In vitro fertilization embryo transfer

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In vitro fertilization embryo transfer

  1. 1. A seminar on IN VITRO FERTILIZATION-EMBRYO TRANSFER (IVF-ET)Presented byNIYAMAT M. PANJESHA Modern College Of Arts , Science & Commerce. Shivajinagar, Pune-05.
  2. 2. WHAT IS IVF? In vitro fertilization broadly deals with “the removal of egg’s from a women, fertilizing them in the laboratory, and transferring the fertilized eggs (zygotes) into the uterus a few days later.
  3. 3. WHY IVF? Infertility: Extremely Prevalent Definition: inability to achieve pregnancy 17-26% of couples worldwide (90 million women) 27-47% of infertile couples have impaired male fertility; decline in semen quality worldwide over last 50 years
  4. 4. WHY THE INCREASE IN INFERTILITY? Delayed marriage and child-bearing Sexually transmitted diseases Hormonal contraception Abortion Obesity Environmental Pollution
  5. 5.  Male infertility Female infertility
  6. 6. IVF: HISTORY In vitro fertilization (IVF) is a fertility procedure which first succeeded as recently as 1978 by Dr. Edwards ( an embryologist) and Dr. Steptoe ( a gynecologist) in England. Since then the technology has been further refined and developed by physicians and embryologists, with over 20,000 babies born worldwide.
  7. 7. METHODOLOGY OF IVF The ivf broadly involves the fowllowig stages:-1. Ovarian stimulation and monitoring2. Egg (oocyte) retrieval3. Fertilization4. Intracytoplasmic Sperm Injection5. Embryo transfer
  8. 8. STAGE 1: OVARIAN STIMULATION ANDMONITORING Ovarian stimulation is used to produce multiple mature follicles, rather than the single egg normally developed each month.
  9. 9. STAGE 2: EGG RETRIEVAL Egg recovery is accomplished by a transvaginal procedure, which can be performed under light sedation or local anesthesia.
  10. 10. NORMAL EGG ABNORMAL EGG
  11. 11. STAGE 3: FERTILIZATION Once mature eggs have been retrieved, the sperm and eggs are placed together in the laboratory and incubated in a meticulously prepared culture medium at a temperature identical to that of the woman’s body.
  12. 12. STAGE 4: INTRACYTOPLASMIC SPERMINJECTION During the process of ICSI, an embryologist isolates a sperm cell, draws it up into a microscopic needle and injects it inside an egg using a high power microscope.
  13. 13. STAGE 5: EMBRYO TRANSFER Embryo transfer is not a painful procedure and can be performed without sedation. Usually up to three embryos are placed together in a catheter ( a tubular instrument) and transferred, via the
  14. 14. SUCCESS RATE OF IVF Varies from programme to programme. It is dependent upon correct diagnosis of patient, and age. Pregnancy rate is in the range of 25-30% per oocyte retrieval. The take home is about 15-20% per procedure.
  15. 15. FACTORS Increased risk of abortion. Multiple pregnancy. Ectopic pregnancy. Low birth weigh baby. Premature delivery.
  16. 16. LIMITATION OF IVF Genetic defect in oocytes. Genetic defect in fertilizing sperm. Environmental mutagenesis. Inadequate supply of nutrients and hormones. Exposure to toxic agents and free radicals.
  17. 17. WORLDS FIRST TEST TUBE BABY
  18. 18. REFERENCES
  19. 19. ANY QUESTION
  20. 20. THANK YOU

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