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Retinopathy of Prematurity (ROP)
PBMA’S H. V. DESAI EYE HOSPITAL
Learning Objectives:
At the end of this lecture you should be able to know
- What is ROP?
- Why is ROP relevant for India?
- Who are at risk of ROP?
- When to screen for ROP and screening methods.
PBMA’S H. V. DESAI EYE HOSPITAL
Let’s start with a quiz…
• ROP is a disease of…
-cornea
- retina
- lens
• ROP occurs in…
- school children
- infants
- old persons
PBMA’S H. V. DESAI EYE HOSPITAL
• Potential impact of ROP on vision…
- no impact
- blindness
- mild blurring of vision
PBMA’S H. V. DESAI EYE HOSPITAL
• Definition - Vascular disorder of the retina
which occurs principally in the preterm infants.
• Specifically, occurs in the incompletely
vascularized retina.
• May lead to permanent blindness in a child.
Introduction
PBMA’S H. V. DESAI EYE HOSPITAL
Likely distribution of blindness in children due to retinopathy of prematurity using infant
mortality rates as an indicator. [Eye 2007 21: 1338−43].
Why do you think IMR can be a proxy indicator for estimating distribution of ROP blindness??
PBMA’S H. V. DESAI EYE HOSPITAL
Courtesy: Prof. Clare Gilbert, LSHTM, London
PBMA’S H. V. DESAI EYE HOSPITAL
Why should we care?
Poverty
relationship
s
Development
Isolation
Impact of Blindness*-
1. Kulkarni, S; Gilbert, C; Zuurmond, M ; Agashe S; Deshpande M. Blinding Retinopathy of Prematurity in Western India: Characteristics of Children, Reasons for Late Presentation and Impact on Families. 2018;55:665–70.
PBMA’S H. V. DESAI EYE HOSPITAL
Can you differentiate between ‘normal’ and ‘abnormal’?
PBMA’S H. V. DESAI EYE HOSPITAL
ROP : Who is at risk?
-Preterm (born < 34 weeks of pregnancy)
- low birth weight (< 2Kg ) infants
OR
- Bigger Infants (> 2kg) with critical illness during first
month after birth
Biggest baby treated by us- 2.4 kg BW
PBMA’S H. V. DESAI EYE HOSPITAL
Risk Factors:
• Prematurity - <34 weeks/ < 2kg
• ‘Unmonitored’ oxygen supply
• Infection (sepsis)
• Anemia requiring Blood transfusion
• Multiple births and many more…..
PBMA’S H. V. DESAI EYE HOSPITAL
ROP screening : Why?
• Premature babies are not born with the
disease
• ROP starts developing after 2-3 weeks of
birth.
• Blindness preventable with timely treatment
in most cases.
PBMA’S H. V. DESAI EYE HOSPITAL
ROP Screening - When
Govt of India guidelines 2017
• First screening: at or before Day 30 of life
• For extremely premature baby(<1200 gm/ <30 weeks): Day 20
PBMA’S H. V. DESAI EYE HOSPITAL
Screening: How?
Indirect Ophthalmoscopy
PBMA’S H. V. DESAI EYE HOSPITAL
Screening: How?
Imaging with a Digital Camera
PBMA’S H. V. DESAI EYE HOSPITAL
Do all preterm babies develop ROP?
• Less than half 20-44% (Indian reports)
• Sight threatening ROP: 3-10%
• Only sight threatening ROP requires laser treatment/
injections.
• Complications of ROP (retinal detachment) require surgery.
Good news: 90/100 preterm babies DO NOT develop blinding
ROP.
Stage 1 Stage 2 Stage 3
Stage 4 APROP
Post Laser stage 5
How does ROP look like?
PBMA’S H. V. DESAI EYE HOSPITAL
Is a preterm child free of risk once ROP is taken care of?
• No
• Other ocular diseases not uncommon in preterm*:
- High myopia
- Amblyopia, squint
- Cataract, glaucoma
- Delayed visual maturation
- Retinal detachment
1. Kulkarni Sucheta; Shah Mukti, Dole Kuldeep et al. Ocular Outcomes and Co-morbidities in preterm infants enrolled for Retinopathy of Prematurity screening: a Cohort study
from Western India. Oman J Ophthalmol. 2018;
PBMA’S H. V. DESAI EYE HOSPITAL
Need of follow up
• Every 3 months till 1 yr of age.
