Alterations of Mitochondrial Functions and DNA in Diabetic Cardiomyopathy of CCK1 Receptors-Deficient Rats by Abdelbary Prince, Magdy A Ghoneim, Abdallah M El-Ebidi, Hala A Mousa and Jin Han in Interventions in Obesity & Diabetes
COMPARISON OF SERUM LEVELS OF ZINC AND LEPTIN IN FEMALE ENDURANCE AND SPRINTI...EDITOR IJCRCPS
This study compared serum levels of zinc and leptin in female endurance runners, sprinters, and non-athletes. Blood samples were taken from 15 athletes and 15 non-athletes to measure zinc and leptin levels. The study found no significant differences in zinc or leptin levels between athletes and non-athletes. There was also no significant correlation found between zinc and leptin levels within the study groups. While previous research has shown some relationship between zinc and leptin, this study of female athletes found no relationship between the two factors.
Room a a08. mcgee-utility of qsofa lactate sepsis_(en)SoM
This document discusses the utility of qSOFA and SIRS criteria for diagnosing sepsis and predicting mortality. It presents a case study of a 55-year-old male with abdominal pain, fever, and elevated lactate who is diagnosed with a urinary tract infection. It then reviews literature comparing qSOFA to SIRS for sepsis diagnosis and mortality prediction, finding qSOFA superior. Organ dysfunction scores and lactate levels are discussed as predictors of mortality, with higher lactate and more organ failures correlating with increased risk of death. The role of lactate in shock resuscitation is also examined.
Transplantation of Autologous Bone Marrow- Derived Stromal Cells in Type 2 Di...CrimsonpublishersITERM
Type 2 Diabetes is a debilitating metabolic disorder which is also the seventh leading cause of death worldwide. Current therapeutic regimes to date have failed to achieve significant long-term glycemic control even with intensive insulin therapy as revealed by deregulated Hb1Ac and C-peptides levels. In the current study, we have evaluated the effect of regenerative cellular therapy for functional recovery from Diabetic pathophysiology. 10 patients with a median age of 51 years were selected for the study and subjected to bone marrow isolation. These samples were processed under sterile conditions for the enrichment of mononuclear cells (BM MNCs) from bone marrow. After strict quality control and characterization of cells, 2 x 106 cells/kg of BM MNCs were infused back into the patient through the anterior pancreaticoduodenal artery. We performed an evaluation of clinical parameters like Body Mass Index, Fasting Plasma Glucose, Fasting Plasma Insulin, HbA1c and C-peptide levels, and followed up the patients for 12 months. Our study showed a reduction in insulin dependency by ≥ 50%.
This document discusses chronic fatigue syndrome (CFS) and proposes that mitochondrial dysfunction may play a role in its pathogenesis. It presents two hypotheses: (A) CFS symptoms are due to psychological factors and normal metabolism, and (A') symptoms are due to deconditioning; (B) CFS results from a metabolic dysfunction causing insufficient energy production. The document reviews evidence that mitochondrial abnormalities have been found in CFS patients and may explain various symptoms. It then describes a study using a commercial "ATP profile" test on CFS patients and healthy controls, finding unexpected results that correlated mitochondrial dysfunction with illness severity.
Anti-Mullerian hormone (AMH) is a glycoprotein, a member of the transforming growth factor-B super family. This hormone is a sensitive marker of ovarian reserve. The present study aims to measure the Anti-Mullerian hormone in thalassemic females receiving the regular blood transfusion as well as patients of chronic idiopathic thrombocgtopenic purpura and age and sex matched controls. Serum Anti-Mullerian hormone was measured by ELISA and Ferritin were measured by RIA. Clinical evaluation was done for all patients including anthropometric measurements, pubertal staging and history taking. Results of the study were analyzed by appropriate statistical methods. Obtained results revealed that the values of Body Mass Index as well as Anti-Mullerian were significantly higher in controls than thalassemics and chronic idiopathic thrombocytopenic purpura and there was a negative correlation between serum Ferritin and Anti-Mullerian hormone. Moreover, Anti-Mullerian hormone was significantly higher in patients receiving Desferal than in those receiving Deferriprone. Reduced Anti-Mullerian hormone in thalassemics as well as chronic ITP patients are considered an important indicator declines in ovarian function which entail modification in the therapeutic plans for thalassemic and chronic ITP patients.
This study investigated the effects of reducing Fsp27 (fat-specific protein 27) levels through antisense oligonucleotides (ASOs) in mouse models of obesity and insulin resistance. Mice fed a high-fat diet or leptin-deficient ob/ob mice were treated with Fsp27 ASOs. Partial reduction of Fsp27 resulted in decreased visceral fat, improved insulin sensitivity and blood glucose control, and changes in genes related to lipid metabolism. The results suggest that reducing FSP27 activity through ASOs could be a potential therapeutic approach for insulin resistance and obesity in patients.
The document discusses a study that investigated the effects of Strobilanthes crispus extracts on atherosclerosis in hypercholesterolemic rabbits. Rabbits were divided into four groups: one receiving a high cholesterol diet only, one receiving the diet plus simvastatin, one receiving the diet plus S. crispus extract, and a control group. Histological analysis found lesser thickening of the aorta in the S. crispus and simvastatin groups compared to the high cholesterol group. Liver tissue from the S. crispus group showed no fatty or inflammatory changes seen in the other groups. The results support that S. crispus may slow atherosclerosis development through hypocholesterolemic effects.
Dietary Supplementation with Calcium in Healthy Rats Administered with Artemi...IOSR Journals
Reports on the role of calcium on predisposition to cardiovascular disease have been rather inconsistent while studies on its interaction with other medications are ongoing. We therefore investigated the effect of separate and combine administration of calcium supplement with artemisinin-based combination drug on hepatic and serum lipid profile. Thirty two male wistar rats were randomly assigned into four groups of eight rats each. The control (group A) received normal saline. Group B and D were placed on 10mg/Kg calcium twice daily for four weeks. On the thirtieth day, therapeutic dose of artemisinin-based combination was simultaneously administered to group C and group D twice daily for three days. All the rats were then sacrificed after 12 hours fasting, blood was withdrawn and the liver removed and homogenized in an appropriate buffer. Biochemical analysis showed no significant (p>0.05) variation in hepatic triaacylglycerol in all the treated groups whereas calcium supplementation was observed to induce a significant (p<0.05) reduction in hepatic cholesterol. Significant elevations due to calcium supplementation were also observed in serum total cholesterol, LDL cholesterol level and atherogenic risk index with a concomitant reduction in serum HDL cholesterol. No significant change was observed in serum total cholesterol, triacylglycerol and serum lipoproteins in all other treatment groups. Our study suggests that calcium supplementation may predispose to cardiovascular disease and that its co administration with ACT may not aggravate nor reduced the predisposition risk.
COMPARISON OF SERUM LEVELS OF ZINC AND LEPTIN IN FEMALE ENDURANCE AND SPRINTI...EDITOR IJCRCPS
This study compared serum levels of zinc and leptin in female endurance runners, sprinters, and non-athletes. Blood samples were taken from 15 athletes and 15 non-athletes to measure zinc and leptin levels. The study found no significant differences in zinc or leptin levels between athletes and non-athletes. There was also no significant correlation found between zinc and leptin levels within the study groups. While previous research has shown some relationship between zinc and leptin, this study of female athletes found no relationship between the two factors.
