Parkinson's disease is a neurodegenerative disease causing severe disability. In the past 10-15 years, a lot of new medicines and treatments have become successful in helping patients with PD. The current review focuses in all approved treatments for PD
Presentation on recent advances in Parkinsons disease. Tried to cover up new drugs as well as new devices like Duodopa set up. . i have tried to put a light on the established treatment of Parkinson's disease along with its mechanism of actions in circuit loops which will help to understand the topic in depth!
Advances in Management of Parkinson's DiseaseSultana Shaikh
Parkinson's disease [PD] is one of the most common neurodegenerative disorders. There have been significant recent advances in the understanding of the pathogenesis of the disease. There has also been a greater realization that the disorder may be associated with significant non-motor disturbances in addition to the more commonly recognized motor complications. There are many drugs like levodopa and carbidopa, ropinirole, pramipexole, rotigotine etc. and some MAO-B INHIBITOR like selegiline and rasagiline which are used in treatment of Parkinson’s disease. Some COMT INHIBITOR
and others drugs are also available and some herbs like turmeric, ginger, garlic etc. provides temporary relief from Parkinson’s disease. There are two vaccines which are under development for the treatment of Parkinson’s disease.
Presentation on recent advances in Parkinsons disease. Tried to cover up new drugs as well as new devices like Duodopa set up. . i have tried to put a light on the established treatment of Parkinson's disease along with its mechanism of actions in circuit loops which will help to understand the topic in depth!
Advances in Management of Parkinson's DiseaseSultana Shaikh
Parkinson's disease [PD] is one of the most common neurodegenerative disorders. There have been significant recent advances in the understanding of the pathogenesis of the disease. There has also been a greater realization that the disorder may be associated with significant non-motor disturbances in addition to the more commonly recognized motor complications. There are many drugs like levodopa and carbidopa, ropinirole, pramipexole, rotigotine etc. and some MAO-B INHIBITOR like selegiline and rasagiline which are used in treatment of Parkinson’s disease. Some COMT INHIBITOR
and others drugs are also available and some herbs like turmeric, ginger, garlic etc. provides temporary relief from Parkinson’s disease. There are two vaccines which are under development for the treatment of Parkinson’s disease.
In this slide contains definition, types, causes, inducers and inhibitors, complex drug interactions.
Presented by: SUMASHREE AGGIM (Department of pharmacology).
RIPER, anantapur
Introduction to Genetic Variation in GPCR
G-Protein couple Receptor
Genetic variation in GPCRs
V2 Vasopressin Receptor, Thrombroxane Receptor, P2Y 12ADP Receptor, Chemokine Receptor, Biogenic amine receptors
Presented by
R. REKHA
Department of Pharmacology
Its a about chrono-pharmacology of diabetes
The accurate and detail information about chrono- pharmacology its not available but this information is sufficient or useful.
Newer drugs for the treatment of motor symptoms of Parkinson's DiseaseSudhir Kumar
Parkinson's disease is a common movement disorder with prominent motor symptoms such as tremors, bradykinesia and rigidity. Many patients suffer from motor fluctuations including on off phenomena, and freezing. This presentation looks at the latest drugs for treating these.
In this slide contains definition, types, causes, inducers and inhibitors, complex drug interactions.
Presented by: SUMASHREE AGGIM (Department of pharmacology).
RIPER, anantapur
Introduction to Genetic Variation in GPCR
G-Protein couple Receptor
Genetic variation in GPCRs
V2 Vasopressin Receptor, Thrombroxane Receptor, P2Y 12ADP Receptor, Chemokine Receptor, Biogenic amine receptors
Presented by
R. REKHA
Department of Pharmacology
Its a about chrono-pharmacology of diabetes
The accurate and detail information about chrono- pharmacology its not available but this information is sufficient or useful.
Newer drugs for the treatment of motor symptoms of Parkinson's DiseaseSudhir Kumar
Parkinson's disease is a common movement disorder with prominent motor symptoms such as tremors, bradykinesia and rigidity. Many patients suffer from motor fluctuations including on off phenomena, and freezing. This presentation looks at the latest drugs for treating these.
Anti Parkinson Disease | PDF | Pharmacology | Assignment MrHotmaster1
An anti-parkinson is a type of drug which is intended to treat and relieve the symptoms of parkinson’s disease.
Most of these agents act by either increasing dopamine activity or reducing acetylcholine activity in the central nervous system.
