Synthetic Cannabinoids such as kratom are psychoactive designer drugs derived of natural herbs sprayed with synthetic chemicals that, when consumed, allegedly mimic the pleasurable effects of cannabinoids.
A seminar presentation I made as part of my residency. The drugs covered are Synthetic Cathinones, Synthetic Cannabinoids, Ecstacy/MDMA, GHB, Ketamine and Mephedrone.
Cannabis (also known as marijuana) is the most frequently used illicit psychoactive substance in the world, with more than 500 components. Cannabinoids are psychoactive compounds extracted from the cannabis plants (cannabis stavia), and classified mainly into 5 classes: classical cannabinoids, non-classical cannabinoids, hybrid cannabinoids, aminoalkylindoles, and eicosanoids cannabinoids. Cannabinoids are endogenous in humans, animals and plants, or synthetically produced. In recent years, the use of synthetic cannabinoids as a substitute for cannabis has been on the increase. However, there is also some concern about their potential effects on users. Cannabidiol and tetrahydrocannabinol (THC) are the most studied cannabinoids and both interact with endocannabinoid receptors in various human tissues, so there are a trend to use cannabinoids in Medicine and Pharmacology. Cannabis plants produce many compounds of possible medical importance. In this article, we discuss the natural cannabis and synthetic cannabinoids and their extraction, their principle components, their abuses, and their effects on the human body, and their roles in medicine and pharmacology, also we discus the biosynthesis of cannabinoids, and the synthetic cannabinoid classification system.
Pharmacodynamics and Pharmacokinetics of Synthetic CannabinoidsNMS Labs
Presented on February 21, 2012 at the AAFS 64th Annual Scientific Meeting by Barry K. Logan, PhD, DABFT, NMS Labs National Director of Forensic Services and Wendy R. Adams, Ph.D., DABFT, Forensic Toxicologist
Synthetic Cannabinoids such as kratom are psychoactive designer drugs derived of natural herbs sprayed with synthetic chemicals that, when consumed, allegedly mimic the pleasurable effects of cannabinoids.
A seminar presentation I made as part of my residency. The drugs covered are Synthetic Cathinones, Synthetic Cannabinoids, Ecstacy/MDMA, GHB, Ketamine and Mephedrone.
Cannabis (also known as marijuana) is the most frequently used illicit psychoactive substance in the world, with more than 500 components. Cannabinoids are psychoactive compounds extracted from the cannabis plants (cannabis stavia), and classified mainly into 5 classes: classical cannabinoids, non-classical cannabinoids, hybrid cannabinoids, aminoalkylindoles, and eicosanoids cannabinoids. Cannabinoids are endogenous in humans, animals and plants, or synthetically produced. In recent years, the use of synthetic cannabinoids as a substitute for cannabis has been on the increase. However, there is also some concern about their potential effects on users. Cannabidiol and tetrahydrocannabinol (THC) are the most studied cannabinoids and both interact with endocannabinoid receptors in various human tissues, so there are a trend to use cannabinoids in Medicine and Pharmacology. Cannabis plants produce many compounds of possible medical importance. In this article, we discuss the natural cannabis and synthetic cannabinoids and their extraction, their principle components, their abuses, and their effects on the human body, and their roles in medicine and pharmacology, also we discus the biosynthesis of cannabinoids, and the synthetic cannabinoid classification system.
Pharmacodynamics and Pharmacokinetics of Synthetic CannabinoidsNMS Labs
Presented on February 21, 2012 at the AAFS 64th Annual Scientific Meeting by Barry K. Logan, PhD, DABFT, NMS Labs National Director of Forensic Services and Wendy R. Adams, Ph.D., DABFT, Forensic Toxicologist
Reviews types of stimulants including decongestants, side effects and effects on sports performance.
NBCC, NAADAC, CAADAC, and California Board of Behavioral Sciences approved Mental Health continuing education and addictions counselor training series. Narrated versions and CEUs available at http://www.allceus.com
Here is a concise and conceptual view of Drug Addiction,explaining how physiologically and psychologically a person become addict,also what are the chemical changes in which part of brain responsible for addiction.
