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EuroCTO Club 2015
Saturday, September 19, 2015
Prevalence and treatment of balloon
uncrossable or untreatable CTOs
4.30 -4.45 pm
Emmanouil S. Brilakis, MD, PhD
Director, Cardiac Catheterization Laboratories
VA North Texas Health Care System
Professor of Medicine, University of Texas
Southwestern Medical School, Dallas, Texas
Speaker honoraria/consulting fees:
Abbott Vascular, Asahi, Boston
Scientific, Elsevier, Somahlution, St
Jude Medical, Terumo
Research funding: InfraRedx, Boston
Scientific
Employment (spouse): Medtronic
Grants: VA - CLIN-007-11F
VA CSP#571 – DIVA
Disclosures
Prevalence
DO NOT TRY ANYTHING OF WHAT
WILL BE PRESENTED
UNTIL AFTER
YOU HAVE CONFIRMED THAT
YOUR WIRE IS INTO THE DISTAL
TRUE LUMEN USING TWO
ORTHOGONAL PROJECTIONS!
DOING OTHERWISE MAY RESULT
IN SEVERE INJURY OR DEATH…
DISCLAIMER
Dual injection
Mid RCA
occlusion
PDA fills by collaterals
from the LAD
Dual injection: RAO
Antegrade crossing
Finecross
Pilot 200
Finecross and 1.5 mm balloon: No crossing
Modify lesion
Approach to “balloon uncrossable” CTO
Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013
Improve support
Approach to “balloon uncrossable” CTO
 Long length (20 mm)
 Rx balloon – more pushable
 Different brands - can alternatively try larger balloons
1st line
“Balloon Uncrossable” CTO
• Inflate 1.20-1.5 mm balloon, Threader, Glider
• Rupture balloon in vessel (grenadoplasty)
Grenadoplasty
aka “BAM” – “Balloon Assisted Microdissection”
Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013
1st line
2nd line
Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013
Approach to “balloon uncrossable” CTO
“Balloon Uncrossable” CTO
• Inflate 1.20-1.5 mm balloon, Threader, Glider
• Rupture balloon in vessel (grenadoplasty)
• Tornus, Corsair, Turnpike, Finecross
• Wire “cutting”
FINECROSS MG
Tornus Counter-
clockwise
advancement
• Support Catheter:
• Constructed with eight (8) individual wires stranded together
to form the catheter
• Two sizes:
• 2.1Fr - Diameter increases from 0.024” to 0.028”
• 2.6Fr - Diameter increases from 0.028” to 0.035”
Corsair: Support and Penetration
2 Thick Braids
③②①
8 Thin Braids




Counter or
clockwise
advancement
Tsuchikane et al. J Am Coll Cardiol Intv. 2010;3(2):165-171
Turnpike Multi-Layer Shaft
Pebax outer layer
for smooth outer surface
Dual-layer, bidirectional coil
for kink-resistance with torque
Braid
for longitudinal strength
PTFE liner
for excellent
guidewire movement
Corsair will not go…
Corsair
The “Wire‐Cutting” Technique
Hu et al. Journal of Interventional Cardiology 2012;25:297-303
1st line
2nd line
Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013
Approach to “balloon uncrossable” CTO
“Balloon Uncrossable” CTO
• Inflate 1.20-1.5 mm balloon, Threader, Glider
• Rupture balloon in vessel (grenadoplasty)
• Tornus, Corsair, Finecross
• Wire “cutting”
• Guide catheter extensions
• Anchor balloon strategies
Guide catheter support
Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013
If you want peace, prepare for war!!
Guide catheter extensions
≤15 cm
Guideliner
Deep-seated Guideliner
Side branch anchor
Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013
1st line
2nd line
Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013
Approach to “balloon uncrossable” CTO
“Balloon Uncrossable” CTO
• Inflate 1.20-1.5 mm balloon, Threader, Glider
• Rupture balloon in vessel (grenadoplasty)
• Tornus, Corsair, Finecross
• Wire “cutting”
• Guide catheter extensions
• Anchor balloon strategies
combinations
Importance of combinations
+
1st line
2nd line
Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013
Approach to “balloon uncrossable” CTO
“Balloon Uncrossable” CTO
• Inflate 1.20-1.5 mm balloon, Threader, Glider
• Rupture balloon in vessel (grenadoplasty)
• Tornus, Corsair, Finecross
• Wire “cutting”
• Guide catheter extensions
• Anchor balloon strategies
• Laser
• Rotational atherectomy
combinations
3rd line
0.9 mm laser
0.9 mm - peripheral
Energy: 30-80 mJ/mm2
frequency 25 – 80
No need to
change wire!
