SlideShare a Scribd company logo
RO TA RUS V CCI E
     VI    A N
T E T SAVE YOUR K
 IM O            IDS




  DR.SMRUTIRANJAN PATANAIK
RO TA RUS
                  VI
 A VIRUS OF THE FAMILY
  REOVIRIDAE
 WHEEL SHAPED APPEARANCE –
  ROTA
 MAJOR CAUSE OF DIARRHEA AND
  GASTROENTERITIS UNDER THE
  AGE OF FIVE
 MORTALITY 6 LAKHS ACROSS THE
  GLOBE (29 TO 45 % OF ALL
  DIARRHEAL DEATHS)
 OVER 2 MILLION HOSPITALIZED
  EACH YEAR
STRUCTURE




CLASSIFICATION
BASIS :- IMMUNOLOGICAL REACTIVITIES OF VARIOUS
         COMPONENTS OF PARTICLES & FROM
 GENOMIC COMPOSITION INTO GROUPS A-G:-
GROUP A HAVING SEROTYPES & GENOTYPES
REPLI TI N
               CA O
SITE- CYTOPLASM OF ENTEROCYTES
        REMOVAL OF OUTER CAPSID

            mRNA SYNTHESIS

          mRNA (CYTOPLASM)
                    TRANSLATION

            VIRAL PROTEINS

              VIROPLASM
                    REPLICATION

                ds RNA

    DOUBLE SHELLED PARTICLES FORMED

            VIRUS RELEASED
ROUTE OF TRANSMISSION-FAECO ORAL
 ROUTE (1012 VIRIONS PER GM. OF EXCRETA
 IN ACUTE INFECTION)
INFECTIVE DOSE-LOW (100-1000 VIRAL
 PARTICLES)
INCUBATION PERIOD-2 TO 3 DAYS
IMMUNITY:-
        IgA ANTIBODIES
        CTL
NEED FO R AV CCI E
                       A N

 NATURALLY ACQUIRED IMMUNITY AFTER THE DISEASE.
 TRANSMISSION RATES UNAFFECTED BY IMPROVING
  SANITATION.
 UNAVAILABILITY OF LIFE SAVING I.V. TREATMENT TO
  ALL PATIENTS.
 COST EFFECTIVE METHODS.


 HISTORYOF VACCINE DEVELOPMENT
• 1993-94—LIVE ATTENUATED ROTAVIRUS VACCINE
           FROM RHESUS MONKEY.
• 1996-COCKTAIL VACCINE (RRV-TV).
• 1998-ROTASHIELD
PRESEN V CCI ES A ALA LE
      T A N      VI B
CHALLEN GES FO R V CCI E
                         A N
  I TRO DUCTI N& FUTURE PRO SPECTS
   N         O


UNCERTAIN DEMAND, INSUFFICIENT SUPPLY
 AND HIGH PRICES OF THE VACCINE.
LACK OF INFORMATION ON BURDEN OF
 DISEASE IN SOME COUNTRIES.
NEW EMERGING MUTANT & RECOMBINANT
 STRAINS OF VIRUS.
I AN
          N UTSHELL
THE 2 VACCINES ROTATEQ AND ROTARIX
LAUNCHED IN THE YEAR 2006 HELP IN
PREVENTION OF ROTAVIRUS INFECTION AT THE
ENTEROCYTE LEVEL HAVING A PROMISING
EFFICACY OF AROUND 95 TO 100%.
Rotavirus

More Related Content

What's hot

9 rotavirus vaccines considerations
9 rotavirus vaccines considerations9 rotavirus vaccines considerations
9 rotavirus vaccines considerations
Ruth Vargas Gonzales
 
Arenaviruses
ArenavirusesArenaviruses
Arenaviruses
Prenesh
 
Rotavirus kellermann 20121129
Rotavirus kellermann 20121129Rotavirus kellermann 20121129
Rotavirus kellermann 20121129
Sirid Kellermann, PhD, MBA
 
Kanchan Parsad and Sinead Mc Coy
Kanchan Parsad and Sinead Mc CoyKanchan Parsad and Sinead Mc Coy
Kanchan Parsad and Sinead Mc Coy
Kanchan Parsad
 
Rift valley fever
Rift valley feverRift valley fever
Rift valley fever
Tariq Mustafa Mohamed Ali
 
