The document discusses managing uncertainty in supply chains through the use of safety inventory. It defines safety inventory as inventory carried to satisfy unexpected demand. The appropriate level of safety inventory is determined by the uncertainty in demand and supply as well as the desired level of product availability. Higher safety inventory improves availability but increases holding costs. The document provides formulas and examples for calculating safety inventory levels required to meet a desired cycle service level, fill rate, or both, given factors like demand uncertainty and lead time. Reducing lead time and demand uncertainty can lower the required safety inventory.