Periapical inflammatory lesions occur as a local bone response around the apex of a tooth due to necrosis of the pulp or destruction of periapical tissues by periodontal disease. This includes conditions like acute/chronic apical periodontitis, periapical abscess, and periapical granuloma. Clinically, these lesions range from being asymptomatic to causing toothache, facial swelling, fever and lymphadenopathy. Imaging shows lytic or sclerotic changes around the apex that start within the periodontal ligament space and often have ill-defined borders, representing inflammation of the bone (osteitis) and resorption of bone (rarefaction).