Rotavirus vaccine presentation Rotateq 28 june 2013
Rotavirus vaccine presentation Rotateq   28 june 2013Rotavirus vaccine presentation Rotateq   28 june 2013
Rotavirus vaccine presentation Rotateq 28 june 2013
Gaurav Gupta
 
Candidate Vaccines to Manage Rift Valley Fever
Candidate Vaccines to Manage Rift Valley FeverCandidate Vaccines to Manage Rift Valley Fever
Candidate Vaccines to Manage Rift Valley Fever
FAZDCenter
 
Ebola virus ppt
Ebola virus pptEbola virus ppt
Ebola virus ppt
Deepak Sarangi
 
Astrovirus.pptx
Astrovirus.pptxAstrovirus.pptx
Astrovirus.pptx
kelvinrogie
 
Malaria vaccine
Malaria vaccineMalaria vaccine
Malaria vaccine
Kavya Liyanage
 
Parvo virus
Parvo virusParvo virus
Rotavirus - Simplified Virology, Statistics, Symptoms, Vaccination & Common FAQs
Rotavirus - Simplified Virology, Statistics, Symptoms, Vaccination & Common FAQsRotavirus - Simplified Virology, Statistics, Symptoms, Vaccination & Common FAQs
Rotavirus - Simplified Virology, Statistics, Symptoms, Vaccination & Common FAQs
Gaurav Gupta
 
Prevention of rotavirus in india is vaccination the only strategy.
Prevention of rotavirus in india  is vaccination the only strategy.Prevention of rotavirus in india  is vaccination the only strategy.
Prevention of rotavirus in india is vaccination the only strategy.
Dr. Dharmendra Gahwai
 
Rift valley fever
Rift valley feverRift valley fever
Rift valley fever
Coreena Luna
 
Poxviruses
PoxvirusesPoxviruses
Poxviruses
Latha jithin
 
Genomic surveillance of the Rift Valley fever: From sequencing to Lineage ass...
Genomic surveillance of the Rift Valley fever: From sequencing to Lineage ass...Genomic surveillance of the Rift Valley fever: From sequencing to Lineage ass...
Genomic surveillance of the Rift Valley fever: From sequencing to Lineage ass...
ILRI
 
Rhabdoviridae ppt
Rhabdoviridae pptRhabdoviridae ppt
Rhabdoviridae ppt
Faria Khan
 
Rotavirus vaccine update
Rotavirus vaccine updateRotavirus vaccine update
Rotavirus vaccine update
drskverma2
 
Arbo Virus by Dr. Rakesh Prasad Sah
Arbo Virus  by Dr. Rakesh Prasad SahArbo Virus  by Dr. Rakesh Prasad Sah
Arbo Virus by Dr. Rakesh Prasad Sah
Dr. Rakesh Prasad Sah
 

What's hot (19)

9 rotavirus vaccines considerations
9 rotavirus vaccines considerations9 rotavirus vaccines considerations
9 rotavirus vaccines considerations
 
Arenaviruses
ArenavirusesArenaviruses
Arenaviruses
 
Rotavirus kellermann 20121129
Rotavirus kellermann 20121129Rotavirus kellermann 20121129
Rotavirus kellermann 20121129
 
Kanchan Parsad and Sinead Mc Coy
Kanchan Parsad and Sinead Mc CoyKanchan Parsad and Sinead Mc Coy
Kanchan Parsad and Sinead Mc Coy
 
Rift valley fever
Rift valley feverRift valley fever
Rift valley fever
 
Rotavirus vaccine presentation Rotateq 28 june 2013
Rotavirus vaccine presentation Rotateq   28 june 2013Rotavirus vaccine presentation Rotateq   28 june 2013
Rotavirus vaccine presentation Rotateq 28 june 2013
 
Candidate Vaccines to Manage Rift Valley Fever
Candidate Vaccines to Manage Rift Valley FeverCandidate Vaccines to Manage Rift Valley Fever
Candidate Vaccines to Manage Rift Valley Fever
 
