Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints. It affects around 1-2% of the population, most often women. Treatment involves controlling inflammation to slow disease progression and manage symptoms. This is achieved through a combination of pharmacological and non-pharmacological therapies including NSAIDs, corticosteroids, DMARDs, biologics, exercise, and assistive devices. The goal of treatment is reduced joint tenderness, swelling and pain as well as improved quality of life. Careful monitoring is required due to potential adverse effects of long-term drug therapy.
This document discusses ankylosing spondylitis and anti-TNF therapies. It describes ankylosing spondylitis as a seronegative spondyloarthropathy characterized by sacroiliitis and spinal inflammation, resulting in back pain, stiffness, and new bone formation causing ankylosis. It presents criteria for diagnosis and notes therapies aim to relieve symptoms and improve spinal mobility, including NSAIDs, DMARDs, and anti-TNF therapies like adalimumab and etanercept, which block TNF-alpha and reduce inflammation. Side effects of these therapies can include injection site reactions and infections.
- Fibromyalgia affects 3 to 6 million Americans, with 80-90% being women who are usually diagnosed in middle age.
- It is characterized by widespread pain in the muscles and soft tissues. Common symptoms include fatigue, sleep issues, headaches, and tender points in various areas of the body.
- While drugs can help manage symptoms, natural therapies like exercise, stress reduction, and nutrition have shown more long-term promise for fibromyalgia sufferers. Regular exercise in particular can help reduce pain and fatigue and improve overall health.
Surgery should be reserved for carefully selected patients who have not achieved significant weight loss with nonsurgical methods, or for patients with life-threatening obesity-related conditions who may benefit more from early surgical intervention.
Coenzyme Q10 is a lipid-soluble antioxidant that is synthesized in the body and functions as a cofactor in ATP synthesis. It accepts and donates electrons during oxidative phosphorylation and also acts as an antioxidant. Due to its roles in energy production and antioxidant properties, Coenzyme Q10 supplementation has shown promise in treating cardiovascular diseases, neurodegenerative diseases, cancer, and diabetes, though more research is still needed to validate its therapeutic benefits.
L-arginine is a semi-essential amino acid that plays an important role in nitric oxide production. Nitric oxide is involved in vascular regulation, immune activity, and other physiological processes. While humans can synthesize L-arginine, dietary intake is important for maintaining adequate plasma levels. L-arginine supplementation has been studied for conditions like hypertension, preeclampsia, erectile dysfunction, and more due to its role in nitric oxide production and vasodilation. Studies have found L-arginine reduces risks of preeclampsia and preterm birth in at-risk women. Further research is still needed but L-arginine may help prevent and treat preeclampsia. Typical effective doses range from 1
Cancer is describes as the disease that results due to cellular changes and these changes cause the uncontrolled growth and division of cells. A cell receives instructions to die so that the body can replace it with a newer cell that functions better. Cancerous cells lack the components that instruct them to stop dividing and to die. Chemotherapeutic drugs CDs are the most widespread worldwide modality used in cancer treatment, and other autoimmune diseases. However, their non selective mechanism of action affects both cancerous and non cancerous cells, that resulting in well documented side effects. Nurses are at risk of suffering side effects. Little negligence or mistake may lead to adverse unpleasant effects for patients, staff and environment. Miss. Madhu Rajput | Mr. Raghavendran M "Chemotherapeutic Drugs" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43941.pdf Paper URL: https://www.ijtsrd.com/medicine/nursing/43941/chemotherapeutic-drugs/miss-madhu-rajput
Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints. It affects around 1-2% of the population, most often women. Treatment involves controlling inflammation to slow disease progression and manage symptoms. This is achieved through a combination of pharmacological and non-pharmacological therapies including NSAIDs, corticosteroids, DMARDs, biologics, exercise, and assistive devices. The goal of treatment is reduced joint tenderness, swelling and pain as well as improved quality of life. Careful monitoring is required due to potential adverse effects of long-term drug therapy.
This document discusses ankylosing spondylitis and anti-TNF therapies. It describes ankylosing spondylitis as a seronegative spondyloarthropathy characterized by sacroiliitis and spinal inflammation, resulting in back pain, stiffness, and new bone formation causing ankylosis. It presents criteria for diagnosis and notes therapies aim to relieve symptoms and improve spinal mobility, including NSAIDs, DMARDs, and anti-TNF therapies like adalimumab and etanercept, which block TNF-alpha and reduce inflammation. Side effects of these therapies can include injection site reactions and infections.
- Fibromyalgia affects 3 to 6 million Americans, with 80-90% being women who are usually diagnosed in middle age.
- It is characterized by widespread pain in the muscles and soft tissues. Common symptoms include fatigue, sleep issues, headaches, and tender points in various areas of the body.
- While drugs can help manage symptoms, natural therapies like exercise, stress reduction, and nutrition have shown more long-term promise for fibromyalgia sufferers. Regular exercise in particular can help reduce pain and fatigue and improve overall health.
Surgery should be reserved for carefully selected patients who have not achieved significant weight loss with nonsurgical methods, or for patients with life-threatening obesity-related conditions who may benefit more from early surgical intervention.
Coenzyme Q10 is a lipid-soluble antioxidant that is synthesized in the body and functions as a cofactor in ATP synthesis. It accepts and donates electrons during oxidative phosphorylation and also acts as an antioxidant. Due to its roles in energy production and antioxidant properties, Coenzyme Q10 supplementation has shown promise in treating cardiovascular diseases, neurodegenerative diseases, cancer, and diabetes, though more research is still needed to validate its therapeutic benefits.
