A 38-year-old male presented with a rash all over his body and skin peeling for 2 weeks after taking penicillin. Examination found purpuric macules on palms and soles, and erythema of the lips and conjunctiva. Lab results showed abnormalities. He was diagnosed with Stevens-Johnson syndrome/toxic epidermal necrolysis and secondary impetigo. Treatment included IV methylprednisolone, IV vancomycin, topical paraffin, and monitoring for complications. Goals were to relieve symptoms, prevent further skin detachment and improve mucosal healing.