Ebola virus ppt
Ebola virus pptEbola virus ppt
Ebola virus ppt
 
Astrovirus.pptx
Astrovirus.pptxAstrovirus.pptx
Astrovirus.pptx
 
Malaria vaccine
Malaria vaccineMalaria vaccine
Malaria vaccine
 
Parvo virus
Parvo virusParvo virus
Parvo virus
 
Rotavirus - Simplified Virology, Statistics, Symptoms, Vaccination & Common FAQs
Rotavirus - Simplified Virology, Statistics, Symptoms, Vaccination & Common FAQsRotavirus - Simplified Virology, Statistics, Symptoms, Vaccination & Common FAQs
Rotavirus - Simplified Virology, Statistics, Symptoms, Vaccination & Common FAQs
 
Prevention of rotavirus in india is vaccination the only strategy.
Prevention of rotavirus in india  is vaccination the only strategy.Prevention of rotavirus in india  is vaccination the only strategy.
Prevention of rotavirus in india is vaccination the only strategy.
 
Rift valley fever
Rift valley feverRift valley fever
Rift valley fever
 
Poxviruses
PoxvirusesPoxviruses
Poxviruses
 
Genomic surveillance of the Rift Valley fever: From sequencing to Lineage ass...
Genomic surveillance of the Rift Valley fever: From sequencing to Lineage ass...Genomic surveillance of the Rift Valley fever: From sequencing to Lineage ass...
Genomic surveillance of the Rift Valley fever: From sequencing to Lineage ass...
 
Rhabdoviridae ppt
Rhabdoviridae pptRhabdoviridae ppt
Rhabdoviridae ppt
 
Rotavirus vaccine update
Rotavirus vaccine updateRotavirus vaccine update
Rotavirus vaccine update
 
Arbo Virus by Dr. Rakesh Prasad Sah
Arbo Virus  by Dr. Rakesh Prasad SahArbo Virus  by Dr. Rakesh Prasad Sah
Arbo Virus by Dr. Rakesh Prasad Sah
 

Viewers also liked

Vacunas rotavirus
Vacunas rotavirusVacunas rotavirus
Vacunas rotavirus
Herbert Aruquipa
 
Vacunas: preguntas frecuentes
Vacunas: preguntas frecuentesVacunas: preguntas frecuentes
Vacunas: preguntas frecuentes
el gipi
 
Vacuna
VacunaVacuna
Vacuna para hepatitis B
Vacuna para hepatitis BVacuna para hepatitis B
Vacuna para hepatitis B
WebmasterSadi
 
Vacuna Pentavalente Acelular + Vacuna DPT
Vacuna Pentavalente Acelular + Vacuna DPTVacuna Pentavalente Acelular + Vacuna DPT
Vacuna Pentavalente Acelular + Vacuna DPT
Alonso Pérez Peralta
 
Vacuna BCG
Vacuna BCGVacuna BCG
Vacuna BCG
MIRSHA R.L.
 
Lineamientos hepatitis b
Lineamientos hepatitis bLineamientos hepatitis b
Lineamientos hepatitis b
oliverioquijivix
 

Viewers also liked (7)

Vacunas rotavirus
Vacunas rotavirusVacunas rotavirus
Vacunas rotavirus
 
Vacunas: preguntas frecuentes
Vacunas: preguntas frecuentesVacunas: preguntas frecuentes
Vacunas: preguntas frecuentes
 
Vacuna
VacunaVacuna
Vacuna
 
Vacuna para hepatitis B
Vacuna para hepatitis BVacuna para hepatitis B
Vacuna para hepatitis B
 
Vacuna Pentavalente Acelular + Vacuna DPT
Vacuna Pentavalente Acelular + Vacuna DPTVacuna Pentavalente Acelular + Vacuna DPT
Vacuna Pentavalente Acelular + Vacuna DPT
 
Vacuna BCG
Vacuna BCGVacuna BCG
Vacuna BCG
 
Lineamientos hepatitis b
Lineamientos hepatitis bLineamientos hepatitis b
Lineamientos hepatitis b
 

Similar to Rotavirus

chickenpox
chickenpoxchickenpox
chickenpox
SudhaSanjibanee1
 
Infective endocardiitis
Infective endocardiitis  Infective endocardiitis
Infective endocardiitis
India CTVS
 
ANTIBIOTICS IN COLORECTAL SURGERY
ANTIBIOTICS IN COLORECTAL SURGERYANTIBIOTICS IN COLORECTAL SURGERY
ANTIBIOTICS IN COLORECTAL SURGERY
sanoopzac
 