L-arginine is a semi-essential amino acid that plays an important role in nitric oxide production. Nitric oxide is involved in vascular regulation, immune activity, and other physiological processes. While humans can synthesize L-arginine, dietary intake is important for maintaining adequate plasma levels. L-arginine supplementation has been studied for conditions like hypertension, preeclampsia, erectile dysfunction, and more due to its role in nitric oxide production and vasodilation. Studies have found L-arginine reduces risks of preeclampsia and preterm birth in at-risk women. Further research is still needed but L-arginine may help prevent and treat preeclampsia. Typical effective doses range from 1
Cancer is describes as the disease that results due to cellular changes and these changes cause the uncontrolled growth and division of cells. A cell receives instructions to die so that the body can replace it with a newer cell that functions better. Cancerous cells lack the components that instruct them to stop dividing and to die. Chemotherapeutic drugs CDs are the most widespread worldwide modality used in cancer treatment, and other autoimmune diseases. However, their non selective mechanism of action affects both cancerous and non cancerous cells, that resulting in well documented side effects. Nurses are at risk of suffering side effects. Little negligence or mistake may lead to adverse unpleasant effects for patients, staff and environment. Miss. Madhu Rajput | Mr. Raghavendran M "Chemotherapeutic Drugs" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43941.pdf Paper URL: https://www.ijtsrd.com/medicine/nursing/43941/chemotherapeutic-drugs/miss-madhu-rajput
This document discusses the pharmacotherapy of osteoporosis. It begins by defining osteoporosis and describing the problem it presents. It then covers the types of osteoporosis and risk factors. Diagnostic methods like DEXA scans and laboratory tests are outlined. Current treatment options are explained, including bisphosphonates, selective estrogen receptor modulators, calcitonin, vitamin D, and teriparatide. Specific drugs like alendronate, pamidronate, ibandronate, and raloxifene are described in detail. Non-pharmacological treatment and recent advances like neridronate and denosumab are also summarized.
Lung cancer is the leading cause of cancer death worldwide. Smoking is responsible for 85-90% of lung cancer cases and the risk increases with the number of cigarettes smoked daily and lifetime duration of smoking. The two main types are non-small cell lung cancer (NSCLC), which makes up about 80% of cases, and small cell lung cancer. Symptoms vary but may include cough, hemoptysis, dyspnea, and chest pain. Treatment depends on cancer type and stage but may include surgery, radiation, chemotherapy, or palliative care.
Rheumatoid arthritis is a chronic autoimmune disease that causes inflammation of the joints. It affects around 1% of the global population and is three times more common in women than men. While the exact cause is unknown, genetic and environmental factors are believed to play a role. RA results in painful swelling of the joints, stiffness, and over time can cause permanent joint damage and deformity. Diagnosis involves physical exam, blood tests to check for inflammatory markers and autoantibodies, and x-rays. Treatment aims to reduce inflammation and prevent further joint damage through medications, exercise, and assistive devices. While there is no cure, early and aggressive treatment can help control symptoms and minimize disability.
Osteoporosis is a disease characterized by low bone density and deterioration of bone tissue, leading to fragile bones and increased fracture risk. It is diagnosed through bone mineral density tests and can be caused by many factors including older age, female sex, family history, and lifestyle factors. Management focuses on lifestyle modifications like calcium and vitamin D supplementation, exercise, and fall prevention, as well as pharmacological therapies to slow bone loss and increase bone density. Complications include fractures which can lead to disability, loss of independence, and even death in severe cases.
This document discusses palliative and supportive care in oncology. It defines palliative care as preventing and relieving suffering through early management of pain and other physical, psychosocial, and spiritual problems across the cancer experience. The goals of palliative care are to anticipate, prevent, and reduce suffering and support the best possible quality of life regardless of disease stage. Early palliative care involvement has benefits like improved quality of life and mood over traditional late palliative care. An interdisciplinary team approach to palliative care is recommended.
Coenzyme Q10 (CoQ10) is a vitamin-like substance present in cells that is involved in energy production. It was first discovered in 1957 and plays a key role in the electron transport chain in mitochondria to generate energy in the form of ATP. CoQ10 levels can decrease with age or with statin use, and taking CoQ10 supplements along with statins may reduce side effects while maintaining cardio protection. Clinical studies have shown improvements in cardiac function and symptoms in heart failure patients taking CoQ10 supplements.
Coenzyme Q10, also known as ubiquinone, is an essential cofactor in the body's electron transport chain and is important for energy production. It exists in three forms - oxidized, semiquinone, and reduced - and functions as an antioxidant. Dietary sources include meats, soybean oil, and broccoli. CoQ10 levels are reduced in many diseases and it has shown benefits for heart health, hypertension, and gum disease. Absorption is enhanced when taken with fat and statin drugs can lower CoQ10 levels. While it has an excellent safety profile, it may interact with warfarin and anthracyclines. Typical supplemental dosages range from 100-200mg daily
Coenzyme Q10 (COQ10) is an essential vitamin-like substance that has important antioxidant and energy-producing properties. It supports cardiovascular and organ health. COQ10 fights free radicals, aids heart health, and increases energy. Good sources of COQ10 include meats like beef and fish. Vegetables such as broccoli and spinach also contain COQ10. If dietary sources are not enough, supplements provide an effective way to increase COQ10 intake.
This document summarizes the mechanisms of gastrointestinal toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs). It discusses how NSAIDs inhibit cyclooxygenase enzymes, which protect the gastrointestinal mucosa. This inhibition impairs the production of prostaglandins, compromising gastrointestinal integrity and increasing the risk of ulcers and complications. The document outlines risk factors for NSAID-induced toxicity and recommendations for prevention and management.
The document discusses inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease. IBD is believed to be caused by a combination of genetic and environmental factors that lead to dysregulated immune function in the intestines. Some of the key clinical features of IBD described include abdominal pain, diarrhea, bleeding, weight loss, and fatigue. Common treatments involve medications to reduce inflammation and immune activity like 5-aminosalicylates, corticosteroids, azathioprine, infliximab, and sometimes surgery. Nursing care focuses on monitoring symptoms, providing support, and watching for complications of the conditions and their treatments.
