The document discusses the role of splicing in protein creation and its implications in cancer, highlighting that abnormal RNA splicing is linked to tumor initiation and metastasis. It mentions that retained introns could differentiate between normal and cancerous cells, while alternative splicing presents new targets for therapeutic intervention. The author notes the potential for developing novel therapies and preventative measures against cancer through deeper understanding of splicing and gene regulation.

1. Daniela Martínez
Rivera
Medicine Student

4. Splicing allows to create proteins
with the coding sequence on the
mature mRNA.
The regulatory mechanism is given by the
order in which the exons are located, if
the same exons change the order, the
reading changes and thus also the
protein.

5. Most cancer
transcriptomes are
bloated by widespread
intron retention. Kocarnik
, JM. (2015, August 17).

6. Most cancer transcriptomes are
bloated by widespread intron
retention
Abnormal RNA splicing is
a common characteristic
of most cancers because
helps with the initiation
and metastasis.

7. Most cancer transcriptomes are
bloated by widespread intron
retention
The retention of introns on
abnormal splicing produced
an abnormal protein.

8. Most cancer transcriptomes are
bloated by widespread intron
retention
These retained introns were
specific to a particular
cancer, his deregulation
may be usefull to
differentiating normal versus
cancerous cells.

9. Most cancer transcriptomes are
bloated by widespread intron
retention
Student’s observation:
I think the splicing process regarding a
global issue such as the cancer is, will have
a great impact , the deepening
knowledge will help the development of
new therapies targeting tumor cells and
also to the prevention of cancer as a
disease and his expression.

10. 'Decoding' gene
regulation. Medical
University of Vienna .
(2015, June 11).

11. 'Decoding' gene regulation
Alternative splicing is a key step in
controlling gene expression, is also
linked to numerous human diseases.

12. 'Decoding' gene regulation
Now, has been reported a
novel type of alternative
splicing that occurs in many
important genes on humans,
the exitron splicing.

13. 'Decoding' gene regulation
Therefore, alternative splicing is giving
promising targets for clinical diagnosis
and therapeutic intervention.

14. 'Decoding' gene regulation
Student’s observation:
I think this research promises a lot of hopes for
the future in the therapy and diagnosis
framework ,even being a theme to deepen, it
has great possibilities to find genes with high
medical relevance.

15. MEDICAL UTILITY

16. Medical Utility
 Both investigations are
seeking the therapeutic
use of alternative
splicing.

17.  The use of small molecules that inhibit
the splicing also have a anti-tumor
activity and it help to design novel
therapies targeting tumor cells.
Medical Utility

18.  Control of gene expression with the
alternative splicing not only helps the
therapeutic treatment , also to the
prevention of diseases.
Medical Utility

19. Bibliography
 Medical University of Vienna . (2015, June 11).
'Decoding' gene regulation. ScienceDaily. Retrieved
August 25, 2015 from
http://www.sciencedaily.com/releases/2015/06/150
611081526.htm
 Kocarnik , JM. (2015, August 17). Most cancer
transcriptomes are bloated by widespread intron
retention. Fred Hutch. Retrieved August 27, 2015
from
http://www.fredhutch.org/en/news/spotlight/import
s/most-cancer-transcriptomes-are-bloated-by-
widespread-intron-rete.html
 Martinez Sánchez, Lina Maria. Biologia
molecular.8.ed.Medellin: UPB. Fac.Medicina.