Topic presentation on emerging communicable diseases
Topic presentation on emerging communicable diseasesTopic presentation on emerging communicable diseases
Topic presentation on emerging communicable diseases
vishnu vm
 
Weapons of mass destruction
Weapons of mass destructionWeapons of mass destruction
Weapons of mass destruction
Alissha Kumari
 
BIOTERRORISM.pptx
BIOTERRORISM.pptxBIOTERRORISM.pptx
BIOTERRORISM.pptx
VisheshMishra20
 
BIOTERRORISM.pptx
BIOTERRORISM.pptxBIOTERRORISM.pptx
BIOTERRORISM.pptx
VisheshMishra20
 
Au , malaria
Au , malariaAu , malaria
Au , malaria
nuwama
 
Hiv part 1
Hiv part 1Hiv part 1
Hiv part 1
Aureus Desouza
 
AIDS.ppt
AIDS.pptAIDS.ppt
AIDS.ppt
BijayaSaha5
 
Unraveling Virus Complexes in Plants/ CIAT APR 2015
Unraveling Virus Complexes in Plants/ CIAT APR 2015Unraveling Virus Complexes in Plants/ CIAT APR 2015
Unraveling Virus Complexes in Plants/ CIAT APR 2015
CIAT
 
Meningitis in Children.
Meningitis in Children.Meningitis in Children.
Meningitis in Children.
SabaNoor97
 
Future Of Healthcare Dr Dev Taneja
Future Of Healthcare Dr Dev TanejaFuture Of Healthcare Dr Dev Taneja
Future Of Healthcare Dr Dev Taneja
DrDevTaneja
 
kawasaki syndrome
kawasaki syndromekawasaki syndrome
kawasaki syndrome
Mahtab Alam
 
fever.ppt
fever.pptfever.ppt
fever.ppt
benny Jackson
 
Mycovirus - A Natural Fungicide
Mycovirus - A Natural FungicideMycovirus - A Natural Fungicide
Mycovirus - A Natural Fungicide
ABHISEK RATH
 
Rabies virus
Rabies virus Rabies virus
Rabies virus
Ansar ahmad Paray
 
Rabies virus by ansar ah paray
Rabies virus by ansar ah parayRabies virus by ansar ah paray
Rabies virus by ansar ah paray
Ansar ahmad Paray
 
Hiv in orthopaedics
Hiv in orthopaedicsHiv in orthopaedics
Hiv in orthopaedics
Maulik Patel
 
Foot and Mouth Disease : Dr Ananya
Foot and Mouth Disease : Dr AnanyaFoot and Mouth Disease : Dr Ananya
Foot and Mouth Disease : Dr Ananya
NarayananSajeev
 

Similar to Rotavirus (20)

chickenpox
chickenpoxchickenpox
chickenpox
 
Infective endocardiitis
Infective endocardiitis  Infective endocardiitis
Infective endocardiitis
 
ANTIBIOTICS IN COLORECTAL SURGERY
ANTIBIOTICS IN COLORECTAL SURGERYANTIBIOTICS IN COLORECTAL SURGERY
ANTIBIOTICS IN COLORECTAL SURGERY
 
Topic presentation on emerging communicable diseases
Topic presentation on emerging communicable diseasesTopic presentation on emerging communicable diseases
Topic presentation on emerging communicable diseases
 
Weapons of mass destruction
Weapons of mass destructionWeapons of mass destruction
Weapons of mass destruction
 
BIOTERRORISM.pptx
BIOTERRORISM.pptxBIOTERRORISM.pptx
BIOTERRORISM.pptx
 
BIOTERRORISM.pptx
BIOTERRORISM.pptxBIOTERRORISM.pptx
BIOTERRORISM.pptx
 
Au , malaria
Au , malariaAu , malaria
Au , malaria
 
Hiv part 1
Hiv part 1Hiv part 1
Hiv part 1
 
AIDS.ppt
AIDS.pptAIDS.ppt
AIDS.ppt
 
Unraveling Virus Complexes in Plants/ CIAT APR 2015
Unraveling Virus Complexes in Plants/ CIAT APR 2015Unraveling Virus Complexes in Plants/ CIAT APR 2015
Unraveling Virus Complexes in Plants/ CIAT APR 2015
 
Meningitis in Children.
Meningitis in Children.Meningitis in Children.
Meningitis in Children.
 
