Webinar Series on COVID-19 vaccine: Jointly organized by Malaysian Society of Infection Control and Infectious Diseases (MyICID) & Institute for Clinical Research (ICR), NIH
Speaker: Dr. Low Lee Lee, Infectious Disease Physician at the Hospital Sultanah Bahiyah, Ministry of Health Malaysia.
The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).
the ppt describes the pentavalent and trivalent according to the national immunisation program,india in an easy to understand and interactive form.useful for students and tutors.
also has a FAQ section.
This slide presentation historically, statistically and attractively explains various vaccines for covid19 available in India. (Please update the statistical data to current values)
Webinar Series on COVID-19 vaccine: Jointly organized by Malaysian Society of Infection Control and Infectious Diseases (MyICID) & Institute for Clinical Research (ICR), NIH
Speaker: Dr. Low Lee Lee, Infectious Disease Physician at the Hospital Sultanah Bahiyah, Ministry of Health Malaysia.
The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).
the ppt describes the pentavalent and trivalent according to the national immunisation program,india in an easy to understand and interactive form.useful for students and tutors.
also has a FAQ section.
This slide presentation historically, statistically and attractively explains various vaccines for covid19 available in India. (Please update the statistical data to current values)
Ebola virus disease (EVD; also Ebola hemorrhagic fever, or EHF), or simply Ebola, is a disease of humans and other primates caused by ebolaviruses. Ebola virus disease is a serious illness that originated in Africa, where there is currently an outbreak
Monkeypox is a rare zoonosis caused by monkeypox virus. This disease is similar to smallpox disease but with lesser severity. This disease is common among Africans. It can be prevented by avoiding contact with contaminated animal and human fluids as well as respiratory droplets. It require a multidisciplinary approach to achieve cure and prevention.
Scale up of Prevention of Mother to Child HIV Transmission Programme in Delhi...Anil Gupta
We are still using SD NVP prophylaxis even though there is enough evidence that multi-drug regimens are much better. NACO, MoHFW, Govt of India is implementing new PMTCT strategy in Delhi in 2013-14 which will eliminate Pediatric HIV infections in the coming years.The presentation highlights key features of the New PMTCT Strategy of the country.
Ebola virus disease (EVD; also Ebola hemorrhagic fever, or EHF), or simply Ebola, is a disease of humans and other primates caused by ebolaviruses. Ebola virus disease is a serious illness that originated in Africa, where there is currently an outbreak
Monkeypox is a rare zoonosis caused by monkeypox virus. This disease is similar to smallpox disease but with lesser severity. This disease is common among Africans. It can be prevented by avoiding contact with contaminated animal and human fluids as well as respiratory droplets. It require a multidisciplinary approach to achieve cure and prevention.
Scale up of Prevention of Mother to Child HIV Transmission Programme in Delhi...Anil Gupta
We are still using SD NVP prophylaxis even though there is enough evidence that multi-drug regimens are much better. NACO, MoHFW, Govt of India is implementing new PMTCT strategy in Delhi in 2013-14 which will eliminate Pediatric HIV infections in the coming years.The presentation highlights key features of the New PMTCT Strategy of the country.
AIDS and its vengeance saw a back seat after we achieved the zero level of growth for it. But worries regarding the people living with AIDS are still on and we need to take care of these segments in an integrated manner
HIV AIDS is one of the most dreadful of all diseases. Newer drugs and drug combination are coming quite frequently. Attempts to design an HIV vaccine is also underway.
This seminar is my attempt this interesting topic with all the latest data I could collect on the internet.
After the successful NSP 2017-2025,Goi is lauching NSP 2017-2025 for elimination of TB on 24th march( World TB day ) 2017. Module is on MOHFW site but i have try to keep it brief,hope its ll be useful specially for academic and administrative purposes.
These slides contain detailed description of HIV in children including : Introduction, Definition, HIV structure, Incidence, Impact of HIV on infant and child survival, Mode of transmission - Vertical transmission and horizontal transmission, Pathophysiology, Clinical features, Laboratory investigations, Management, Prevention, Nursing management, Nursing diagnosis.