UNDERSTANDING OF CHEMICAL CARCINOGENESIS:CURRENT AND FUTURE PERSPECTIVES
Carcinogenesis refers to the process by which a normal cell is transformed into a malignant cell and repeatedly divides to become a cancer
Chemicals which initiate this process is called chemical carcinogens
Chemicals which increase the effectiveness of carcinogens is called co-carcinogens
CLASSIFICATION OF CHEMICAL CARCINOGENS
MECHANISM OF ACTION
STAGES OF CARCINOGENESIS
ROLE OF PROTO-ONCOGENES AND TUMOR SUPPRESSOR GENES
ACTIVATION OF PROTO ONCOGENES
INACTIVATION OF TUMOR SUPPRESSOR GENE
OXIDATIVE STRESS IN CARCINOGENESIS
ROS can be produced from both endogenous and exogenous sources
Attack both purine and pyrimidine bases, as well as the deoxyribose backbone
Induces DNA damage which includes single or double-strand breakage, deoxyribose modification, and DNA cross-link
If DNA damage is not properly repaired it may result in mutation which leads to cancer
BIOMARKERS
REGULATORY BACKGROUND
OECD guidelines
451- Carcinogenecity studies
453- Combined chronic toxicity/carcinogenecity
ICH guidelines
S1A- Guideline on the need for carcinogenicity studies of
pharmaceuticals
S1B- Testing for carcinogenicity of pharmaceuticals
S1C- Dose selection for carcinogenicity studies of pharmaceuticals
The system you must inquire more about for this patient is the gastrointestinal system. Her presentation of fatigue, dizziness, anorexia and pale appearance suggests potential blood loss, likely from NSAID-induced peptic ulcer disease given her risk factors of long-term NSAID use and past history of peptic ulcer. A thorough GI exam and labs are warranted to evaluate for potential bleeding.
Abhijeet Danve, MD, FACP, FACR, prepared useful Practice Aids pertaining to axial spondyloarthritis for this CME activity titled “Overcoming Challenges in the Diagnosis and Management of Axial Spondyloarthritis: New Insights and Implications for Clinical Practice.” For the full presentation, monograph, complete CME information, and to apply for credit, please visit us at https://bit.ly/2A6Xi8d. CME credit will be available until August 27, 2021.
This document provides information on cancer prevention and screening strategies. It discusses overall prevention approaches, strategies for specific cancers like breast and lung, and where to find screening guidelines. Key websites for cancer prevention and statistics are listed. The document discusses estimating cancer risk based on lifestyle factors like diet, exercise and smoking. It provides cancer statistics in the US and probabilities of developing different cancers. Screening is recommended only when proven beneficial and cost-effective. Healthy lifestyle choices can significantly reduce cancer and other disease risks.
Fibromyalgia is a chronic disorder characterized by widespread muscle pain, tenderness, and stiffness. It predominantly affects women between 25-55 years old. Common symptoms include fatigue, headaches, sleep disturbances, and abnormal pain sensation. While the cause is unknown, genes and physical trauma may play a role. Treatments include exercise, acupuncture, massage, medications, and psychotherapy to manage pain and fatigue.
Chapter 2.3 tumor biomarkers and vascular accessNilesh Kucha
This document discusses various tumor biomarkers, including what they are, their clinical uses, and specifics about common biomarkers like AFP, CA125, CA19-9, CA15-3, CEA, hCG, and PSA. It provides details on what types of cancers and conditions can cause elevations, reference ranges, half-lives, and how they are used for screening, diagnosis, prognosis, prediction, and monitoring of cancers. Ideal biomarkers are defined as highly specific and sensitive, correlating with tumor viability, reproducible, cheap, and detectable in occult disease.
The document summarizes the history, chemical structure, biosynthesis, functions, disease treatments, efficacy data, recommended dosages, forms, and regulations of coenzyme Q10. It was first isolated in 1957 and its structure determined in 1958. It plays a key role in ATP synthesis as an antioxidant, and research shows benefits for heart disease, hypertension, and Parkinson's. Doses range from 30-100mg depending on the condition. It is considered a dietary supplement under DSHEA and cannot claim to treat or cure diseases.
Osteoporosis is a progressive systemic skeletal disease characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk.
School-based drug prevention programs aim to reduce substance use among children and adolescents. Most interventions target youth ages 10-16 when most begin experimenting. Programs should start in elementary school and continue with developmentally appropriate curricula. Effective programs provide medically accurate information using interactive methods to build social skills and resist peer pressure. While D.A.R.E. was widely used, research found it ineffective. Programs like Life Skills Training are evidence-based and teach drug resistance and self-management skills to reduce risk. Developing successful prevention requires assessing community needs, involving families and schools, and evaluating outcomes.
Michigan Model Substance Abuse Conference 9 08Wendy Sellers
The document discusses the Michigan Model for Health, a comprehensive K-12 health education curriculum that aims to prevent drug abuse. It provides skills-based lessons addressing various health topics including social-emotional health, nutrition, safety, and alcohol/tobacco prevention. Research shows this approach is effective by building students' knowledge, self-efficacy, and skills to make healthy choices. The curriculum is implemented statewide with support from regional coordinators.
This document discusses the pharmacotherapy of osteoporosis. It begins by defining osteoporosis and describing the problem it presents. It then covers the types of osteoporosis and risk factors. Diagnostic methods like DEXA scans and laboratory tests are outlined. Current treatment options are explained, including bisphosphonates, selective estrogen receptor modulators, calcitonin, vitamin D, and teriparatide. Specific drugs like alendronate, pamidronate, ibandronate, and raloxifene are described in detail. Non-pharmacological treatment and recent advances like neridronate and denosumab are also summarized.
Lung cancer is the leading cause of cancer death worldwide. Smoking is responsible for 85-90% of lung cancer cases and the risk increases with the number of cigarettes smoked daily and lifetime duration of smoking. The two main types are non-small cell lung cancer (NSCLC), which makes up about 80% of cases, and small cell lung cancer. Symptoms vary but may include cough, hemoptysis, dyspnea, and chest pain. Treatment depends on cancer type and stage but may include surgery, radiation, chemotherapy, or palliative care.
Rheumatoid arthritis is a chronic autoimmune disease that causes inflammation of the joints. It affects around 1% of the global population and is three times more common in women than men. While the exact cause is unknown, genetic and environmental factors are believed to play a role. RA results in painful swelling of the joints, stiffness, and over time can cause permanent joint damage and deformity. Diagnosis involves physical exam, blood tests to check for inflammatory markers and autoantibodies, and x-rays. Treatment aims to reduce inflammation and prevent further joint damage through medications, exercise, and assistive devices. While there is no cure, early and aggressive treatment can help control symptoms and minimize disability.