Room a a08. mcgee-utility of qsofa lactate sepsis_(en)SoM
This document discusses the utility of qSOFA and SIRS criteria for diagnosing sepsis and predicting mortality. It presents a case study of a 55-year-old male with abdominal pain, fever, and elevated lactate who is diagnosed with a urinary tract infection. It then reviews literature comparing qSOFA to SIRS for sepsis diagnosis and mortality prediction, finding qSOFA superior. Organ dysfunction scores and lactate levels are discussed as predictors of mortality, with higher lactate and more organ failures correlating with increased risk of death. The role of lactate in shock resuscitation is also examined.
Transplantation of Autologous Bone Marrow- Derived Stromal Cells in Type 2 Di...CrimsonpublishersITERM
Type 2 Diabetes is a debilitating metabolic disorder which is also the seventh leading cause of death worldwide. Current therapeutic regimes to date have failed to achieve significant long-term glycemic control even with intensive insulin therapy as revealed by deregulated Hb1Ac and C-peptides levels. In the current study, we have evaluated the effect of regenerative cellular therapy for functional recovery from Diabetic pathophysiology. 10 patients with a median age of 51 years were selected for the study and subjected to bone marrow isolation. These samples were processed under sterile conditions for the enrichment of mononuclear cells (BM MNCs) from bone marrow. After strict quality control and characterization of cells, 2 x 106 cells/kg of BM MNCs were infused back into the patient through the anterior pancreaticoduodenal artery. We performed an evaluation of clinical parameters like Body Mass Index, Fasting Plasma Glucose, Fasting Plasma Insulin, HbA1c and C-peptide levels, and followed up the patients for 12 months. Our study showed a reduction in insulin dependency by ≥ 50%.
This document discusses chronic fatigue syndrome (CFS) and proposes that mitochondrial dysfunction may play a role in its pathogenesis. It presents two hypotheses: (A) CFS symptoms are due to psychological factors and normal metabolism, and (A') symptoms are due to deconditioning; (B) CFS results from a metabolic dysfunction causing insufficient energy production. The document reviews evidence that mitochondrial abnormalities have been found in CFS patients and may explain various symptoms. It then describes a study using a commercial "ATP profile" test on CFS patients and healthy controls, finding unexpected results that correlated mitochondrial dysfunction with illness severity.
Anti-Mullerian hormone (AMH) is a glycoprotein, a member of the transforming growth factor-B super family. This hormone is a sensitive marker of ovarian reserve. The present study aims to measure the Anti-Mullerian hormone in thalassemic females receiving the regular blood transfusion as well as patients of chronic idiopathic thrombocgtopenic purpura and age and sex matched controls. Serum Anti-Mullerian hormone was measured by ELISA and Ferritin were measured by RIA. Clinical evaluation was done for all patients including anthropometric measurements, pubertal staging and history taking. Results of the study were analyzed by appropriate statistical methods. Obtained results revealed that the values of Body Mass Index as well as Anti-Mullerian were significantly higher in controls than thalassemics and chronic idiopathic thrombocytopenic purpura and there was a negative correlation between serum Ferritin and Anti-Mullerian hormone. Moreover, Anti-Mullerian hormone was significantly higher in patients receiving Desferal than in those receiving Deferriprone. Reduced Anti-Mullerian hormone in thalassemics as well as chronic ITP patients are considered an important indicator declines in ovarian function which entail modification in the therapeutic plans for thalassemic and chronic ITP patients.
This study investigated the effects of reducing Fsp27 (fat-specific protein 27) levels through antisense oligonucleotides (ASOs) in mouse models of obesity and insulin resistance. Mice fed a high-fat diet or leptin-deficient ob/ob mice were treated with Fsp27 ASOs. Partial reduction of Fsp27 resulted in decreased visceral fat, improved insulin sensitivity and blood glucose control, and changes in genes related to lipid metabolism. The results suggest that reducing FSP27 activity through ASOs could be a potential therapeutic approach for insulin resistance and obesity in patients.
The document discusses a study that investigated the effects of Strobilanthes crispus extracts on atherosclerosis in hypercholesterolemic rabbits. Rabbits were divided into four groups: one receiving a high cholesterol diet only, one receiving the diet plus simvastatin, one receiving the diet plus S. crispus extract, and a control group. Histological analysis found lesser thickening of the aorta in the S. crispus and simvastatin groups compared to the high cholesterol group. Liver tissue from the S. crispus group showed no fatty or inflammatory changes seen in the other groups. The results support that S. crispus may slow atherosclerosis development through hypocholesterolemic effects.
Dietary Supplementation with Calcium in Healthy Rats Administered with Artemi...IOSR Journals
Reports on the role of calcium on predisposition to cardiovascular disease have been rather inconsistent while studies on its interaction with other medications are ongoing. We therefore investigated the effect of separate and combine administration of calcium supplement with artemisinin-based combination drug on hepatic and serum lipid profile. Thirty two male wistar rats were randomly assigned into four groups of eight rats each. The control (group A) received normal saline. Group B and D were placed on 10mg/Kg calcium twice daily for four weeks. On the thirtieth day, therapeutic dose of artemisinin-based combination was simultaneously administered to group C and group D twice daily for three days. All the rats were then sacrificed after 12 hours fasting, blood was withdrawn and the liver removed and homogenized in an appropriate buffer. Biochemical analysis showed no significant (p>0.05) variation in hepatic triaacylglycerol in all the treated groups whereas calcium supplementation was observed to induce a significant (p<0.05) reduction in hepatic cholesterol. Significant elevations due to calcium supplementation were also observed in serum total cholesterol, LDL cholesterol level and atherogenic risk index with a concomitant reduction in serum HDL cholesterol. No significant change was observed in serum total cholesterol, triacylglycerol and serum lipoproteins in all other treatment groups. Our study suggests that calcium supplementation may predispose to cardiovascular disease and that its co administration with ACT may not aggravate nor reduced the predisposition risk.
This study examined the association between angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and type-2 diabetic nephropathy in Eastern Indian populations. The researchers genotyped 91 subjects, including 30 with diabetic nephropathy, 30 with diabetes but no nephropathy, and 31 healthy controls. They found no significant differences in genotype or allele frequencies between the groups. Specifically, the frequency of the DD genotype, associated with higher ACE levels, was similar between those with and without nephropathy. This suggests ACE insertion/deletion polymorphism is not significantly associated with type-2 diabetic nephropathy in this population.
Mitochondrial Medicine Society MitoAction Updates 4.1.16mitoaction
Areas of discussion include: Transplantation in Mito patients, Stroke protocol for MELAS, Standards of care for Mito patients, Centers of Excellence and the need for community involvement/input (v2 slides)
Association of cardio metabolic risk factors, serum nitric oxide metabolite a...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
This study aimed to investigate using reticulocyte hemoglobin equivalent (RetHe) measurement and serum hepcidin level to differentiate iron deficiency anemia (IDA) from anemia of chronic disease (ACD), with the goal of reducing the number of tests required. The study analyzed data from 77 subjects and found that a serum ferritin level of 30μg/L differentiated IDA and ACD with reasonable sensitivity and specificity. A serum hepcidin level of 40ng/mL also differentiated the conditions, though with lower specificity for IDA. For subjects with mixed etiology, RetHe helped identify those likely to respond to iron therapy. The study concludes that using RetHe and serum hepcidin could reduce the diagnostic
This clinical trial demonstrated persistent graft function and regulated insulin secretion in a patient with type 1 diabetes who received an allogeneic islet transplant using a novel oxygenated chamber system without immunosuppression. The patient showed basal C-peptide production and stimulated insulin response over 10 months. The chamber protected the islets from immune rejection while continuously supplying oxygen. This approach may enable widespread application of islet and other cell-based therapies by overcoming limitations of donor availability and need for immunosuppression.
