1) ADMA levels are significantly elevated in patients with severe sepsis compared to healthy controls and correlate with severity of organ failure and mortality.
2) Higher ADMA levels on day 1 are associated with need for inotropic support and higher levels on day 7 correlate with increased mortality.
3) While CRP and ADMA both increase in sepsis, only ADMA levels correlate with severity of organ dysfunction.
Polymorphism in Glutatione S-Transferase P1 and ManganeseSuperoxide Dismmutas...iosrjce
Susceptibility to preeclampsia is believed to have a genetic component. Several studies have reported
associations between polymorphisms of oxidative stress- related genes and preeclampsia. The aim of the present
study was to study the polymorphisms in anti-oxidant genes glutathione S-transferase P1 (GSTP1) and Mnsuperoxide
dismutase (Mn-SOD) in patients with of preeclampsia. Seventy four preeclampsia patients and fifty
age-matched healthy pregnant female controls were genotyped for GSTP1 and Mn-SOD. DNA was extracted
from peripheral blood of all patients and control women. DNA analysis was carried out by polymerase chain
reaction (PCR), and then digestion of the PCR products by restriction enzymes (RFLP) for both genes was
performed. As regards GSTP1, the carriers of Val (G) allele were significantly more frequent among
preeclampsia patients when compared to the control group (45.95% Vs. 19%, X
2=10.40, OR=2.418, 95%CI
(1.3698 - 4.269); p=0.0023). Preeclampsia patients had a lower frequency of GSTP1 Ile/Ile (AA) genotype
(31.1% Vs. 68% in control; X
2=13.09, OR=0.457, 95%CI (0.241 - 0.866); p =0.0164). The frequency of
GSTP1 Ile/Val (AG) and Val/Val (GG) genotypes was higher in preeclampsia patients than control (68.9%Vs.
32%; X
2= 12.83, OR=2.154, 95%CI (1.106 - 4.194); p =0.0241). However, non significant frequencies
differences as regards Mn-SOD genotypes or alleles were found between preeclampsia patients and control. It
could be concluded that, pregnant Egyptian women carrying the Val (G) allele of GSTP1 GSTP1 -105 Ile →Val
(-313 A to G) polymorphism may be more susceptible to preeclampsia either in homozygous or heterozygous state
Vol 1,issue 7 Leptin receptor rs1137101 variant is risk factor for obesity an...IJAMHC
Genetic variations at the leptin receptor gene locus have been linked to diseases accompanying obesity and/or
obesity-related diseases in different populations.
However, the results from Previous studies have reported conflicting results. The aim of this study was to investigate whether LEPR gene SNP Gln223Arg (rs1137101) is associated with obesity and type II diabetes in Saudi adult women.
Therefore, SNP rs1137101 in LEPR gene in a total of 425 women (150 obese diabetic, 130 obese non-diabetic, and 145 normal weight) was investigated using PCR and sequencing techniques.
Polymorphism in Glutatione S-Transferase P1 and ManganeseSuperoxide Dismmutas...iosrjce
Susceptibility to preeclampsia is believed to have a genetic component. Several studies have reported
associations between polymorphisms of oxidative stress- related genes and preeclampsia. The aim of the present
study was to study the polymorphisms in anti-oxidant genes glutathione S-transferase P1 (GSTP1) and Mnsuperoxide
dismutase (Mn-SOD) in patients with of preeclampsia. Seventy four preeclampsia patients and fifty
age-matched healthy pregnant female controls were genotyped for GSTP1 and Mn-SOD. DNA was extracted
from peripheral blood of all patients and control women. DNA analysis was carried out by polymerase chain
reaction (PCR), and then digestion of the PCR products by restriction enzymes (RFLP) for both genes was
performed. As regards GSTP1, the carriers of Val (G) allele were significantly more frequent among
preeclampsia patients when compared to the control group (45.95% Vs. 19%, X
2=10.40, OR=2.418, 95%CI
(1.3698 - 4.269); p=0.0023). Preeclampsia patients had a lower frequency of GSTP1 Ile/Ile (AA) genotype
(31.1% Vs. 68% in control; X
2=13.09, OR=0.457, 95%CI (0.241 - 0.866); p =0.0164). The frequency of
GSTP1 Ile/Val (AG) and Val/Val (GG) genotypes was higher in preeclampsia patients than control (68.9%Vs.
