The document discusses various routes of drug administration including oral, parenteral, and topical routes. The oral route is the most commonly used as it is convenient, allows self-administration, and is inexpensive. However, it has disadvantages like first-pass metabolism and variable absorption. Parenteral routes like intravenous, intramuscular, and subcutaneous allow direct entry of drugs into systemic circulation but require more technical skill. Topical routes provide local drug effects without systemic absorption. The choice of route depends on the drug properties and patient condition.
This ppt is for pharmacology students of MBBS UG&PG and other healthcare persons who needs basic science like BDS, Nursing Ayurveda unani homeopathy etc.
Dosage forms and routes of drug administrationFatenAlsadek
this presentation give an over review about Routes of drug administrations and dosage forms
Done by: Faten Al-Sadek , Pharmacy student at Mohammed Al-Mana college for Health Sciences -MACHS
It will provide you a complete journey through the routes of drug administration, with all the basics covered I hope this presentation will make your fundamentals crystal clear.
This ppt is for pharmacology students of MBBS UG&PG and other healthcare persons who needs basic science like BDS, Nursing Ayurveda unani homeopathy etc.
Dosage forms and routes of drug administrationFatenAlsadek
this presentation give an over review about Routes of drug administrations and dosage forms
Done by: Faten Al-Sadek , Pharmacy student at Mohammed Al-Mana college for Health Sciences -MACHS
It will provide you a complete journey through the routes of drug administration, with all the basics covered I hope this presentation will make your fundamentals crystal clear.
short and simple study on the topic of laxative and purgatives which is very usefull for the student , teachers, as well as health cares peoples. this study is done by the student with the help of teachers
For More Medicine Free PPT - http://playnever.blogspot.com/
For Health benefits and medicine videos Subscribe youtube channel - https://www.youtube.com/playlist?list=PLKg-H-sMh9G01zEg4YpndngXODW2bq92w
This is the second part of my presentation. It is all about the review on Routes and rights of drug administration. The slide also covers IP & Drug Laws too.
short and simple study on the topic of laxative and purgatives which is very usefull for the student , teachers, as well as health cares peoples. this study is done by the student with the help of teachers
For More Medicine Free PPT - http://playnever.blogspot.com/
For Health benefits and medicine videos Subscribe youtube channel - https://www.youtube.com/playlist?list=PLKg-H-sMh9G01zEg4YpndngXODW2bq92w
This is the second part of my presentation. It is all about the review on Routes and rights of drug administration. The slide also covers IP & Drug Laws too.
A route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied.
Route of drug administration is an important topic in the medical field. doctors, nurses, and other staff members are trained on the various routes of drug administration/ medication. there are routes that do not require any assistance and some that require trained medical personnel.
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4. 1. ORAL ROUTE
Oral refers to two methods of
administration:
Applying topically to the mouth
Swallowing for absorption
along the gastrointestinal (GI)
tract into systemic circulation
po (from the Latin per os) is
the abbreviation used to
indicate oral route of
medication administration
5. Advantages :
Most commonly preferred and used route of drug
administration.
Convenient - can be self- administered, pain free, easy
to take.
It does not require any special skills.
Absorption - takes place along the whole length of the
GI tract .
Cheap - compared to most other parenteral or topical
routes.
6. Disadvantages :
It can not be used in case of unconscious and in-
cooperative patients.
Sometimes inefficient - only part of the drug may be
absorbed.
First-pass effect - drugs absorbed orally are initially
transported to the liver via the portal vein .
irritation to gastric mucosa - nausea and vomiting.
Certain drugs like insulin undergo degradation in GI tract
to avoid this degradation by digestive juices it cannot be
given by oral route.
Onset of action of drugs takes 3 – 4hrs so cannot be used
in medical emergency.
unpleasant taste of some drugs.
7. Common dose forms for oral administration
tablets
capsules
liquids
solutions
suspensions
syrups
elixirs
8. 2. Buccal/sublingual route
Drugs are taken as smaller tablets which are held in
the mouth(buccal) or under the tongue (sublingual)
sublingual buccal
9.
10. Advantages
Havinng drug stability.Economical.
Quick termination.
FIRST-PASS effect is avoided .
drug absorption is quick.
Disadvantages
it is inconvenient to patient.
Unpalatable & bitter taste of drugs may result in poor
patient compliances.
Irritation of oral mucosa.
Large quantities not given, may lead to toxicity.
