This document presents the development and validation of an RP-HPLC method for the simultaneous determination of ramipril and amlodipine in tablets. The method utilizes a C18 column with a mobile phase of acetonitrile, sodium perchlorate buffer and triethylamine at pH 2.6 and 55°C. Ramipril and amlodipine were well resolved with retention times of 5.2 and 9.8 minutes respectively. The method was validated per ICH guidelines and demonstrated selectivity, linearity, accuracy, precision, robustness and ability to detect ramipril and amlodipine in the presence of degradation products. Forced degradation studies showed the drugs were stable except under acidic and alkaline conditions