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Stanford Engineering,
European Entrepreneurship
& Innovation
Claus Crone Fuglsang
Managing Director           January 30th 2012
Novozymes Inc.
A growing global
population puts pressure
on our natural resources.

With bioinnovation in the
form of, for example,
industrial enzymes and
microorganisms, industries
can rethink their processes
and products, and produce
more with less.




                              2
Novozymes –
The World Leader in Bioinnovation

• Business consists of two segments:
  Enzyme Business and BioBusiness                                     Founded             1941

• 2011 sales: USD ~ 2 billion                                           Listed            2000

• 2011 EBIT margin: 22.3%                                               Ticker            NZYM B

                                                                 Exchange                 Copenhagen
• More than 700 products used in 130
  countries in over 40 different industries                  Market Cap*                  ~ 10 Billion USD

• ~ 7,000 granted and pending patents

• + 5,800 employees

• Two share classes; A and B shares
  • A share capital and 11% of B shares
    (25.5% of O/S; 70.1% of votes) held by
                                                      Enzyme Business                               BioBusiness
    Novo A/S, the management company of
    the Novo Nordisk Foundation

                                              Household    Food &                    Feed &        Micro-
                                                                       Bioenergy                             Biopharma
                                                Care      Beverages                other Tech.   organisms




                                                                                                  *A+B shares January, 2012


                                                                                                                         3
Uniquely Diversified Group Creates Synergies and
New Opportunities
•   Unique biotech-focused business with a strong legacy of delivering growth, earnings, and cash flow
•   ~ 14% of annual sales invested in R&D
•   Global provider of enzymes to all market segments creates global market leader position
•   Leveraging competencies across segments accelerates pace of innovation, reduces competition and creates
    high barriers to entry


         31%             29%               17%                13%               7%                   3%

      Household          Food &         Bioenergy          Feed & other       Micro-             Biopharma
        Care           Beverages                             Technical      organisms
                        enzymes




     • Laundry &     • Baking         • Corn ethanol   •   Animal feed    • BioAgriculture   • Drug delivery &
       Dishwasher    • Brewing        • Cellulosic     •   Textile        • Wastewater         formulation
       detergents    • Starch to        biofuels       •   Leather        • Institutional    • Medical devices
                       syrups                          •   Pulp & Paper     & household
                     • Wine & juice                                         cleaning




                    Enzyme Business                                          BioBusiness

                                                                                                                 4
Diversification in Revenue Streams Underpins
the Company’s Strong Financial Position

•   Enzymes account for 90% of turnover
•   Sales FY 2011 of DKK 10,510 billion (USD ~ 2 billion)
•   Strong profitability, ~ 22% in EBIT margin FY 2011
•   ROIC of ~ 21% for FY 2011



             2011 Sales by geography                                  2011 Sales by industry

                                                                                   Biopharma
                                                                       Microorga
                                                                                      3%
                                                                         nisms
                                                             Feed &
                                                                          7%
                                                              other
                        Latin                                 Tech.
                       America                              enzymes
                        10%      Europe,                      13%
                                                                                         Household
                                  Middle
              Asia                                                                          Care
                                 East and
             Pacific                                                                      enzymes
                                  Africa
              19%                                                                           31%
                                   36%

                                                                  Bioenergy
                                                                  enzymes
                                                                     19%
                                                                                      Food &
                        North                                                       Beverages
                       America                                                       enzymes
                        35%                                                            29%




                                                                                                     5
Undisputed Market Leader
Expanding Enzyme Application

Global enzyme market value:
      2000:                                          2011:                      Global enzyme market value
    DKK ~ 12bn                                     DKK ~ 20bn                       2011: DKK ~ 20bn



              Novozymes                         Rest of   Novozymes
    Rest of                                                  47%                 Others and
                 42%                            market
    market
                                                 53%                              captive
     58%
                                                                                    26%

                                                                                                               Novozymes
                                                                                                                  47%
                                                                             DSM
                                                                             6%
                      Market potential*
                                                                                      Genencor
                                   Current enzyme market                              (DuPont)
                                        DKK ~ 20bn                                      21%




                          Untapped market
                          Multi-billion (US$)
                                                                              Rules of competition
                                                                             dictated by innovation

                                                                      *Global markets for chemicals, food ingredients, feed additives, etc.