The role of curcumin in streptozotocin induced hepatic damage and the trans-d...Prof. Hesham N. Mustafa
Diabetic patients frequently suffer from non-alcoholic steatohepatitis. The current study aimed to investigate the role of curcumin and the response of hepatic stellate cells in streptozotocin (STZ)-induced hepatic damage. Sixty male rats were divided into three groups. The normal control injected with a citrate buffer vehicle and the diabetic control group which was injected intraperitoneally (IP) with a single-dose of streptozotocin (50mg/kg body weight) and a diabetic group was treated with an oral dose of curcumin at 80 mg/kg body weight daily for 60 days. Curcumin effectively counteracts oxidative stress-mediated hepatic damage and improves biochemical parameters. Alpha-smooth muscle actin (α-SMA) was significantly reduced, and insulin antibodies showed strong positive immunoreactivity with curcumin administration. These results optimistically demonstrate the potential use of curcumin, which is attributed to its antiradical/antioxidant activities and its potential β-cell regenerative properties. Also, it has the capability to encourage the trans-differentiation of hepatic stellate cells into insulin-producing cells for a period of time. In addition, as it is an anti-fibrotic mediator that inhibits hepatic stellate cell activation and the transition to myofibroblast-like cells, this suggests the possibility of considering curcumin's novel therapeutic effects in reducing hepatic dysfunction in diabetic patients.
Search for atoxic cereals: a single blind, cross-over study on the safety of...Enrique Moreno Gonzalez
Cereals of baking quality with absent or reduced toxicity are actively sought as alternative therapy to a gluten-free diet (GFD) for patients with coeliac disease (CD). Triticum monococcum, an ancient wheat, is a potential candidate having no toxicity in in-vitro and exvivo studies. The aim of our study was to investigate on the safety of administration of a single dose of gluten of Tm in patients with CD on GFD.
Background and objectives: Iron is one of the major component
of hemoglobin, is required for transport of oxygen, ferritin is a
protein for storage iron, and transferring is a protein for iron
transport, all these it may be change in breast cancer.
The aim of present study was to measure the serum ferritin, iron,
total iron binding capacity, transferring, and C-reactive protein
concentration in breast tumors.
Material and method: A prospective study was carried out from
April 2013 to August 2014 by clinical biochemistry department in
College of Pharmacy-University of Sulaimani on (45) healthy
female individuals, (group 1) and (50) females with breast tumor
(group 2).
Results: The mean value of serum iron, transferring, total iron
binding capacity were significantly lower in females with breast
tumors (group 2), than that of healthy female individuals, (group
1), while serum ferritin was significantly higher in females with
breast tumors (group2), than that of healthy individuals (group
1).
Conclusion: Based on findings of the present study it can be
concluded that breast tumors can cause deficient of all iron
profile except ferritin will be increase in female breast cancers.
Key words- Serum iron, S.Ferritin, S. Total iron binding, S.
Transferrin, S.C-Reactive protein, breast tumors.
39689944 Age Loc Vitality Ingredient Vtudies[1]Laura Fallon
This study examined the effects of Cordyceps sinensis Cs-4 supplementation on age-related changes in the expression of mitochondrial genes in mouse skeletal muscle and brain tissue. The researchers identified 393 genes related to mitochondria that changed expression with age in these tissues. Cs-4 supplementation opposed age-related changes in 52 of these genes, with 92% changing in a direction associated with younger gene expression. Analysis also showed Cs-4 impacted several gene pathways associated with aging in muscle tissue. The results provide evidence that Cs-4 can modulate aging effects at the transcriptional level in muscles and brain.
Serum il17 and il6 levels in a sample of iraqi patients with rheumatoid arthr...Alexander Decker
This study examined serum levels of IL-17 and IL-6 in 50 Iraqi patients with rheumatoid arthritis and 30 healthy controls. Serum levels of both IL-17 and IL-6 were significantly higher in patients compared to controls. There was a strong, highly statistically significant correlation between serum IL-17 and IL-6 levels. The optimum cut-off values for differentiating patients from controls were a serum IL-17 level of ≥71.8 pg/ml and a serum IL-6 level of ≥8.1 pg/ml. This suggests IL-17 and IL-6 may help diagnose rheumatoid arthritis and identify potential treatment targets.
Polymorphism in Glutatione S-Transferase P1 and ManganeseSuperoxide Dismmutas...iosrjce
This study examined polymorphisms in the glutathione S-transferase P1 (GSTP1) and manganese superoxide dismutase (Mn-SOD) genes in 74 Egyptian women with preeclampsia and 50 healthy pregnant controls. DNA was extracted from blood samples and genotyped using polymerase chain reaction and restriction fragment length polymorphism analysis. Carriers of the GSTP1 Val allele were more frequent among preeclampsia patients compared to controls. Preeclampsia patients also had a lower frequency of the GSTP1 Ile/Ile genotype and higher frequency of the Ile/Val and Val/Val genotypes. However, no significant differences in Mn-SOD genotypes or
Evaluation of anti atherosclerotic activity of virgin coconut oilRam Sahu
1. The study evaluated the anti-atherosclerotic effects of virgin coconut oil (VCO) in male Wistar rats fed high lipid and high carbohydrate diets to induce atherosclerosis.
2. Rats fed VCO along with normal, high carbohydrate, and high lipid diets had significantly lower body weight, total cholesterol, triglycerides, LDL, and VLDL, but higher HDL compared to control diet groups after 8 weeks.
3. VCO treatment also significantly reduced the atherogenic index and increased percentage of protection against atherosclerosis in all diet groups compared to controls. This suggests VCO has anti-atherosclerotic properties.
This study examined the association between the ACE gene I/D polymorphism and type 2 diabetes in the Mewari population of Udaipur city, Rajasthan, India. The study genotyped 111 Mewari individuals, including 50 type 2 diabetic patients and 61 healthy controls. The frequencies of the DD, ID, and II genotypes were calculated for males and females. While the odds ratio suggested an increased risk of diabetes for males with the DD genotype, this was not statistically significant. No association was found between the D allele and increased risk of type 2 diabetes when considering gender.
This research article studied the effects of quercetin (QCT) on experimentally induced diabetes in rats. Rats were divided into three groups: a control group, a diabetic group induced with streptozotocin (STZ), and a QCT-treated group that received QCT before and after STZ induction. Blood glucose levels increased significantly in the diabetic group but decreased in the QCT-treated group. Histological analysis found that STZ caused pancreatic beta cell degeneration and inflammation in the diabetic group. QCT treatment reversed many of these changes in the pancreas and increased beta cell numbers. Immunohistochemistry revealed that STZ increased iNOS and caspase-3, markers of inflammation and apoptosis, while QCT
Association between polymorphisms of the DNA repair gene (OGG1) in Iraqi pati...iosrjce
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Insulin resistance and cancer the role of insulin and IGFsBladimir Viloria
This document discusses the role of insulin and insulin-like growth factors (ILFs) such as IGF1 and IGF2 in linking insulin resistance to cancer risk. It summarizes evidence that ILPs regulate cell proliferation, differentiation, and apoptosis through signaling pathways involved in carcinogenesis. While some epidemiological studies found associations between ILP levels and cancer risk, the data is still debated. The document reviews how ILP signaling through insulin and IGF receptors can activate pathways driving cell growth and inhibiting cell death, thus playing a role in cancer development and progression. It proposes ILPs may represent a link between the pathogenic processes of insulin resistance, inflammation, diabetes, and certain cancers.