K2 and the Synthetic Cannabinoids: Pharmacology, Effects and Chemical AnalysisNMS Labs
Presented September 16, 2010 by Dr. Barry K. Logan, PhD, DABFT, NMS Labs National Director of Forensic Services
NMS Labs has responded to the recent explosive growth in popularity of synthetic cannabinoid agonists in so-called “herbal blends” by developing new tests for the active chemicals in botanical material, and most recently for the parent drugs and their metabolites in blood and urine. This presentation describes the history and origin of the chemicals of concern, the composition of the various commercial products containing them, their known pharmacology, and the documented effects on drivers, and human test subjects. We also review the adverse effects that have resulted in hospitalization, and even allegedly in deaths. This presentation describes the challenges around providing a chemical test for these new drugs, information on their stability in biological fluids, and the validation of quantitative methods for their determination.
Reviews types of stimulants including decongestants, side effects and effects on sports performance.
NBCC, NAADAC, CAADAC, and California Board of Behavioral Sciences approved Mental Health continuing education and addictions counselor training series. Narrated versions and CEUs available at http://www.allceus.com
Here is a concise and conceptual view of Drug Addiction,explaining how physiologically and psychologically a person become addict,also what are the chemical changes in which part of brain responsible for addiction.
K2 and the Synthetic Cannabinoids: Pharmacology, Effects and Chemical AnalysisNMS Labs
Presented September 16, 2010 by Dr. Barry K. Logan, PhD, DABFT, NMS Labs National Director of Forensic Services
NMS Labs has responded to the recent explosive growth in popularity of synthetic cannabinoid agonists in so-called “herbal blends” by developing new tests for the active chemicals in botanical material, and most recently for the parent drugs and their metabolites in blood and urine. This presentation describes the history and origin of the chemicals of concern, the composition of the various commercial products containing them, their known pharmacology, and the documented effects on drivers, and human test subjects. We also review the adverse effects that have resulted in hospitalization, and even allegedly in deaths. This presentation describes the challenges around providing a chemical test for these new drugs, information on their stability in biological fluids, and the validation of quantitative methods for their determination.
Watch the recorded webinar at http://www.mainewellness.org/cannbis_in_cancer_treatment_webinar_recording
From prevention through treatment and remission, cannabis is a powerful tool in the fight against cancer–the government’s National Cancer Institute has even updated its information to reflect the plant’s anti-cancer properties!
Join us and special guest, Molly Stewart, of the Cancer Community Center, for a discussion of the scientifically-proven and real-life benefits of cannabis in cancer treatment, and to learn more about support services and resources for cancer patients and their families.
This presentation provides information about synthetic drugs, including Bath Salts and K2/Spice, and identifies resources from The Partnership at Drugfree.org
Nulife module 5 long term sequelae in natural and surgical menopause editedManinder Ahuja
These six modules from 2-7 are on mid life health care of women and were made with intention of training general gynecologist and other speciality into care of mid life women and have Mid Life OPD cards as mainstay of care.
While these are not stand-alone qualifying conditions in Maine, they accompany many serious illnesses. Join us for an in-depth conversation with special guest, Dr. Carey Clark, about how medical cannabis can aid with stress, anxiety, and depression.
2nd International Hemp Building Symposium 2011 GranadaSteve Allin
2nd International Hemp Building Symposium 2011, Granada, Spain. 2 days of presentations and demonstrations of the building materials and systems developed from the worlds most versatile plant. www.internationalhempbuilding.org/event.html
Understanding Cannabinoids - How Cannabis Helps Our BodiesJonathan Russell
In this Understanding Cannabinoids Slide Share we discuss the Endocannabinoid System, the major cannabinoids in cannabis & their benefits, the Entourage (or Ensemble) Effect and how it all works together.
The content of this presentation was taken from the:
MIT Open Course Ware http://ocw.mit.edu
ES.S10 Drugs and the Brain
This was made on behalf of the final requirements for:
CEIT321 Course in Middle East Technical University
E, K, G, BZP, 2CB, 5MeO-DIPT...