Osteoporosis is a disease characterized by low bone density and deterioration of bone tissue, leading to fragile bones and increased fracture risk. It is diagnosed through bone mineral density tests and can be caused by many factors including older age, female sex, family history, and lifestyle factors. Management focuses on lifestyle modifications like calcium and vitamin D supplementation, exercise, and fall prevention, as well as pharmacological therapies to slow bone loss and increase bone density. Complications include fractures which can lead to disability, loss of independence, and even death in severe cases.
This document discusses palliative and supportive care in oncology. It defines palliative care as preventing and relieving suffering through early management of pain and other physical, psychosocial, and spiritual problems across the cancer experience. The goals of palliative care are to anticipate, prevent, and reduce suffering and support the best possible quality of life regardless of disease stage. Early palliative care involvement has benefits like improved quality of life and mood over traditional late palliative care. An interdisciplinary team approach to palliative care is recommended.
Coenzyme Q10 (CoQ10) is a vitamin-like substance present in cells that is involved in energy production. It was first discovered in 1957 and plays a key role in the electron transport chain in mitochondria to generate energy in the form of ATP. CoQ10 levels can decrease with age or with statin use, and taking CoQ10 supplements along with statins may reduce side effects while maintaining cardio protection. Clinical studies have shown improvements in cardiac function and symptoms in heart failure patients taking CoQ10 supplements.
Coenzyme Q10, also known as ubiquinone, is an essential cofactor in the body's electron transport chain and is important for energy production. It exists in three forms - oxidized, semiquinone, and reduced - and functions as an antioxidant. Dietary sources include meats, soybean oil, and broccoli. CoQ10 levels are reduced in many diseases and it has shown benefits for heart health, hypertension, and gum disease. Absorption is enhanced when taken with fat and statin drugs can lower CoQ10 levels. While it has an excellent safety profile, it may interact with warfarin and anthracyclines. Typical supplemental dosages range from 100-200mg daily
Coenzyme Q10 (COQ10) is an essential vitamin-like substance that has important antioxidant and energy-producing properties. It supports cardiovascular and organ health. COQ10 fights free radicals, aids heart health, and increases energy. Good sources of COQ10 include meats like beef and fish. Vegetables such as broccoli and spinach also contain COQ10. If dietary sources are not enough, supplements provide an effective way to increase COQ10 intake.
This document summarizes the mechanisms of gastrointestinal toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs). It discusses how NSAIDs inhibit cyclooxygenase enzymes, which protect the gastrointestinal mucosa. This inhibition impairs the production of prostaglandins, compromising gastrointestinal integrity and increasing the risk of ulcers and complications. The document outlines risk factors for NSAID-induced toxicity and recommendations for prevention and management.
The document discusses inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease. IBD is believed to be caused by a combination of genetic and environmental factors that lead to dysregulated immune function in the intestines. Some of the key clinical features of IBD described include abdominal pain, diarrhea, bleeding, weight loss, and fatigue. Common treatments involve medications to reduce inflammation and immune activity like 5-aminosalicylates, corticosteroids, azathioprine, infliximab, and sometimes surgery. Nursing care focuses on monitoring symptoms, providing support, and watching for complications of the conditions and their treatments.
UNDERSTANDING OF CHEMICAL CARCINOGENESIS:CURRENT AND FUTURE PERSPECTIVES
Carcinogenesis refers to the process by which a normal cell is transformed into a malignant cell and repeatedly divides to become a cancer
Chemicals which initiate this process is called chemical carcinogens
Chemicals which increase the effectiveness of carcinogens is called co-carcinogens
CLASSIFICATION OF CHEMICAL CARCINOGENS
MECHANISM OF ACTION
STAGES OF CARCINOGENESIS
ROLE OF PROTO-ONCOGENES AND TUMOR SUPPRESSOR GENES
ACTIVATION OF PROTO ONCOGENES
INACTIVATION OF TUMOR SUPPRESSOR GENE
OXIDATIVE STRESS IN CARCINOGENESIS
ROS can be produced from both endogenous and exogenous sources
Attack both purine and pyrimidine bases, as well as the deoxyribose backbone
Induces DNA damage which includes single or double-strand breakage, deoxyribose modification, and DNA cross-link
If DNA damage is not properly repaired it may result in mutation which leads to cancer
BIOMARKERS
REGULATORY BACKGROUND
OECD guidelines
451- Carcinogenecity studies
453- Combined chronic toxicity/carcinogenecity
ICH guidelines
S1A- Guideline on the need for carcinogenicity studies of
pharmaceuticals
S1B- Testing for carcinogenicity of pharmaceuticals
S1C- Dose selection for carcinogenicity studies of pharmaceuticals
The system you must inquire more about for this patient is the gastrointestinal system. Her presentation of fatigue, dizziness, anorexia and pale appearance suggests potential blood loss, likely from NSAID-induced peptic ulcer disease given her risk factors of long-term NSAID use and past history of peptic ulcer. A thorough GI exam and labs are warranted to evaluate for potential bleeding.
Abhijeet Danve, MD, FACP, FACR, prepared useful Practice Aids pertaining to axial spondyloarthritis for this CME activity titled “Overcoming Challenges in the Diagnosis and Management of Axial Spondyloarthritis: New Insights and Implications for Clinical Practice.” For the full presentation, monograph, complete CME information, and to apply for credit, please visit us at https://bit.ly/2A6Xi8d. CME credit will be available until August 27, 2021.
This document provides information on cancer prevention and screening strategies. It discusses overall prevention approaches, strategies for specific cancers like breast and lung, and where to find screening guidelines. Key websites for cancer prevention and statistics are listed. The document discusses estimating cancer risk based on lifestyle factors like diet, exercise and smoking. It provides cancer statistics in the US and probabilities of developing different cancers. Screening is recommended only when proven beneficial and cost-effective. Healthy lifestyle choices can significantly reduce cancer and other disease risks.
Fibromyalgia is a chronic disorder characterized by widespread muscle pain, tenderness, and stiffness. It predominantly affects women between 25-55 years old. Common symptoms include fatigue, headaches, sleep disturbances, and abnormal pain sensation. While the cause is unknown, genes and physical trauma may play a role. Treatments include exercise, acupuncture, massage, medications, and psychotherapy to manage pain and fatigue.