Future Of Healthcare Dr Dev Taneja
Future Of Healthcare Dr Dev TanejaFuture Of Healthcare Dr Dev Taneja
Future Of Healthcare Dr Dev Taneja
 
kawasaki syndrome
kawasaki syndromekawasaki syndrome
kawasaki syndrome
 
fever.ppt
fever.pptfever.ppt
fever.ppt
 
Mycovirus - A Natural Fungicide
Mycovirus - A Natural FungicideMycovirus - A Natural Fungicide
Mycovirus - A Natural Fungicide
 
Rabies virus
Rabies virus Rabies virus
Rabies virus
 
Rabies virus by ansar ah paray
Rabies virus by ansar ah parayRabies virus by ansar ah paray
Rabies virus by ansar ah paray
 
Hiv in orthopaedics
Hiv in orthopaedicsHiv in orthopaedics
Hiv in orthopaedics
 
Foot and Mouth Disease : Dr Ananya
Foot and Mouth Disease : Dr AnanyaFoot and Mouth Disease : Dr Ananya
Foot and Mouth Disease : Dr Ananya
 

More from Smruti Patanaik

VVF DR SR PATANAIK
VVF DR SR PATANAIKVVF DR SR PATANAIK
VVF DR SR PATANAIK
Smruti Patanaik
 
Eplusclinic story
Eplusclinic storyEplusclinic story
Eplusclinic story
Smruti Patanaik
 
Sweety and her story
Sweety and her storySweety and her story
Sweety and her story
Smruti Patanaik
 
eplusclinic
eplusclinic eplusclinic
eplusclinic
Smruti Patanaik
 
Management of snake bite victims
Management of snake bite victimsManagement of snake bite victims
Management of snake bite victims
Smruti Patanaik
 
Leptin and obesity cycle
Leptin and obesity cycleLeptin and obesity cycle
Leptin and obesity cycle
Smruti Patanaik
 
Insomnia show
Insomnia showInsomnia show
Insomnia show
Smruti Patanaik
 
A S T H M A I N I N D I A N C H I L D R E N
A S T H M A  I N  I N D I A N  C H I L D R E NA S T H M A  I N  I N D I A N  C H I L D R E N
A S T H M A I N I N D I A N C H I L D R E N
Smruti Patanaik
 
24 Hour Anonymous Medical Information Service
24 Hour Anonymous Medical Information Service24 Hour Anonymous Medical Information Service
24 Hour Anonymous Medical Information Service
Smruti Patanaik
 
A C C I D E N T R E S C U E T R A I N I N G M O D U L E F O R A M B U L ...
A C C I D E N T  R E S C U E  T R A I N I N G  M O D U L E  F O R  A M B U L ...A C C I D E N T  R E S C U E  T R A I N I N G  M O D U L E  F O R  A M B U L ...
A C C I D E N T R E S C U E T R A I N I N G M O D U L E F O R A M B U L ...
Smruti Patanaik
 
A European Patient Summary Infrastructure
A European Patient Summary InfrastructureA European Patient Summary Infrastructure
A European Patient Summary Infrastructure
Smruti Patanaik
 
Accute Abdomen
Accute Abdomen  Accute Abdomen
Accute Abdomen
Smruti Patanaik
 
THE ONCOLOGY NETWORK IN KERALA
THE ONCOLOGY NETWORK IN KERALATHE ONCOLOGY NETWORK IN KERALA
THE ONCOLOGY NETWORK IN KERALA
Smruti Patanaik
 
M health presented by Dr. K. ganapathy
M health presented by Dr. K. ganapathyM health presented by Dr. K. ganapathy
M health presented by Dr. K. ganapathy
Smruti Patanaik
 
Alzheimer disease
Alzheimer diseaseAlzheimer disease
Alzheimer disease
Smruti Patanaik
 
The knee joint
The knee jointThe knee joint
The knee joint
Smruti Patanaik
 
Dna fingerprinting
Dna fingerprintingDna fingerprinting
Dna fingerprinting
Smruti Patanaik
 