Glenn et al-Body Endogenous Nutritive Support Following TBI Dr. George A. Brooks
This document discusses a study evaluating the hypothesis that after traumatic brain injury (TBI), nutritive needs of the injured brain are supported by large increases in lactate shuttling throughout the body. Using dual isotope tracers, the study found that patients with TBI had a 71% increase in systemic lactate production compared to healthy controls, which was largely cleared by greater glucose production via gluconeogenesis from lactate. Specifically, gluconeogenesis from lactate accounted for 67.1% of glucose production in TBI patients versus 15.2% in controls. This suggests that after TBI, elevations in blood glucose result from mobilization of lactate from body stores to indirectly make substrate available for organs like the brain
The document discusses the role of albumin in the pediatric intensive care unit. It summarizes the controversy around albumin administration based on conflicting results from meta-analyses in the late 1990s and 2000s. Specifically, the first meta-analysis in 1998 suggested albumin administration could be harmful, while the second in 2001 found it was safe but not beneficial, and the third in 2003 was in favor of clinical use. More recent large trials like SAFE from 2004 found albumin was as safe as saline for volume resuscitation in critically ill patients, though subgroups like severe sepsis and traumatic brain injury showed different outcomes. Maintaining normal albumin levels above 3 g/dL was found to be beneficial to organ function in Dubois
Raised Lipid Profile In Rheumatoid Arthritis- A Risk For CVDiosrjce
IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB) covers studies of the chemical processes in living organisms, structure and function of cellular components such as proteins, carbohydrates, lipids, nucleic acids and other biomolecules, chemical properties of important biological molecules, like proteins, in particular the chemistry of enzyme-catalyzed reactions, genetic code (DNA, RNA), protein synthesis, cell membrane transport, and signal transduction. IOSR-JBB is privileged to focus on a wide range of biotechnology as well as high quality articles on genetic engineering, cell and tissue culture technologies, genetics, microbiology, molecular biology, biochemistry, embryology, cell biology, chemical engineering, bioprocess engineering, information technology, biorobotics.
Background: High serum phosphate level is associated with increased CVD morbidity and mortality in CKD patients. We sought to compare the efϐicacy of non-calcium containing phosphate binder Sevelamer Carbonate (SC) with Lanthanum Carbonate (LC) in patients with CKD stage 3-5.
П. Сутерс "Проявления инсулинорезистентности и гликемический контроль в интен...rnw-aspen
Доклад с 15 Межрегиональной научно-практической конференции "Искусственное питание и инфузионная терапия больных в медицине критических состояний" 21-22 мая 2015 г
This study investigated how insulin signaling through Akt regulates mitochondrial oxidative phosphorylation complex V activity in cardiac muscle. The key findings were:
1) Insulin stimulation causes Akt to translocate sequentially to the mitochondrial intermembrane space, inner membrane, and matrix.
2) Only the Akt1 isoform translocates to mitochondria in response to insulin, and this translocation is blunted in models of diabetes.
3) Activating mitochondrial Akt1 increases complex V activity in normal cardiac muscle and restores its lower activity in diabetic models. Basal complex V activity is also lower in Akt1 knockout mice.
4) Insulin-stimulated complex V activity is maintained in Akt1 knockout mice due to compens
This study examined the association between angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and type-2 diabetic nephropathy in Eastern Indian populations. The researchers genotyped 91 subjects, including 30 with diabetic nephropathy, 30 with diabetes but no nephropathy, and 31 healthy controls. They found no significant differences in genotype or allele frequencies between the groups. Specifically, the frequency of the DD genotype, associated with higher ACE levels, was similar between those with and without nephropathy. This suggests ACE insertion/deletion polymorphism is not significantly associated with type-2 diabetic nephropathy in this population.
Mitochondrial Medicine Society MitoAction Updates 4.1.16mitoaction
Areas of discussion include: Transplantation in Mito patients, Stroke protocol for MELAS, Standards of care for Mito patients, Centers of Excellence and the need for community involvement/input (v2 slides)
Association of cardio metabolic risk factors, serum nitric oxide metabolite a...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
This study aimed to investigate using reticulocyte hemoglobin equivalent (RetHe) measurement and serum hepcidin level to differentiate iron deficiency anemia (IDA) from anemia of chronic disease (ACD), with the goal of reducing the number of tests required. The study analyzed data from 77 subjects and found that a serum ferritin level of 30μg/L differentiated IDA and ACD with reasonable sensitivity and specificity. A serum hepcidin level of 40ng/mL also differentiated the conditions, though with lower specificity for IDA. For subjects with mixed etiology, RetHe helped identify those likely to respond to iron therapy. The study concludes that using RetHe and serum hepcidin could reduce the diagnostic
This clinical trial demonstrated persistent graft function and regulated insulin secretion in a patient with type 1 diabetes who received an allogeneic islet transplant using a novel oxygenated chamber system without immunosuppression. The patient showed basal C-peptide production and stimulated insulin response over 10 months. The chamber protected the islets from immune rejection while continuously supplying oxygen. This approach may enable widespread application of islet and other cell-based therapies by overcoming limitations of donor availability and need for immunosuppression.
The role of curcumin in streptozotocin induced hepatic damage and the trans-d...Prof. Hesham N. Mustafa
Diabetic patients frequently suffer from non-alcoholic steatohepatitis. The current study aimed to investigate the role of curcumin and the response of hepatic stellate cells in streptozotocin (STZ)-induced hepatic damage. Sixty male rats were divided into three groups. The normal control injected with a citrate buffer vehicle and the diabetic control group which was injected intraperitoneally (IP) with a single-dose of streptozotocin (50mg/kg body weight) and a diabetic group was treated with an oral dose of curcumin at 80 mg/kg body weight daily for 60 days. Curcumin effectively counteracts oxidative stress-mediated hepatic damage and improves biochemical parameters. Alpha-smooth muscle actin (α-SMA) was significantly reduced, and insulin antibodies showed strong positive immunoreactivity with curcumin administration. These results optimistically demonstrate the potential use of curcumin, which is attributed to its antiradical/antioxidant activities and its potential β-cell regenerative properties. Also, it has the capability to encourage the trans-differentiation of hepatic stellate cells into insulin-producing cells for a period of time. In addition, as it is an anti-fibrotic mediator that inhibits hepatic stellate cell activation and the transition to myofibroblast-like cells, this suggests the possibility of considering curcumin's novel therapeutic effects in reducing hepatic dysfunction in diabetic patients.
Search for atoxic cereals: a single blind, cross-over study on the safety of...Enrique Moreno Gonzalez
Cereals of baking quality with absent or reduced toxicity are actively sought as alternative therapy to a gluten-free diet (GFD) for patients with coeliac disease (CD). Triticum monococcum, an ancient wheat, is a potential candidate having no toxicity in in-vitro and exvivo studies. The aim of our study was to investigate on the safety of administration of a single dose of gluten of Tm in patients with CD on GFD.
Background and objectives: Iron is one of the major component
of hemoglobin, is required for transport of oxygen, ferritin is a
protein for storage iron, and transferring is a protein for iron
transport, all these it may be change in breast cancer.
