Protein structure-based design and engineering can provide insights into protein function and improve protein properties through molecular modelling and targeted mutations. Molecular modelling generates 3D protein structures from sequences to understand structure-function relationships and identify active sites, domains, and other structural features. It also enables large-scale in silico mutation screening to focus experimental efforts on the most promising recombinant protein variants for applications in health, environment, and technology.

2. Protein-based Technologies are widely used in our daily life Molecular Modelling Mini Tutorial Health Environment Technology

3. Proteins Enzymes and Peptides are made of a sequence of aminoacids 1 MASPFALLMV LVVLSCKSSC SLGCDLPETH SLDNRRTLML LAQMSRISPS SCLMDRHDFG 61 FPQEEFDGNQ FQKAPAISVL HELIQQIFNL FTTKDSSAAW DEDLLDKFCT ELYQQLNDLE 121 ACVMQEERVG ETPLMNADSI LAVKKYFRRI TLYLTEKKYS PCAWEVVRAE IMRSLSLSTN 181 LQERLRRKE This is the sequence of a well known protein. Can you guess what it is, what it does and how it performs it function? Molecular Modelling Mini Tutorial

4. Protein function can be understood by its 3D molecular structure Protein structures can be determined by: X-ray NMR Homology Modelling Molecular Modelling Mini Tutorial

6. Bimolecular Modelling can help you! Active site Protein-protein aggregation site Conserved domain Mobile domain Hydrophobic patch Molecular Modelling Mini Tutorial We model a 3D structure from your sequence , and provide detailed structural and dynamic insights concerning it’s function

7. What about engineering improved protein function and structure? We can perform large scale aminoacid mutation screening , so you can focus your effort on the most promising recombinant proteins. Molecular Modelling Mini Tutorial Focus your effort on the most promising recombinant proteins predicted by our computer-aided protein structure design platform