In clinical practice, anti-cholinergic drugs, amantadine, and the anti-histamines have their primary use of treatment for medication induced parkinsonism, acute dystonia, and medication induced tremor.
How to switch oral antiparkinsonian drugs to intravenous drugs in Parkinson d...Daisuke Yamamoto
There are no clear guidelines to switch oral antiparkinsonian drugs to intravenous drugs in Parkinson disease.Through this slide, I would like suggest a way to resolve this problem. I hope this presentation is helpful, especially for medical doctors who cannot consult a specialist.
HOPE IN THE MANAGEMENT OF ADVANCED PARKINSONS DISEASE.pptxAjay Kumar
Related to symptoms of advanced Parkinson's disease and ways to manage those by device therapies including Levodopa intestinal gel and Apomorphine subcutaneous injection.
Neurological Evaluation of Acute Ischemic stroke in Emergency RoomSudhir Kumar
Neurological evaluation of acute ischemic stroke in ER should focus on:
1. Exclude stroke mimics
2. Ascertain time of onset of symptoms,
3. Neurological examination
4. NIHSS score
5. Investigations to be done in ER
6. Ascertain eligibility for thrombolysis and exclude any contraindications
7. Informed consent
Lifestyle Measures to Prevent Brain Diseases.pptxSudhir Kumar
Disease prevention is more important in neurology than treatment. This is because treatments are not 100% effective and cure may not be possible. In this presentation, I discuss the evidence-based measures to prevent stroke and dementia. These include adequate sleep, physical activity, eating healthy foods, and reducing stress.
This talk summarizes the definition, diagnosis and management strategies of migraine. It will be useful for general public as well as healthcare professionals.
This is more of a summary of recent evidence available on migraine management. It is easy to read and understand. Please post your queries and comments.
COVID-19 Presenting as stroke- mechanisms, diagnosis and treatmentSudhir Kumar
Covid 19 infection can affect nervous system in many ways, including an increased risk of stroke. This presentation looks at the association of COVID 19 infection and stroke. Mechanisms of stroke in COVID 19 have been elucidated. Approach to diagnosis and management has also been discussed via case studies. Prompt diagnosis and early initiation of treatment ensures a good outcome in covid 19 infected patients presenting with stroke.
CHRONIC PAIN AND DEPRESSION: Cause or Effect or Linked?Sudhir Kumar
Chronic pain and depression are both common conditions, and in many patients, they co-exist. This presentation looks at the link between chronic pain and depression. Various drugs that can be used to treat chronic pain/depression have been discussed, with a special emphasis on tricyclic antidepressants.
Neurological Manifestations of COVID-19 InfectionSudhir Kumar
COVID-19 primarily affects respiratory system, however, it can affect other systems too, including nervous system. This presentation offers details about neurological symptoms and disorders seen in patients with COVID-19.
Zonisamide is among the newer broad spectrum anti-epileptic drugs, effective against focal and generalized epilepsies. It can be taken once daily and is well tolerated. The current article focuses on clinical efficacy and safety of zonisamide in epilepsy (as add on or as monotherapy). There is long term data as well as comparative studies against carbamazepine.
Multiple sclerosis: fighting the invisibleSudhir Kumar
Multiple sclerosis affects about 100 per 1,00,000 population. Women get affected 3 times more commonly than men. It is a leading cause of disability. This presentation aims at educating people with MS about the symptoms, diagnosis, treatment and prognosis of MS.
Stroke is common. This presentation discusses the broad outlines of acute stroke management, especially in the first 24 hours after onset of symptoms. It would be useful for physicians as well as neurologists.
Stroke is common in pregnancy. All physicians and obstetricians caring for pregnant women should be familiar with symptoms of stroke, as well as its diagnosis and treatment. This presentation gives an overview about the latest management of stroke in pregnant women.
Stroke is a leading cause of death and disability. All doctors should have a basic knowledge about stroke management. This presentation gives a summary of treatment options in acute brain stroke.
Multiple sclerosis is a demyelinating disease affecting brain, optic nerves and spinal cord. It is characterised by frequent relapses. Now, there are a number of effective treatment options for MS. Earlier, only clinical parameters were considered to evaluate the efficacy of MS treatments. However, now, we need to look at disability as well as MRI parameters. All these points are included in NEDA (no evidence of disease activity). This presentation looks at the definition and classification of NEDA. It also looks at NEDA rates with various treatment options.
