This document discusses radiographic interpretation and describes how to analyze lesions seen on radiographs. It explains that radiographs along with clinical information are used to formulate a differential diagnosis. It then describes the normal radiographic anatomy seen on x-rays. The document outlines a systematic process for interpreting periapical radiographs which involves describing the size, shape, location, density, borders, internal architecture, and effect on adjacent structures of any lesions. Specific examples are provided for analyzing each of these characteristics to determine possible diagnoses.