Disruptive innovation in cleantech is accelerating technological change. Exponential improvements in computing power, data storage, networking and other technologies are enabling disruption across trillion dollar markets like energy and transportation. This interdisciplinary renaissance is a perpetual driver of disruption, creating a virtuous cycle of opportunity for entrepreneurs to build new companies. Disruptions will continue lowering costs and improving performance of clean technologies like solar, batteries, LED lighting, and electric vehicles. Examples discussed include more efficient data centers and smart grids, molecular manufacturing, synthetic biology, and gene sequencing.