The cerebral cortex is divided into four lobes - the frontal, parietal, occipital and temporal lobes. Each lobe has a primary area that receives sensory input or sends motor commands, and association areas that integrate information from different areas for higher-level functions. The frontal lobe is involved in motor control and complex cognition. Damage to Broca's area in the frontal lobe causes Broca's aphasia, characterized by difficulties with speech production. The parietal lobe processes somatosensation and the occipital lobe processes vision. The temporal lobe is involved in hearing and memory formation. Within the temporal lobe, Wernicke's area is important for language comprehension and damage causes Wernicke's aph
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The Brocas area is located in the frontal part of the brain on the.pdfannaistrvlr
The Broca\'s area is located in the frontal part of the brain on the left hemisphere. ... Thus, when
Broca\'s aphasia occurs, it can have a debilitating effect on the person\'s communication skills.
The damage forces people to speak in fragmented sentences that include only nouns and verbs.
The Wernicke\'s area is located in the temporal lobe on the left side of the brain and is
responsible for the comprehension of speech (Broca\'s area is related to the production of
speech). ... When this area of the brain is damaged, a disorder known as Wernicke\'s aphasia can
result
The ventral stream is associated with object recognition and form representation. Also described
as the \"what\" stream, it has strong connections to the medial temporal lobe(which stores long-
term memories), the limbic system (which controls emotions), and the dorsal stream (which
deals with object locations and motion).All the areas in the ventral stream are influenced by
extraretinal factors in addition to the nature of the stimulus in their receptive field. These factors
include attention, working memory, and stimulus salience. Thus the ventral stream does not
merely provide a description of the elements in the visual world—it also plays a crucial role in
judging the significance of these elements.Damage to the ventral stream can cause inability to
recognize faces or interpret facial expression
The function of the dorsal pathway is to map auditory sensory representations onto articulatory
motor representations. Hickok & Poeppel claim that the dorsal pathway is necessary because,
\"learning to speak is essentially a motor learning task. The primary input to this is sensory,
speech in particular. So, there must be a neural mechanism that both codes and maintains
instances of speech sounds, and can use these sensory traces to guide the tuning of speech
gestures so that the sounds are accurately reproduced.Conduction aphasia affects a subject\'s
ability to reproduce speech (typically by repetition), though it has no influence on the subject\'s
ability to comprehend spoken language. This shows that conduction aphasia must reflect an
impairment of the ventral pathway but instead of the dorsal pathway. Hickok and Poeppel found
that conduction aphasia can be the result of damage, particularly lesions, to the Spt (Sylvian
parietal temporal). This is shown by the Spt\'s involvement in acquiring new vocabulary, for
while experiments have shown that most conduction aphasiacs can repeat high-frequency, simple
words, their ability to repeat low-frequency, complex words is impaired.
Hippocampal damage can result in anterograde amnesia: loss of ability to form new memories,
although older memories may be safe. Thus, someone who sustains an injury to the hippocampus
may have good memory of his childhood and the years before the injury, but relatively little
memory for anything that happened since.
Solution
The Broca\'s area is located in the frontal part of the brain on the left hemispher.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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3. The role of the cerebral
cortex
The cerebral cortex is the part of the brain that
is responsible for such higher mental
processes as thinking, perceiving and
remembering.
4. Lobes of the cerebral cortex
The four lobes are:
The frontal lobe
The parietal lobe
The occipital lobe
The temporal lobe
5. So What Makes Up A Lobe?
Primary area- Each lobe has a primary area,
which may be motor or sensory. These areas
are involved in receiving sensory messages or
sending movement messages to muscles.
Association area- Each lobe also has
association areas, which are involved in higher
order brain functions such as learning,
memory, thought and language. They receive
information from primary sensory areas and
from the lower parts of the brain. Association
areas make up 75% of the cerebral cortex.
6. The Frontal Lobe
The Frontal lobe is the largest lobe. It is located at the
front of the cerebral cortex.
It contains the motor cortex. The motor cortex is a
narrow strip, located at the back of the frontal lobe, in
front of the central fissure. The motor cortex controls
virtually all INTENTIONAL bodily actions.
7. Structures Within the Frontal Lobe
Premotor area-
Located immediately
in front of the primary
motor area, and is
one of the secondary
areas of the frontal
lobe. The premotor
area selects
movements in
response to external
cues.
8. Structures Within the Frontal Lobe
Supplementary motor
areas- Located in
front of the primary
motor area next to the
premotor area. The
supplementary area
selects movements in
response to internal
events.
9. The Association Area of the Frontal
Lobe
Prefrontal cortex- The association area- The
prefrontal cortex refers to all of the cortical
tissue that lies in front of the premotor cortex
of the frontal lobes. It receives sensory input
from other cortical lobes. This means that
sensory information is involved in the cognitive
processes of planning, selecting and carrying
out behaviours.
10. An Example of the Association Area in
Action
E.g. The process of passing a ball to a teammate during
a game of netball not only requires the selection and
execution of the appropriate movements, but also
knowledge about your environment. All the planning
necessary for this behaviour relies on information
received from external circumstances.
11. Association Area
Another source that may affect the planning of
movements comes from internal sources, such
as memory and emotion. The frontal lobes are
believed to be involved in memory formation,
personality and the control and expression of
emotions, although our understanding of this
process is limited.
The prefrontal lobe is capable of integrating
information from both internal and external
sources in order to plan behaviour.
12. Broca’s Area
Broca’s area is located in the LEFT Frontal
lobe.
It is located close to the motor cortex, near the
areas responsible for the muscles of the face,
tongue, jaw and throat.
