Varicocele is the abnormal dilation of the veins within the pampiniform venous plexus that drains the testes. It often presents as a bag of worms feeling in the scrotum and is a common cause of male infertility. Varicocele can cause issues like testicular atrophy and pain due to increased heat and ischemia within the testes. In Ayurveda, varicocele is understood as sanga (obstruction) of the shukra vaha srotas (channels carrying reproductive fluids), leading to klaibya (infertility). Treatment involves surgical ligation of the affected veins to relieve obstruction of the srotas.
Ovulation was initially monitored by conventional methods like BBT, mid luteal serum progesterone and urinary LH.
Nowadays, USG is used for follicular monitoring for both natural and stimulated cycles.
Nuchal translucency
It is a sonographic pre natal screening scan to detect cardiovascular abnormality in a fetus.
NT can also detect altered extra cellular matrix composition and limited lymphatic drainage
Ovulation was initially monitored by conventional methods like BBT, mid luteal serum progesterone and urinary LH.
Nowadays, USG is used for follicular monitoring for both natural and stimulated cycles.
Nuchal translucency
It is a sonographic pre natal screening scan to detect cardiovascular abnormality in a fetus.
NT can also detect altered extra cellular matrix composition and limited lymphatic drainage
Common penile abnormalities such as paraphimosis, phimosis, and hypospadias, risk factors, presentation, pathophysiology, investigations, and treatment.
This presentation is about Anorectal Malformation.
No specific cause of anorectal malformation has been described.
The average incidence worldwide is 1 in 5000 live births.
Families have a genetic predisposition, with anorectal malformations being diagnosed in succeeding generations.
A slight male preponderance exists
Imperforate anus without fistula occurs in 5% of patients.
Interestingly, 50% of them also have Down syndrome
Patients with Down syndrome and anorectal malformations have this type of defect 95% of the time
Cardiovascular anomalies are present in approximately one third of patients but only 10% of these require treatment.
The most common lesions are: Atrial septal defect and patent ductus arteriosus followed by tetralogy of Fallot and ventricular septal defect
Similar to Testicular varicocele and its effects on male infertility (20)
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
NVBDCP.pptx Nation vector borne disease control program
Testicular varicocele and its effects on male infertility
1. TESTICULAR VARICOCELE AND ITS
EFFECTS ON MALE INFERTILITY
PRESENTER GUIDE
DR.Kiran.H.Gundagi DR.Prathibha.Kulkarni
1st Year PG Scholar Associate Professor &
HOD
DEPARTMENT OF SHAREERA KRIYA
Sri Dharmasthala Manjunatheshwara College of Ayurveda & Hospital
Hassan
15/5/2017
3. INTRODUCTION
• Testicular Varicocele is abnormal dilation and tortuosity of veins
of pampiniform venous plexus that drains the testis.
• Caused secondary to Internal spermatic vein reflux.
• Seen commonly in aged 15-30 years and rarely after 40yrs of
age,and it occur commonly on the left side of scrotum.
• Varicocele often described as feeling like bag of worms in
scrotum.
35/5/2017
4. Anatomy of Pampiniform venous plexus
• The pampiniform plexus is a
network of many small veins found
in the human spermatic cord.
• It is formed by the union of
multiple spermatic veins from the
back of the testis and tributaries
from the epididymis.
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5. Aetiology
• Dysfunction of valves
• Raised temperature
• Increased hydrostatic pressure
• Idiopathic causes
55/5/2017
7. Clinical Features
• Painless lump
• Twisted veins in scrotum, which are often described as looking like
a bag of worms
• Dragging pain if testis is unsupported or after long standing.
• The scrotum on the affected side hangs lower than normal.
75/5/2017
9. Physical examination
9
• Performing the valsalva maneuver
while standing increases the dilation of
effected testis
• In long standing cases the effected
testis is smaller and softer and owing
to a minor degree of atrophy.
5/5/2017
11. Grades of Varicocele
11
Grade I Palpable during Valsulva Maneuver.
Grade II Palpable without Valsulva in standing
position.
Grade III Visible through scrotal skin.
5/5/2017
12. Varicocele:Predilection for the left side
• Left Testicular vein drains into the left renal vein at right
angle.
• Right testicular vein opens into the inferior venacava
obliquely
• The total length of left testicular vein is longer than the
right
• The loaded sigmoid colon may compress the left
testicular vein
125/5/2017
14. Treatment
• Ligation of testicular vein above the inguinal ligament of
testicular vein where the pampiniform plexus has
coalesced into one or two vessles.
• Laproscopic
• Embolisation of the testicular vein
under the radiographic control
145/5/2017
20. VARICOCELE AND INFERTILITY
Heat
– It has been observed that minor fluctuations in
the temperature can effect spermatogenesis.
Ischemia
– Due to varicocele the artery input to the testis is
hampered leading to hypoxia.
215/5/2017
21. Contd..
Obstruction to epidydimis
– Varicocele when very large may cause obstruction
to epidydimal duct there by impairing maturation
of spermatozoa.
This condition (Varicocele) can be correlated as
Sanga of shukra vaha srotus leading to klaibhya.
225/5/2017
22. CONCLUSION
Varicocele is abnormal dilation and tortuosity of
veins of pampiniform venous plexus that drains
the testis.
Varicocele causes abnormality such as :-
1. Pain
2. Testicular discomfort and failure of testicular growth
and Infertility.
Obstruction caused by dialatation of veins can be
considered as sanga to shukra vaha srotus leading
to dusti hence klaibhya.
235/5/2017