This is a discussion of hepatitis B, hepatitis C and HIV in pregnancy, the optimal screening for these infections and the integration of management approach based on evidence. Lecture given during the 2018 PIDSOG post-graduate course "High-Yield OBGYN Infections 2.0: From Confusion to Clarity" at the Conrad Manila on November 12, 2018.
Dr. Laura Guay, the Foundation’s Vice President of Research, also conducted a journalist training today sponsored by the National Press Foundation, teaching reporters about some of the most misunderstood issues concerning HIV and children
management of childhood tuberculosis in 2023.pptxPathKind Labs
diagnosis of childhood TB is a challange, but if we follow a system of screening and then appropriate diagnostic tests following contact tracing, we are likely to identify children with infection or disease and put them on appropriate treatment.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
2. 1. Introduction
2. PPTCT
3. ICTC
4. ART
5. PEP
6. NACP-IV introduction
7. Care, Support and treatment
8. HIV-TB coinfection
9. Sentinel suviellence
3. India has the third largest HIV epidemic in the world.
In India (2016)
Approx. 2.5 million people living with HIV.
0.3% adult HIV prevalence.
86,000 new HIV infections.
HIV prevention in India- NACO is the body responsible for
prevention and control of the HIV epidemic in INDIA.
Current programme, NACP-IV (2012-2017) , aims to reduce the
HIV infections by 50%.
4.
5. The rate of HIV transmission during pregnancy, labor or
delivery from mothers infected with HIV is
25% - 30% with no interventions
But can be reduced
up to <2% with
appropriate intervention.
8. All pregnant women detected positive for HIV should be started
on life long ART irrespective of disease stage and CD4 count.
Preferred regimen-
Tenofovir 300mg + Lamivudine 300mg+ Efavirenz 600mg
Alternate regimen
Azathioprine + Lamivudine + Efavirenz,
Azathioprine + Lamivudine + Nevirapine,
Tenofovir + Lamivudine + Nevirapine
According to NACO guideline- Dec 2013
Previous it was single dose Nevirapine.
9. Daily Nevirapine
prophylaxis for 6 weeks
If mother
received ART
adequately in the
antenatal period
Daily Nevirapine
prophylaxis for 12 weeks
If mother has not
received ART
Received ART
for less than 24
weeks
OR
According to NACO guideline- Dec 2013
10. 1) Exclusive breastfeeding is the recommended infant feeding
choice in the first 6 months.
2) In situations where breastfeeding cannot be done (maternal
death, severe maternal illness) or individual mother’s choice (at
her own risk), then exclusive replacement feeding may be
considered only if AFASS Criteria for exclusive replacement
feeding is fulfilled.
3) After 6 months complementary feeding should be introduced
gradually.
4) MIXED FEEDING should NOT be done during the first 6
months. (Feeding a baby with both breast feeds and
replacement feeds in the first 6 months is known as mixed
feeding which leads to mucosal abrasions in the gut of the baby
facilitating HIV virus entry through these abrasions).
11. • Breastfeeding continued until 12 month of
age.
If EID Is negative
• Breastfeeding continue until the baby is 2
year old.
If EID Is positive
Breast-feeding should NOT be stopped ABRUPTLY
16. An ICTC is a place where a person is counseled and tested for
HIV, on his/her own will (self- initiated) or as advised by a
medical provider (provider- initiated).
Functions of ICTC
Early detection of HIV
provide basic information on modes of transmission and
prevention of HIV for promoting behavioural changes and
reducing vulnerability.
Linking PLHIV with other HIV prevention, care and
treatment services.
18. Public private partner (PPP) ICTC- These are established
in private facilities (NGOs, community based organizations,
federation of Self-Help Groups (SHGs), hospitals, nursing
homes, clinics and laboratories)
Infrastructure
A counselling room
Laboratory
Sample collection room
Manpower in an ICTC
ICTC manager
Counsellor
Laboratory technician
Outreach workers
19. Counselling in ICTC done by GATHER approach
G
A
T
H
E
R
Greet the client
Ask the problem
•Active listener
•Access degree of risk behavior
•Show respect and tolerance
•Enable patient to express freely
•Determine assess to support and help in family and
community
Tell the client about the specific information which
he/she desires
Help them to making decision
Explain the myths or misconceptions
Return for follow up or Referral
20.
21.
