School-based drug prevention programs aim to reduce substance use among children and adolescents. Most interventions target youth ages 10-16 when most begin experimenting. Programs should start in elementary school and continue with developmentally appropriate curricula. Effective programs provide medically accurate information using interactive methods to build social skills and resist peer pressure. While D.A.R.E. was widely used, research found it ineffective. Programs like Life Skills Training are evidence-based and teach drug resistance and self-management skills to reduce risk. Developing successful prevention requires assessing community needs, involving families and schools, and evaluating outcomes.