Mrs. Dipali M.K. Kulkarni is an assistant professor at the Yash Institute of Pharmacy in Aurangabad. Astringents are agents that are applied locally and cause protein precipitation on surfaces. They constrict tissues and reduce cell permeability by contracting and wrinkling tissues as well as constricting local blood vessels and inhibiting the movement of plasma proteins through capillaries. The net effects of astringents are that they have anti-inflammatory, hemostatic, and antimicrobial properties by decreasing blood supply, coagulating proteins to decrease bleeding, reducing sweating by shrinking skin pores, and inhibiting microbes through protein precipitation reactions.

1. Mrs. Dipali M.Kulkarni,
Assistant Professor,
Yash Institute of Pharmacy,
Aurangabad.
ASTRINGENTS

2. ASTRINGENTS
Agents which are applied locally and gives surface protein
precipitation action.
Cause contraction and wrinkling of the tissue
Reduces the cell permeability
Constrict the local blood vessels
Inhibit the transcapillary movement of plasma protein

3. The net effects:
Anti-inflammatory
effect – by decreasing
blood supply to site of
injury
Decrease blood lose
by coagulating plasma
protein
Antiperspirant effect –
by decreasing
secretion of sweating
by decreasing the size
of pores of skin
Antimicrobial – by
protein precipitation
reaction in microbes

13. Thank you