22. CLINICAL GOALS : Prolongation of life and improvement in quality of
life
VIROLOGICAL GOALS : Greatest possible reduction in viral load for as
long as possible
IMMUNOLOGICAL GOALS : Immune reconstitution both quantitative
and qualitative
THERAPEUTIC GOALS : Rational sequencing of drugs that achieves
clinical , virological and immunological goals while maintaining treatment
options limiting drug toxicity and facilitating drug adherence
REDUCTION OF HIV TRANSMISSION : By suppression of viral load
23. ART should be initiated in all adults, adolescent , pregnant and breast
feeding living with HIV regardless of WHO clinical stage and at any
CD4 cell count
As a priority, ART should be initiated in all with severe or advanced
HIV clinical disease{WHO clinical stage 3 and 4}and with CD4 count
<350cells/mm3
In infant and children younger than 10 years of age:
Infants diagnosed in the first year of life
Children living with HIV 1 year old to less than 10 year
Children <2 years and younger than 5 years of age with WHO clinical
stage 3 & 4 & or CD4 count <750 cells/mm3 and 5 years of age and
older with CD4 count <350 cells/mm3
24. FIRST LINE ART PREFFERED FIRST LINE
REGIMENS
ALTERNATIVE FIRST LINE
REGIMENS
ADULTS TDF+3TC[or FTC]+EFV AZT+3TC+EFV[OR NVP]
TDF+3TC[or FTC]+DTG
TDF+3TC[or FTC]+EFV
TDF+3TC[or FTC]+NVP
PREGNANT OR BREASTFEEDING
MOTHER
TDF+3TC[or FTC]+EFV AZT+3TC+EFV[or NVP]
TDF+3TC[or FTC]+NVP
ADOLESCENTS TDF+3TC[or FTC]+EFV AZT+3TC+EFV[or NVP]
TDF[or ABC]+3TC[or FTC]+DTG
TDF[or ABC]+3TC[or FTC]+EFV
TDF[or ABC]+3TC[or FTC]+NVP
CHILDREN 3 YEARS TO LESS
THAN 10 YEARS
ABC+3TC+EFV ABC+3TC+NVP
AZT+3TC+EFV[or NVP]
TDF+3TC[or FTC]+EFV[or NVP]
CHILDREN LESS THAN 3 YEARS ABC[or AZT]+3TC+LPV/r ABC[or AZT]+3TC+NVP
25. PHASE OF HIV
MANAGEMENT
RECOMMENDED
HIV DIAGNOSIS HIV TESTING
CD4 CELL COUNT
TB SYMPTOMS SCREENING
FOLLOW UP
BEFORE ART
CD4 CELL COUNT[EVERY 6-12 MONTHS IF ART IS DELAYED]
RECEIVING ART HIV VIRAL LOAD[AT 6 MONTHS AND 12 MONTHS THEN EVERY 12
MONTHS THEREAFTER]
SUSPECTED
TREATMENT
FAILURE
SERUM CREATININE
PREGNANCY TEST
26. FAILURE DEFINITION COMMENTS
CLINICAL NEW OR RECURRENT CLINICAL EVENT
[SEVERE IMMUNODEFICIENCY]AFTER 6
MONTHS
CONDITION MUST BE DIFFERENTIATED
FROM IRIS OCCURING AFTER INITIATING
ART
IMMUNOLOGICA
L
ADULTS & ADOLOSCENTS-
CD4 COUNT <250 CELLS/MM3
FOLLOWING CLINICAL FAILURE OR
PERSISTENT CD4 LEVELS BELOW 100
CELLS/MM3
CHILDREN-< 5 YEARS PERSISTENT CD4
LEVEL BELOW 200 CELLS/MM3
> 5 YEARS PERSISTENT CD4 LEVELS
BELOW 100CELLS/MM3
WITHOUT CONCOMITANT OR RECENT
INFECTION TO CAUSE A TRANSIENT
DECLINE IN THE CD4 CELL COUNT
VIROLOGICAL VIRAL LOAD ABOVE 1000 COPIES/ml
BASED ON TWO CONSECUTIVE VIRAL
LOAD MEASUREMENTS IN 3 MONTHS
WITH ADHERENCE SUPPORT FOLLOWING
THE FIRST VIRAL LOAD TEST
AN INDIVIDUAL MUST BE TAKING ART
FOR AT LEAST 6 MONTHS BEFORE IT CAN
BE DETERMINED THAT A REGIMEN HAS
FAILED
27. POPULATION FAILING FIRST –LINE
REGIMEN
PREFERRED SECOND
LINE REGIMEN
ADULTS AND
ADOLESCENTS
2 NRTIs+EFV[ or NVP]
2 NRTIs +DTG
2NRTIs +ATV/r or LPV/r
PREGNANT OR BREAST
FEEDING
2NRTIs+EFV[or NVP] 2NRTIs+ATV/r or LPV/r
CHILDREN
<3 years
>3 years to <10 years
2NRTIs+LPV/r
2NRTIs+NVP
2NRTIs+LPV/r
2NRTIs+EFV[or NVP]
2NRTIs+RAL