Even if laser does
not cross lesion is
modified
saline
50% contrast
100% contrast
Caveat: need to change guidewire –
may lose position…
Rotablator
1st line
2nd line
Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013
Approach to “balloon uncrossable” CTO
“Balloon Uncrossable” CTO
• Inflate 1.20-1.5 mm balloon, Threader, Glider
• Rupture balloon in vessel (grenadoplasty)
• Tornus, Corsair, Finecross
• Wire “cutting”
• Guide catheter extensions
• Anchor balloon strategies
• Laser
• Rotational atherectomy
• Subintimal: external “crush” - retrograde
• Subintimal: distal anchor
combinations
3rd line
4th line
Subintimal techniques
Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013
Subintimal wiring
2nd wire
“Subintimal” Distal Anchor
Subintimal
distal
anchor
Balloon crosses now!
Final result
Retrograde distal anchor!
Mahmood, Banerjee, Brilakis. J INVASIVE CARDIOL 2011;23:291–294
RCA CTO PCI had failed two months prior
Retrograde for balloon uncrossable CTO
RCA CTO
Easy crossing with Pilot 200 –
but Corsair will not cross!
Reverse CART
Final result
Retrograde for balloon uncrossable CTO
Patel S et al. J Invasive Cardiol 2015;27:78-84
6,7
93,3
1st line
2nd line
Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013
Approach to “balloon uncrossable” CTO
“Balloon Uncrossable” CTO
• Inflate 1.20-1.5 mm balloon, Threader, Glider
• Rupture balloon in vessel (grenadoplasty)
• Tornus, Corsair, Finecross
• Wire “cutting”
• Guide catheter extensions
• Anchor balloon strategies
• Laser
• Rotational atherectomy
• Subintimal: external “crush” - retrograde
• Subintimal: distal anchor
combinations
3rd line
4th line
Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013
Approach to “balloon undilatable” CTO
“Balloon Undilatable” CTO
1. High pressure balloon inflation
2. One (or more) buddy wires
3. Angiosculpt or cutting balloon
4. Laser
5. Atherectomy
6. Subintimal lesion crossing
PREVENTION :
Predilation
with 1:1 sized
balloon
Saturday 1630 – brilakis   balloon uncrossable

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Saturday 1630 – brilakis balloon uncrossable

  • 1. EuroCTO Club 2015 Saturday, September 19, 2015 Prevalence and treatment of balloon uncrossable or untreatable CTOs 4.30 -4.45 pm Emmanouil S. Brilakis, MD, PhD Director, Cardiac Catheterization Laboratories VA North Texas Health Care System Professor of Medicine, University of Texas Southwestern Medical School, Dallas, Texas
  • 2. Speaker honoraria/consulting fees: Abbott Vascular, Asahi, Boston Scientific, Elsevier, Somahlution, St Jude Medical, Terumo Research funding: InfraRedx, Boston Scientific Employment (spouse): Medtronic Grants: VA - CLIN-007-11F VA CSP#571 – DIVA Disclosures
  • 4. DO NOT TRY ANYTHING OF WHAT WILL BE PRESENTED UNTIL AFTER YOU HAVE CONFIRMED THAT YOUR WIRE IS INTO THE DISTAL TRUE LUMEN USING TWO ORTHOGONAL PROJECTIONS! DOING OTHERWISE MAY RESULT IN SEVERE INJURY OR DEATH… DISCLAIMER
  • 5. Dual injection Mid RCA occlusion PDA fills by collaterals from the LAD
  • 7. Antegrade crossing Finecross Pilot 200 Finecross and 1.5 mm balloon: No crossing
  • 8. Modify lesion Approach to “balloon uncrossable” CTO Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013 Improve support
  • 9. Approach to “balloon uncrossable” CTO  Long length (20 mm)  Rx balloon – more pushable  Different brands - can alternatively try larger balloons 1st line “Balloon Uncrossable” CTO • Inflate 1.20-1.5 mm balloon, Threader, Glider • Rupture balloon in vessel (grenadoplasty)
  • 10.