AIDS PPT. www.medicotesting.com
AIDS PPT. www.medicotesting.comAIDS PPT. www.medicotesting.com
AIDS PPT. www.medicotesting.com
Smruti Patanaik
 
Ventilator Graphics
Ventilator GraphicsVentilator Graphics
Ventilator Graphics
Smruti Patanaik
 
www.medicotesting.com , AIDS ppt
www.medicotesting.com , AIDS pptwww.medicotesting.com , AIDS ppt
www.medicotesting.com , AIDS ppt
Smruti Patanaik
 

More from Smruti Patanaik (20)

VVF DR SR PATANAIK
VVF DR SR PATANAIKVVF DR SR PATANAIK
VVF DR SR PATANAIK
 
Eplusclinic story
Eplusclinic storyEplusclinic story
Eplusclinic story
 
Sweety and her story
Sweety and her storySweety and her story
Sweety and her story
 
eplusclinic
eplusclinic eplusclinic
eplusclinic
 
Management of snake bite victims
Management of snake bite victimsManagement of snake bite victims
Management of snake bite victims
 
Leptin and obesity cycle
Leptin and obesity cycleLeptin and obesity cycle
Leptin and obesity cycle
 
Insomnia show
Insomnia showInsomnia show
Insomnia show
 
A S T H M A I N I N D I A N C H I L D R E N
A S T H M A  I N  I N D I A N  C H I L D R E NA S T H M A  I N  I N D I A N  C H I L D R E N
A S T H M A I N I N D I A N C H I L D R E N
 
24 Hour Anonymous Medical Information Service
24 Hour Anonymous Medical Information Service24 Hour Anonymous Medical Information Service
24 Hour Anonymous Medical Information Service
 
A C C I D E N T R E S C U E T R A I N I N G M O D U L E F O R A M B U L ...
A C C I D E N T  R E S C U E  T R A I N I N G  M O D U L E  F O R  A M B U L ...A C C I D E N T  R E S C U E  T R A I N I N G  M O D U L E  F O R  A M B U L ...
A C C I D E N T R E S C U E T R A I N I N G M O D U L E F O R A M B U L ...
 
A European Patient Summary Infrastructure
A European Patient Summary InfrastructureA European Patient Summary Infrastructure
A European Patient Summary Infrastructure
 
Accute Abdomen
Accute Abdomen  Accute Abdomen
Accute Abdomen
 
THE ONCOLOGY NETWORK IN KERALA
THE ONCOLOGY NETWORK IN KERALATHE ONCOLOGY NETWORK IN KERALA
THE ONCOLOGY NETWORK IN KERALA
 
M health presented by Dr. K. ganapathy
M health presented by Dr. K. ganapathyM health presented by Dr. K. ganapathy
M health presented by Dr. K. ganapathy
 
Alzheimer disease
Alzheimer diseaseAlzheimer disease
Alzheimer disease
 
The knee joint
The knee jointThe knee joint
The knee joint
 
Dna fingerprinting
Dna fingerprintingDna fingerprinting
Dna fingerprinting
 
AIDS PPT. www.medicotesting.com
AIDS PPT. www.medicotesting.comAIDS PPT. www.medicotesting.com
AIDS PPT. www.medicotesting.com
 
Ventilator Graphics
Ventilator GraphicsVentilator Graphics
Ventilator Graphics
 
www.medicotesting.com , AIDS ppt
www.medicotesting.com , AIDS pptwww.medicotesting.com , AIDS ppt
www.medicotesting.com , AIDS ppt
 

Recently uploaded

Dehradun #ℂall #gIRLS Oyo Hotel 8107221448 #ℂall #gIRL in Dehradun
Dehradun #ℂall #gIRLS Oyo Hotel 8107221448 #ℂall #gIRL in DehradunDehradun #ℂall #gIRLS Oyo Hotel 8107221448 #ℂall #gIRL in Dehradun
Dehradun #ℂall #gIRLS Oyo Hotel 8107221448 #ℂall #gIRL in Dehradun
chandankumarsmartiso
 
The Best Ayurvedic Antacid Tablets in India
The Best Ayurvedic Antacid Tablets in IndiaThe Best Ayurvedic Antacid Tablets in India
The Best Ayurvedic Antacid Tablets in India
Swastik Ayurveda
 
