The document discusses DNA repair mechanisms in human lymphocytes. It describes how oxidized purines in DNA are repaired through the base excision repair pathway involving the OGG1 glycosylase. This repair requires activation by the transcription factor NF-YA, which upregulates OGG1 expression when DNA is at risk of oxidation. The repair of oxidized bases by OGG1 in human lymphocytes is slow but can be activated by phytohemagglutinin. Disruption of this global repair of oxidized purines may be due to downregulation of OGG1. A second document discusses how green tea acts as an antioxidant to protect against oxidative stress and influence DNA damage and repair through activation of the Nrf2 transcription factor and upreg
Periodontal disease susceptible group present advanced periodontal breakdown even though they achieve a high standard of oral hygiene. Various destructive enzymes and inflammatory mediators are involved in destruction. These are elevated in case of periodontal destruction. Host modulation aims at bringing these enzymes and mediators to normal level.
This ppt aims in highlighting the various host modulatory agents that can be put to use in periodontal therapy.
Host Modulation Therapy (HMT) is a treatment concept that reduces tissue destruction and stabilizes or even regenerates inflammatory tissue by modifying host response factors. It has been used for treating osteoporosis and arthritis for several decades; and its application in treating periodontal disease.
Nutrients present in Nutrease powder play an important role in maintaining the normal functions of the human body. The major nutrients present in Nutrease powder include Natural carbohydrates, proteins, lipids, vitamins, and minerals. Besides these, there are some bioactive food components known as “phytonutrients” that play an important role in human health. They have tremendous impact on the health care system and may provide medical health benefits including the prevention and/or treatment of disease and various physiological disorders such as Andropause or Male menopause. Phytonutrients play a positive role by maintaining and modulating immune function to prevent specific diseases. Being natural products, they hold a great promise in clinical therapy. Phytonutrients in Nutrease powder are the plant nutrients with specific biological activities that support human health. Some of the important bioactive phytonutrients in Nutrease powder include polyphenols, terpenoids, resveratrol, flavonoids, isoflavonoids, carotenoids, limonoids, glucosinolates, phytoestrogens, phytosterols, anthocyanins, and probiotics. They play specific pharmacological effects in human health such as anti-microbial, anti-oxidants, anti-inflammatory, anti-allergic, anti-spasmodic, anti-cancer, anti-aging, hepatoprotective, hypolipidemic, neuroprotective, hypotensive, diabetes, osteoporosis, CNS stimulant, analgesic, protection from UVB-induced carcinogenesis, immuno-modulator, and carminative. This article reviews the current available scientific literature regarding the effect of Nutrease powder as an effective supplementation in Male & Female Fertility.
Host modulation therapy: An indispensable part of perioceuticsMinkle Gulati
Traditionally, only antimicrobials have been used as the chemotherapeutic modality for the treatment of
periodontitis. Though bacteria are the primary etiologic factors of periodontal diseases, yet the extent and severity
of tissue destruction seen in periodontitis is determined by the host immuno‑inflammatory response to these
bacteria. This increasing awareness and knowledge of the host‑microbial interaction in periodontal pathogenesis
has presented the opportunity for exploring new therapeutic strategies for periodontitis by means of targeting host
response via host‑modulating agents. This has lead to the emergence of the field of “Perioceutics” i.e. the use of
parmacotherapeutic agents including antimicrobial therapy as well as host modulatory therapy for the management
of periodontitis. These host‑modulating agents used as an adjunct tip the balance between periodontal health
and disease progression in the direction of a healing response. In this article the host‑modulating role of various
systemically and locally delivered perioceutic agents will be reviewed.
Host modulation therapy is recommended as an adjunct to scaling and root planing in the periodontal therapy. The basic purpose of host modulation therapy is to restore the balance between pro-inflammatory and anti-inflammatory mediators.
Periodontal disease susceptible group present advanced periodontal breakdown even though they achieve a high standard of oral hygiene. Various destructive enzymes and inflammatory mediators are involved in destruction. These are elevated in case of periodontal destruction. Host modulation aims at bringing these enzymes and mediators to normal level.
This ppt aims in highlighting the various host modulatory agents that can be put to use in periodontal therapy.
Host Modulation Therapy (HMT) is a treatment concept that reduces tissue destruction and stabilizes or even regenerates inflammatory tissue by modifying host response factors. It has been used for treating osteoporosis and arthritis for several decades; and its application in treating periodontal disease.