NEUROLOGICAL DISORDERS DUE TO METABOLIC DERANGEMENTSSudhir Kumar
Metabolic and endocrine disorders can present with neurological signs and symptoms. It is important to recognise them so that can be promptly treated. Majority of symptoms fully reverse if treatment is started on time. This presentation looks at some common metabolic/endocrine disorders with neurological manifestations. The description is in the form of case series.
Management of High Disease Activity in Multiple Sclerosis (MS)Sudhir Kumar
Multiple sclerosis is a common disease affecting the central nervous system. Immunotherapy with interferon is the first line therapy for MS. This presentation discusses the treatment options of high disease activity in patients with MS. Role of natalizumab (tysabri) has been highlighted.
This presentation discusses the revised McDonald's criteria (2017) for the diagnosis of multiple sclerosis. Major changes from the last diagnostic criteria proposed in 2010 have been discussed. Clinical and MRI criteria for dissemination in space and time have been discussed.
Today, everyone needs to market self. Some market their products, and others market their skills. Is marketing difficult? It is difficult, however, it can become easy, if we follow certain protocol. This talk gives you some insights into effective ways of marketing.
Addressing hypertension to reduce the burden of stroke 19 feb2018 (1)Sudhir Kumar
Hypertension is the commonest risk factor for stroke. Management of hypertension is important in ensuring best outcomes for stroke patients. Adequate control of bP is also important to prevent stroke recurrence. This presentation looks at the role of high BP in stroke occurrence and antihypertensive agents that can be used to achieve target BP.
Role of Blood Pressure in Recurrent StrokeSudhir Kumar
Hypertension is a major risk factor for the first stroke as well as recurrent stroke. Therefore, adequate control of BP is necessary to reduce the risk of stroke recurrence. This presentation looks at the ABCD 2 score to predict the exact risk of stroke recurrence after TIA. Target BP that needs to be achieved has been discussed. Various antihypertensive agents based on the scientific evidence have been discussed.
Palmitoylethanolamide in the Treatment of Neuropathic Pain Sudhir Kumar
Neuropathic pain is quite common. It is associated with severe disability and adversely affects the quality of life of sufferers. Current treatment options for neuropathic are not very effective. Moreover, they are associated with significant adverse effects. A new naturally occurring substance- PALMITOYLETHANOLAMIDE (PEA)- has been found to be effective and safe in treating neuropathic pain. The current presentation looks at the efficacy of PEA in neuropathic pain.
Acute ischemic stroke is an emergency. There are good thrombolytic agents available now. Aspirin or clopidogrel along with statins should be given to all stroke patients. Control of BP and sugar is of paramount importance.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Pharynx and Clinical Correlations BY Dr.Rabia Inam Gandapore.pptx
Recent advances in the management of Parkinson's Disease (PD)
1. D R S U D H I R K U M A R M D D M
C O N S U L T A N T N E U R O L O G I S T
A P O L L O H O S P I T A L S , H Y D E R A B A D
RECENT ADVANCES IN
MANAGEMENT OF PD: DRUGS,
DEVICES AND PROCEDURES
2. SCOPE OF MY TALK
Recent drugs approved for reducing “off” time and
increasing “on” time (safinamide and opicapone),
Strategies to treat “off” episodes on SOS basis
(subcutaneous and sublingual apomorphine),
Apomorphine infusion for patients not fulfilling DBS
criteria,
Noninvasive alternative for treating tremor-
predominant PD (MR guided FUS thalamotomy),
New FDA approved drugs for treating nonmotor
symptoms (psychosis and orthostatic hypotension)
3. SAFINAMIDE (1)
Safinamide is the first new molecule approved by
USFDA for treating PD in more than 10 years.
It was approved in March 2017, as add-on treatment
for PD, who are currently taking levodopa-carbidopa
and are experiencing “off” episodes.
Approval was based on two phase III trials that
included 1200 PD patients with motor fluctuations.
Safinamide provided a significant reduction in the
“off time” and significant increase in the “on time”
without troublesome dyskinesia.