2NRTIs+LPV/r
2NRTIs+EFV
2NRTIs +LPV/r
If ABC+3TC orTDF(or FTC) was used in first-failing regimen , AZT +3TC should
be used in second line
28. POPULATION THIRD LINE REGIMEN
ADULTS AND ADOLESCENTS(>10
years)
DRV/r + DTG(or RAL)+1-2 NRTIs
PREGNANT OR BREASTFEEDING
WOMAN
DRV/r + DTG(or RAL)+1-2 NRTIs
CHILDREN(0-10 years) RAL(or DTG)+2 NRTIs
DRV/r+2 NRTIs
DRV/r + RAL(or DTG)+1-2 NRTIs
RAL can be used in children failing PI based treatment when DTG is not available
and when RAL has not been used in a previous regimen
DRV/r should not be used in children younger than 3 years of age.
30. "Post exposure prophylaxis" (PEP) refers to the
comprehensive management given to minimize the risk
of infection following potential exposure to blood-borne
pathogens (e.g.HIV,HBV,HCV).
It includes-
1. First aid
2. Counseling
3. Risk assessment Relevant laboratory investigations based on
informed consent of the source and exposed person.
4. Depending on the risk assessment, the provision of short term (4
weeks) of antiretroviral drugs.
6. Follow up and support.
33. • Immediately wash the wound with water
and soap.Skin
• Irrigate exposed eye immediately with
water or normal salineEye
• Spit fluid out immediately
• Rinse the mouth thoroughly, using water or
saline and spit again
Mouth
34. Mild exposure
• Mucus membrane
/non intact skin
with small volume
• e.g. superficial
wound with plain
or low calibre
needle
Moderate exposure
• Mucus membrane
/non intact skin
with large volume.
• cut or needle stick
injury penetrating
gloves.
Severe exposure
• Percutaneous with
large vol.
• An accident with
caliber needle
visibly
contaminated with
blood.
Step 2.1-assessing nature of exposure and risk of transmission
35. • PEP is not effective when given more than 72 hours after
exposure. A baseline rapid HIV testing should be done before
starting PEP.
• Initiation of PEP where indicated should not be delayed while
waiting for the results of HIV testing of the source of exposure.
• Informed consent should be obtained before testing of the
source as per national HIV testing guidelines.
PEP must be initiated as soon as possible, preferably within 2 hours
36. Source h.i.v
status
Definition of risk
h.i.v. negative Source is not h.i.v. infected
Low risk h.i.v positive and clinically asymptomatic
Moderate risk h.i.v. positive and clinically symptomatic
unknown Status of patient is unknown (risk assessment will be
based upon h.i.v. prevalence in that locality)
37. • The exposed individual should have confidential counseling and assessment
by an experience physician.
• The exposed individual should be assessed for pre-existing HIV infection
intended for people who are HIV negative at the time of their potential exposure
to HIV.
• Exposed individuals who are known or discovered to be HIV positive should
not receive PEP. They should be offered counseling and information on
prevention of transmission and referred to clinical and laboratory assessment
to determine eligibility for antiretroviral therapy (ART).
38. • Exposed persons should receive appropriate information about PEP and risk
and benefits of PEP in order to get informed consent.
• It should be clear that PEP is not mandatory.
