SSL pinning is a technique used to validate secure connections in mobile apps where the client checks that the server certificate matches a known copy of the certificate stored in the app, to prevent man-in-the-middle attacks. This differs from regular SSL in that it does not rely on certificate authorities and pinning certificates will eventually expire, requiring an app update or downloading a new certificate. The AndroidPinning library facilitates certificate pinning in Android apps, while M2Crypto provides Python wrappers for OpenSSL including SSL functionality.