Nutrients present in Nutrease powder play an important role in maintaining the normal functions of the human body. The major nutrients present in Nutrease powder include Natural carbohydrates, proteins, lipids, vitamins, and minerals. Besides these, there are some bioactive food components known as “phytonutrients” that play an important role in human health. They have tremendous impact on the health care system and may provide medical health benefits including the prevention and/or treatment of disease and various physiological disorders such as Andropause or Male menopause. Phytonutrients play a positive role by maintaining and modulating immune function to prevent specific diseases. Being natural products, they hold a great promise in clinical therapy. Phytonutrients in Nutrease powder are the plant nutrients with specific biological activities that support human health. Some of the important bioactive phytonutrients in Nutrease powder include polyphenols, terpenoids, resveratrol, flavonoids, isoflavonoids, carotenoids, limonoids, glucosinolates, phytoestrogens, phytosterols, anthocyanins, and probiotics. They play specific pharmacological effects in human health such as anti-microbial, anti-oxidants, anti-inflammatory, anti-allergic, anti-spasmodic, anti-cancer, anti-aging, hepatoprotective, hypolipidemic, neuroprotective, hypotensive, diabetes, osteoporosis, CNS stimulant, analgesic, protection from UVB-induced carcinogenesis, immuno-modulator, and carminative. This article reviews the current available scientific literature regarding the effect of Nutrease powder as an effective supplementation in Male & Female Fertility.
Host modulation therapy: An indispensable part of perioceuticsMinkle Gulati
Traditionally, only antimicrobials have been used as the chemotherapeutic modality for the treatment of
periodontitis. Though bacteria are the primary etiologic factors of periodontal diseases, yet the extent and severity
of tissue destruction seen in periodontitis is determined by the host immuno‑inflammatory response to these
bacteria. This increasing awareness and knowledge of the host‑microbial interaction in periodontal pathogenesis
has presented the opportunity for exploring new therapeutic strategies for periodontitis by means of targeting host
response via host‑modulating agents. This has lead to the emergence of the field of “Perioceutics” i.e. the use of
parmacotherapeutic agents including antimicrobial therapy as well as host modulatory therapy for the management
of periodontitis. These host‑modulating agents used as an adjunct tip the balance between periodontal health
and disease progression in the direction of a healing response. In this article the host‑modulating role of various
systemically and locally delivered perioceutic agents will be reviewed.
Host modulation therapy is recommended as an adjunct to scaling and root planing in the periodontal therapy. The basic purpose of host modulation therapy is to restore the balance between pro-inflammatory and anti-inflammatory mediators.
In genetics, genotoxicity describes the property of chemical agents that damage the genetic information within a cell causing mutations(Genotoxicity is often confused with mutagenicity. All mutagens are genotoxic, whereas not all genotoxic substances are mutagenic.). The alteration can have direct or indirect effects on the DNA: the induction of mutations, mistimed event activation, and direct DNA damage resulting in mutations.
DNA Methylation and Epigenetic Events Underlying Renal Cell Carcinomaskomalicarol
Renal cell carcinoma (RCC) refers to a group of tumors that develop from the epithelium of the kidney tubes, including clear cell
RCC, papillary RCC, and chromophobe RCC. Most clear cell renal
carcinomas have a large histologic subtype, genetic or epigenetic
genetic von Hippel-Lindau (VHL). A comprehensive analysis of
the genetic modification genome suggested that chromosome 3p
loss and chromosome gains 5q and 7 may be a significant copy
defect in the development of clear kidney cell cancer. A more potent renal cell carcinoma may develop if chromosome 1p, 4, 9,
13q, or 14q is also lost. Renal carcinogenesis is not associated with
chronic inflammation or histological changes. However, regional hypermethylation of DNA in CpG C-type islands has already
accumulated in cancer-free kidney tissue, implying that the presence of malignant kidney lesions may also be detected by modified
DNA methylation. Modification of DNA methylation in cancerous
kidney tissue may advance kidney tissue to epigenetic mutations
and genes, leading to more serious cancers and even determining
a patient’s outcome
Fundamentals Of Genetic Toxicology In The Pharmaceutical Industry Sept 2010TigerTox
Historical and current perspectives on genetic toxicology, with commentary and slides on assay predictivity and shortcomings, regulatory guidance, and high-throughput screens to enhance preclinical drug safety.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
4.
INTRODUCTION
The DNA repair is a set
of processes, that take
care the cell of the
adverse events, like as
defective protein
synthesis.
This defective synthesis
could result in a cellular
aging or diseases.
6.
THE REPAIR OF OXIDIZED PURINES IN THE DNA OF HUMAN
LYMPHOCYTES REQUIRES AN ACTIVATION INVOLVING NF-YA
MEDIATED UPREGULATION.
7.
THE REPAIR OF OXIDIZED PURINES IN THE DNA OF HUMAN
LYMPHOCYTES REQUIRES AN ACTIVATION INVOLVING NF-YA MEDIATED
UPREGULATION.
The elevated levels of 8-oxoG (a
modificated base) increased GC-
TA mutation frequencies.
The OGG1 (oxoguanina
glicosilasa) repair the oxidized
bases by Base excision repair
(BER), and this one is the major
repair glycosylase for 8oxoG in
eukaryotic cells.
8.