The aim of present study was to measure the serum ferritin, iron,
total iron binding capacity, transferring, and C-reactive protein
concentration in breast tumors.
Material and method: A prospective study was carried out from
April 2013 to August 2014 by clinical biochemistry department in
College of Pharmacy-University of Sulaimani on (45) healthy
female individuals, (group 1) and (50) females with breast tumor
(group 2).
Results: The mean value of serum iron, transferring, total iron
binding capacity were significantly lower in females with breast
tumors (group 2), than that of healthy female individuals, (group
1), while serum ferritin was significantly higher in females with
breast tumors (group2), than that of healthy individuals (group
1).
Conclusion: Based on findings of the present study it can be
concluded that breast tumors can cause deficient of all iron
profile except ferritin will be increase in female breast cancers.
Key words- Serum iron, S.Ferritin, S. Total iron binding, S.
Transferrin, S.C-Reactive protein, breast tumors.
39689944 Age Loc Vitality Ingredient Vtudies[1]Laura Fallon
This study examined the effects of Cordyceps sinensis Cs-4 supplementation on age-related changes in the expression of mitochondrial genes in mouse skeletal muscle and brain tissue. The researchers identified 393 genes related to mitochondria that changed expression with age in these tissues. Cs-4 supplementation opposed age-related changes in 52 of these genes, with 92% changing in a direction associated with younger gene expression. Analysis also showed Cs-4 impacted several gene pathways associated with aging in muscle tissue. The results provide evidence that Cs-4 can modulate aging effects at the transcriptional level in muscles and brain.
Serum il17 and il6 levels in a sample of iraqi patients with rheumatoid arthr...Alexander Decker
This study examined serum levels of IL-17 and IL-6 in 50 Iraqi patients with rheumatoid arthritis and 30 healthy controls. Serum levels of both IL-17 and IL-6 were significantly higher in patients compared to controls. There was a strong, highly statistically significant correlation between serum IL-17 and IL-6 levels. The optimum cut-off values for differentiating patients from controls were a serum IL-17 level of ≥71.8 pg/ml and a serum IL-6 level of ≥8.1 pg/ml. This suggests IL-17 and IL-6 may help diagnose rheumatoid arthritis and identify potential treatment targets.
Polymorphism in Glutatione S-Transferase P1 and ManganeseSuperoxide Dismmutas...iosrjce
This study examined polymorphisms in the glutathione S-transferase P1 (GSTP1) and manganese superoxide dismutase (Mn-SOD) genes in 74 Egyptian women with preeclampsia and 50 healthy pregnant controls. DNA was extracted from blood samples and genotyped using polymerase chain reaction and restriction fragment length polymorphism analysis. Carriers of the GSTP1 Val allele were more frequent among preeclampsia patients compared to controls. Preeclampsia patients also had a lower frequency of the GSTP1 Ile/Ile genotype and higher frequency of the Ile/Val and Val/Val genotypes. However, no significant differences in Mn-SOD genotypes or
Evaluation of anti atherosclerotic activity of virgin coconut oilRam Sahu
1. The study evaluated the anti-atherosclerotic effects of virgin coconut oil (VCO) in male Wistar rats fed high lipid and high carbohydrate diets to induce atherosclerosis.
2. Rats fed VCO along with normal, high carbohydrate, and high lipid diets had significantly lower body weight, total cholesterol, triglycerides, LDL, and VLDL, but higher HDL compared to control diet groups after 8 weeks.
3. VCO treatment also significantly reduced the atherogenic index and increased percentage of protection against atherosclerosis in all diet groups compared to controls. This suggests VCO has anti-atherosclerotic properties.
This study examined the association between the ACE gene I/D polymorphism and type 2 diabetes in the Mewari population of Udaipur city, Rajasthan, India. The study genotyped 111 Mewari individuals, including 50 type 2 diabetic patients and 61 healthy controls. The frequencies of the DD, ID, and II genotypes were calculated for males and females. While the odds ratio suggested an increased risk of diabetes for males with the DD genotype, this was not statistically significant. No association was found between the D allele and increased risk of type 2 diabetes when considering gender.
This research article studied the effects of quercetin (QCT) on experimentally induced diabetes in rats. Rats were divided into three groups: a control group, a diabetic group induced with streptozotocin (STZ), and a QCT-treated group that received QCT before and after STZ induction. Blood glucose levels increased significantly in the diabetic group but decreased in the QCT-treated group. Histological analysis found that STZ caused pancreatic beta cell degeneration and inflammation in the diabetic group. QCT treatment reversed many of these changes in the pancreas and increased beta cell numbers. Immunohistochemistry revealed that STZ increased iNOS and caspase-3, markers of inflammation and apoptosis, while QCT
Association between polymorphisms of the DNA repair gene (OGG1) in Iraqi pati...iosrjce
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Insulin resistance and cancer the role of insulin and IGFsBladimir Viloria
This document discusses the role of insulin and insulin-like growth factors (ILFs) such as IGF1 and IGF2 in linking insulin resistance to cancer risk. It summarizes evidence that ILPs regulate cell proliferation, differentiation, and apoptosis through signaling pathways involved in carcinogenesis. While some epidemiological studies found associations between ILP levels and cancer risk, the data is still debated. The document reviews how ILP signaling through insulin and IGF receptors can activate pathways driving cell growth and inhibiting cell death, thus playing a role in cancer development and progression. It proposes ILPs may represent a link between the pathogenic processes of insulin resistance, inflammation, diabetes, and certain cancers.
Glenn et al-Body Endogenous Nutritive Support Following TBI Dr. George A. Brooks
This document discusses a study evaluating the hypothesis that after traumatic brain injury (TBI), nutritive needs of the injured brain are supported by large increases in lactate shuttling throughout the body. Using dual isotope tracers, the study found that patients with TBI had a 71% increase in systemic lactate production compared to healthy controls, which was largely cleared by greater glucose production via gluconeogenesis from lactate. Specifically, gluconeogenesis from lactate accounted for 67.1% of glucose production in TBI patients versus 15.2% in controls. This suggests that after TBI, elevations in blood glucose result from mobilization of lactate from body stores to indirectly make substrate available for organs like the brain
The document discusses the role of albumin in the pediatric intensive care unit. It summarizes the controversy around albumin administration based on conflicting results from meta-analyses in the late 1990s and 2000s. Specifically, the first meta-analysis in 1998 suggested albumin administration could be harmful, while the second in 2001 found it was safe but not beneficial, and the third in 2003 was in favor of clinical use. More recent large trials like SAFE from 2004 found albumin was as safe as saline for volume resuscitation in critically ill patients, though subgroups like severe sepsis and traumatic brain injury showed different outcomes. Maintaining normal albumin levels above 3 g/dL was found to be beneficial to organ function in Dubois
Raised Lipid Profile In Rheumatoid Arthritis- A Risk For CVDiosrjce
IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB) covers studies of the chemical processes in living organisms, structure and function of cellular components such as proteins, carbohydrates, lipids, nucleic acids and other biomolecules, chemical properties of important biological molecules, like proteins, in particular the chemistry of enzyme-catalyzed reactions, genetic code (DNA, RNA), protein synthesis, cell membrane transport, and signal transduction. IOSR-JBB is privileged to focus on a wide range of biotechnology as well as high quality articles on genetic engineering, cell and tissue culture technologies, genetics, microbiology, molecular biology, biochemistry, embryology, cell biology, chemical engineering, bioprocess engineering, information technology, biorobotics.
