Shingles, or herpes zoster, affects about 1 million people in the U.S. annually, primarily those over 50 or with weakened immune systems due to various conditions. Caused by the varicella-zoster virus, the disease can present with early symptoms of pain and a subsequent rash, requiring diagnosis and treatment from healthcare providers. While there is no cure, antiviral medications can lessen the severity and duration of the attack, and vaccination is recommended for those 60 and older to reduce incidence and severity.