Histololgy of Female Reproductive System.pptx
Histololgy of Female Reproductive System.pptxHistololgy of Female Reproductive System.pptx
Histololgy of Female Reproductive System.pptx
AyeshaZaid1
 
Best Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and IndigestionBest Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and Indigestion
Swastik Ayurveda
 
Basavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Basavarajeeyam - Ayurvedic heritage book of Andhra pradeshBasavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Basavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Dr. Madduru Muni Haritha
 
Top Effective Soaps for Fungal Skin Infections in India
Top Effective Soaps for Fungal Skin Infections in IndiaTop Effective Soaps for Fungal Skin Infections in India
Top Effective Soaps for Fungal Skin Infections in India
SwisschemDerma
 
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdfCHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
rishi2789
 
Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdfOsteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdf
Jim Jacob Roy
 
Efficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in AyurvedaEfficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in Ayurveda
Dr. Jyothirmai Paindla
 
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
bkling
 
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.GawadHemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
NephroTube - Dr.Gawad
 
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
Donc Test
 
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
Holistified Wellness
 
ABDOMINAL TRAUMA in pediatrics part one.
ABDOMINAL TRAUMA in pediatrics part one.ABDOMINAL TRAUMA in pediatrics part one.
ABDOMINAL TRAUMA in pediatrics part one.
drhasanrajab
 
OCT Training Course for clinical practice Part 1
OCT Training Course for clinical practice Part 1OCT Training Course for clinical practice Part 1
OCT Training Course for clinical practice Part 1
KafrELShiekh University
 
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxDoes Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
walterHu5
 
The Electrocardiogram - Physiologic Principles
The Electrocardiogram - Physiologic PrinciplesThe Electrocardiogram - Physiologic Principles
The Electrocardiogram - Physiologic Principles
MedicoseAcademics
 
Light House Retreats: Plant Medicine Retreat Europe
Light House Retreats: Plant Medicine Retreat EuropeLight House Retreats: Plant Medicine Retreat Europe
Light House Retreats: Plant Medicine Retreat Europe
Lighthouse Retreat
 
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
rishi2789
 
Thyroid Gland- Gross Anatomy by Dr. Rabia Inam Gandapore.pptx
Thyroid Gland- Gross Anatomy by Dr. Rabia Inam Gandapore.pptxThyroid Gland- Gross Anatomy by Dr. Rabia Inam Gandapore.pptx
Thyroid Gland- Gross Anatomy by Dr. Rabia Inam Gandapore.pptx
Dr. Rabia Inam Gandapore
 

Recently uploaded (20)

Dehradun #ℂall #gIRLS Oyo Hotel 8107221448 #ℂall #gIRL in Dehradun
Dehradun #ℂall #gIRLS Oyo Hotel 8107221448 #ℂall #gIRL in DehradunDehradun #ℂall #gIRLS Oyo Hotel 8107221448 #ℂall #gIRL in Dehradun
Dehradun #ℂall #gIRLS Oyo Hotel 8107221448 #ℂall #gIRL in Dehradun
 
The Best Ayurvedic Antacid Tablets in India
The Best Ayurvedic Antacid Tablets in IndiaThe Best Ayurvedic Antacid Tablets in India
The Best Ayurvedic Antacid Tablets in India
 
Histololgy of Female Reproductive System.pptx
Histololgy of Female Reproductive System.pptxHistololgy of Female Reproductive System.pptx
Histololgy of Female Reproductive System.pptx
 
Best Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and IndigestionBest Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and Indigestion
 
Basavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Basavarajeeyam - Ayurvedic heritage book of Andhra pradeshBasavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Basavarajeeyam - Ayurvedic heritage book of Andhra pradesh
 
Top Effective Soaps for Fungal Skin Infections in India
Top Effective Soaps for Fungal Skin Infections in IndiaTop Effective Soaps for Fungal Skin Infections in India
Top Effective Soaps for Fungal Skin Infections in India
 
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdfCHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
 
Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdfOsteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdf
 
Efficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in AyurvedaEfficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in Ayurveda
 
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
 
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.GawadHemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
 
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
 
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
 
ABDOMINAL TRAUMA in pediatrics part one.
ABDOMINAL TRAUMA in pediatrics part one.ABDOMINAL TRAUMA in pediatrics part one.
ABDOMINAL TRAUMA in pediatrics part one.
 