Chapter 2.3 tumor biomarkers and vascular accessNilesh Kucha
This document discusses various tumor biomarkers, including what they are, their clinical uses, and specifics about common biomarkers like AFP, CA125, CA19-9, CA15-3, CEA, hCG, and PSA. It provides details on what types of cancers and conditions can cause elevations, reference ranges, half-lives, and how they are used for screening, diagnosis, prognosis, prediction, and monitoring of cancers. Ideal biomarkers are defined as highly specific and sensitive, correlating with tumor viability, reproducible, cheap, and detectable in occult disease.
The document summarizes the history, chemical structure, biosynthesis, functions, disease treatments, efficacy data, recommended dosages, forms, and regulations of coenzyme Q10. It was first isolated in 1957 and its structure determined in 1958. It plays a key role in ATP synthesis as an antioxidant, and research shows benefits for heart disease, hypertension, and Parkinson's. Doses range from 30-100mg depending on the condition. It is considered a dietary supplement under DSHEA and cannot claim to treat or cure diseases.
Osteoporosis is a progressive systemic skeletal disease characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk.
School-based drug prevention programs aim to reduce substance use among children and adolescents. Most interventions target youth ages 10-16 when most begin experimenting. Programs should start in elementary school and continue with developmentally appropriate curricula. Effective programs provide medically accurate information using interactive methods to build social skills and resist peer pressure. While D.A.R.E. was widely used, research found it ineffective. Programs like Life Skills Training are evidence-based and teach drug resistance and self-management skills to reduce risk. Developing successful prevention requires assessing community needs, involving families and schools, and evaluating outcomes.
Michigan Model Substance Abuse Conference 9 08Wendy Sellers
The document discusses the Michigan Model for Health, a comprehensive K-12 health education curriculum that aims to prevent drug abuse. It provides skills-based lessons addressing various health topics including social-emotional health, nutrition, safety, and alcohol/tobacco prevention. Research shows this approach is effective by building students' knowledge, self-efficacy, and skills to make healthy choices. The curriculum is implemented statewide with support from regional coordinators.
Substance abuse prevention requires a comprehensive approach that addresses risk and protective factors from early childhood through young adulthood. Schools play a key role in prevention by delivering developmentally appropriate programming to reduce substance use. The Safe Schools/Healthy Students initiative integrates substance abuse prevention activities into a collaborative, district-wide approach that builds community commitment and reduces related risk factors. Evaluation found the initiative helped decrease student substance use and increased protective factors.
The document discusses approaches to drug prevention and education. It describes how most drug prevention funds in the US come from the federal government and are allocated to various agencies. Effective drug prevention programs are school-based, involve peers, emphasize social influences and life skills, aim to change social norms, and include parent and community involvement. While early efforts focused on supply reduction, the focus is now on prevention and underlying factors contributing to drug abuse. Successful programs provide skills training, social resistance training, and normative education in a culturally sensitive way over multiple years.
The document discusses substance abuse prevention programs for youth. It notes that substance abuse is rising among younger children and teens. Current prevention programs are not addressing this issue, as drugs are affecting children at younger ages. It proposes creating new prevention programs that target younger children, involve the community, and increase education on newer drugs that are affecting youth. A key part of new programs would be evaluating existing programs, gathering input from students and the community, and developing initiatives to build social skills and drug education at younger grades to try to reduce substance abuse among youth.
This document discusses approaches to drug prevention and education. It covers topics like the goals of prevention, levels of prevention from primary to tertiary, risk factors for drug abuse, and the effectiveness of different prevention strategies. School-based drug education programs are most effective when they are developmentally appropriate, teach social resistance skills, involve normative education, and receive sufficient time and support. Peer-led and health education models can also be effective approaches.
This document discusses approaches to drug prevention and education. It notes that effective programs incorporate skills training to resist peer pressure, correct misperceptions about drug use norms, and emphasize short-term health consequences. School-based programs work best when they are interactive, developmentally appropriate, involve parents and community, and are part of a multi-year curriculum. While DARE had little impact, programs focusing on life skills and social resistance training can reduce drug use if adequately implemented and evaluated.
The document discusses the health belief model, which is a theoretical framework used in healthcare to guide health promotion plans and disease prevention. It has five stages: precontemplation, contemplation, preparation, action, and maintenance. The model focuses on perceived susceptibility, severity, benefits, and confidence. It can be used to understand behaviors like substance abuse in youth. Barriers to implementing it include lack of resources. Benefits are improving health knowledge and behaviors.
This document discusses prevention of problematic substance use. It defines prevention as efforts to prevent harmful patterns of substance use at any level, from preventing onset to reducing harm for those with existing issues. Effective prevention requires education and awareness plus broader collaborative approaches. Key evidence shows that information alone does not work and that prevention must address individual, social, and environmental risk and protective factors through multi-level interventions. Professionals are advised to understand what approaches have evidence, what does not work, and to focus on potential harms rather than substance use alone.
3. Ecological framework in health promotion.pptx (1).pdfPujaDey19
The document discusses the ecological framework for health promotion and disease prevention. It explains that the ecological model recognizes multiple levels of influence on health behaviors, including intrapersonal, interpersonal, organizational, community, and public policy factors. The ecological perspective provides a useful framework for understanding the range of factors that influence health and for designing comprehensive health promotion programs that address multiple levels of influence simultaneously.
This document discusses the importance of mental health promotion in schools. It notes that schools provide an opportunity to promote wellbeing and prevent mental illness during childhood and adolescence when most mental disorders emerge. The document summarizes evidence that school-based mental health promotion programs and early intervention for disorders lead to improved mental health, educational and life outcomes, and economic savings. It argues for implementing evidence-based, proportionate universal approaches to address mental health in schools given the broad impacts of mental illness and benefits of prevention.
In the area of violence prevention, the need for programs in schools and other institutions that work with youth has increased at a faster pace than the availability of solid evaluation research. Source: https://ebookscheaper.com/2021/01/21/effective-school-based-violence-prevention/
- Prevention efforts for substance abuse traditionally focus on primary, secondary, and tertiary interventions. Primary prevention aims to prevent initial use, secondary focuses on early identification of problems, and tertiary refers to treatment for those with substance abuse issues or dependence.
