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Kegg

The document describes several key databases within the KEGG resource, including: - The PATHWAY database containing molecular network maps of metabolic and genetic pathways. - The BRITE database providing hierarchical classifications of biological systems beyond what is shown in pathways. - The LIGAND database consisting of chemical compounds, carbohydrates, reactions, and enzyme information. KEGG aims to comprehensively capture biological knowledge through integrated databases covering genomes, pathways, diseases and drugs.

Education◦
BHARATHIDASAN UNIVERSITY DEPT OF BIOINFORMATICS PRESENTED BY: S.VIJAY MSFBI1521 .
INTRODUCTION • KEGG (Kyoto Encyclopedia of Genes and Genomes) is a series of databases developed by both the Bioinformatics Center of Kyoto University and Human Genome Center of the University of Tokyo. • This database has been available for over 10 years • The “Pathway” section of KEGG consists mainly of metabolic pathways. • URL: http://www.genome.jp/kegg/
CONTINUE…. • KEGG is a collection of biological information compiled from published material • Includes information on genes, proteins, metabolic pathways, molecular interactions, and biochemical reactions associated with specific organisms • Provides a relationship (map) for how these components are organized in a cellular structure or reaction pathway. • The Good: Information is reliable! • The Bad: Information is not available for many organisms.
19 KEGG Databases Systems information (6) • PATHWAY, MODULE: Network information • BRITE: Hierarchical classification • DISEASE, DRUG, EDRUG: Medical and pharmaceutical information
Genomic information (7) •ORTHOLOGY: Orthology for functional annotation •GENOMES: Entrance of all information for each species •GENES, DGENES: Genes for complete and draft genomes •SSDB: All to all sequence similarity score and best-hit information •EGENES, MGENES: Genes for EST assemblies and metagenomes
Chemical information (6): •COMPOUND: Chemical compounds in metabolic pathways •GLYCAN: Carbohydrate structures •REACTION: Chemical reactions in metabolic pathways •RPAIR, RCLASS: Reactant pairs and patterns from REACTION •ENZYME: IUPAC Enzyme nomenclature
KEGG2 search
KEGG2 Search Results
KEGG2 Search Results
PATHWAY DATABASE KEGG PATHWAYS: represent molecular relationships and reactions networks. These networks can be grouped as follows: 1. The set of chemical reactions (metabolism) that happen in living organisms. These processes allow organisms to grow, reproduce and respond to their environment. 2. Genetic information processing, such as DNA replication. 3. Environmental information processing, such as signalling molecules and interactions. 4. Cellular processes, such as the growth and death of cells.
PATHWAY DATBASE INFORMATIONS • Metabolism • Genetic Information Processing • Environmental Information Processing • Cellular Processes • Human Diseases • Drug Development
Pathway text search results
BRITE DATABASE • A collection of hierarchical classifications showing knowledge of various aspects of biological systems. • In comparison with KEGG PATHWAY, KEGG BRITE provides many different types of relationships not shown in KEGG PATHWAYS, so that KEGG BRITE can be viewed as a global picture of KEGG PATHWAYS • INFORMATIONS  Genes and Proteins  Compounds and Reactions  Drugs and Diseases  Cells and Organisms
LIGAND DATABASE  Consisting of chemical building blocks for endogenous and exogenous substances.  It is a composite database consisting of COMPOUND, GLYCAN, REACTION, RPAIR, RCLASS, and ENZYME databases
Disease and Drug Information in KEGG
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