This document discusses estimating returns to fertilizer from crop simulation modeling in Malawi. It provides an overview of different data sources and methods used to measure yield response and their reliability. Crop simulation modeling was used to estimate yield responses under smallholder conditions. The modeling found that hybrid maize varieties, early planting, good agronomic practices, and the application of fertilizer can all increase yields and returns. Specifically, the modeling estimated local maize varieties had a yield response of 18 kg of grain per kg of nitrogen applied, while hybrid varieties responded with 22 kg of grain per kg of nitrogen.