- There are three major models of prevention: the sociocultural model aims to influence social norms, the distribution/consumption model focuses on restricting availability, and the proscriptive model prohibits availability and advocates total abstinence.
- Common prevention strategies include education programs in schools, mass media campaigns, and programs targeting at-risk groups like college students where binge drinking leads to health, academic, and legal problems for many.
Prevention programs should address risk and protective factors, tailor interventions to the specific risks and population, and enhance protective factors like family bonding. Effective programs provide parenting skills, teach families how to develop and enforce drug policies, and give parents drug education to discuss with their children. School-based programs can intervene early to address risk factors for drug abuse.
Mentor_submission to the Education Committee inquiry on PSHE and SREJamila Boughelaf
This document discusses the importance of Personal, Social, Health and Economic (PSHE) education in schools. It argues that PSHE should have statutory status to ensure it is properly prioritized and taught in all schools. It provides evidence that PSHE education improves educational outcomes, reduces risky behaviors, and yields long term social and economic benefits by developing students' life skills. The document recommends making PSHE a core subject within the Ofsted inspection framework and providing consistent training for PSHE teachers.
This document discusses the role of education in curbing drug and alcohol abuse. It outlines traditional and contemporary educational approaches, and their effectiveness. Traditional approaches focused on information dissemination about the dangers of substance abuse, but evaluations showed only temporary impacts. Contemporary approaches emphasize teaching social resistance skills and competence enhancement to increase students' ability to resist peer pressure. Studies found these approaches reduced substance use by 40-80% and had effects lasting up to six years. However, effective programs face challenges being widely adopted in schools and implemented with fidelity.
School governors presentation - drugs and alcoholMentor
This document provides information on drugs and substance use among young people. It summarizes trends showing declines in smoking, drinking, and drug use among 14-year-olds over the past decade. However, it notes some young people are still engaging in risky behaviors. The document discusses Ofsted standards for personal, social, health and economic education and how schools should manage drug-related incidents, identify students in need, and include arrangements in their drug policies. It provides questions for governors to consider and ensures schools fulfill their duties in promoting wellbeing and safety.
Similar to Health promotion for decreasing substance (20)
1) Recent advances in exposure therapy involve deriving customized information about feared cues, events, consequences, and coping mechanisms.
2) Exposure therapy follows the principles of graduated, repeated, and prolonged exposure to feared stimuli to develop non-threat expectancies and reduce fear through inhibitory learning.
3) Maximizing exposure therapy involves combining multiple contextual cues, varying contexts and order of exposure, using reminder cues, and emphasizing credibility, expectancy, therapeutic alliance, and goal setting to enhance treatment effects.
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1. HEALTH PROMOTION FOR
REDUCING SUBSTANCE ABUSE
Samantaray, Narendra nath.
(2016)
Faculty Clinical Psychologist
Mental Health Institute
SCB Medical College &
Hospital, Cuttack
Email id:
narendra.samantaray@gmail.co
m
3. Facts 1
Worldwide psychoactive substance use is estimated at 2
billion alcohol users, 1.3 billion smokers and 185 million
drug users (UNDCP/WHO, 2002).
4% of the global burden of disease is attributed to
alcohol,
which contributes to 3.2% of deaths and 4.0% of the
disability.
One of the leading risk factor for disease burden in
developing countries, the third largest risk factor for
developed countries (Doran, 2003;WHO, 2004).
4. Facts 2
Substance behaviour is not only shaped by individual
choices and motivation but also strongly influenced by
organizational, economic, environmental, and social
factors (WHO, 2004; WMA, 2005).
Many studies prove environmental cues and reinforces
exert an important influence (Geller et al., 1991).
These influences may include social cues, such as use
by family members and peers, or images of alcohol
use promulgated by advertising and media (USDHHS,
1997a).
5. Facts 3
Despite the scope of alcohol related problems
globally, there is increasing evidence of effectiveness
of some prevention strategies.
Over the past three decades, high-income countries
experienced a substantial reduction in mortality and
morbidity from substance-related cases, traffic
cases(Peden et al., 2004).
These are attributed to behavioral changes
associated with public education, organizational
policies, legislation, law enforcement, and economic
actions, in multiple settings involving multiple sectors
(Commonwealth Department of Health and Aging,
6. So what idea we get or can be
summarized from above facts?
Therefore, approaches that attempt to bring about
change in drinking behavior through education
alone are likely to have limited or no success
(Gielen & Sleet, 2003; Howat et al., 2004; Peden
et al., 2004; Sleet et al., 1989),
whereas those that combine educational with
other behavioral, environmental, policy and
organizational changes are likely to be the most
effective (Shults et al., 2001; Waller 1998; WHO,
1986)
7. Health Promotion-Definition.
WHO defines Health Promotion as “ the process
of enabling people to increase control over their
health and its determinants and thereby improve
their health”.
Consists of balance of individually-focused and
environments focused measures that support
healthy behaviours.
8. Hence, health promotion is: a combination of
educational, organizational, .economic and
political actions designed with consumer
participation, to enable individuals, groups and
whole communities to increase control over, and
to improve health through changes in knowledge,
attitudes, behavior, policy, and social and
environmental conditions (Howat et al., 2003)
9. Protective Factors
(core of complete presentation)
well-developed social skills,
strong family bonds,
Involvement of parents in lives of children
attachment to school,
Self esteem
and active involvement in the community and religious
organizations
Strict policies and law
Recent research suggests that resilience is also an
important factor
Environmental constraints in getting substance
10. Risk Factors
Substance abuse by a parent,
(statisticss latter)
Ineffective parental guidance
Lack of parent child attachment,
or a disruptive, abusive family are very strong
predictors,
as are school failure or experience,
affiliation with peers showing deviant behaviours
early experimentation with drugs,
easy availability of substance in community.
11.
12. All well planned and evidenced
proof management plan
includes??????
14. Teaching prevention in Schools
*Huge chunk of protective as well as risk factors lies
in school.