32%; X
2= 12.83, OR=2.154, 95%CI (1.106 - 4.194); p =0.0241). However, non significant frequencies
differences as regards Mn-SOD genotypes or alleles were found between preeclampsia patients and control. It
could be concluded that, pregnant Egyptian women carrying the Val (G) allele of GSTP1 GSTP1 -105 Ile →Val
(-313 A to G) polymorphism may be more susceptible to preeclampsia either in homozygous or heterozygous state
Vol 1,issue 7 Leptin receptor rs1137101 variant is risk factor for obesity an...IJAMHC
Genetic variations at the leptin receptor gene locus have been linked to diseases accompanying obesity and/or
obesity-related diseases in different populations.
However, the results from Previous studies have reported conflicting results. The aim of this study was to investigate whether LEPR gene SNP Gln223Arg (rs1137101) is associated with obesity and type II diabetes in Saudi adult women.
Therefore, SNP rs1137101 in LEPR gene in a total of 425 women (150 obese diabetic, 130 obese non-diabetic, and 145 normal weight) was investigated using PCR and sequencing techniques.
"Glutathione supplementation attenuates lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in a mouse model of acute lung injury" appeared in a 2012 issue of 'Physiology' and summarized the research Stephen M. Black and his team conducted into acute lung injury.
Learn more about his research on his blog: http://stephenmblack.com/blog/
Jeremy Cohen - Raging Hormones and the Critically IllSMACC Conference
Jeremy Cohan took us on an Adrenal Function journey at SMACC Chicago with his talk Raging Hormones in Critical Care.
Cohan explores the natural roll of cortisol in the human body, various schools of thought and recent research in the areas of sepsis and cortisol resistance.
Alterations of Mitochondrial Functions and DNA in Diabetic Cardiomyopathy of ...CrimsonPublishersIOD
Alterations of Mitochondrial Functions and DNA in Diabetic Cardiomyopathy of CCK1 Receptors-Deficient Rats by Abdelbary Prince, Magdy A Ghoneim, Abdallah M El-Ebidi, Hala A Mousa and Jin Han in Interventions in Obesity & Diabetes
Whitney Stuart - Infection with PRRSV Affects Body Protein Deposition and Alt...John Blue
Infection with PRRSV Affects Body Protein Deposition and Alters Amino Acid Metabolism in Growing Pigs - Whitney Stuart, Texas Tech University, from the 2016 Allen D. Leman Swine Conference, September 17-20, 2016, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2016-leman-swine-conference-material
"Glutathione supplementation attenuates lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in a mouse model of acute lung injury" appeared in a 2012 issue of 'Physiology' and summarized the research Stephen M. Black and his team conducted into acute lung injury.
Learn more about his research on his blog: http://stephenmblack.com/blog/
Jeremy Cohen - Raging Hormones and the Critically IllSMACC Conference
Jeremy Cohan took us on an Adrenal Function journey at SMACC Chicago with his talk Raging Hormones in Critical Care.
Cohan explores the natural roll of cortisol in the human body, various schools of thought and recent research in the areas of sepsis and cortisol resistance.