13. Broca’s Area
It is named after the French neurologist Pierre Broca
(1824- 1880), as he is considered the person who first
identified its function.
Broca treated a man named ‘Tan’. Tan had experienced
a number of strokes and as a result his verbal
communication was limited to ‘tan- tan’, however, he
could comprehend what others said to him. After Tan
passed away Broca examined his brain.
Broca conducted examined the brains of other clients
(after they died!) who displayed similar symptoms to Tan
all had damage to this part of the brain.
14. Broca’s Area
Broca’s area is responsible for/ plays a part in:
Coordinating messages to the parts of the
body that allow you to produce speech in a
clear and fluent manner.
Interacting with areas of the cerebral cortex
involved in deriving meaning from language,
sentence structure and grammar.
15. Broca’s Aphasia
Damage to Broca’s area leads to a condition called Broca’s
aphasia, which is characterised by difficulties with speech
production but generally not with speech comprehension. The
language of Broca’s aphasia patients provides only the
content- the nouns, adjectives, verbs and adverbs.
Patients have difficulty using functional words that provide
grammatical meaning, such as on, and, at and about.
Other language abilities that aren’t dependent on speech
such as reading and writing, do not seem affected by damage
to Broca’s area.
Evidence also suggests that speech comprehension can be
impaired when the usual order of words has been changed.
17. Parietal Lobe
Extending towards the back
of the brain is the parietal
lobe. The parietal lobe is
involved in the functions
such as the sense of touch,
detection of movement, the
location of objects in the
surrounding environment and
the sensations felt by the
body as it moves. As with the
frontal lobe, the parietal lobe
has primary, secondary and
association areas.
18. Primary Somatosensory Cortex
Primary somatosensory cortex-
Is located at the front of the
parietal lobe. It receives
information about what the body
is touching and feeling. It is
organised in a contralateral
manner. The sensory input
comes from the tracts of neurons
that extend from the spinal cord
up through the hindbrain and
midbrain.
The area of cortex relates to the
sensitivity of the body part.
20. Secondary and Association
Areas
Posterior parietal cortex
Input from other areas of the brain is
integrated in this secondary and association
area to inform sensational experiences.
The other functions include visual attention
and spatial reasoning.
21. Occipital Lobe
The Occipital
lobe is located
behind the
Parietal lobe,
towards the
back of the
cortex. It is the
smallest of the
four lobes.
22. Primary Visual Cortex
The primary visual cortex is
responsible for the initial
processing of visual
information by the brain. The
primary visual cortex
receives information via a
pathway of neurons that
extends from a part of the
brain known as the
thalamus, which transmits
information directly from the
optic nerve at the back of
the eye.
23. Primary Visual Cortex
Information received from the visual cortex is
organised in a contralateral manner. The left
primary visual cortex receives information from
the left visual field, not the left eye and vice
versa.
The primary visual area does not devote equal
amounts of the cortex to all parts of the visual
field. Most of the cortex is devoted to stimuli in
the centre of the visual field than to the
peripheral aspects of the field.
25. Association Areas
To see an object as a whole, rather than its
components the visual information needs to be
further processed in the secondary and
association areas of the occipital lobe.
26. Temporal Lobe
The temporal lobe contains
the primary auditory cortex.
The primary auditory cortex
is involved with the sense of
hearing. The primary auditory
cortex is organised in bands
according to the frequency of
sounds to which they
respond. Bands at the front
respond to low frequency
sounds, the bands at the
back to high frequency
sounds.
27. Primary Auditory Cortex
The area of the cortex is disproportionate, with
middle frequencies having a greater amount of
cortex space dedicated to them. This is
because they are the frequencies generally
used in speech.
28. Secondary Areas
The several areas of secondary auditory
cortex surround the primary auditory cortex.
How these areas function is not fully
understood, but are believed to be activated in
response to more complex sounds. May be
involved in the detection of pitch, change in
frequency, identifying the location of sound in
the environment.
29. Association Area
The association areas is significant in
size. The area towards the back of the
temporal lobe, near the occipital lobe is
thought to be involved in the
labelling/naming of visual stimuli and
coupling visual and auditory stimuli. Other
areas are involved in memory formation
and emotions. The closeness of memory
and emotion areas may explain the link
between recalling memories and emotions
The temporal lobe appears to have a
significant role in memory, including
receiving, processing and storing
memories. Different types of memory are
involved, they are: semantic, procedural
and episodic memories.
30. Wernicke’s Area
The primary function of Wernicke’s area is to
interpret sounds, primarily the sound of human
speech. It is located near the auditory cortex
and emphasising the link between hearing and
language. It is located in the left hemisphere. It
seems to play a central role in associating the
sound of a word with its meaning. It could also
be where memories for the sounds that make
up words are stored. Wernicke’s area may
also control other areas involved in speech
production, such as Broca’s area.
31. Wernicke’s Aphasia
When someone has lesions in
Wernicke’s area they are said to
suffer Wernicke’s aphasia.
Speech is still fluent, but the
content is disrupted. They tend
to make sound substitutions or
word substitutions. They
typically have trouble with
understanding information the
read or see.
They express a “word salad”
32. Cerebellum
The Cerebellum is part of the
hindbrain. It is important for balance
and coordination.
More recent research also indicates
that it also plays a role in attention and
timing (including sensory timing).
People with damage to the cerebellum
have trouble shifting their attention
between auditory and visual stimuli.
An example of how timing may be
affected is that they may have trouble
distinguishing the pace of two rhythms
(i.e. Which one is faster).