School first to detect warning signs
Peer influence
Hence, effective school programme consists of
training of social skills, such as decision making,
stress management, communication, conflict
resolution, and assertiveness.
these programs can enhance awareness and
16. 3 interrelated facts regarding Prevention in
school
Delayed initiation is beneficial, giving children
time to develop social competence and
resistance skills.
Delay in beginning to smoke during the early teen
years improves the future prognosis for
quitting (The Department of Health and Human
Services, 2005).
Delayed onset of smoking is also associated with
a lower incidence of disease and death (BGDD,
17. Other operational techniques in
SP
Increase participation of students in various
programmes
Link students to supervised recreational
activities,mentoring, and other services
No tolerance policies to substance
Sufficient reward system for prosocial behaviour*
Work on Self esteem
Prevention is most effective when school
lessons are reinforced by a clear, consistent
social message that teen alcohol, tobacco, and
other drug use is harmful and unacceptable
(Making the Grade, 1999).
18. Now lets see & understand
through certain examples
of well received
programmes of SP around
the globe.
19. Making the Grade: A Guide to School Drug Prevention Programs,
successful school based drug prevention programs incorporate :
Help students recognize internal pressures, like
anxiety and stress, and external pressures, like peer
attitudes and advertising, that influence them to use
alcohol, tobacco, and other drugs;
Develop personal, social, and refusal skills to resist
these pressures;
Teach that using substance is not the norm among
teenagers, even they believe “everyone is doing it”;
developmentally-appropriate information about the
short-term effects and long-term consequences
use interactive teaching techniques, such as role
plays, discussions, brainstorming, and cooperative
learning;
actively involve the family and the community
20. Child Development Project (CDP)
Program Type: Teaching Prevention in Schools.
Target Audience: Elementary school students, their
parents and teachers.
Years in Operation: 1992-present.
Program Goals: To increase student attachment to
school, thereby reducing risk factors that
contribute to substance abuse and other high-risk
behaviours.
21. CDP…..continues
program focuses on an entire school rather....
CDP does not address substance abuse directly, its
character building program is designed to reduce risk
factors for alcohol and other drug use
22. Life Skills Training (LST)
Program Type: Teaching Prevention in Schools.
Target Audience: Middle school students.
Years in Operation: 1997-present.
Program Goals: To teach alcohol and other drug
prevention skills to all middle school students.
23. LST….continues
LST is one of the best-evaluated substance
abuse prevention programs available, having
been evaluated in 12 rigorous field trials in
developed countries over the past two decades.
LST provides information on alcohol, tobacco,
and marijuana and addresses substance use risk
and protective factors.
In the 1999-2000 school year the program
reached approximately 3,968 sixth graders, 3,789
seventh graders, and 3,851 eighth graders.
24. LST….continues
Curriculum uses a variety of interactive techniques,
including discussions, brainstorming, role playing, and
skill rehearsal.
Students learn, for example, that contrary to myth,
smoking does not help people relax.
LST develops personal or selfmanagement skills. Like
managing anxiety, including deep breathing, mental
rehearsal, and muscle relaxation.
The third module - hones students’ social skills. To
help students feel comfortable in social situations and
less vulnerable to peer pressure.
Practical training on assertive skills.
25. Reconnecting Youth (RY)
• Midland, Texas
• Program Type: Teaching Prevention in Schools
• Target Audience: High-risk high school students.
• Years in Operation: 1997-present.
• Program Goals: To increase school performance
and decrease drug use and emotional distress.
26. RY…..continues
RY targets students who fall behind their peers in
school, have high absenteeism, experience a
drop in grades, or drop out of school.
It includes a semester-long course. The RY class
is taught for 55 minutes each day and includes
four modules: Decision- Making, Personal
Control, Self-Esteem Enhancement, and
Interpersonal Communication.
27. RY…..continues
RY has three primary goals:
(1) increase academic performance by enhancing
school bonding, school attendance, and grades,
and increasing the number of pre-college courses
taken;
(2) decrease drug involvement by increasing
control over drug use; and
(3) decrease emotional distress by lessening risk
factors, such as depression, and increasing
protective factors, such as self-esteem.
29. Approximately one-third of all violent juvenile
crimes occur between the hours of 3 p.m. and 7
p.m. when many children are unsupervised.
Targeted programs during these vulnerable hours
can help prevent, reduce, or delay the onset of
alcohol, tobacco, and other drug use.
30. Building Family Bonds
Involvement
of parent in
lives of
children
Self Esteem
Strong
Family
Bonds Risk
Facto
r
Lack of
Parent
Child
Attachment
Substanc
abuse by
parent
Mental
Illness
Disruptive
family
Inconsistent
discipline
31. Certain Principles for Increasing
Parent Child Bond… (IS & V)
CREATE OPPURTUNITIES TO TALK
Rewards for prosocial behaviour, or recognition of
positive behaviours - Remember power of praise
Communication of limits
Teaching Responsibility- Self esteem- opportunities to
express themselves and be involved in family,
Engaging Activities
Parents aware of their child’s friends- Interesting Stat
Role Model- Interesting statistics
Main idea is that we have to match the positive
valence of friendship with family
32. National Institute on Drug Abuse (NIDA) recommends
that family-based prevention should have:
Train parents in behavioral skills improve parent child
relationships, provide consistent discipline and
rulemaking, and monitor children’s activities during
adolescence;
Direct services to families with children in
kindergarten through 12th grade to enhance
protective factors; and
33. Parents have a critical role to play—not only within
the family, but also in collaboration with schools and
community groups.
Recent research suggests that the most effective
programs promote positive relationships between
parents and children
34. Federal Center for Substance
Abuse Prevention (FCSAP)
It recommends three family-centered approaches that
show great potential.
The first, parent and family skills training, teaches parents
how to build protective factors and reduce risk factors
linked to substance abuse.
These risk factors include communication problems, too
lax or too stringent discipline, parental substance use, and
child abuse or neglect.
Family protective factors include close-knit familial
relationships, consistent discipline, and parental
supervision of children’s daily activities.
These programs can improve poor parent-child
communication, child behavior, and parenting skills, and
reduce family conflict. Such interventions are directed at
families with children who have no apparent risk factors for
substance abuse as well as those at moderate and high
risk
35. The second approach, family in-home support,
provides crisis intervention (such as food, shelter,
clothing) and long-range training.