Alterations of Mitochondrial Functions and DNA in Diabetic Cardiomyopathy of ...CrimsonPublishersIOD
Alterations of Mitochondrial Functions and DNA in Diabetic Cardiomyopathy of CCK1 Receptors-Deficient Rats by Abdelbary Prince, Magdy A Ghoneim, Abdallah M El-Ebidi, Hala A Mousa and Jin Han in Interventions in Obesity & Diabetes
Whitney Stuart - Infection with PRRSV Affects Body Protein Deposition and Alt...John Blue
Infection with PRRSV Affects Body Protein Deposition and Alters Amino Acid Metabolism in Growing Pigs - Whitney Stuart, Texas Tech University, from the 2016 Allen D. Leman Swine Conference, September 17-20, 2016, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2016-leman-swine-conference-material
Effective Localisation for Websites is important. See How TYPO3 supports flexible Localisation and Translationworkflows: Online and Offline Translation, Localisation through Visibility and Fallbacksettings, Translationagency connection.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
Assessment of immunomolecular_expression_and_prognostic_role_of_tlr7_among_pa...dr.Ihsan alsaimary
Dr. ihsan edan abdulkareem alsaimary
PROFESSOR IN MEDICAL MICROBIOLOGY AND MOLECULAR IMMUNOLOGY
ihsanalsaimary@gmail.com
mobile : 009647801410838
university of basrah - college of medicine - basrah -IRAQ
Journal Club about the Phase 2 study of Selonsertib in Diabetic Kidney Disease to Our Division on 12/9/19.
Also an intro about the Phase 3 study (MOSAIC) we will be launching before the end of the year
ABO Gene Polymorphism and Thrombomodulin −33G>A Polymorphism Were Not Risk Fa...UniversitasGadjahMada
Genetic factors contribute to about a half of coronary artery diseases. During the last several decades, some studies suggested that non-O blood group and thrombomodulin polymorphism −33G>A are the risk factors of coronary artery disease especially in Asia. There was no prior study in Indonesia regarding this issue. Hence, this study was designed to investigate the correlation of ABO polymorphism and thrombomodulin polymorphism −33G>A with the incidence of acute myocardial infarction (AMI). A total of 192 subjects were enrolled in this case control study. AMI patients were diagnosed based on World Health Organization criteria. Healthy patients were subjects with AMI risk factor without any sign and symptoms of AMI. Patients with diabetes mellitus, cancer, and arrhythmia were excluded from this study. Genotyping for both polymorphisms was performed by PCR RFLP methods. The result of this study suggested that ABO polymorphism and thrombomodulin polymorphism −33G>A were not risk factors of AMI, p= 0.727 and 푝p = 0.699, respectively. Furthermore, the analysis to identify the synergy of these polymorphisms failed to prove their correlation with AMI (p= 0.118). Conclusively, this study showed that ABO polymorphism and thrombomodulin polymorphism −33G>A were not risk factors of AMI.
dkNET Webinar: Leveraging Computational Strategies to Identify Type 1 Diabete...dkNET
dkNET New Investigator Pilot Program in Bioinformatics Awardee Webinar Series
Presenter: Wenting Wu, PhD. Research Assistant Professor, Center for Diabetes and Metabolic Diseases, Department of Medical and Molecular Genetics, Associate Director of Data and Analytics Core for Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine
Abstract
Type 1 diabetes (T1D) is an immune-mediated disease that results in insulin insufficiency and affects 0.3% of the population, including both children and adults. To support clinical trial efforts, there is an urgent need to develop reliable biomarkers capable of predicting T1D risk and guiding therapeutic interventions. Recently, whole blood bulk RNA sequencing has been used to guide T1D clinical trial design and assess response to disease modifying interventions. While the use of bulk RNA sequencing is cost-effective, these datasets provide limited information about cell specific gene expression changes. Here, we aimed to apply computational strategies to deconvolute cell type composition using cell specific gene expression references. Single-cell RNA sequencing (scRNA-seq) was conducted to profile peripheral blood mononuclear cells obtained from youth within recent T1D onset and age- and sex-matched controls and identified 31 distinct cell clusters. Using this pre-defined reference dataset, we ran computational algorithms CIBERSORTx and other deconvolution methods simultaneously to deconvolute cell proportions using public clinical trial data. We focused our initial analysis on data from the TN-20 Rituximab trial, which tested the anti-CD20 monoclonal antibody rituximab vs placebo in recent onset T1D. This talk will introduce recent advances of scRNA-seq techniques and computational deconvolution methods and demonstrate that how we apply different deconvolution approaches for secondary analysis of existing clinical trial data, in the purpose of linking cell specific immune signatures associated with drug responder status.
