This chapter discusses how to write effective research questions and hypotheses for qualitative, quantitative, and mixed methods studies. For qualitative research, broad central questions and narrower subquestions are used to explore a phenomenon without directional hypotheses. Quantitative research involves questions or hypotheses about relationships between variables, which can be null, directional, or nondirectional. Mixed methods studies include qualitative and quantitative research questions/hypotheses and may also include an overarching mixed methods question addressing both approaches and their integration. Clear, focused questions and hypotheses are important for guiding a study.