This document provides guidelines for developing research questions and hypotheses for qualitative, quantitative, and mixed methods studies. For qualitative research, questions should be broad and open-ended using words like "what" or "how". They focus on a single phenomenon and allow participants to explain their ideas. Quantitative research questions inquire about relationships between variables, while hypotheses predict relationships and can be null or directional. Mixed methods studies include both quantitative and qualitative questions as well as an overarching question on integrating the two approaches.