Mobile Security Framework (MobSF) is an open source framework for automated static and dynamic analysis of Android and iOS mobile applications. It can analyze APK and IPA files as well as zipped source code. MobSF also includes an API fuzzer to test for vulnerabilities like XXE, SSRF, and path traversal in web APIs. It involves downloading MobSF from GitHub, installing Python 3, Git, required libraries and dependencies, and running commands to set up and run the framework.