Upcoming webinars schedule: https://dknet.org/about/webinar
ABSTRACT- Background: Tuberculosis is one of the commonest chronic infectious diseases; highly endemic in India kills five lakh patients every year. Oxidative Stress plays important role in inflammatory and degenerative diseases including pulmonary tuberculosis. There is hardly any one study available in literature correlating oxidative stress, lipid profile values and antioxidant status together with the pulmonary tuberculosis; so we decided to conduct this study.
Methods: Study group included newly diagnosed 50 cases of pulmonary tuberculosis and control group included 50, age and sex matched healthy volunteers and employees. All the cases were subjected to complete physical and systemic examinations, routine investigations including Sputum for AFB by Ziehl-Neelsen staining, AFB culture and Chest X-ray and special tests like Erythrocyte sedimentation rate (ESR), Malondialdehyde (MDA) and Adenosine deaminase (ADA) and findings recorded and statistically analysed.
Results: In the study group with 33 males and 17 females, we were found Serum MDA mean ± SD 2.91±0.99; Serum ADA 38.15±13.47, while the mean levels of pleural fluid MDA and ADA in tubercular patients were found to be 1.65+0.53 nmoles/ml and 56.88+22.1 U/L respectively. While in controls with 61 males and 39 females, these values were 1.72±0.45 nmoles/ml (MDA), 20.15± 6.70 U/L (ADA) respectively.
Conclusion: Malondialdehyde (MDA) and Adenosine deaminase (ADA) were found statistically significantly higher in study group when compared with control, (p <0.001). Antioxidant plays important role for prevention of pulmonary Tuberculosis.
Key-words- Tuberculosis, Malondialdehyde, Adenosine deaminase, Lipid peroxidation, Oxidative stress
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using Deplo...James Anderson
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
Smart TV Buyer Insights Survey 2024 by 91mobiles.pdf91mobiles
91mobiles recently conducted a Smart TV Buyer Insights Survey in which we asked over 3,000 respondents about the TV they own, aspects they look at on a new TV, and their TV buying preferences.
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024Albert Hoitingh
In this session I delve into the encryption technology used in Microsoft 365 and Microsoft Purview. Including the concepts of Customer Key and Double Key Encryption.
Transcript: Selling digital books in 2024: Insights from industry leaders - T...BookNet Canada
The publishing industry has been selling digital audiobooks and ebooks for over a decade and has found its groove. What’s changed? What has stayed the same? Where do we go from here? Join a group of leading sales peers from across the industry for a conversation about the lessons learned since the popularization of digital books, best practices, digital book supply chain management, and more.
Link to video recording: https://bnctechforum.ca/sessions/selling-digital-books-in-2024-insights-from-industry-leaders/
Presented by BookNet Canada on May 28, 2024, with support from the Department of Canadian Heritage.
Software Delivery At the Speed of AI: Inflectra Invests In AI-Powered QualityInflectra
In this insightful webinar, Inflectra explores how artificial intelligence (AI) is transforming software development and testing. Discover how AI-powered tools are revolutionizing every stage of the software development lifecycle (SDLC), from design and prototyping to testing, deployment, and monitoring.
Learn about:
• The Future of Testing: How AI is shifting testing towards verification, analysis, and higher-level skills, while reducing repetitive tasks.
• Test Automation: How AI-powered test case generation, optimization, and self-healing tests are making testing more efficient and effective.
• Visual Testing: Explore the emerging capabilities of AI in visual testing and how it's set to revolutionize UI verification.
• Inflectra's AI Solutions: See demonstrations of Inflectra's cutting-edge AI tools like the ChatGPT plugin and Azure Open AI platform, designed to streamline your testing process.
Whether you're a developer, tester, or QA professional, this webinar will give you valuable insights into how AI is shaping the future of software delivery.
LF Energy Webinar: Electrical Grid Modelling and Simulation Through PowSyBl -...DanBrown980551
Do you want to learn how to model and simulate an electrical network from scratch in under an hour?
Then welcome to this PowSyBl workshop, hosted by Rte, the French Transmission System Operator (TSO)!