THE REPAIR OF OXIDIZED PURINES IN THE DNA OF HUMAN LYMPHOCYTES
REQUIRES AN ACTIVATION INVOLVING NF-YA MEDIATED UPREGULATION.
NF-YA is a transcription factor,
and this one is responsible for
the OGG1 regulation when the
DNA is a risk of oxidation, for
example the exposure of cells
to alkylating agent methyl
methanesulphonate.
9.
THE REPAIR OF OXIDIZED PURINES IN THE DNA OF HUMAN
LYMPHOCYTES REQUIRES AN ACTIVATION INVOLVING NF-YA
MEDIATED UPREGULATION.
The repair of OGG1 in
primary human
lymphocytes is very slow
but can be a efficient repair
with the activation by the
phytohemagglutinin(PHA).
A shutdown of the global
repair of oxidized purines
in lymphocytes must be
to a down-regulation of
the OGG-1
10.
In my opinion the regulation of the DNA´s repair is a
essential factor in the maintenance of the DNA
stability, and this allows that the human organism
correct the mutations that can be present by internal
o external factors preventing these mutations lead to
life-threatening diseases.
Student observation
12.
Redox-linked effects of green tea on DNA damage and repair, and influence of
microsatellite polymorphism in HMOX-1: results of a human intervention trial
The green tea is a
good antioxidant
that can protect
susceptible
individuals at
oxidative stress such
as Type 2 diabetes
patients .
Acts taking part
in the activation
of Antioxidant
(Electrophile)
Response
Element (ARE).
13.
Redox-linked effects of green tea on DNA damage and repair, and influence of
microsatellite polymorphism in HMOX-1: results of a human intervention trial
The nuclear transcription
factor (Nrf2 ) is a factor
that regulates the
expression of genes
encoding cytoprotective .
Reduced apoptosis
Increses the cell’s survival.
Increased drug resistance.
14.
In the organism, there are
various cytoprotective proteins
like the hOGG1 AND THE heme
oxygenase 1 (HMOX-1) , the last
one is a important
cytoprotective protein and this
increased indicated the response
to the oxidative stress.
Redox-linked effects of green tea on DNA damage and repair, and
influence of microsatellite polymorphism in HMOX-1: results of a
human intervention trial
15.
Redox-linked effects of green tea on DNA damage and repair, and
influence of microsatellite polymorphism in HMOX-1: results of a
human intervention trial
Is suggested that in the microsatellite
polymorphism of HMOX-1 in the GT
repeats is associated with a poorer
protective activity , cells homozygous for
short (n < 25) GT(n) were shown to have
higher HMOX-1 expression after oxidant
challenge than cells homozygous for long (n
≥ 25) GT(n) (13).
the people with a long GT do not respond
efficiently to increased oxidative stress.
16.
for my this type of investigations has a very
important relevance in the determination of the
different mechanism whereby the organic
compounds can prevent diseases and also we can to
know the reason whereby these compounds have no
activity in some people.
Student observation
18.
through the knowledge of the beneficial properties, the natural compounds, could
develop natural treatments that prevent diseases .
This investigations could bring a new diagnostic methods for genetic disorders.
trying to enhance the expression the factors involved in DNA repair could bring a
cancer`s cure that don´t affect the good cells .
to improve the patient´s quality life with diseases chronicles.
Medical utility
19. http://www.nature.com/nchembio/journal/v10/n7/fig_tab/nchembio.1553_F1.html
http://omicsonline.org/differentiation-of-embryonic-stem-cells-and-oxidative-dna-damage-dna-repair-systems-2157-
7633.S10-005.php?aid=6278
http://medmol.es/glosario/57/
Niture SK1, Jaiswal AK.Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis.
http://culturacolectiva.com/campanas-publicitarias-para-la-prevencion-del-cancer-de-mama/
http://centromedicodepies.
mx/principal/salud-de-sus-pies/pie-diabetico/
MARTINEZ,SÁNCHEZ,M,Lina.GRISALES,VARGAS,Natalia.MONTOYA,TORO,Andrés,E.SIERRA,PAMPLONA,Ana,paulina.ORREG
O,QUEVEDO,Esteban.BIOLOGÍA MOLECULAR SÉPTIMA EDICIÓN,Editorial,upb,pág,85-88
LIPEN,VON,DER,Carina.SAHU,Sanjeeb.SEIFERMANN,Marco,TIWARI,K,VIJAY The repair of oxidized purines in the DNA of
human lymphocytes requires an activation involving NF-YA-mediated upregulation of OGG1. Institute of Pharmacy and
Biochemistry, University of Mainz, Staudingerweg 5, D-55099 Mainz, Germany Institute of Molecular Biology, D-55218
Mainz, Germany.
CHI,WAI,Sin.YEUNG,T,F,Vincent.COLLINS,R,Andrew.BENZIE,F,F,Iris Redox-linked effects of green tea on DNA damage and
repair, and influence of microsatellite polymorphism in HMOX-1: results of a human intervention trial.
REFERENCES
