This document discusses various routes of drug administration and factors affecting their selection. It describes both enteral and parenteral routes, including oral, sublingual, rectal, intravenous, intramuscular, subcutaneous, inhalation, intranasal, topical, and others. For each route, it outlines advantages and disadvantages related to onset of action, absorption, convenience, cost, and other considerations. The optimal route depends on the drug's properties, desired effects, and patient condition.
Definition and Classification of routes of drug administration. Along with an explanation of it. Advantages and Disadvantages of different routes of administration. Intravenous routes give faster onset of action than any other route. 100% bioavailability is possible in the case of IV. The choice of route depends upon the patient condition.
Know About Your Drug ,,, Part - II ( Route of Drug Administration) for study purpose pharmaceutical professional such as students and other specialized field. Presentation for "LEARN & EARN KNOWLEDGE" based.
Thanks all of you for your support...Part-I success and your comments.
Routes of drug administration - I for mbbsmani goel
No single method of drug administration is ideal for all drugs in all circumstances .A knowledge of advantages and disadvantages of different routes of administration is essential.
This ppt is for pharmacology students of MBBS UG&PG and other healthcare persons who needs basic science like BDS, Nursing Ayurveda unani homeopathy etc.
Definition and Classification of routes of drug administration. Along with an explanation of it. Advantages and Disadvantages of different routes of administration. Intravenous routes give faster onset of action than any other route. 100% bioavailability is possible in the case of IV. The choice of route depends upon the patient condition.
Know About Your Drug ,,, Part - II ( Route of Drug Administration) for study purpose pharmaceutical professional such as students and other specialized field. Presentation for "LEARN & EARN KNOWLEDGE" based.
Thanks all of you for your support...Part-I success and your comments.
Routes of drug administration - I for mbbsmani goel
No single method of drug administration is ideal for all drugs in all circumstances .A knowledge of advantages and disadvantages of different routes of administration is essential.
This ppt is for pharmacology students of MBBS UG&PG and other healthcare persons who needs basic science like BDS, Nursing Ayurveda unani homeopathy etc.
Drugs may be administered by various routes. The choice of the route in a given patient depends on the tissue or organ to be treated, the characteristics of the drug and urgency of the situation, etc. Knowledge of the advantages and disadvantages of the different routes of administration is essential. The routes can be broadly divided into Enteral, Parenteral, and Local.
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Routes of drug administration:
A route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body.[1] Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration. Routes can also be classified based on where the target of action is. Action may be topical (local), enteral (system-wide effect, but delivered through the gastrointestinal tract), or parenteral (systemic action, but delivered by routes other than the GI tract)
This is the second part of my presentation. It is all about the review on Routes and rights of drug administration. The slide also covers IP & Drug Laws too.
Pharmacology Routes of drug administration seminarDr. Ritu Gupta
This seminar is helpful for the postgraduate students includes recent advancements in the routes of drug administration with illustrations, oral, sublingual, also, fastest route amongst all the techniques
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
3. Factors Affecting Choice Of Route
• Physical & chemical properties of drug
• Site of desired action-
a. Local, b. Generalized
• Rate & extent of absorption from various routes
• Effect of digestive juices & first pass metabolism
• Rapidity of the desired response- emergency/routine
• Condition of the patient
• Accuracy of dosage
5. ORAL ROUTE
The most common and oldest route
Liquid or solid preparations are given
Drug is given through oral cavity.
ADVANTAGES
Safe
More Convenient- self-administered
Painless
Economical- compared to other parenteral routes
Usually good absorption
No need for sterilization
6. DISADVANTAGES
1. Slow action of drug - can not used in emergency
2. Irritable and unpalatable drugs- Difficult to administer
3. Cannot be used uncooperative, unconscious and vomiting patients
4. Causes- Nausea and vomiting
5. Some drugs destroyed- Digestive juice (Eg- Insulin, streptomycin)
6. First-pass effect (Liver)- Due to Biotransformation (Eg-
Testosterone, Lidocaine)
7. Food–Drug interactions and Drug-Drug interactions
8. SUBLINGUAL / BUCCAL ROUTE
Advantages
•Drug absorption is quick
•Rapid onset of action
•Quick termination
•First-pass avoided
•Can be self administered
•Overdose can be avoided
Disadvantages
•Unpalatable & bitter drugs
•Irritation of oral mucosa
•Large quantities not given
Tab or pellet containing the drug - under tongue
Crushed in mouth and
Absorbed by- Buccal mucous membrane
Ex- GTN, Isoprenaline