                                                                                                                                         6
R&D on the geographical map
- 9 global competence centers / 1000 employees

     105 employees              30 employees                   553 employees
      Strain dev.               Pharma center                 All basic technologies
      Bioinformatics            Albumin and                   All application
      Protein Engineering        Albufusion                     technologies except
      Protein Chemistry         Patent and regulatory          textile
      Biomass                                                  Patent and regulatory
                                                                                            37 employees
      Metabolic Engineering                                                                 Strain development
      Patent                                                                                Protein Engineering
                                                                                             New applications
                                                                                             Regulatory

 58 Employees
  Strain discovery
  Microbial physiology
   of mixed cultures
  Microbial ecology
  Microbe application
   expertise within
   technical microbes &
   BioAg



                                                                                          77 employees
   66 employees                                                                            Fungal screening
    Biofuel
                                                          27 employees                     New applications
    New Industries                                        Protein Engineering            Detergents
    Renewal of chemicals                                  Protein Chemistry              Textiles
                               7employees                  Application dev. W&J           Biomass
    Patent and Regulatory
                                Biofuel                   Surface fermentation           Patent and Regulatory
From gene-bank to product in 12 months
Technologies                               Process
Individual shuffling

Family shuffling
                                             Creating Biological    Nature’s diversity
                                                 Diversity
Bioinformatics                                                     Molecular evolution
Mega libraries (int. and ext.)
                                               1° Screening
Protein Engineering

   Screening technology
                                               2° Screening
   •High throughput screening: Microbial
    and Molecular level
   •Targeted assay
                                                 Creating
                                                Expression


Expression (bacterial, fungal)
                                                  System

                                                                     Fermentation
                                                 Up-scaling
                                                  Process             Purification
Lab fermentation

Pilot and tox material                          Production
                                                                      Formulation
Full scale application test


                                           Biosolution based on Novozymes Technology
Novozymes, Inc



                               Our key core technologies
NZCA:                          today cover:
 Established in 1992
 Located in Davis, CA         System Biology, Genomics &
 45% males : 55 % females     Bioinformatics
 We have around 110 FTE       Fungal & Bacterial Expression
 Average seniority: 8 years   Technology
 Historically we file 12-25
                               Metabolic engineering
patents/year
                               Microbial Physiology &
                               Fermentation
                               Robotics, Assay Technology & HTS
                               Protein Chemistry
                               Artificial evolution
10




Significant achievements
CTec1 and CTec2 incl. discovery of GH61

Numerous improved production strains and molecular tools
• Savinase, Polarzyme, Everlase, Pullulanase, Novamyl
• Improved promoters, genomic loci for expression

Genome sequencing and systems biology
• Sequencing the genomes of more than 30 NZ organisms; host strains and BioAg
  strains incl. collaboration with JGI on T. reesei TV10
• Developed technology to identify specific nucleotide changes conferring improved
  yields in Bacillus strains

Metabolic engineering
• HA-strain development
• CoRe projects established and running with 3 major partners: Cargill (3-HP), ADM,
  Braskem (Green PP)

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Claus Fuglsang - Novozymes - Denmark - Stanford Engineering - Jan 30 2012