Background: High serum phosphate level is associated with increased CVD morbidity and mortality in CKD patients. We sought to compare the efϐicacy of non-calcium containing phosphate binder Sevelamer Carbonate (SC) with Lanthanum Carbonate (LC) in patients with CKD stage 3-5.
П. Сутерс "Проявления инсулинорезистентности и гликемический контроль в интен...rnw-aspen
Доклад с 15 Межрегиональной научно-практической конференции "Искусственное питание и инфузионная терапия больных в медицине критических состояний" 21-22 мая 2015 г
This study investigated how insulin signaling through Akt regulates mitochondrial oxidative phosphorylation complex V activity in cardiac muscle. The key findings were:
1) Insulin stimulation causes Akt to translocate sequentially to the mitochondrial intermembrane space, inner membrane, and matrix.
2) Only the Akt1 isoform translocates to mitochondria in response to insulin, and this translocation is blunted in models of diabetes.
3) Activating mitochondrial Akt1 increases complex V activity in normal cardiac muscle and restores its lower activity in diabetic models. Basal complex V activity is also lower in Akt1 knockout mice.
4) Insulin-stimulated complex V activity is maintained in Akt1 knockout mice due to compens
The deposition of cholesterol in blood vessels can lead to blood clotting and coronary artery disease. High intake of saturated fats increases cholesterol levels in the blood. Cholesterol is carried by lipoproteins and problems arise with increased low-density lipoprotein uptake. This study compared the effects of fenugreek, turmeric, and lemon on lowering blood lipid levels. 90 patients were divided into groups taking one of the herbs daily for 2 months. Results showed that all three herbs significantly reduced total cholesterol, triglycerides, and LDL cholesterol, but did not increase HDL cholesterol. Turmeric provided the greatest reductions of 16.1%, 20.01%, and 17.59% respectively. The study concluded these herbs are mild to
This study investigated how insulin deficiency affects mitochondrial oxidative phosphorylation in the hearts of diabetic mice. The key findings were:
1) Activity of oxidative phosphorylation complex V (ATP synthase) was significantly reduced in the hearts of streptozotocin-induced diabetic mice.
2) Normalizing blood glucose with phlorizin treatment did not improve complex V activity, but insulin treatment did normalize it, indicating the reduction was caused by insulin deficiency rather than hyperglycemia.
3) Acute insulin stimulation induced phosphorylation and translocation of Akt to mitochondria in heart muscle. This translocation was enhanced in diabetic mice and blocked inhibition of Akt, blunting the activation of complex V by insulin.
This document reviews the link between obesity, insulin resistance, and cancer. It discusses how obesity leads to hyperinsulinemia and insulin resistance, which are linked to increased cancer risk. Specifically, it summarizes that insulin signaling through the insulin receptor A isoform can have direct oncogenic effects on cancer cells by activating pathways like PI3K-AKT and Ras-MAPK that promote cell growth and inhibit apoptosis. Lowering insulin levels and resistance through drugs like metformin may help reduce cancer risk and improve outcomes for obese and diabetic patients. The review focuses on defining the molecular mechanisms connecting obesity, insulin resistance, and cancer development.
1. Adiponectin is a hormone produced by adipose tissue that plays an important role in glucose regulation and fatty acid catabolism. Low levels are associated with obesity, diabetes, and other insulin resistant states.
2. The document discusses the history, structure, receptors and metabolic effects of adiponectin. It acts through receptors AdipoR1/R2 to increase fatty acid oxidation and insulin sensitivity.
3. Dysregulation of adiponectin is implicated in metabolic syndrome and related conditions. Certain drugs like thiazolidinediones are shown to increase adiponectin levels and may have therapeutic potential.
Potential role of uric acid in correlation with epidemics of hypertension and...Apollo Hospitals
This document summarizes a study examining the potential role of uric acid in correlation with hypertension and albumin creatinine ratio in patients with diabetic nephropathy. The study included 180 subjects divided into three groups: healthy controls, those with type 2 diabetes but without nephropathy, and those with both type 2 diabetes and nephropathy. Results showed higher levels of factors like blood sugar, HbA1c, creatinine and albumin creatinine ratio in the nephropathy group compared to the other groups. While uric acid correlated positively with blood pressure and albumin creatinine ratio in the diabetes groups, no significant difference was found. Larger future studies are needed to better evaluate
Study of serum magnesium and fasting blood glucose in hypertensioniosrjce
A study was carried out to determine the fasting blood glucose and serum magnesium levels in
patients with hypertension. A total of 80 hypertensive patients were evaluated, of which, 58 were males and 22
were females. The mean ages of male and female hypertensive subjects were 48.06±6.53 and 50.83±7.62
respectively. Hypomagnesemia was observed in 61.25% subjects and raised fasting blood glucose was identified
in 55.1% of individuals. Therefore occurrence of low serum magnesium and raised blood sugar level in patients
with hypertension was observed
This study analyzed proteins in the skin of mice with diet-induced type 2 diabetes compared to non-diabetic controls. Mice were fed a high-fat diet for 16 weeks to induce obesity and diabetes. Skin samples were then analyzed using proteomics. Out of over 1000 protein spots, 28 were significantly altered between diabetic and control mice, with 6 decreased and 22 increased. 17 of the altered proteins were involved in energy metabolism. This study identified proteins altered in diabetic mouse skin and suggests that skin proteomics could provide a noninvasive method for early diabetes diagnosis.
Lipoproteins and Lipid Peroxidation in Thyroid disordersIOSR Journals
1) The study evaluated lipids and oxidative stress in 80 patients with thyroid dysfunction, including 53 hypothyroid and 27 hyperthyroid patients, compared to 40 healthy controls.
2) In hypothyroid patients, T3, T4 levels were significantly decreased while TSH was elevated. Total cholesterol, triglycerides, LDL, and VLDL were significantly increased compared to controls.
3) MDA levels were higher in both hypothyroid and hyperthyroid patients compared to controls, indicating oxidative damage in thyroid disorders.
Low beneficial effects of short term antidiabetic diet treatment in streptozo...iosrphr_editor
Oxidative stress is currently suggested to play a role in the pathogenesis of Diabetes mellitus. The role of dietary management in diabetes mellitus is to provide a proper balance of total nutrients while meeting the special dietary needs of the patient. The present study was designated to evaluate the effect of special antidiabetic diet treatment upon oxidative stress parameters in the initial stages of the development of diabetes. Male Wistar strain rats were used as an experimental model, divided into five groups. A significant decrease in superoxide dismutase and total glutathione activities were observed in the liver of diabetic rats when compared with control animals. The plasma level of aminotransferases, creatine kinase, lactate dehydrogenase and urea were significantly increased after induction of diabetes, in all groups under treatment. In contrast, rats fed special diet food, have shown slight different, but not significant changes. The findings of the present study suggest that special diet formula useful for prevention of progressive hyperglycaemia in age induced diabetes in dogs, could not restore the imbalance of cellular defence mechanism provoked by streptozotocin.
Background: Body of literature are becoming pronounced that pathological condition in one organ of the body might have an effect on other distal organs owing to the fact, that the entire body metabolism is orchestrated centrally.
Pathological events occurring in an organ are likely to be extended to other organs. Pretreatment that minimize these events are presumed to be beneficial to the extended organs.