• Every 6 months thereafter till 3 yrs.
• Annual check up after 3 yrs.
Laser treated babies need lifelong follow up.
PBMA’S H. V. DESAI EYE HOSPITAL
What can we do to prevent ROP?
• Not possible in ALL cases but…
• Tight monitoring of oxygen supply
• Hand hygiene (prevent infection)
• Mother’s milk- weight gain, reduced infection
PBMA’S H. V. DESAI EYE HOSPITAL
KBC Time again……..
• Write your ‘code number’ on the top of a sheet of paper.
• Write your answers in front of question number.
(Example- Q 1- b, Q 3- a and so on)
• Exchange your answer sheet with your neighbor after
completion.
• Check your neighbor’s answers- One mark for each correct
answer.
PBMA’S H. V. DESAI EYE HOSPITAL
1. Blindness from ROP is preventable.
a. True
b. False
2. Birth weight cut off for ROP screening.
a. 1 kg
b. 2 kg
c. 2.5 kg
PBMA’S H. V. DESAI EYE HOSPITAL
3. What can a mother do to reduce risk of ROP in her child?
a. Oxygen monitoring
b. Observe eyes
c. breastfeeding
PBMA’S H. V. DESAI EYE HOSPITAL
4. What will you advise to a family of newborn preterm baby?
a. Ask your pediatrician about ROP screening.
b. Go to any ophthalmologist for ROP check up.
c. Go to a nearby PHC for screening.
PBMA’S H. V. DESAI EYE HOSPITAL
5. Your neighbor’s preterm child (BW 1.5 kg) is now 2 weeks old
and discharged from NICU. Parents were told about eye check up
but not told when? When would you advise them to get their
child’s ROP screening done?
At or before-
a. 3 months
b. 6 months
c. 1 month
Exchange your answer sheet with your neighbor and give 1 mark for each correct answer.
PBMA’S H. V. DESAI EYE HOSPITAL
Thank you!!!

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Retinopathy of prematurity

  • 2. PBMA’S H. V. DESAI EYE HOSPITAL Learning Objectives: At the end of this lecture you should be able to know - What is ROP? - Why is ROP relevant for India? - Who are at risk of ROP? - When to screen for ROP and screening methods.
  • 3. PBMA’S H. V. DESAI EYE HOSPITAL Let’s start with a quiz… • ROP is a disease of… -cornea - retina - lens • ROP occurs in… - school children - infants - old persons
  • 4. PBMA’S H. V. DESAI EYE HOSPITAL • Potential impact of ROP on vision… - no impact - blindness - mild blurring of vision
  • 5. PBMA’S H. V. DESAI EYE HOSPITAL • Definition - Vascular disorder of the retina which occurs principally in the preterm infants. • Specifically, occurs in the incompletely vascularized retina. • May lead to permanent blindness in a child. Introduction
  • 6. PBMA’S H. V. DESAI EYE HOSPITAL Likely distribution of blindness in children due to retinopathy of prematurity using infant mortality rates as an indicator. [Eye 2007 21: 1338−43]. Why do you think IMR can be a proxy indicator for estimating distribution of ROP blindness??
  • 7. PBMA’S H. V. DESAI EYE HOSPITAL Courtesy: Prof. Clare Gilbert, LSHTM, London
  • 8. PBMA’S H. V. DESAI EYE HOSPITAL Why should we care? Poverty relationship s Development Isolation Impact of Blindness*- 1. Kulkarni, S; Gilbert, C; Zuurmond, M ; Agashe S; Deshpande M. Blinding Retinopathy of Prematurity in Western India: Characteristics of Children, Reasons for Late Presentation and Impact on Families. 2018;55:665–70.
  • 9. PBMA’S H. V. DESAI EYE HOSPITAL Can you differentiate between ‘normal’ and ‘abnormal’?