4. SAFINAMIDE (2)
Safinamide is an α-aminoamide,
Mechanism of action- both dopaminergic and
nondopaminergic
1. Inhibition of MAO-B
2. Na+ Channel blockade,
3. Modulation of stimulated release of glutamate
6. SAFINAMIDE TRIALS (2)
Patients aged 30-80 years, with mid-late stage PD of
3 or more yrs duration, having motor fluctuations
(>1.5 hours off time/day) on levodopa and other
dopaminergic medications, were included
Randomized into 3 groups: 50 mg/d, 100 mg/d or
placebo, OD dose, treated for 24 weeks
8. FINDINGS OF THIS STUDY
“On” time without troublesome dyskinesia
significantly increased
“Off” time significantly reduced,
No significant treatment related adverse events were
noted.
100 mg/d was better than 50 mg/d, but both doses
of safinamide were better than placebo.
10. MAIN FINDINGS OF THIS STUDY
549 patients with PD having more than 1.5 hours off
time despite pharmacotherapy
Treated with safinamide or placebo for 24 weeks,
Safinamide taken once daily increased the “on” time
without dyskinesia by 1.42 hours as compared to
0.57 hour with placebo.
Safinamide was well tolerated.
11. OPICAPONE
Novel 3rd generation catechol-O Methyl transferase
inhibitor,
Convenient once daily dosing,
Free of potential adverse effects on the liver,
Approved by European Commission in June 2016 as
an adjunct therapy in patients on levodopa/DCI with
end of dose fluctuations.
13. BI-PARK 1 STUDY
600 PD patients 30-83 year age, on levodopa with
end of dose motor fluctuations were randomized to
receive opicapone (5 mg, 25 mg or 50 mg OD),
placebo or entacapone (200 mg with every levodopa
dose).
Mean “off” time was significantly reduced with
opicapone 25 mg and 50 mg OD.
Opicapone was non-inferior to entacapone.
15. BI-PARK II STUDY
427 patients were randomized to receive opicapone
(25 mg or 50 mg OD) or placebo,
Were treated for 14-15 weeks, followed by 1 year
open-label extension phase with opicapone,
Significant reduction in the “off” time was noted in
the 50 mg OD dose (and not 25 mg OD dose) of
opicapone, as compared to placebo.
This reduction in “off-time” was sustained for one
year.
No significant electrocardiographic or hepatic
adverse effects were noted.
16. LEVODOPA-CARBIDOPA INTESTINAL GEL
Studies have shown that motor fluctuations are
partly due to intermittent oral doses of
levodopa/carbidopa, as this results in fluctuating
levels of levodopa
Continuous jejunal infusion can provide steady state
levels of levodopa and reduce motor fluctuations,
Efficacy and safety of levodopa-carbidopa intestinal
gel (Duodopa) was demonstrated in clinical trials
It was approved by US FDA in Jan 2015. In Europe,
it was already approved in 2005.
18. LCIG STUDY
71 patients with advanced PD were randomized to
receive LCIG infusion (n=37) with LC IR placebo or
LC IR with LCIG infusion placebo (n=34) for 12
weeks,
LCIG infusion was given by PEG-J tube for 16
waking hours, and stopped overnight
Mean reduction in off time with LCIG infusion was 4
hours (1.9 hours more than LC IR tablets)
Mean increase in on time with LCIG infusion was 4
hours (1.86 hours more than LC IR tablets)
19. LEVODOPA INHALATION POWDER
Levodopa inhalation powder (CVT-301) can be used
SOS during “off” episodes,
86 patients were studied for 4 weeks (Lewitt et al,
Mov Disord 2016); 35-50 mg dose was used.
Provides rapid onset of action (10 min)
UPDRS Part III score favored CVT-301 by 7 points
Mean OFF time reduced by 0.9 hours
Main side effects were dizziness, cough and nausea.
20. PHASE III STUDY CVT 301
SPAN-PD study on 339 patients, treated with 84 mg of
inhaled levodopa (CVT 301),
Poster presented at MDS conference at Vancouver (June
2017)
CVT-301 led to significant improvement in motor
function (as compared to placebo) as evidenced by mean
change in UPDRS III at 30 min at week 12 (-9.83 vs -
5.91)
Cough was the most common AE (15% vs 2%); 2 out of
114 patients receiving CVT 301 discontinued the drug due
to cough
Data submitted to FDA on June 29th 2017 regarding CVT
301 (Inbrija)
21. APOMORPHINE
Subcutaneous apomorphine (Apokyn) has been approved
(by FDA) for treating hypomobility episodes (end of dose
wearing off or unpredictable on/off episodes) in
advanced PD since 2004, as an adjunct to levodopa
therapy.