  • 1. Stanford Engineering, European Entrepreneurship & Innovation Claus Crone Fuglsang Managing Director January 30th 2012 Novozymes Inc.
  • 2. A growing global population puts pressure on our natural resources. With bioinnovation in the form of, for example, industrial enzymes and microorganisms, industries can rethink their processes and products, and produce more with less. 2
  • 3. Novozymes – The World Leader in Bioinnovation • Business consists of two segments: Enzyme Business and BioBusiness Founded 1941 • 2011 sales: USD ~ 2 billion Listed 2000 • 2011 EBIT margin: 22.3% Ticker NZYM B Exchange Copenhagen • More than 700 products used in 130 countries in over 40 different industries Market Cap* ~ 10 Billion USD • ~ 7,000 granted and pending patents • + 5,800 employees • Two share classes; A and B shares • A share capital and 11% of B shares (25.5% of O/S; 70.1% of votes) held by Enzyme Business BioBusiness Novo A/S, the management company of the Novo Nordisk Foundation Household Food & Feed & Micro- Bioenergy Biopharma Care Beverages other Tech. organisms *A+B shares January, 2012 3
  • 4. Uniquely Diversified Group Creates Synergies and New Opportunities • Unique biotech-focused business with a strong legacy of delivering growth, earnings, and cash flow • ~ 14% of annual sales invested in R&D • Global provider of enzymes to all market segments creates global market leader position • Leveraging competencies across segments accelerates pace of innovation, reduces competition and creates high barriers to entry 31% 29% 17% 13% 7% 3% Household Food & Bioenergy Feed & other Micro- Biopharma Care Beverages Technical organisms enzymes • Laundry & • Baking • Corn ethanol • Animal feed • BioAgriculture • Drug delivery & Dishwasher • Brewing • Cellulosic • Textile • Wastewater formulation detergents • Starch to biofuels • Leather • Institutional • Medical devices syrups • Pulp & Paper & household • Wine & juice cleaning Enzyme Business BioBusiness 4
  • 5. Diversification in Revenue Streams Underpins the Company’s Strong Financial Position • Enzymes account for 90% of turnover • Sales FY 2011 of DKK 10,510 billion (USD ~ 2 billion) • Strong profitability, ~ 22% in EBIT margin FY 2011 • ROIC of ~ 21% for FY 2011 2011 Sales by geography 2011 Sales by industry Biopharma Microorga 3% nisms Feed & 7% other Latin Tech. America enzymes 10% Europe, 13% Household Middle Asia Care East and Pacific enzymes Africa 19% 31% 36% Bioenergy enzymes 19% Food & North Beverages America enzymes 35% 29% 5
  • 6. Undisputed Market Leader Expanding Enzyme Application Global enzyme market value: 2000: 2011: Global enzyme market value DKK ~ 12bn DKK ~ 20bn 2011: DKK ~ 20bn Novozymes Rest of Novozymes Rest of 47% Others and 42% market market 53% captive 58% 26% Novozymes 47% DSM 6% Market potential* Genencor Current enzyme market (DuPont) DKK ~ 20bn 21% Untapped market Multi-billion (US$) Rules of competition dictated by innovation *Global markets for chemicals, food ingredients, feed additives, etc. 6
  • 7. R&D on the geographical map - 9 global competence centers / 1000 employees 105 employees 30 employees 553 employees  Strain dev.  Pharma center  All basic technologies  Bioinformatics  Albumin and  All application  Protein Engineering Albufusion technologies except  Protein Chemistry  Patent and regulatory textile  Biomass  Patent and regulatory 37 employees  Metabolic Engineering  Strain development  Patent  Protein Engineering  New applications  Regulatory 58 Employees  Strain discovery  Microbial physiology of mixed cultures  Microbial ecology  Microbe application expertise within technical microbes & BioAg 77 employees 66 employees  Fungal screening  Biofuel 27 employees  New applications  New Industries  Protein Engineering  Detergents  Renewal of chemicals  Protein Chemistry  Textiles 7employees  Application dev. W&J  Biomass  Patent and Regulatory  Biofuel  Surface fermentation  Patent and Regulatory
  • 8. From gene-bank to product in 12 months Technologies Process Individual shuffling Family shuffling Creating Biological Nature’s diversity Diversity Bioinformatics Molecular evolution Mega libraries (int. and ext.) 1° Screening Protein Engineering Screening technology 2° Screening •High throughput screening: Microbial and Molecular level •Targeted assay Creating Expression Expression (bacterial, fungal) System Fermentation Up-scaling Process Purification Lab fermentation Pilot and tox material Production Formulation Full scale application test Biosolution based on Novozymes Technology
  • 9. Novozymes, Inc Our key core technologies NZCA: today cover:  Established in 1992  Located in Davis, CA System Biology, Genomics &  45% males : 55 % females Bioinformatics  We have around 110 FTE Fungal & Bacterial Expression  Average seniority: 8 years Technology  Historically we file 12-25 Metabolic engineering patents/year Microbial Physiology & Fermentation Robotics, Assay Technology & HTS Protein Chemistry Artificial evolution
  • 10. 10 Significant achievements CTec1 and CTec2 incl. discovery of GH61 Numerous improved production strains and molecular tools • Savinase, Polarzyme, Everlase, Pullulanase, Novamyl • Improved promoters, genomic loci for expression Genome sequencing and systems biology • Sequencing the genomes of more than 30 NZ organisms; host strains and BioAg strains incl. collaboration with JGI on T. reesei TV10 • Developed technology to identify specific nucleotide changes conferring improved yields in Bacillus strains Metabolic engineering • HA-strain development • CoRe projects established and running with 3 major partners: Cargill (3-HP), ADM, Braskem (Green PP)