OCT Training Course for clinical practice Part 1
OCT Training Course for clinical practice Part 1OCT Training Course for clinical practice Part 1
OCT Training Course for clinical practice Part 1
 
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxDoes Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
 
The Electrocardiogram - Physiologic Principles
The Electrocardiogram - Physiologic PrinciplesThe Electrocardiogram - Physiologic Principles
The Electrocardiogram - Physiologic Principles
 
Light House Retreats: Plant Medicine Retreat Europe
Light House Retreats: Plant Medicine Retreat EuropeLight House Retreats: Plant Medicine Retreat Europe
Light House Retreats: Plant Medicine Retreat Europe
 
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
 
Thyroid Gland- Gross Anatomy by Dr. Rabia Inam Gandapore.pptx
Thyroid Gland- Gross Anatomy by Dr. Rabia Inam Gandapore.pptxThyroid Gland- Gross Anatomy by Dr. Rabia Inam Gandapore.pptx
Thyroid Gland- Gross Anatomy by Dr. Rabia Inam Gandapore.pptx
 

Rotavirus

  • 1. RO TA RUS V CCI E VI A N T E T SAVE YOUR K IM O IDS DR.SMRUTIRANJAN PATANAIK
  • 2. RO TA RUS VI  A VIRUS OF THE FAMILY REOVIRIDAE  WHEEL SHAPED APPEARANCE – ROTA  MAJOR CAUSE OF DIARRHEA AND GASTROENTERITIS UNDER THE AGE OF FIVE  MORTALITY 6 LAKHS ACROSS THE GLOBE (29 TO 45 % OF ALL DIARRHEAL DEATHS)  OVER 2 MILLION HOSPITALIZED EACH YEAR
  • 3. STRUCTURE CLASSIFICATION BASIS :- IMMUNOLOGICAL REACTIVITIES OF VARIOUS COMPONENTS OF PARTICLES & FROM GENOMIC COMPOSITION INTO GROUPS A-G:- GROUP A HAVING SEROTYPES & GENOTYPES
  • 4. REPLI TI N CA O SITE- CYTOPLASM OF ENTEROCYTES REMOVAL OF OUTER CAPSID mRNA SYNTHESIS mRNA (CYTOPLASM) TRANSLATION VIRAL PROTEINS VIROPLASM REPLICATION ds RNA DOUBLE SHELLED PARTICLES FORMED VIRUS RELEASED
  • 5. ROUTE OF TRANSMISSION-FAECO ORAL ROUTE (1012 VIRIONS PER GM. OF EXCRETA IN ACUTE INFECTION) INFECTIVE DOSE-LOW (100-1000 VIRAL PARTICLES) INCUBATION PERIOD-2 TO 3 DAYS IMMUNITY:- IgA ANTIBODIES CTL
  • 6. NEED FO R AV CCI E A N  NATURALLY ACQUIRED IMMUNITY AFTER THE DISEASE.  TRANSMISSION RATES UNAFFECTED BY IMPROVING SANITATION.  UNAVAILABILITY OF LIFE SAVING I.V. TREATMENT TO ALL PATIENTS.  COST EFFECTIVE METHODS. HISTORYOF VACCINE DEVELOPMENT • 1993-94—LIVE ATTENUATED ROTAVIRUS VACCINE FROM RHESUS MONKEY. • 1996-COCKTAIL VACCINE (RRV-TV). • 1998-ROTASHIELD
  • 7. PRESEN V CCI ES A ALA LE T A N VI B
  • 8. CHALLEN GES FO R V CCI E A N I TRO DUCTI N& FUTURE PRO SPECTS N O UNCERTAIN DEMAND, INSUFFICIENT SUPPLY AND HIGH PRICES OF THE VACCINE. LACK OF INFORMATION ON BURDEN OF DISEASE IN SOME COUNTRIES. NEW EMERGING MUTANT & RECOMBINANT STRAINS OF VIRUS.
  • 9. I AN N UTSHELL THE 2 VACCINES ROTATEQ AND ROTARIX LAUNCHED IN THE YEAR 2006 HELP IN PREVENTION OF ROTAVIRUS INFECTION AT THE ENTEROCYTE LEVEL HAVING A PROMISING EFFICACY OF AROUND 95 TO 100%.