Recommended dose is 0.2 to 0.6 ml, subcutaneous,
delivered by metered injector pen,
Significant improvement in UPDRS motor scores and
effective in ending hypomobile episodes within 20 min
Mild-to-moderate nausea/vomiting common;
antiemetics are effective.
22. SUBCUTANEOUS APOMORPHINE INFUSION
TOLEDO phase 3 trial, presented at AAN meeting
(Boston, April 2017)
106 patients with advanced PD from Europe were
randomized to receive APO SCI or placebo (53 each)
APO infusion given for 16 hours (during waking
time)
At 12 weeks, apomorphine group had reduction of
“off” time by 2.47 hours, as compared to 0.58 hours
with placebo
Available in Europe, however, US FDA approval
pending.
23. SUBLINGUAL APOMORPHINE
Many people do not like injections; moreover, sublingual
route is easier to administer,
Sublingual apomorphine (APL-130277) tested in phase
2/phase 3 studies, FDA approval pending
Dose: 10-30 mg during OFF phase,
ON state achieved in 15-30 min of dose in about 80% of
patients,
Mean duration of ON phase is 50 min and 60% remain
ON for >90 min
Common side effects are dizziness, somnolence and
nausea.
24. ROTIGOTINE TRANSDERMAL PATCH
Rotigotine is an non ergoline dopamine agonist,
administered as a transdermal patch, provides rotigotine
for 24 hours
Approved by FDA in 2012,
Dose: For early PD, initial 2 mg/24 h, can be increased
by 2 mg/24 h at weekly intervals to 6 mg/24 h. For
advanced PD, dose is 4 mg/24 h, can be increased to 8
mg/24 h.
Can be used as monotherapy in early PD, or as an
adjunct treatment with levodopa in advanced PD,
Low dose oral dopamine agonists (equivalent to 8 mg/24
h) can be switched overnight to rotigotine transdermal
patch.
25. MRI-GUIDED FOCUSED ULTRASOUND
MRI guided FUS thalamotomy has been approved by
FDA for ET,
MRI-guided FUS thalamotomy (via thermal ablation) has
shown benefit in treating medication-resistant tremor
predominant PD (Zaroor M, J Neurosurg, 2017),
30 patients (ET:18; PD:9; ET-PD:3) were treated with
MRgFUS VIM thalamotomy.
Significant reduction in tremors were noted, that lasted
for six months,
Side effects were minor and transient
Larger randomized trials are needed.
26. PIMAVANSERIN FOR PD PSYCHOSIS
Currently available anti-psychotic drugs work on both
serotonin and dopamine systems, thereby worsening the
motor symptoms of PD,
Pimavanserin (Nuplazid) works only on serotonin
system,
Improves psychotic symptoms without worsening of
motor symptoms,
Approved by USFDA
Dose is 34 mg OD (taken as two 17 mg tablets),
Should be avoided in dementia-related psychosis and
patients with prolonged QT interval.
27. DROXIDOPA FOR ORTHOSTATIC
HYPOTENSION
Droxidopa is a norepinephrine prodrug taken orally,
Starting dose is 100 mg TID (max dose 600 mg TID),
Significant reduction in falls, quality of life
Significant increase in systolic and diastolic bP,
Effects sustained for a year,
No serious side effects are noted.
28. STEM CELL TREATMENT FOR PD
Stem cell treatment is still in experimental stage and
not approved by FDA,
MDS also does not recommend using stem cell
treatment in clinical practice,
Clinical trials are underway in Australia, Europe and
elsewhere; and we need to await their results, before
any further conclusions can be made.
29. CONCLUSIONS (1)
Safinamide and opicapone are effective in reducing “off”
time and increasing “on” time in patients with mid-to-
late PD,
Apomorphine (sublingual or subcutaneous) are
promising treatments for SOS use to treat “off” episodes,
Apomorphine infusion is a good option for patients who
do not fit the criteria for DBS (can be used in conjunction
with DBS too)
MRgFUS VIM thalamotomy could be a noninvasive
alternative to DBS in selected patients with tremor-
predominant PD,
30. CONCLUSIONS (2)
Nonmotor symptoms can be treated more effectively
with FDA approved drugs,
PD psychosis with Pimavanserin and orthostatic
hypotension with droxidopa.