Several institutions have studied stereotactic body radiation therapy (SBRT) for primary lung cancer. Indiana University studies showed a maximum tolerated dose of 66 Gy for T2 lesions delivered over 3 fractions, with 1-year local control rates of 98%. Other studies from Aarhus University, Kyoto University, Air Force General Hospital in Beijing, and University of Marburg demonstrated 1-2 year local control rates ranging from 85-95% using SBRT dose fractions between 30-60 Gy delivered over 1 to 10 fractions.

31. Prospective studies of SBRT in Primary Lung Cancer
Institution N SBRT dose and
Fractionation
Results
Indiana University 47 60Gy/3# Phase I study; MTD not
reached for T1 lesions; MTD
66 Gy for T2 lesions
Indiana University 70 60 – 66Gy /3# 1-y local control 98%
Aarhus University 40 45 Gy/3 # 2-y local control 85%
Kyoto University 45 48Gy / 4# 2-y local control 95%
Air Force General
hospital, Beijing
43 50Gy/ 10 # 1-y local control 95%
University of
Marburg
33 30 Gy/1 # 1-y local control 94%