• Psychological support: Many people will feel anxious after exposure. This
will help to relieve part of the anxiety, but some may require further
specialized psychological support.
.
39. • HIV testing of the source patient should not delay the decision about
whether or not to start PEP.
• In the case of a high risk exposure from a source patient who has
been exposed to or is taking antiretroviral medications, consult an
expert to choose the PEP regimen, as the risk of drug resistance is
high.
40. EXPOSURE HIV + AND
ASYMPOMATIC
HIV + AND CLINICALLY
SYMTOMATIC
HIV SATUS
UNKNOWN
MILD
Consider 2-drug PEP Start 2-drug PEP Usually no PEP or
Consider 2-drug PEP
MODERATE
Start 2-drug PEP Start 3-drug PEP Usually no PEP or
Consider 2-drug PEP
SEVERE
Start 3-drug PEP Start 3-drug PEP Usually no PEP or
Consider 2-drug PEP
Step 4.1-Deciding on PEP regimen
There are two types of regimens-
• Basic regimen: 2-drug combination (Zidovudine, Stavudine)
• Expanded regimen: 3-drug combination (Zidovudine, Stavudine, Lamivudine)
• All clients starting on PEP must take 4 weeks (28 days) of medication.
41. Step 4.2 Selection of the PEP regimen when the source patient is
known to be on ART:
The physician should consider the comparative risk represented by the
exposure and information about the exposure source, including-
history of and response to antiretroviral therapy based on clinical response,
CD4cell counts,
viral load measurements(if available)
current disease stage (WHO clinical staging and history).
When the source person's virus is known or suspected to be resistant to one or
more of the drugs considered for the PEP regimen, the selection of drugs to
which the source person's virus is unlikely to be resistant is recommended.
42. • All clients starting on PEP must take 4 weeks (28 days) of
medication.
• In all cases, the first dose of PEP should be offered as soon as
possible, once the decision to give PEP is made.
• HIV testing or results of the source HIV test can come later.
Step 4.3 Amount of Medication to dispense for PEP
43. The reason for HIV testing soon after an occupational exposure is to establish a
"baseline“ against which to compare future test results.
• If the person is HIV-negative at the baseline test, it is in principle possible to prove
that subsequent infection identified by follow-up testing is related to the occupational
exposure (Depending on the timing of infection and consideration of other risks or
exposures) .
• When offered HIV testing, the exposed person should receive standard pre-test
counseling according to the national HIV testing and counseling guidelines, and
should give informed consent for testing.
• Confidentiality of the test result must be ensured..
Do not delay PEP if HIV testing is not available.
Step 5 – Laboratory Evaluation
44. • An exposed person should be advised to use precautions (e.g., avoid
blood or tissue donations, breastfeeding, unprotected sexual relations or
pregnancy) to prevent secondary transmission, especially during the first
6-12 weeks following exposure. Condom use is essential.
Whether or not PEP prophylaxis has been started, follow up is indicated
to monitor for possible infections and provide psychological support.
Step 6- FOLLOW UP
LABORATORY FOLLOW UP
• Follow-up HIV testing: exposed persons should have post-PEP
HIV tests at the completion of PEP
• Therefore, testing at 3 months and again at 6 months is
recommended.
45. Adherence and side effect counseling should be provided and
reinforced at every follow-up visit. Psychological support and
mental health counseling is often required.
46.
47.
48. 1986=1st case of HIV detected
1992= NACP1= to slow down the spread
1999=NACP 2=focussing on behaviour change
2007=NACP3
2012=NACP 4
49. The epidemic continues to progress with the following
characteristics
High risk groups to low risk groups
Urban to rural areas
High prevalence states to all states
High vulnerability of young persons and women
MSM and IDUs not received appropriate attention
Growing number of people living with HIV/AIDS has
increased the need for care , support and treatment
50.
51.
52.
53. Providing psychosocial support to the infected and affected
individual esp. to marginalised woman and children affected by
epidemic
Ensure accessible, affordable and sustainable treatment services.
Free antiretroviral therapy
Prevention and treatment of opportunistic infections includingTB
Facilitating home based care and impact mitigation
54. Medicine Departments of Medical Colleges and District hospitals.
Based on prevalence of HIV in the region
Provide free comprehensive services including ART, CD4
testing & drugs required for treatment of Opportunistic Infections.
