has Multiple Relatively Stable Equilibria
“The Application of Ecological Theory Toward an Understanding of the Human Microbiome,”
Elizabeth Costello, Keaton Stagaman, Les Dethlefsen, Brendan Bohannan, David Relman
Science 336, 1255-62 (2012)
35. Disease State Has a Different Microbiome Equilibrium
Than Healthy
Expansion of
Actinobacteria
Collapse of
Bacteroidetes
Explosion of
Proteobacteria
36. Lessons From Ecological Dynamics II:
Invasive Species Dominate After Major Species Destroyed
”In many areas following these burns
invasive species are able to establish themselves,
crowding out native species.”
Source: Ponderosa Pine Fire Ecology
http://cpluhna.nau.edu/Biota/ponderosafire.htm
37. Almost All Abundant Species (≥1%) in Healthy Subjects
Are Severely Depleted in Larry’s Gut Microbiome
38. Top 20 Most Abundant Microbial Species
In LS vs. Average Healthy Subject
152x
765x
148x
Number Above
LS Blue Bar is Multiple
of LS Abundance
Compared to Average
Healthy Abundance
Per Species
849x
483x
220x
201x169x
522x
Source: Sequencing JCVI; Analysis Weizhong Li, UCSD
LS December 28, 2011 Stool Sample
39. Homing in on the Dynamic Interactions of
the Coupled Human Immune System & Gut Microbiome
“Advances in our understanding
of the interplay between components
of the innate and adaptive arms
of the immune system
will be central to future progress.”
-Judy H. Cho,
The Genetics and
Immunopathogenesis
of Inflammatory Bowel Disease,
Nature Reviews Immunology (2008)
40. Fine Time Resolution Sampling Revealed Regular
Oscillations of the Innate and Adaptive Immune System
LS Data from Yourfuturehealth.com
Lysozyme
& SIgA
From Stool
Tests
Innate Immune System
Normal
Therapy: 1 Month Antibiotics
+2 Month Prednisone
Adaptive Immune System
Normal
Time Points of
Metagenomic
Sequencing
of LS Stool Samples
41. Time Series Reveals Autoimmune Dynamics
of Gut Microbiome by Phyla
Therapy
Six Metagenomic Time Samples Over 16 Months
42. Next Step: Time Series of Metagenomic Gut Microbiomes
and Immune Variables in an N=100 Clinic Trial
Goal: Understand
The Coupled Human Immune-Microbiome
Dynamics
In the Presence of Human Genetic Predispositions
Drs. William J. Sandborn, John Chang, & Brigid Boland
UCSD School of Medicine, Division of Gastroenterology
43. From War to Gardening:
New Therapeutical Tools for Managing the Microbiome
“I would like to lose the language of warfare,”
said Julie Segre, a senior investigator at
the National Human Genome Research Institute.
”It does a disservice to all the bacteria
that have co-evolved with us
and are maintaining the health of our bodies.”
44. Where I Believe We are Headed: Predictive,
Personalized, Preventive, & Participatory Medicine
I am Lee Hood’s Lab Rat!
www.newsweek.com/2009/06/26/a-doctor-s-vision-of-the-future-of-medicine.html
45. Thanks to Our Great Team!
UCSD Metagenomics Team
JCVI Team
Weizhong Li
Sitao Wu
Karen Nelson
Shibu Yooseph
Manolito Torralba
SDSC Team
Calit2@UCSD
Future Patient Team
Jerry Sheehan
Tom DeFanti
Kevin Patrick
Jurgen Schulze
Andrew Prudhomme
Philip Weber
Fred Raab
Joe Keefe
Ernesto Ramirez
Michael Norman
Mahidhar Tatineni
Robert Sinkovits
UCSD Health Sciences Team
William J. Sandborn
Elisabeth Evans
John Chang
Brigid Boland
David Brenner