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REGLATION OF RESPIRATION
MARYAM MOHAMMADZADEHSARI
Respiration is a reflex process. But it can be controlled voluntarily for a short period of about 40 seconds.
However, by practice, breathing can be withheld for a long period. At the end of that period, the person is
forced to breathe.
Respiration is subjected to variation, even under normal physiological conditions. For example, emotion
and exercise increase the rate and force of respira- tion. But the altered pattern of respiration is brought
back to normal, within a short time by some regulatory mechanisms in the body.
Normally, quiet regular breathing occurs because
1. Nervous or neural mechanism
2. Chemical mechanism.
NERVOUS MECHANISM
Nervous mechanism that regulates the respiration includes:
1. Respiratory centers
2. Afferent nerves
3. Efferent nerves.
RESPIRATORY CENTERS
Respiratory centers are group of neurons, which control the rate, rhythm and force of respiration. These
centers are bilaterally situated in reticular formation of the brainstem Depending upon the situation in
brainstem, the respiratory centers are classified into two groups:
A. Medullary centers consisting of
1. Dorsal respiratory group of neurons
2. Ventral respiratory group of neurons
B. Pontine centers
3. Apneustic center
4. Pneumotaxic center.
PNEUMOTAXIC CENTER
Pneumotaxic center is situated in the dorsolateral part of reticular formation in upper pons. It is formed by
neurons of medial parabrachial and subparabrachial nuclei. Subparabrachial nucleus is also called ventral
parabrachial or Kölliker-Fuse nucleus.
Function:
Primary function of pneumotaxic center is to control the medullary respiratory centers, particularly the
dorsal group neurons. It acts through apneustic center. Pneumotaxic center inhibits the apneustic center so
that the dorsal group neurons are inhibited. Because of this, inspiration stops and expiration
Thus, pneumotaxic center influences the switching between inspiration and expiration.
Pneumotaxic center increases respiratory rate by reducing the duration of inspiration.
Experimental evidence
Stimulation of pneumotaxic center does not produce any typical effect, except slight prolongation of
expiration, by inhibiting the dorsal respiratory group of neurons through apneustic center. Destruction or
inactivation of pneumotaxic center results in apneusis.
SLEEPAPNEA SYNDROME
Sleep apnea is the temporary stoppage of breathing repeatedly during sleep. Sleep apnea syndrome is the
disorder that involves fluctuations in the rate and force of respiration during REM sleep with short apneic
episode. Apnea is due to decreased stimulation of respiratory centers, arrest of diaphragmatic movements,
airway obstruction or the combination of all these factors. When breathing stops, the resultant
hypercapnia and hypoxia stimulate respiration.
Sleep apnea syndrome occurs in obesity, myx- edema, enlargement of tonsil and lesion in brainstem.
Common features of this syndrome are loud snoring restless movements, nocturnal insomnia, daytime
sleepiness, morning headache and fatigue. In severe conditions, hypertension, right heart failure and
stroke occur
PERIPHERAL CHEMORECEPTORS
Peripheral chemoreceptors are the chemoreceptors present in carotid and aortic region.
Mechanism of Action:
Hypoxia is the most potent stimulant for peripheral chemoreceptors. It is because of the presence of
oxygen sensitive potassium channels in the glomus cells of peripheral chemoreceptors.
Hypoxia causes closure of oxygen sensitive potassium channels and prevents potassium efflux. This leads
to depolarization of glomus cells (receptor potential) and generation of action potentials in nerve ending
These impulses pass through aortic and Hering nerves and excite the dorsal group of neurons. Dorsal
group of neurons in turn, send excitatory impulses to respiratory muscles, resulting in increased
ventilation. Thisprovidesenoughoxygenandrectifiesthelackof oxygen.
In addition to hypoxia, peripheral chemoreceptors are also stimulated by hypercapnea and increased
hydrogen ion concentration.
However, the sensitivity of peripheral chemoreceptors to hypercapne
PROTECTIVE REFLEXES OR FLEXOR REFLEXES :
Protective reflexes are the reflexes which protect the body from nociceptic (harmful) stimuli. These reflexes
are also called withdrawal reflexes or flexor reflexes. Protective reflexes involve flexion at different joints
hence the name flexor reflexes.
AIRWAY RESISTANCE
Airway resistance is the resistance offered to the passage of air through respiratory tract. Resistance
increases during bronchiolar constriction, which in creases the work done by the muscles during breathing.
Work done to overcome the airway resistance is called airway resistance work.

