This study compares the detection of residual multiple myeloma (MM) in bone marrow biopsy specimens using immunoperoxidase staining with noninvasive studies using serum protein electrophoresis (SPE) and urine protein electrophoresis (UPE). The study analyzed 83 bone marrow biopsies and found that SPE and UPE were sensitive methods for detecting residual disease. Negative SPE and UPE results made bone marrow biopsies unnecessary for monitoring residual MM.