The document summarizes the structure and function of F1Fo ATP synthase, a membrane-bound enzyme that catalyzes ATP synthesis using an electrochemical proton gradient. It consists of two main components, F1, which protrudes into the mitochondrial matrix and contains the catalytic sites, and Fo, which forms a proton channel embedded in the membrane. During ATP synthesis, protons flow through the Fo channel, causing the central stalk to rotate and drive conformational changes in the F1 catalytic sites that catalyze ATP formation from ADP and phosphate. The rotation mechanism and roles of key subunits like c and a are described.
- Mechanochemistry involves the coupling of mechanical and chemical phenomena on a molecular scale. Molecular motors harness chemical energy, like from ATP hydrolysis, to perform mechanical work.
- ATP synthase is a molecular motor that uses the proton gradient generated by oxidative phosphorylation to drive the synthesis of ATP from ADP and inorganic phosphate. It rotates at around 6,000 revolutions per minute.
- The flow of protons through ATP synthase causes the gamma subunit to rotate, triggering conformational changes in the three beta subunits that allow for sequential binding of substrates and production of ATP.
不定期開催のEMCNAカンファレンスです。EMCNAとは「Emergency Medicine Clinics of North America」の略で、救急外来や集中治療室、麻酔領域において遭遇する症候・疾患についての総説をまとめた、年4回発行の良著です。
初回のテーマは「Severe ARDSの初期治療(Emerg Med Clin N Am 34 (2016) 1–14 )」救急外来および集中治療室でしばしば遭遇するARDS, その基本的対応を再確認しました。
The document summarizes the structure and function of F1Fo ATP synthase, a membrane-bound enzyme that catalyzes ATP synthesis using an electrochemical proton gradient. It consists of two main components, F1, which protrudes into the mitochondrial matrix and contains the catalytic sites, and Fo, which forms a proton channel embedded in the membrane. During ATP synthesis, protons flow through the Fo channel, causing the central stalk to rotate and drive conformational changes in the F1 catalytic sites that catalyze ATP formation from ADP and phosphate. The rotation mechanism and roles of key subunits like c and a are described.
- Mechanochemistry involves the coupling of mechanical and chemical phenomena on a molecular scale. Molecular motors harness chemical energy, like from ATP hydrolysis, to perform mechanical work.
- ATP synthase is a molecular motor that uses the proton gradient generated by oxidative phosphorylation to drive the synthesis of ATP from ADP and inorganic phosphate. It rotates at around 6,000 revolutions per minute.
- The flow of protons through ATP synthase causes the gamma subunit to rotate, triggering conformational changes in the three beta subunits that allow for sequential binding of substrates and production of ATP.
不定期開催のEMCNAカンファレンスです。EMCNAとは「Emergency Medicine Clinics of North America」の略で、救急外来や集中治療室、麻酔領域において遭遇する症候・疾患についての総説をまとめた、年4回発行の良著です。
初回のテーマは「Severe ARDSの初期治療(Emerg Med Clin N Am 34 (2016) 1–14 )」救急外来および集中治療室でしばしば遭遇するARDS, その基本的対応を再確認しました。