“Party Drugs” such as Ecstasy, Ketamine and GHB have not gone away. However, there have been significant changes to purity and associated risks. As well, a proliferation of new substances are quickly appearing.
What are some of the current substances being used and the risk reduction messages we should be sharing, particularly with today’s youth?
We will look at:
Street Drugs --> Party Drugs --> NPS
Specific substances:
- What they are
- How they work
- Immediate risks
- Longer-term concerns
- Risk reduction strategies
Program required by St. Clair County Community College in order for their students to mentor/ride along during his/her Basic EMT or Paramedic Program. Covers rules and regulations monitored by the college and addresses expectations of student and preceptor.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
3. The First Epidemic
1850-1914
• The Chinese immigrate to
California
•20 Years Later Opium
becomes “sporty”
•1890’s Opium Dens common
place in America
•America’s Response
4. The Explosion - 1960-
1970
• 50 years later... America
forgot!
• The New Message -
Drugs and Altered states
are “hip”
• Promote drug use as
“normal”
• 76 Million Baby Boomers
embrace the drugs and its
business opportunities
5. 1970 - 1980
• Cocaine - Expensive,
No serious
consequences
• Used by the “elite”
• Columbia’s
involvement brings
down the price of
cocaine.
• Mid 80’s - 6 Million
Americans using
regularly
6. 1986
• Death of College
Basketball star Len
Bias
• Cocaine found to be
dangerous and highly
addictive
• People turn away from
cocaine for other
drugs
• Columbia makes a
business move
7. What about the 90’s?
• Marijuana, inhalants,
methamphetamines “first time use”
decreased in 1999 (20%) from that of
1981(38%)
• Club Drugs
8. Synthetic
Cannabinoids
• John W. Huffman -
Clemson University
• Research for medical
uses of cannabinoids
as an alternative to
medical marijuana
• Published research
became available to
public
9.
10.
11.
12. How they Sell it!
• Mixed herbs are sprayed with the
synthetic cannabinoids
• Marketed under the name “Incense”
• Labeled as “Not for human
Consumption”
13. How it works
• Binds to cannabinoid receptors in the
human body, primarily the brain
• Some strains up to 800 times more
powerful than THC
• Causes euphoric/numbing sensations.
• Altered Mental Perception and
confusion
• Neurological Disturbances
14. Common Names
• K2 (JWH-018)
• Spice
• Gold
• Genie
• Zohai
• Black Mamba
Each one of these is a different
strain
of the synthetic cannabinoid
15. Side Effects
• Pale
• Diaphoresis
• Tremors
• Seizures
• Altered LOC
• Bizarre Behavior
• Respiratory
Depression
• Violent Behavior
• Respiratory or Cardiac
Arrest
16. Management
• NO KNOWN
ANTIDOTES
• Respiratory Control
• Neurological Care
• Cardiac Care
• Supportive Care
• IV Access
• Oxygen administration
• 12 Lead ECG
Monitoring
• Patient safety
• Continued Monitoring
20. Understanding Bath Salts
• Mephedrone
• Why are they called
Bath Salts?
• Are they Legal
• The Experience
21. The Experience
• Agitation
• Paranoia
• Hallucinations
• Chest Pain
• Suicidal Ideation
• Hypertension
• Tachycardia
• Psychosis
There is no test for Bath Salts...
30. Nutmeg
• Smoked or Ingested in large quantities
• Effects that can last up to 3 days
• Hallucinations, voices
31. Inhaling Moth Balls!
• Hallucinations
• Naphthalene - The highly toxic
chemical that causes the
hallucinations
• N/V, Burning Eyes, Dyspnea, Diarrhea,
Anemia (Long term exposure),
Confusion, convulsions, coma
32. Nyquil & Cloricidin
• Nyquil & Triple “C”
• DXM, Skittles
• Effects achieved by intentional
overdose (8-16 Pills)
• Dextromethorphane
• Taken in large amounts causes a
person to hallucinate