EBCTCG METAANALYSIS
INDICATION OF POST OP RADIOTHERAPY
Immobilization devices
Conventional planning
Alignment of the Tangential Beam with the Chest Wall Contour
Doses To Heart & Lung By Tangential Fields
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
A Predictive Factor For Short-Term Outcome In Patients With COVID-19: CT Scor...JohnJulie1
This study enrolled 253 patients (63 died in the hospital, 190 were discharged). Compared to survivors, non-survivors were older, mostly male, had a higher prevalence of preexisting comorbidity, higher incidences of hypoxemia, lymphopenia and bacterial coinfection (p<0.001 for each). Regarding CT evaluations, non-survivors had higher CT scores (14.3±3.4 vs. 8.1±2.9), higher incidences of bronchial dilation with mosaic (34.9% vs. 10.5%), emphysema (28.6% vs. 10.5%), and diffuse opacity distribution (76.1% vs. 36.8%; all p<0.001).
A Predictive Factor For Short-Term Outcome In Patients With COVID-19: CT Scor...suppubs1pubs1
This study enrolled 253 patients (63 died in the hospital, 190 were discharged). Compared to survivors, non-survivors were older, mostly male, had a higher prevalence of preexisting comorbidity, higher incidences of hypoxemia, lymphopenia and bacterial coinfection (p<0.001 for each). Regarding CT evaluations, non-survivors had higher CT scores (14.3±3.4 vs. 8.1±2.9), higher incidences of bronchial dilation with mosaic (34.9% vs. 10.5%), emphysema (28.6% vs. 10.5%), and diffuse opacity distribution (76.1% vs. 36.8%; all p<0.001).
A Predictive Factor For Short-Term Outcome In Patients With COVID-19: CT Scor...suppubs1pubs1
This study enrolled 253 patients (63 died in the hospital, 190 were discharged). Compared to survivors, non-survivors were older, mostly male, had a higher prevalence of preexisting comorbidity, higher incidences of hypoxemia, lymphopenia and bacterial coinfection (p<0.001 for each). Regarding CT evaluations, non-survivors had higher CT scores (14.3±3.4 vs. 8.1±2.9), higher incidences of bronchial dilation with mosaic (34.9% vs. 10.5%), emphysema (28.6% vs. 10.5%), and diffuse opacity distribution (76.1% vs. 36.8%; all p<0.001).
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
3. 60 y/o F with stage IIIb non-small cell lung cancer Before 2 months after completion of R/T 9 months after completion of R/T
4.
5. HRCT findings in Lymphangitic Carcinomatosis Interlobular septal thickening, thickening of fissures and thickening of the peribronchovascular interstitium (bronchial cuffing). Depending on filling with fluid or with tumor cells, septal thickening is irregular or smooth.
6. Subacute hypersensitivity pneumonitis The key findings in the subacute hypersensitivity pneumonitis are: ill-defined centrilobular nodules of ground-glass opacity (80% of cases) or mosaic pattern of a combination of patchy ground-glass opacity due to lung infiltration and patchy lucency due to bronchiolitis with air trapping
10. Factors predicting radiation pneumonitis in lung cancer patients a retrospective study Radiotherapy and Oncology 67 (2003) 275–283 Tiziana Rancatia, Giovanni Luca Ceresolib, Giovanna Gagliardic, Stefano Schipanib, Giovanni Mauro Cattaneod, * Physics Department, University of Milano, Via Celoria 16, 20133, Milan, Italy; Radiochemotherapy Department, Scientific Institute H.S. Raffaele, Via Olgettina 60, 20132 Milan, Italy; Department of Hospital Physics, Karolinska Hospital, Stockholm, Sweden ; Medical Physics Department, Scientific Institute H.S. Raffaele, Via Olgettina 60, 20132 Milan, Italy Purpose: To evaluate clinical and lung dose–volume histogram based factors as predictors of radiation pneumonitis (RP) in lung cancer patients (PTs) treated with thoracic irradiation
11.
12.
13. Probit model (Lyman) TD 50 (1) : the tolerance dose for reference volume irradiation m : the steepness slope of the dose response curve V ref : the reference volume n : tissue-specific parameter
24. Epidemiology Ref.: UpToDate: Radiation-induced lung injury Clinical pneumonitis Radiographic abnormalities Breast ca. 0 ~ 10 % 27 ~ 40 % Lung ca. 5 ~ 15 % 66%
25.
26. Capillary lumen Type I pneumocyte Type I pneumocyte Type II pneumocyte Endothelium Alveolar space Type II pneumocyte secreting surfactant: lower surface tension
27.
28.
29.
30.
31. Grading of Acute Pneumonitis Ref.: Semin Oncol 32(Suppl 3): S42-S54. Int j Radiation Oncology biol Phys 63(1):5-24. ADL: activities of daily living Radiation Therapy Oncology Group South-West Oncology Group National Cancer Institute
32. Grading of Late Lung Toxicity Ref.: Semin Oncol 32(Suppl 3): S42-S54.
41. RESULTS: The median time between radiotherapy completion and FDG-PET imaging was 47 days (range, 34-71 days). The removal of the tumor volume from analysis was possible using a threshold planning dose . The median of the mean standard uptake value in the lung that received 0-5 Gy was 0.51 (range, 0.35-1.15), 5-10 Gy was 0.77 (range, 0.40-1.36), 10-20 Gy was 0.80 (range, 0.40-1.69), and >20 Gy was 1.08 (range, 0.55-2.70). A hierarchical linear regression model of the radiation dose and normalized FDG uptake per case found an adequate fit with the linear model . The 18 cases had a posterior mean of slopes range of 0.0011-0.064. The slope of this relationship varied over an order of magnitude, reflecting the range of the underlying pulmonary biological response to radiation among the study population .
![Effects of Radiation Therapy on the Lung: Radiologic Appearance ,[object Object],[object Object],[object Object],[object Object],[object Object]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)