This study evaluated the role of atypical pathogens and viruses in acute exacerbations of bronchial asthma (AEBA) in adults and children. The study found that acute infection with Chlamydia pneumoniae or Mycoplasma pneumoniae played an important role in AEBA among adults. However, infection with these atypical pathogens did not contribute to AEBA among children. Additionally, viral infections, such as from influenza, adenovirus, and respiratory syncytial virus, were found to play an important role in AEBA in both adults and children. The study recommends further research to evaluate the therapeutic implications of these findings.