Parkinson's disease [PD] is one of the most common neurodegenerative disorders. There have been significant recent advances in the understanding of the pathogenesis of the disease. There has also been a greater realization that the disorder may be associated with significant non-motor disturbances in addition to the more commonly recognized motor complications. There are many drugs like levodopa and carbidopa, ropinirole, pramipexole, rotigotine etc. and some MAO-B INHIBITOR like selegiline and rasagiline which are used in treatment of Parkinson’s disease. Some COMT INHIBITOR and others drugs are also available and some herbs like turmeric, ginger, garlic etc. provides temporary relief from Parkinson’s disease. There are two vaccines which are under development for the treatment of Parkinson’s disease.

1. RECENT ADVANCES IN MANAGEMENT OF
PARKINSON'S DISEASE
MISS.SULTANA SHAIKH
(M.PHARM STUDENT)
ORIENTAL COLLEGE OF
PHARMACY
GUIDED BY:
Dr. (Mrs.) SHRUTI WAGLE
1

2. Parkinson's disease [PD] is one of the most common
neurodegenerative disorders.
A progressive disease of the nervous system marked by tremor,
muscular rigidity, and slow, imprecise movement, chiefly affecting
middle-aged and elderly people. It is associated with degeneration
of the basal ganglia of the brain and a deficiency of the
neurotransmitter dopamine.
2

3. 3

4. Non motor symptoms:
1- Dysautonomia
2-nocturia
3-constipation
4-dementia
5-Orthostatic hypotension
4

5. Drug affecting dopaminergic system in
brain:
1- Dopa precursor: Levodopa
2- Peripheral decarboxylase inhibitor: carbidopa
3- Dopaminergic agonist: Bromocriptin
4- MAO-B inhibitor: Salagiline
5-COMT inhibitor: Entacapone
Drug affecting cholinergic system in brain:
1-Anti-cholinergics: Bipiriden
2-Anti-histamins: Orphenadrine
5

6. 6

7. 1. A2A antagonists Tozadenant
2. Perampanel
3. Duodopa gel is a combination of levodopa and carbidopa [ratio
4:1] in a gel for continuous intestinal infusion in advanced Parkinson's
disease with severe motor fluctuations.
4.Comt Inhibitor Nebicapone
5.Mao B Inhibitor Safinamide
7

8. ROLE OF SURGERY IN PARKINSON’S DISEASE......
1. Deep brain stimulation [DBS] DBS is a neurosurgical procedure
involving the implantation of a medical device called a brain
pacemaker. which sends electrical impulses, through implanted
electrodes, to specific parts of the brain[brain nucleus] for the
treatment of movement and affective disorders.
8

9. In Parkinson's disease, a part of the brain called
the globuspallidus is overactive. This causes a
decrease in the activity of a different part of
the brain that controls movement. In a
pallidotomy, the surgeon destroys a tiny part of
the globuspallidus by creating a scar.
2. Pallidotomy
ROLE OF SURGERY IN PARKINSON’S DISEASE......
9

10. AYURVEDIC TREATMENT
1. Turmeric Juice
2. Ginger Juice
3. Garlic Juice
4. Lemon Juice
5. Honey
6. Apple Cider Vinegar with Mother
2. PRX002
VACCINATION
1. PD01A
10

11. Gene therapy in Parkinson's disease consists of the creation of new cells that
produce a specific neurotransmitter (dopamine)
Gene therapy in Parkinson's disease
11

12. Stem-cell therapy is the use of stem cells to treat or prevent a disease or
condition.
Bone marrow transplant is the most widely used stem-cell therapy.
12

13. Parkinson's disease is a relatively common, progressive, movement disorder. Drugs only
provide symptomatic relief and give most patient an additional 3-6 years of happier and
productive life. Although there is no cure, there are several management options for the
early treatment of Parkinson’s disease. Conventional drug therapy is more effective and
economically beneficial than new drug thearapies. As the disease progresses, further
treatment options are available; however, the management of late-stage motor
complications and non-motor symptoms remains particularly challenging and will benefit
from further clinical research.
13

14. 1- World journal of pharmaceutical research “TREATMENT OF PARKINSON’S DISEASE”
volume 4,issue 8, 804-818.
2.http://www.oxforddictionaries.com/definition/english/Parkinson's-disease.
3.GBD 2013 Mortality and Causes of Death, Collaborators [17 December
2014]. "Global, regional, and national age-sex specific all-cause and cause-
specific mortality for 240 causes of death, 1990–2013: a systematic analysis
for the Global Burden of Disease Study., 2013; 385: 117–71.
4.http://www.prokerala.com/health/parkinsons-
disease/ayurveda-to-treat-parkinsons-disease.php.
5.http://herbaldaily.in/health_Benefits_haldi.html.
14

15. 15