Few drugs are absorbed.
11. 3. Rectal route
* This route of administration is useful.
* In case of unconscious patients and
children.
* If patient is nauseous or vomiting to
oral route then this route is having more
advantages.
* There is easy to terminate exposure at
any time and whenever necessary.
* This route is good for drugs which
affects the bowels such as laxatives, while
the drugs which are irritating are
contraindicated by this route.
12. PARENTRAL ROUTES
Parenteral administration is the route where a drug
in the form of solution or suspension is injected
in the body with help of hollow needle and a
syringe/injection or in in some cases in the
vapour or fine droplets drugs are inhealed in the
respiratory tract(inhalation).
The term parenteral comes from Greek words:
Para - meaning outside
Enteron - meaning the intestine
This route of administration bypasses the
alimentary canal.
15. INTRAVENOUS
Drug is directly injected into
the veins.
ADVANTAGES
BIOAVAILABILITY 100%(rapid action).
Desired blood concentrations achieved.
Large quantities can be administered (saline solution).
Irritating and hypertonic solutions can be
administered.
Vomiting & diarrhea.
Emergency situations.
Gastric manupalation avoided
16. DISADVANTAGES
It may cause Irritation.
Speed of the drug entering into the vein should be
controlled.
Repeated injections not always feasible.
Less safe .
technical assistance required.
Danger of infection.
Expensive.
Less convenient and painful.
17. INTRAMUSULAR ROUTE
The drug is injected into the muscle
tissues.
Advantages :
Absorption reasonably uniform.
rapid onset of action .
mild irritants can be given .
suspensions and colloids can be given.
Gastric factors can be avoided
Disadvantages
• only upto 10ml drug given
local pain and abcess
expensive
infection
There may be possibility of nerve
damage
Slow absorption of some drugs.
18. SUBCUTANEOUS
Injected under the skin.
Absorption is slow, so action is prolonged.
Only the non irritant drugs can be administered.
IMPLANT :a tablet or porous capsule is inserted into
the loose tissues by incision of the skin, which is then
stiched up. example : certain hormonal drugs
19. INTRA-ARTICULAR
administered directly into the joints.
injections of antibiotics and corticosteroids are
administered in inflammed joined cavities by
experts.
example: hydrocortisone in rheumatoid arthritis
20. INTRA-ARTERIAL
Drug is administered directly into the artery.
Rarely used
Anticancer drugs are given for localized effects
Drugs used for diagnosis of peripheral vascular
diseases
21. INTRADERMAL
drug is injected to the skin layers (dermis)
Small quantity should be given.
Painful
Mainly used for testing sensitivity to drugs.
e.g. penicillin,
ATS (anti tetanus serum)
INOCULATION :administration of vaccine (like
small pox vaccine )
22. INHALATIONS
Drugs are administered either as aerosole systems , or
in the form of vapours.
Certain drugs are sprayed in the form of droplets to
give local effect .
Ex : adrenalin spray administered in bronchial
asthma.
.
23. Advantages :
Absorption of drug is rapid and easy resulting in
rapid local and systemic effect of drug.
Easy to administration
Disadvantages :
Drugs directly enter into the left side of the heart ,
there is a danger of cardiac toxicity.
Certain drugs producing local irritation may increase
respiratory tract secretion.
24. Topical Routes of Administration
Topical administration is the application of a drug
directly to the surface of the skin
Includes administration of drugs to any mucous
membrane
eye
nose
vagina
ears
urethra
colon
lungs
25. Advantages and Disadvantages of the Topical Route
Local therapeutic effects
Not well absorbed into the deeper layers of the skin
or mucous membrane
lower risk of side effects
Transdermal route offers steady level of drug in the
system
sprays for inhalation through the nose may be for
local or systemic effects
26. Topical Dosage Forms Dose forms for topical
administration include:
Skin: creams
ointments
lotions
gels
transdermal patches
disks
Eye or ear: – solutions – suspensions – ointments
Nose and lungs: – sprays and powders
27. Transdermal absorption of drug through skin
(systemic action)
i. stable blood levels
ii. no first pass metabolism
iii. drug must be potent or patch becomes too large
29. SELECTION OF ROUTE The ROA is determined by :
The physical characteristics of the drug.
The speed which the drug is absorbed and/ or
released .
the need to bypass hepatic metabolism.
To achieve high conc. At particular sites.
Accuracy of dosage.
Condition of the patient.