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Hyperbili kravitz

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Loveis1able Khumpuangdee
Loveis1able Khumpuangdee

This document discusses neonatal hyperbilirubinemia or jaundice in newborns. It covers the physiology of bilirubin production and breakdown, risk factors for high bilirubin levels, methods for assessing risk, and therapies for treatment. Key points include the dangers of kernicterus if bilirubin crosses the blood-brain barrier, phototherapy as the main treatment, and factors like gestational age, breastfeeding and family history that influence jaundice risk.

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Michelle B. Kravitz, MD June 29, 2006 NEONATAL HYPERBILIRUBINEMIA
Case 1 ,[object Object],[object Object],[object Object]
Case 2 ,[object Object],[object Object],[object Object]
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object]
BILIRUBIN ,[object Object],[object Object]
BILIRUBIN PHYSIOLOGY ,[object Object],[object Object],[object Object]
BILIRUBIN PHYSIOLOGY Heme Biliverdin Heme oxygenase Bilirubin Biliverdin reductase
Bilirubin Physiology ,[object Object],[object Object]
Enterohepatic Circulation ,[object Object],[object Object],[object Object]
Conjugation ,[object Object],[object Object],[object Object]
CONJUGATED VS UNCONJUNCATED HYPERBILI ,[object Object],[object Object],[object Object]
KERNICTERUS ,[object Object],[object Object],[object Object],[object Object],[object Object]
KERNICTERUS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
KERNICTERUS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
KERNICTERUS AND FREE BILIRUBIN ,[object Object],[object Object]
ALBUMIN ,[object Object],[object Object],[object Object]
ALBUMIN ,[object Object],[object Object]
RISK FACTORS FOR SIGNIFICANT JAUNDICE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
TIME COURSE OF JAUNDICE ,[object Object],[object Object],[object Object]
RISK FACTORS-RACE ,[object Object],[object Object],[object Object],[object Object]
 
RISK FACTORS-GESTATIONAL AGE ,[object Object],[object Object],[object Object],[object Object]
RISK FACTORS-FAMILY HX ,[object Object],[object Object]
RISK FACTORS-HEMOLYSIS ,[object Object],[object Object],[object Object],[object Object]
RISK FACTORS-PATHOLOGIC ,[object Object],[object Object],[object Object],[object Object],[object Object]
BREASTMILK/BREASTFEEDING JAUNDICE ,[object Object],[object Object],[object Object],[object Object]
BREASTMILK/BREASTFEEDING JAUNDICE ,[object Object],[object Object],[object Object],[object Object],[object Object]
ASSESSING THE RISK OF JAUNDICE BY THE NUMBERS ,[object Object]
 
ASSESSING THE RISK OF JAUNDICE BY THE NUMBERS ,[object Object],[object Object],[object Object],[object Object],[object Object]
Copyright ©2004 American Academy of Pediatrics Subcommittee on Hyperbilirubinemia, Pediatrics 2004;114:297-316 Guidelines for phototherapy in hospitalized infants of 35 or more weeks' gestation
ASSESSING THE RISK OF JAUNDICE BY THE NUMBERS ,[object Object],[object Object]
THERAPIES-PHOTOTHERAPY ,[object Object],[object Object],[object Object]
THERAPIES-PHOTOTHERAPY ,[object Object],[object Object],[object Object]
THERAPIES-EXCHANGE TRANSFUSION ,[object Object],[object Object],[object Object]
THERAPIES-Sn Mesoporphyrin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
THERAPIES-Sn Mesoporphyrin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Review of Case 1 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Review of Case 2 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MANAGING JAUNDICE-TAKE HOME POINTS ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
REFERENCES ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object]

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Hyperbili kravitz

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