During the webinar, you will discover the PowSyBl ecosystem as well as handle and study an electrical network through an interactive Python notebook.
PowSyBl is an open source project hosted by LF Energy, which offers a comprehensive set of features for electrical grid modelling and simulation. Among other advanced features, PowSyBl provides:
- A fully editable and extendable library for grid component modelling;
- Visualization tools to display your network;
- Grid simulation tools, such as power flows, security analyses (with or without remedial actions) and sensitivity analyses;
The framework is mostly written in Java, with a Python binding so that Python developers can access PowSyBl functionalities as well.
What you will learn during the webinar:
- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
- For advanced developers: master the skills to efficiently apply PowSyBl functionalities to your real-world scenarios.
Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
Neuro-symbolic (NeSy) AI is on the rise. However, simply machine learning on just any symbolic structure is not sufficient to really harvest the gains of NeSy. These will only be gained when the symbolic structures have an actual semantics. I give an operational definition of semantics as “predictable inference”.
All of this illustrated with link prediction over knowledge graphs, but the argument is general.
Elevating Tactical DDD Patterns Through Object CalisthenicsDorra BARTAGUIZ
After immersing yourself in the blue book and its red counterpart, attending DDD-focused conferences, and applying tactical patterns, you're left with a crucial question: How do I ensure my design is effective? Tactical patterns within Domain-Driven Design (DDD) serve as guiding principles for creating clear and manageable domain models. However, achieving success with these patterns requires additional guidance. Interestingly, we've observed that a set of constraints initially designed for training purposes remarkably aligns with effective pattern implementation, offering a more ‘mechanical’ approach. Let's explore together how Object Calisthenics can elevate the design of your tactical DDD patterns, offering concrete help for those venturing into DDD for the first time!
Securing your Kubernetes cluster_ a step-by-step guide to success !KatiaHIMEUR1
Today, after several years of existence, an extremely active community and an ultra-dynamic ecosystem, Kubernetes has established itself as the de facto standard in container orchestration. Thanks to a wide range of managed services, it has never been so easy to set up a ready-to-use Kubernetes cluster.
However, this ease of use means that the subject of security in Kubernetes is often left for later, or even neglected. This exposes companies to significant risks.
In this talk, I'll show you step-by-step how to secure your Kubernetes cluster for greater peace of mind and reliability.
Securing your Kubernetes cluster_ a step-by-step guide to success !
The Assessment Of Adma 1
1. The assessment of ADMA as a prognostic marker for haemodynamic instability in patients with sepsis Felicity Dempsey Student No. 30478703 Assignment Date September 30th 2005 MSc in Biomedical Science
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7. Results ADMA and CRP Day 1 and Day 7 in patients with Sepsis Comparison of ADMA levels in Sepsis and Control Groups *All values are quoted as median and interquartile ranges* 0.05 0.88 (1.09-0.59 0.63 (0.71-0.57) ADMA umol/L p Sepsis Day 1 46 Control 10 Group n <0.0001 7.39 (13.6-3.89) 18.32(26.1-10.9) CRP mg/dL =0.01 1.06 (1.34-0.73) 0.88 (1.09-0.59) ADMA umol/L p Day 7 n = 32 Day 1 n= 46
8. ADMA levels in relation to Outcome Measures All values are quoted as median and interquartile range 0.03 1.04 (1.15-0.67) n =24 1.53 (1.59-1.14) n =5 ADMA umol/L Discharge Death Day 7 <0.0001 0.56 (0.98-0.49) n =15 0.91 (1.25-0.69) N =29 ADMA umol/L p No Inotrope Inotrope group Day 1
9. Results Correlation coefficients between ADMA levels, SOFA scores and CRP values There was no relationship between CRP and SOFA score on Day 1 or Day 7 0.95 0.012 CRP Day 7 0.0008 -0.53 CRP Day 1 0.02 0.44 SOFA Day 7 0.0007 0.49 SOFA Day 1 p Spearman’s Rho
![Introduction to ADMA ,[object Object],[object Object],[object Object],Fig 1. ,[object Object],[object Object]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)