This document discusses premature luteinization (PL), defined as a rise in progesterone on the day of hCG administration in IVF. It outlines that the incidence of PL varies widely in studies from 13-71% due to different definitions and protocols. Several hypotheses for the pathogenesis of PL are presented, including elevated LH levels and increased LH receptor sensitivity. The impact of PL on IVF outcomes is controversial, with some studies finding negative effects and others no effect. The document concludes by recommending prospective studies are needed to better understand the role of progesterone elevation on IVF success rates and provides suggestions for preventing PL during treatment.