“306 centres providing freeART to more than 4,12,125 patients in
India”.
55.
56. Main constraints-- Distance, travel time and costs to access ART
services and adherence to treatment.
Leads to--Poor drug adherence, lost to follow up and missed cases.
Make -- Accessible and facilitate delivery of ARV drugs, Link ART
Centres are established , located at district level hospitals nearer to the
patient’s residence.
Located -- Integrated Counseling and Testing Centres (ICTC) which
further helped in linkage between ICTC and ART
April 2011-- “612 Link ART Centres facilitate delivery of services
nearer to the patients homes”
57. Patients needed to travel long distance to access the second line
treatment. This issue has resulted in low uptake of second line treatment.
In View of these, it was decided to expand the number of facilities that
can provide second line ART.Previously till 2009 it was given in 2 COE.
For this, some good functioning ART Centres were upgraded & labelled
as ‘ART Plus Centres’
58.
59. OBJECTIVES:
To improve health seeking behaviour of high risk groups
Reduce their risk of acquiring STI and HIV infections.
HIGH RISK GROUP INCLUDES:
Female sex workers
Men who have sex with men
transgenders
Injecting drug users
Bridge population include high risk behaviour migrant and long
distance truckers.
60. SERVICES OFFERED UNDERTHETARGETED
INTERVENTION PROGRAMME
Detection and treatment for sexually
transmitted infections.
Condom promotion and distribution
behaviour change communication
Creating and enabling environment with
community involvement and participation
Linkages to integrated counselling and
testing centres
Linkages with care and support services for
HIV positive HRGs
Community organization and ownership
building
Specific interventions for IDUs
1. Distribution of clean needles and syringes
2. Abscess prevention and management
61.
62. National blood transfusion(NBTA) to be set up as an autonomous body.
Establishment of Centre of Excellence in Transfusion Medicine in
four metro cities of Delhi, Kolkata, Mumbai and Chennai.
Approval for setting up of one Plasma Fractionation Centre has
been obtained, for processing of 1.5 lakh litres of plasma
annually. Land for this purpose has been provided at Chennai.
Achieve 90% of the annual requirement of blood by voluntary
donation.Presently -79.2%
80% of blood collected to be converted to components for appropiate
use.Presently - 155 BCSU with 52% conversion
Standardisation of testing protocol & reagents /kits in use.
Establish blood storage centres in community care centres.
Provide refrigerated vans in 500 districts for networking with blood storage
centres.
63. It is a mandate to strengthen all public health facilities at and above
district level as designated STI/RTI clinics, with the aim to have at least
one NACO supported clinic per district.
Presently - 1,033 designated STI/RTI clinics which are providing STI/RTI
services based on the enhanced syndromic case management. 90 new
clinics to be set up.
Strengthen 7 regional STI training, reference and research centres.
Role of these centres is to provide etiologic diagnosis to the STI/RTI
cases, validation of syndromic diagnosis, monitoring of drug résistance to
gonococci and implementation of quality control for Syphilis testing.
Safdarjung Hospital acts as the Apex Centre in the country.
STI CLINICS
64. Increase condom use during sex with non-regular partner, which is
the key to limiting HIV spread through sexual route.
Increase the number of condoms distributed by social marketing
programmes.
Increase the number of free condoms distributed through STI and
STD clinics, reaching those who are at the highest risk of acquiring or
transmitting HIV.
Increase access to condoms, especially to men who have sex with
non-regular partners.
Increase the number of non-traditional outlets for socially marketed
condoms, e.g., paan shops, lodges, etc. in strategically located
hotspots
CONDOMS NACP IV
Condom promotion continues to be an important prevention strategy
65.