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reglation of respiration

  • 2. Respiration is a reflex process. But it can be controlled voluntarily for a short period of about 40 seconds. However, by practice, breathing can be withheld for a long period. At the end of that period, the person is forced to breathe. Respiration is subjected to variation, even under normal physiological conditions. For example, emotion and exercise increase the rate and force of respira- tion. But the altered pattern of respiration is brought back to normal, within a short time by some regulatory mechanisms in the body.
  • 3. Normally, quiet regular breathing occurs because 1. Nervous or neural mechanism 2. Chemical mechanism.
  • 4. NERVOUS MECHANISM Nervous mechanism that regulates the respiration includes: 1. Respiratory centers 2. Afferent nerves 3. Efferent nerves.
  • 5. RESPIRATORY CENTERS Respiratory centers are group of neurons, which control the rate, rhythm and force of respiration. These centers are bilaterally situated in reticular formation of the brainstem Depending upon the situation in brainstem, the respiratory centers are classified into two groups: A. Medullary centers consisting of 1. Dorsal respiratory group of neurons 2. Ventral respiratory group of neurons B. Pontine centers 3. Apneustic center 4. Pneumotaxic center.
  • 6. PNEUMOTAXIC CENTER Pneumotaxic center is situated in the dorsolateral part of reticular formation in upper pons. It is formed by neurons of medial parabrachial and subparabrachial nuclei. Subparabrachial nucleus is also called ventral parabrachial or Kölliker-Fuse nucleus. Function: Primary function of pneumotaxic center is to control the medullary respiratory centers, particularly the dorsal group neurons. It acts through apneustic center. Pneumotaxic center inhibits the apneustic center so that the dorsal group neurons are inhibited. Because of this, inspiration stops and expiration
  • 7. Thus, pneumotaxic center influences the switching between inspiration and expiration. Pneumotaxic center increases respiratory rate by reducing the duration of inspiration. Experimental evidence Stimulation of pneumotaxic center does not produce any typical effect, except slight prolongation of expiration, by inhibiting the dorsal respiratory group of neurons through apneustic center. Destruction or inactivation of pneumotaxic center results in apneusis.
  • 8. SLEEPAPNEA SYNDROME Sleep apnea is the temporary stoppage of breathing repeatedly during sleep. Sleep apnea syndrome is the disorder that involves fluctuations in the rate and force of respiration during REM sleep with short apneic episode. Apnea is due to decreased stimulation of respiratory centers, arrest of diaphragmatic movements, airway obstruction or the combination of all these factors. When breathing stops, the resultant hypercapnia and hypoxia stimulate respiration. Sleep apnea syndrome occurs in obesity, myx- edema, enlargement of tonsil and lesion in brainstem. Common features of this syndrome are loud snoring restless movements, nocturnal insomnia, daytime sleepiness, morning headache and fatigue. In severe conditions, hypertension, right heart failure and stroke occur
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  • 10. PERIPHERAL CHEMORECEPTORS Peripheral chemoreceptors are the chemoreceptors present in carotid and aortic region. Mechanism of Action: Hypoxia is the most potent stimulant for peripheral chemoreceptors. It is because of the presence of oxygen sensitive potassium channels in the glomus cells of peripheral chemoreceptors. Hypoxia causes closure of oxygen sensitive potassium channels and prevents potassium efflux. This leads to depolarization of glomus cells (receptor potential) and generation of action potentials in nerve ending
  • 11. These impulses pass through aortic and Hering nerves and excite the dorsal group of neurons. Dorsal group of neurons in turn, send excitatory impulses to respiratory muscles, resulting in increased ventilation. Thisprovidesenoughoxygenandrectifiesthelackof oxygen. In addition to hypoxia, peripheral chemoreceptors are also stimulated by hypercapnea and increased hydrogen ion concentration. However, the sensitivity of peripheral chemoreceptors to hypercapne
  • 12. PROTECTIVE REFLEXES OR FLEXOR REFLEXES : Protective reflexes are the reflexes which protect the body from nociceptic (harmful) stimuli. These reflexes are also called withdrawal reflexes or flexor reflexes. Protective reflexes involve flexion at different joints hence the name flexor reflexes.
  • 13. AIRWAY RESISTANCE Airway resistance is the resistance offered to the passage of air through respiratory tract. Resistance increases during bronchiolar constriction, which in creases the work done by the muscles during breathing. Work done to overcome the airway resistance is called airway resistance work.