Aims to decrease domestic violence, child abuse and
neglect, and child placement in foster care, and
Are most effective with high-risk children.
36. Family therapy, the third approach, helps
family members improve the way they
communicate, manage family life, and solve
problems.
Programs are aimed at families with children at
high risk and are designed to improve family
functioning and reduce antisocial behaviour
among both parents and children.
37. Dare to be You
Strengthening Families Program
38. Economic Interventions
Price and taxation:
Among the most effective measures to reduce
substance.
Studies have indicated that a rise in price will lead to
a drop in consumption (Babor et al., 2003; Waller,
Naidoo & Thom, 2002; WHO, 2004).
Decrease in price will likely result in additional alcohol
related deaths (Schancke, 2005).
Pricing policies particularly effective in reducing
consumption by young people,
An increase in the real price of alcohol has been
shown to significantly reduce alcohol attributable
harms (Chikritzhs et al., 2005)
40. Licensing:
Some studies shows prevention regulations
that are aimed at the sellers of alcohol are
more effective than prevention programs that
rely only on education directed at individual
drinkers.
The power to revoke or suspend a license for
breaches causing traffic crashes (Babor et al.,
2003).
41. Alcohol Availability
Some studies have described a clear epidemiological
link between alcohol consumption and suicide and
violence (Rossow, 2000; Rossow, Grøholt &
Wichstrom, 2005).
When Swedish grocery stores were no longer
permitted to sell 4.5% beer, a significant drop in traffic
crashes followed (Babor et al., 2003).
A number of studies indicate that changing the hours
or days of alcohol sales can influence the incidence of
alcohol related problems (Babor et al., 2003;
Chikritzhs & Stockwell, 2002; Chikritzhs & Stockwell,
2006, McMillan & Lapham, 2006)
42. Policy Interventions
Some examples of laws where evidence supports
such benefits include:
A reduction of the legal BAC to .05% in Australia
and .08% in the United States (Howat et al.,
1992; Shults et al., 2001)
Sobriety checkpoints and testing (Jones &
Lacey, 2001; Shults et al., 2001)
Stricter enforcement of drink driving legislation
(Holder, 1998)
An increase in the legal drinking age (Shults et
al., 2001)
Restrictions on advertising and promotion-
Whats beer shampoo??? For this I dont have
any data but??
44. Handling Craving:
At the time of intense craving the recovering individual can
call a sober or abstinent friend and tell them he/she feels
like taking a drink/using a drug, and needs help not to do
so. Similarly, recall negative consequences of returning to
substance use - losing one's job, broken family
relationships, etc.
4 Ds
Delay
Distraction
Deep breathing
Drink water
45. C. Drink Refusal Skills and Assertiveness:
Refusal skills are a specific set of skills which are related to
dealing with social pressure. Hence it needs a strong body
language and confident tone of voice from the person while
refusing to drink/use a drug. In this situation one has to respond
rapidly as the delay is likely to increase the urge. Many patients
feel uncomfortable or guilty about saying “no” and think they
need to make excuses for not using.
Saying things like “maybe later,” “we shall see,” just makes it
likely that they will be pressured again to use. This allows for
possibility of future offers.
So “No” can be followed by changing the subject, suggesting
alternative activities, and clearly requesting that the individual
not offer alcohol or other drug again in the future.
46. Dealing with faulty cognitions like overconfidence, helplessness, etc.
A person’s faulty thought very often becomes a problem for him/her and leads to a
relapse. A simple example is:
“I can stay away from alcohol. Nothing can tempt me.” The consequence is -
going to parties where alcohol may be available, telling myself “I will go, but I’ll not
drink.”
E. Handling Negative Mood States
Negative mood states like anger, anxiety, fear, depression, guilt, getting upset or bored
easily, irritability, tiredness, restlessness, etc. are associated with relapse. Some people
suggest that addicts frequently relapse as a result of joylessness in their lives.
A few ways to handle this are:
The first step is to be aware of one’s self-defeating thoughts and depressed mood.
Realizing the adverse consequences of these negative thoughts.
Creating opposite (positive) thoughts, challenge negative thoughts.
Ignoring negative thoughts, not responding to them.
Accepting oneself as one really is, with strengths as well as limitations.
Having realistic self-expectations.
Editor's Notes
Harmful peristent use
(Availability, Attitude, Advertising)….Do nt read the third point of this slide…
Ask question to floor, then summarize without seeing the next points, then show next points only
Before going to next slide, ask like rhat is there any specific factors in both individual or environmental situation where chances of substances increases or either decreses, if yes that is that quite a excpetion or found in consistent manner.
Viewing this Health Promotion too involves same…..
If a school student feels that he or she has a positive relationship with supportive teachers, involves in more school activities or has a positive school experience, this has a huge effect in terms of reducing the risk of substance.-----Relieve boredom, relax,feel grown up, social group, poor academic per
(why they take in school;
Prognosis for quitting-say when it is compared with others who have early onset, persistently found that those have later onset has better prognosis…
A positive atmosphere helps engage students in school, giving them a sense of identity and reducing the likelihood that they will drop out or participate in delinquent behavior, two factors that can increase risk for later substance abuse problems.
* Prosocial behaviour- difficult to do with each and every student, but teacher must do so in case of highly prone students…simply statement like “yes, this is right way, u need to do more like this”
Much behavioral practice oriented. Nicotine is a stimulant which causes hands to tremble and the heart to beat faster.
Remember this slide. Delete it from here.
Two things say first-Independent seeking urge- Main idea is that we have to match the positive valence of friendship with family & Increase of Family Valence. Showing that parents are highly concerned.
Mental Illness in family.
I will go quick on this.
15% more - two days back I read about ban of shops near highway about Harman Singh.
Breath test procedures are at random and at times systematic in australia and new zeland. Idea sir ji- like helmet check why not this in India. At Australia 30% crashes due to alcohol has decreased just for this. Studies in the United States have produced strong
evidence that increasing the drinking age to 21 years resulted in substantially fewer alcohol-related crashes among young people