Methods: Following 30 min of ischemia and 48 h of reperfusion in the kidney, rats under anesthesia were sacrificed and blood sample collected through cardiac puncture. Serum level of troponin I, and activities of total creatine kinase (CK), mass creatine kinase (CK-MB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma –glutamyl transferase (GGT) were estimated spectrophotometrically.
Results: Serum troponin I increased to 0.031 ± 0.001 ng/ml in the ischemic group, and following pretreatment with Lmm (600mg/kg), serum level of troponin I decreased significantly to 0.021 ± 0.001 ng/ml (P<.05).><.05),><.05)><.05).
ABSTRACT- Coronary artery disease (CAD) is suspected as a leading cause of mortality in developed countries. Due
to cholesterol and fat deposit plaque is forming into the inner walls of the arteries of the heart, which leads to narrowing
of blood vessels of heart and reduce the blood flow rate into heart. Proprotein convertase subtilisin-like kexin type 9
(PCSK9) is one of the candidate gene that regulate lipoprotein retention pathway of CAD development. It is a newly
discovered serine protease that plays a key role in LDL-C homeostasis by mediating LDL receptor (LDLR). The LDL
receptor is breakdown through a post transcriptional mechanism and induces the production of very low-density
lipoprotein in the fasting state. The aim of this study was to investigate the frequency of single nucleotide
polymorphism (SNP) of PCSK9 gene of 155 CAD patients and 102 ages matched healthy controls. Serum lipids
including total cholesterol (TC), triglycerides (TG), HDL, LDL, and VLDL were analyzed. PCR-RFLP analysis was
carried out to genotype regions carrying Eam 1104I restriction site in the PCSK9. Gene considering significant
difference in serum TC, TG, HDL-C, LDL-C and VLDL-C levels (P<0.001, <0.0001) of patients and control samples.
In CAD patients, G allele frequency is less than A allele frequency. G allele is responsible for decreasing the
LDL: HDL ratio which shows evidence in having its protecting effect on the occurrence of CAD in West Bengal Population.
Key-words- CAD, PCSK9, SNP, Eam1104I, Polymorphism, West Bengal population
This document summarizes a sub-analysis of the Japan EPA Lipid Intervention Study (JELIS) that compared the risk of coronary artery disease (CAD) between patients with impaired glucose metabolism (IGM) and normoglycemic (NG) patients, and assessed the effect of eicosapentaenoic acid (EPA) on CAD incidence in IGM patients. The analysis found that IGM patients had a significantly higher risk of CAD compared to NG patients. Treatment with EPA resulted in a 22% decrease in CAD incidence in IGM patients and an 18% decrease in NG patients, although the decrease was only statistically significant for IGM patients.
Diabetes mellitus is spreading around the world, penetrating populations not only in poor and developing countries, but also in developed ones. Propolis, a complex resinous material collected by honey bees from buds and exudates of certain plant sources, containing flavonoids pinocebrin, galangin, chrysin, and caffeic acid phenethyl ester.
The use of propolis as an alternative healing therapy for type-2 diabetes mellitus has been claimed to alleviate the disease. Previous studies state that propolis improves normal homeostasis by balancing the body’s condition through the enhancement of the immune system. The histological analysis of the liver shows that at a dose of 50–200 mg/kg BW propolis does not show a toxic effect so that the dose is categorized safe.
Therefore, the ethanolic soluble derivative of propolis (EEP) extract warrant further studies as an antidiabetic agent that is safe for humans.
This document discusses insulin signaling and diabetes. It describes how insulin is released by the pancreas in response to nutrients to regulate blood glucose levels. Insulin triggers the uptake and storage of glucose, fatty acids, and amino acids in tissues. At the cellular level, insulin binds to receptors on cells and activates downstream signaling pathways involving proteins like IRS and kinases that control processes like metabolism, gene expression, and cell growth. Type 2 diabetes occurs when there is insulin resistance and impaired insulin secretion, leading to hyperglycemia and health complications over time. Chronic inflammation is thought to contribute to the pathogenesis of type 2 diabetes.
Mitochondria and MitoQ – A research updatemitoaction
Greg Macpherson presented an update on research related to mitochondria and MitoQ. Some key points include:
- MitoQ was discovered at Otago University in New Zealand and is a mitochondria-targeted antioxidant.
- Over 200,000 patient months of experience and availability in over 100 countries.
- Research has included over 50 million USD invested and 200+ published papers involving 70+ disease models.
- Clinical trials have shown benefits for conditions such as fibromyalgia, chronic fatigue syndrome, and type 2 diabetes.
- Mouse and human research has demonstrated reductions in oxidative stress, inflammation, and markers of disease from conditions such as liver fibrosis when taking MitoQ.
- Future research
A comparative analysis of biochemical and hematological parameters in diabeti...amsjournal
This study evaluated the biochemical and the hematological parameters in diabetic and non- diabetic patients. The measured biochemical parameters were fasting blood sugar, serum alanine aminotransferase (SGPT/ALT), total cholesterol, urea, creatinine and hematological parameters were hemoglobin, total white blood cell, neutrophil, lymphocyte,monocyte, eosinophil and ESR. There were 403 diabetic and 320 non-diabetic subjects included in this study and the study was carried out in BIRDEM (Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders) General Hospital). It was observed that the mean values of SGPT/ALT (p<0.001),><0.001)><0.001)><0.001),><0.004),><0.001) of hematological parameters were significantly higher in diabetic patients than in the non-diabetic patients. In univariate analysis, all biochemical parameters and only four hematological parameters were found significantly associated with fasting blood sugar after adjusted with age and sex. The fasting blood sugar correlates highly with the other biochemical parameters but less or none with the hematological parameters. Our findings demonstrated that control of increased biochemical parameters and abnormal hematological levels in the early stage of diabetes mellitus may help the patients to raise quality of life.
This document provides information about the Biomed newsletter from Adichunchanagiri Institute of Medical Sciences. It includes the editorial board members and details about the second issue of Biomed from July 2012. The newsletter aims to keep pace with trends in biochemistry and provide valuable information to readers. It thanks the principal for support and encourages readers to provide suggestions. A picture shows members of the Department of Biochemistry.
Similar to Alterations of Mitochondrial Functions and DNA in Diabetic Cardiomyopathy of CCK1 Receptors-Deficient Rats-Crimson Publishers (20)
Minimally Invasive Image Guided Interventions in Gynecology and Women’s HealthCrimsonPublishersIOD
Image guided interventions are increasingly being used in different fields of medicine. A large number of such minimally invasive
interventions are routinely done for surgical, medical and oncological patients, besides the endovascular interventions performed for a variety of vascular conditions and diseases. Minimally invasive
image guided interventions in gynaecology are primarily embolization procedures where supplying arteries or draining veins are
occluded using different embolization materials. The major image
guided interventions.
Healthcare Perceptions of Injectable Therapies for Diabetes Mellitus Type 2CrimsonPublishersIOD
Diabetes mellitus is considered a global epidemic, with financial impacts beyond the cost of treatment. Multiple treatment options are available;
however, many healthcare providers lack knowledge or face perceived barriers to prescription. While the American Diabetes Association publishes
yearly guideline updates for the management and care of diabetes, many health care providers are unfamiliar with these guidelines. These guidelines
recommend insulin and other inject able therapies early in the disease progression, yet the DAWN study demonstrated that physicians delay the initiation
of insulin therapy. This paper will review the knowledge gaps, health care provider barriers, and perceptions of inject able therapies. From this review,
more knowledge is needed by prescribers in the initiation and management of injectable therapies to help patients successfully reach glycemic targets.