  • 10. PBMA’S H. V. DESAI EYE HOSPITAL ROP : Who is at risk? -Preterm (born < 34 weeks of pregnancy) - low birth weight (< 2Kg ) infants OR - Bigger Infants (> 2kg) with critical illness during first month after birth Biggest baby treated by us- 2.4 kg BW
  • 11. PBMA’S H. V. DESAI EYE HOSPITAL Risk Factors: • Prematurity - <34 weeks/ < 2kg • ‘Unmonitored’ oxygen supply • Infection (sepsis) • Anemia requiring Blood transfusion • Multiple births and many more…..
  • 12. PBMA’S H. V. DESAI EYE HOSPITAL ROP screening : Why? • Premature babies are not born with the disease • ROP starts developing after 2-3 weeks of birth. • Blindness preventable with timely treatment in most cases.
  • 13. PBMA’S H. V. DESAI EYE HOSPITAL ROP Screening - When Govt of India guidelines 2017 • First screening: at or before Day 30 of life • For extremely premature baby(<1200 gm/ <30 weeks): Day 20
  • 14. PBMA’S H. V. DESAI EYE HOSPITAL Screening: How? Indirect Ophthalmoscopy
  • 15. PBMA’S H. V. DESAI EYE HOSPITAL Screening: How? Imaging with a Digital Camera
  • 16. PBMA’S H. V. DESAI EYE HOSPITAL Do all preterm babies develop ROP? • Less than half 20-44% (Indian reports) • Sight threatening ROP: 3-10% • Only sight threatening ROP requires laser treatment/ injections. • Complications of ROP (retinal detachment) require surgery. Good news: 90/100 preterm babies DO NOT develop blinding ROP.
  • 17. Stage 1 Stage 2 Stage 3 Stage 4 APROP Post Laser stage 5 How does ROP look like?
  • 18. PBMA’S H. V. DESAI EYE HOSPITAL Is a preterm child free of risk once ROP is taken care of? • No • Other ocular diseases not uncommon in preterm*: - High myopia - Amblyopia, squint - Cataract, glaucoma - Delayed visual maturation - Retinal detachment 1. Kulkarni Sucheta; Shah Mukti, Dole Kuldeep et al. Ocular Outcomes and Co-morbidities in preterm infants enrolled for Retinopathy of Prematurity screening: a Cohort study from Western India. Oman J Ophthalmol. 2018;
  • 19. PBMA’S H. V. DESAI EYE HOSPITAL Need of follow up • Every 3 months till 1 yr of age. • Every 6 months thereafter till 3 yrs. • Annual check up after 3 yrs. Laser treated babies need lifelong follow up.
  • 20. PBMA’S H. V. DESAI EYE HOSPITAL What can we do to prevent ROP? • Not possible in ALL cases but… • Tight monitoring of oxygen supply • Hand hygiene (prevent infection) • Mother’s milk- weight gain, reduced infection
  • 21. PBMA’S H. V. DESAI EYE HOSPITAL KBC Time again…….. • Write your ‘code number’ on the top of a sheet of paper. • Write your answers in front of question number. (Example- Q 1- b, Q 3- a and so on) • Exchange your answer sheet with your neighbor after completion. • Check your neighbor’s answers- One mark for each correct answer.
  • 22. PBMA’S H. V. DESAI EYE HOSPITAL 1. Blindness from ROP is preventable. a. True b. False 2. Birth weight cut off for ROP screening. a. 1 kg b. 2 kg c. 2.5 kg
  • 23. PBMA’S H. V. DESAI EYE HOSPITAL 3. What can a mother do to reduce risk of ROP in her child? a. Oxygen monitoring b. Observe eyes c. breastfeeding
  • 24. PBMA’S H. V. DESAI EYE HOSPITAL 4. What will you advise to a family of newborn preterm baby? a. Ask your pediatrician about ROP screening. b. Go to any ophthalmologist for ROP check up. c. Go to a nearby PHC for screening.
  • 25. PBMA’S H. V. DESAI EYE HOSPITAL 5. Your neighbor’s preterm child (BW 1.5 kg) is now 2 weeks old and discharged from NICU. Parents were told about eye check up but not told when? When would you advise them to get their child’s ROP screening done? At or before- a. 3 months b. 6 months c. 1 month Exchange your answer sheet with your neighbor and give 1 mark for each correct answer.
  • 26. PBMA’S H. V. DESAI EYE HOSPITAL Thank you!!!

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