66. P=PRACTICE SAFE SEX
R=REMOVE MYTHS /MISCONCEPTIONS
E=ENSURE EARLY DETECTION & t/t OF CASES
V= VERTICAL TRANSMISSION TO BE PREVENTED
BY APPROPRIATE CONTRACEPTION
E=ENSURE USE OF STERILISED NEEDLES
N=NEGOTIATION SKILL TO BE DEVELOPED
T=TRANSFER ONLY SCREENED BLOOD /BLOOD
PRODUCTS/ORGAN TRANSPLANTS
I=I.E.C FACILTIY
O=OPEN/ONGOING DISCUSSION WITH THE YOUTH
N=NOTIFICATION /TRACING OF PARTNER
67. Programme Title Days
Rural Youth 5 Down MohabbatExpress Monday-Tuesday
Rural women Babli Boli Wednesday-Thursaday
Migrant Youth Kitney Dur Kitney Pass Saturday -Sunday
RADIO PROGRAMMES AIRED BY NACO
68.
69. • Red, like love, as a symbol of passion and tolerance towards those affected.
• Red, like blood, representing the pain caused by the many people that died of
AIDS.
• Red, like the anger about the helplessness by which we are facing a disease for
which there is still no chance for a cure.
• Red as a sign of warning not to carelessly ignore one of the biggest problems
of our time.“ to carelessly ignore one of the biggest problems of our time."
70.
71. TB and HIV co-infection is when people have
both HIV infection, and also either latent or
activeTB disease. Each disease speeds up the
progress of the other.
The estimated 10% activation of dormantTB
infection over the lifespan of an infected person,
increases to 10% in one year, if HIV infection is
superimposed.
TB is one of the most commonly occurring
opportunistic infections in HIV infected patients.
72. HIV and TB interact in several ways:
- Reactivation of latent infection.
- Primary infection.
- Recurring infection.
- In the community.
73. “When a virus (HIV) and a bacteria (TB) can
work so well together, why can't we?”
- UNAIDS
74. 1. Huge dual burden of both HIV andTB.
2. High mortality ofTB-HIV coinfection.
3. Large country with heterogeneous HIV
epidemic. Health system capacity varies
tremendously.
4. Late diagnosis of HIV.
5. Leaky care cascade for HIV: difficult to track LFU.
6. Airborne infection control difficult due to over-
congested health facilities.
75.
76.
77. Purpose:The overall purpose is to articulate the national
policy forTB/HIV Collaborative Activities between RNTCP and
NACP so as to ensure reduction ofTB and HIV burden in India.
Objectives:
1. To maintain close coordination between RNTCP and NACP at
National, State and District levels.
2. To decrease morbidity and mortality due toTB among
persons living with HIV/AIDS
3. To decrease impact of HIV inTB patients and provide access
to HIV related care and support to HIV-infectedTB patients.
4. To significantly reduce morbidity and mortality due to HIV/TB
through prevention, early detection and prompt management
of HIV andTB together.
78.
79.
80.
81.
82.
83.
84. CD4 cell count ART recommendation
Timing of ART in
relation to treatment
for MDR-TB
≤ 350 cells/cu mm Recommend ART After 2 wk, as soon as
the t/t for MDR-TB is
tolerated.
> 350 cells/cu mm Defer ART Re-evaluate patient
monthly for
consideration of ART.
CD4 testing is
recommended every 3
months during t/t for
MDR-TB.
Not available Recommend ART After 2 wk, as soon as
the t/t for MDR-TB is
tolerated.
85. Started from February 1, 2017.
People who have been tested positive for HIV, and those affected
with tuberculosis, have to collect Fixed Dose Combination (FDC)
from district hospital and ART centre to be taken on a daily basis.
Daily supply of FDC, instead of thrice a week, has been introduced
under the 99 DOTS (Directly ObservedTreatment, Short-Course)
scheme.
The scheme is called 99 DOTS because it has 99% chances of cure of
the patients taking the medical course.
Under this initiative, medicines for 28 days will be given to the
patient and there will be a tab on the consumption of the medicines.
Patient medication is packaged envelopes with dosage instructions,
and a series of hidden numbers behind the pills. Each time a patient
takes a dose of medication, he will have to call on the number and if a
call is not received at the centre, he is called on the registered mobile
number to remind him about the dosage.
86.
87.
88.
89.
90. To determine the level of HIV infection among general
population as well as HRGs in different states.
To understand the trends of HIV epidemic among
general population as well as HRGs in different states.
To understand the geographical spread of HIV
infection and to identify emerging pockets.
To provide information for prioritisation of
programme resources and evaluation of programme
impact.
To estimate HIV prevalence and HIV burden in the
country.