Management of Excess Weight and Obesity: A Global PerspectiveCrimsonPublishersIOD
Non-communicable diseases (NCDs), especially, hypertension, excess weight, obesity, metabolic syndrome, type-2 diabetes, and vascular diseases,
have increased rapidly in the last two decades and have reached an epidemic status worldwide. Some experts have compared this increase in the
incidence of these diseases as “tsunamis”. Tsunamis’ are seasonal and unpredictable whereas, these diseases are predictable and not seasonal. So, what
are we going to do about this situation? Are we going to sit and wait for some miracle to happen? What are the member nations of the United Nations,
World Health Organization, NCD Task Force going to do about this, besides writing and publishing scary reports of future economic and healthcare
disasters? In this overview, we would like to discuss briefly the salient findings on this topic, initiate a healthy dialogue, request suggestions, positive
comments, and offer few suggestions.
Pharmacologic Weight Loss: An Underutilized Practice in the Fight Against Obe...CrimsonPublishersIOD
This document discusses a study that evaluated the effects of Annona cherimola on complications associated with diabetes in experimental diabetic rats. Key findings include:
1) Treatment with Annona cherimola extract significantly reduced blood glucose levels and regulated the release of insulin, C-peptide, and HbA1c in diabetic rats.
2) The extract also helped maintain renal and liver markers near normal levels and improved antioxidant enzymatic levels in the liver and kidney tissues.
3) Infrared thermal imaging showed that treatment reduced asymmetric temperature distribution in the abdominal area of diabetic rats by 1-5%, indicating improved blood circulation.
Microalbuminuria in Saudi Adults with Type 1 Diabetes Mellitus_Crimson Publis...CrimsonPublishersIOD
Background: Diabetes mellitus is among the most common chronic non-communicable diseases. The development of microalbuminuria in type 1 diabetes increases the risk for renal and cardiovascular disease.
Methods: A cross sectional study was conducted at the Primary Health Care Clinics at King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia. A total of 334 Saudi with type 1 diabetes were randomly selected.
Results: Total of 334 patients with T2DM included in this study; 102 (30.5%) male and 232 (69.5%) female with mean age 25.8±3.4. MA was present in 99 (29.6%). MA was not significantly more prevalent in female (69.4%) with female predominance (sex ratio male: female) 1:2.3. HTN with MA was significantly more prevalent in 51(51.5%) of MA group with odd ratio 1.7 (1.2-2.4), p=0.001 with no siginificant difference between both gender. Patients with MA have significant higher HbA1c than patients with normal buminuria and there was a significant difference between gender (p< 0.0001) and when compared to HbA1c groups (p=0.002).
Conclusion: The frequency of microalbuminuria in patients with type 1 diabetes in this study is high. It is mandatory to have adequate diagnostic, therapeutic and educational resources in addition to competent physicians who can manage microalbuminuria in diabetic patients by using a continuing, comprehensive and coordinated approach.
Antihyperglycemic and Anti-hyperlipidemic Effect of Herbamed, A Herbal Formul...CrimsonPublishersIOD
This study evaluated the anti-diabetic effects of an herbal formulation called "Herbamed" in alloxan-induced diabetic rats. Herbamed contains extracts of 4 plants - Vernonia amygdalina, Ocimum gratissimum, Zingiber officinale, and Allium sativum. Rats were made diabetic using alloxan injections. Treatment with Herbamed at 2 doses for 7 days significantly reduced blood glucose levels and improved lipid profiles in diabetic rats in a dose-dependent manner. The effects were comparable to the anti-diabetic drug metformin. The study suggests Herbamed has anti-hyperglycemic and anti-hyperlipidemic properties, supporting its
Canine Obesity: An Inflammatory Disease Related To Oxidative Stress-Crimson ...CrimsonPublishersIOD
This document discusses canine obesity and its relationship to inflammation and oxidative stress. It begins by providing statistics on the prevalence of obesity in dogs in the United States and Brazil. It then explains that obesity causes inflammation of adipose tissue, which leads to the production of pro-inflammatory cytokines and reactive oxygen species, causing oxidative stress. The document reviews the physiology of adipose tissue and how obesity alters it, triggering an inflammatory response. Specifically, it causes the recruitment of macrophages and T-cells that secrete inflammatory cytokines. This chronic low-grade inflammation is linked to metabolic diseases. The review also examines several key pro-inflammatory and anti-inflammatory adipokines involved in obesity, such as TNF-α, C-reactive
This study examined alexithymia, the difficulty identifying and verbalizing emotions, in 121 type I and type II diabetes patients. It found that both groups of diabetic patients showed significantly more difficulties identifying and verbalizing emotions compared to normal populations, but less externally-oriented thinking. No differences in alexithymia were found between type I and type II diabetes patients. The results suggest diabetic patients would benefit from emotional skills training to help regulate stress and emotions, which can impact blood glucose levels and disease management.
Levels of Anxiety and Quality of Life in Overweight Individuals Under Nutriti...CrimsonPublishersIOD
Levels of Anxiety and Quality of Life in Overweight Individuals Under Nutritional Monitoring by Géssika Dutra de Andrade Reis, Virginia Souza Santos* and Martha Elisa Ferreira de Almeida in Interventions in Obesity & Diabetes
Perspectives of Nursing in the Care of the Patient with Diabetes Mellitus-Cr...CrimsonPublishersIOD
This document discusses perspectives on nursing care for patients with diabetes mellitus. It begins by providing statistics on the rising prevalence of diabetes worldwide and in Venezuela. It then discusses the importance of diabetes education and therapeutic education for patients. The document reviews different models of nursing care, emphasizing the importance of the chronic care model to achieve effective self-management. It argues that all caregivers should adopt this model to achieve treatment goals like metabolic control and quality of life.
Development and Organoleptic Evaluation of Sweet Biscuits Formulated by Using...CrimsonPublishersIOD
Development and Organoleptic Evaluation of
Sweet Biscuits Formulated by Using Wheat Flour, Barley Flour and Germinated Fenugreek Seed Powder for Diabetics by Himani Lalit* and Anita Kochhar in Himani Lalit* and Anita Kochhar in Interventions in Obesity & Diabetes
This document summarizes the three main types of diabetes: type 1 caused by an autoimmune reaction destroying insulin-producing cells; type 2 accounting for 90% of cases characterized by insulin resistance and relative deficiency; and gestational diabetes occurring in pregnancy. It discusses the relationship between insulin, glucose, liver and hormones in regulating blood sugar levels. When levels are too high, diabetes occurs. Diabetes increases the risk of numerous complications affecting the cardiovascular, kidney, nervous and eye systems. While type 1 cannot be prevented, type 2 risk can be reduced through lifestyle changes like healthier diet and exercise.
Crimson Publishers-Interventions in Obesity and Diabetes: Point of ViewCrimsonPublishersIOD
Modern medicine has failed to reduce cardio metabolic diseases like obesity, metabolic syndrome, and type 2 diabetes. These diseases have reached epidemic levels globally and represent a major healthcare burden. Prevention strategies must start early, as excess weight and obesity are major drivers of type 2 diabetes epidemics. Lifestyle interventions have been shown to significantly reduce the risk of developing diabetes and cardiovascular disease by up to 58% and 50% respectively, even in those with genetic risk factors.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.