Virtualization and cloud computing introduce new risks to uptime and availability due to single points of failure, I/O and scalability limitations, and challenges with failover and fault isolation. Using fault-tolerant server hardware can help address these issues by eliminating single points of failure, improving I/O performance, and simplifying deployment. Fault-tolerant servers are well-suited for high-performance, high-density, or mission-critical environments that require five-nines uptime.