This chapter discusses over-the-counter (OTC) drugs. It outlines the history of regulating OTC drugs in the United States, from unregulated patent medicines to the 1938 Food, Drug, and Cosmetic Act requiring drugs be proven safe. The chapter categorizes OTC drugs and describes commonly used types like analgesics, cold/allergy medicines, antacids, sleep aids and stimulants. It notes that while OTC drugs provide symptom relief, using them incorrectly can cause side effects and dependency issues.