9. Advantages
Irritant or unpleasant drug can be given
Little or no first pass effect
Used in vomiting or unconscious
patients
Higher concentrations rapidly achieved
Disadvantages
Inconvenient
Absorption is slower, irregular,
unpredictable
Rectal inflammation can occur
RECTAL ROUTE
Administration of liquid or semisolid medicament- Suppositories or
Enema
10. Evacuant Enema Retention Enema
Used to remove fecal matter
Max.qty.- 600 ml
Used before
a. surgical operation
b. Delivery
c. GIT investigation by X ray
• Eg- Soap water enema
Used to retain drugs in rectum
Max.qty.- 120 ml
Used for producing anasthesia
Eg- Paraldehyde enema
Predinisolone enema
11. PARENTERAL ROUTES
Par= beyond, enteral= intestinal
Routes of drug administration other than oral/ alimentary tract
Administering drug directly into blood or tissue fluid
Ampoule iv infusion Vial
13. ADVANTAGES
1. Rapid onset of action
2. Useful in unconscious, unco-operative patients
3. Useful in patient suffering from vomiting, nausea
4. 100% drug absorption
5. No destruction or degradation of drug- Gastric juice
6. No gastric irritation
7. Accurate dosage of drug
8. No first pass metabolism (Liver is bypassed)
14. DISADVANTAGES
1. Costly route
2. Technique is invasive and painful
3. Inconvenient- assistance of other person is needed
4. Self medication is not possible
5. Skilled person- necessary- to avoid injury to nerves, blood vessels
6. Difficult to control or reverse effect of drug- RISKY
15. Introduced directly into Lumen of Vein
Drug is injected IV
1. As Bolus- Eg- Furosemide
2. Over 5-10 min- diluted in 10-20 ml of isotonic glucose or saline
3. In an infusion- Eg- NS, DNS
ADVANTAGES
1. Very rapid onset of action- Most effective in Emergency condition
2. Large qty of drug can be administered- Eg- Fluids in dehydration
3. Irritant and hypertonic solutions can be given
4. Required drug concentration in blood- obtained accurately
5. 100 % bioavailability
INTRAVENOUS ROUTE
16. DISADVANTAGES
1. Care should be taken- Inserting needle into vein
2. Drug should not leak out- site of administration
3. Speed of drug entering into vein- Must be controlled and
maintained
4. Chances of causing air embolism is risky
5. Local irritation – Phlebitis
6. Once drug administered- no retreat
7. Side effects are more quicker than any other route
17. ADVANTAGES
Uniform and slow absorption
of drug
Rapid onset of action
Mild irritants can be given
First pass avoided
Gastric factors can be avoided
DISADVANTAGES
Only up to 10ml drug given
Local pain and abscess
Expensive
Nerve damage
INTRAMUSULAR ROUTE
Large skeletal muscle- Deltoid, triceps, laterofemoral, gluteus maximus
Suitable for administration- soluble substances, Mild irritants,
suspensions and colloids
Eg- Sex hormones, Corticosteroids, Penicillin G
18. Drug injected- loose connective tissue- Subcutaneous tissue under
skin
Only soluble, non-irritant drugs are injected
Small vol.of drug injected- up to 2 ml
Slow absorption of drug as compared to I.V. and I.M. route
Self injection is possible
Eg -Insulin, Testosterone, Morphine
SUBCUTANEOUS ROUTE
20. Subcutaneous injections
Drug can be administered subcutaneously as ;
1. Dermojet- Needleless method, drug is injected
by means of high velocity jet produced through
micro fine orifice
2. Pellet implantation- a tablet or porous capsule
is inserted into the loose tissues by incision of
the skin, which is then stiched up.
21. Type of
Injection
Needle Dia. Needle length Needle Angle
Subcutaneous 25 to 30 guaze 3/8 to 5/8 inch 45 to 90
I.M. 18 to 25 guaze 5/8 to 1 ½ inch 90
0
0
0
22. Intradermal Route
Injected into skin raising bleb
Only small qty is injected (1ml)
Used for detecting allergy to drugs
Eg- Penicillin
Vaccines are also administered
Eg- BCG Vaccine, Small pox vaccine,
Local anaesthetic
Intrathecal
Injected into subarachnoid space
Useful for local and rapid effect- Spinal anaesthetics, antibiotics
Eg- Amphotericin B is used in treating Cryptococcal meningitis
23.
24. Rapid delivery of a drug across the large surface area of alveoli
Producing an effect almost as rapidly as with IV injection.
Used for drugs- Volatile liquids and gases
Effective and convenient - patients with respiratory problems
No first pass effect
Eg- Salbutamol,Albuterol
DISADVANTAGE-
Require special apparatus
Irritation of respiratory tract may takes place
INHALATION
26. INTRANASAL
Drug administered directly into the nose.
Digestive juice and liver is bypassed
Eg-
1. Nasal decongestants- anti-inflammatory corticosteroid.
2. Desmopressin - diabetes insipidus
3. Salmon calcitonin - osteoporosis
27. Route for administration
-Time until effect-
Route Time
Intravenous 30-60 seconds
Inhalation 2-3 minutes
Sublingual 3-5 minutes
Intramuscular 10-20 minutes
Subcutaneous 15-30 minutes
Rectal 5-30 minutes
Ingestion 30-90 min
Transdermal (topical) Variable (minutes to hours)
28. External application of drug
Dusting powders, lotions, paste, ointments, drops, spray
Site of drug action-
Skin, Eye, Ear, Nose, Rectum, Vagina, Throat
Simplest route
Useful - Prolonged effect of drug is required
Drug absorption- depends on lipid solubility of drug
Watery solution of drug- absorbed in blood- undesirable
toxic effect
Topical Route
29. No single method of drug
administration is ideal for all
drugs in all circumstances