  • 11. Grenadoplasty aka “BAM” – “Balloon Assisted Microdissection” Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013
  • 12. 1st line 2nd line Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013 Approach to “balloon uncrossable” CTO “Balloon Uncrossable” CTO • Inflate 1.20-1.5 mm balloon, Threader, Glider • Rupture balloon in vessel (grenadoplasty) • Tornus, Corsair, Turnpike, Finecross • Wire “cutting” FINECROSS MG
  • 13. Tornus Counter- clockwise advancement • Support Catheter: • Constructed with eight (8) individual wires stranded together to form the catheter • Two sizes: • 2.1Fr - Diameter increases from 0.024” to 0.028” • 2.6Fr - Diameter increases from 0.028” to 0.035”
  • 14. Corsair: Support and Penetration 2 Thick Braids ③②① 8 Thin Braids     Counter or clockwise advancement Tsuchikane et al. J Am Coll Cardiol Intv. 2010;3(2):165-171
  • 15. Turnpike Multi-Layer Shaft Pebax outer layer for smooth outer surface Dual-layer, bidirectional coil for kink-resistance with torque Braid for longitudinal strength PTFE liner for excellent guidewire movement
  • 16. Corsair will not go… Corsair
  • 17. The “Wire‐Cutting” Technique Hu et al. Journal of Interventional Cardiology 2012;25:297-303
  • 18. 1st line 2nd line Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013 Approach to “balloon uncrossable” CTO “Balloon Uncrossable” CTO • Inflate 1.20-1.5 mm balloon, Threader, Glider • Rupture balloon in vessel (grenadoplasty) • Tornus, Corsair, Finecross • Wire “cutting” • Guide catheter extensions • Anchor balloon strategies
  • 19. Guide catheter support Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013 If you want peace, prepare for war!!
  • 23. Side branch anchor Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013
  • 24. 1st line 2nd line Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013 Approach to “balloon uncrossable” CTO “Balloon Uncrossable” CTO • Inflate 1.20-1.5 mm balloon, Threader, Glider • Rupture balloon in vessel (grenadoplasty) • Tornus, Corsair, Finecross • Wire “cutting” • Guide catheter extensions • Anchor balloon strategies combinations
  • 26. 1st line 2nd line Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013 Approach to “balloon uncrossable” CTO “Balloon Uncrossable” CTO • Inflate 1.20-1.5 mm balloon, Threader, Glider • Rupture balloon in vessel (grenadoplasty) • Tornus, Corsair, Finecross • Wire “cutting” • Guide catheter extensions • Anchor balloon strategies • Laser • Rotational atherectomy combinations 3rd line
  • 27. 0.9 mm laser 0.9 mm - peripheral Energy: 30-80 mJ/mm2 frequency 25 – 80 No need to change wire! Even if laser does not cross lesion is modified
  • 29. Caveat: need to change guidewire – may lose position… Rotablator
  • 30. 1st line 2nd line Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013 Approach to “balloon uncrossable” CTO “Balloon Uncrossable” CTO • Inflate 1.20-1.5 mm balloon, Threader, Glider • Rupture balloon in vessel (grenadoplasty) • Tornus, Corsair, Finecross • Wire “cutting” • Guide catheter extensions • Anchor balloon strategies • Laser • Rotational atherectomy • Subintimal: external “crush” - retrograde • Subintimal: distal anchor combinations 3rd line 4th line
  • 31. Subintimal techniques Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013
  • 36. Retrograde distal anchor! Mahmood, Banerjee, Brilakis. J INVASIVE CARDIOL 2011;23:291–294
  • 37. RCA CTO PCI had failed two months prior Retrograde for balloon uncrossable CTO RCA CTO
  • 38. Easy crossing with Pilot 200 – but Corsair will not cross!
  • 40. Final result Retrograde for balloon uncrossable CTO
  • 41. Patel S et al. J Invasive Cardiol 2015;27:78-84 6,7 93,3
  • 42. 1st line 2nd line Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013 Approach to “balloon uncrossable” CTO “Balloon Uncrossable” CTO • Inflate 1.20-1.5 mm balloon, Threader, Glider • Rupture balloon in vessel (grenadoplasty) • Tornus, Corsair, Finecross • Wire “cutting” • Guide catheter extensions • Anchor balloon strategies • Laser • Rotational atherectomy • Subintimal: external “crush” - retrograde • Subintimal: distal anchor combinations 3rd line 4th line
  • 43. Brilakis ES. Manual of coronary CTO interventions. Elsevier 2013 Approach to “balloon undilatable” CTO “Balloon Undilatable” CTO 1. High pressure balloon inflation 2. One (or more) buddy wires 3. Angiosculpt or cutting balloon 4. Laser 5. Atherectomy 6. Subintimal lesion crossing PREVENTION : Predilation with 1:1 sized balloon