This document discusses safety instrumented systems (SIS), which are designed to respond to hazardous conditions in industrial plants. An SIS monitors for conditions that could become hazardous and responds by taking actions to prevent or mitigate hazards. Examples provided include a furnace that shuts off fuel valves in response to high pressure and a reactor that opens a coolant valve when temperature rises too high. The document outlines standards for good engineering practices in designing, implementing, and maintaining SIS according to lifecycle phases from planning and design to operations and auditing. Key aspects covered are managing risks to people and procedures, assessing and mitigating risk through assigning safety integrity levels, and proving that SIS designs achieve the desired safety functionality.